Abstract:
OBJECTIVE:Although neurodevelopmental outcomes related to the management of patent ductus arteriosus with intravenous indomethacin and ibuprofen are known, little data on the long-term effects of oral ibuprofen can be found in the literature. METHOD:A follow-up study of 99 infants with birth weight ≤ 1,500 g and gestational age ≤ 32 weeks who received either oral or intravenous ibuprofen for patent ductus arteriosus was conducted to assess at 18 to 24 months (corrected age), abnormal neurological, neurosensory, and cognitive impairment were defined as follows:neurological outcomes included moderate/severe cerebral palsy, neurosensory outcomes included bilateral hearing loss and blindness in either eye, and cognitive impairment included mental developmental index score < 70. RESULTS:The 18- to 24-month (corrected age) long-term outcomes of 30 subjects who received oral ibuprofen were compared with 27 subjects who received intravenous ibuprofen by certified and experienced examiners who were blind to the definitions of the groups. The results revealed that the long-term outcomes of the treatment regimens did not significantly differ. CONCLUSIONS:Preterm infants who were treated with oral ibuprofen for patent ductus arteriosus had similar neurological, neurosensory, and cognitive outcomes to patients who received intravenous ibuprofen at 2 years of age.
journal_name
Am J Perinatoljournal_title
American journal of perinatologyauthors
Eras Z,Gokmen T,Erdeve O,Ozyurt BM,Saridas B,Dilmen Udoi
10.1055/s-0033-1333667subject
Has Abstractpub_date
2013-11-01 00:00:00pages
857-62issue
10eissn
0735-1631issn
1098-8785journal_volume
30pub_type
杂志文章,随机对照试验abstract::Infant respiratory distress syndrome (IRDS) can lead to impaired alveolarization and dysmorphic vascularization of bronchopulmonary dysplasia. Clara cell secretory protein (CC10) has anti-inflammatory properties but is deficient in the premature infant. Because surfactant and vascular endothelial growth factor (VEGF) ...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0028-1090587
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abstract::Neonatal intussusception in premature infants is uncommon and may mimic other abdominal disorders. We present a case of intussusception in a very low birthweight neonate. Presenting signs initially suggested necrotizing enterocolitis and meconium disease, and the diagnosis was confirmed at laparotomy. ...
journal_title:American journal of perinatology
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abstract::Managing preterm rupture of membranes (PPROM) is a balance between benefits of prolonging gestation and the risks of perinatal infection. This study evaluates a real-time polymerase chain reaction (PCR) for the detection of amniotic fluid infection and neonatal complications by amniocentesis following PPROM. A total o...
journal_title:American journal of perinatology
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journal_title:American journal of perinatology
pub_type: 杂志文章
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journal_title:American journal of perinatology
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doi:10.1055/s-0033-1352485
更新日期:2014-05-01 00:00:00
abstract:OBJECTIVE: This article determines the tolerance of neonatal intensive care unit (NICU)-based administration of RV5 in premature infants. This article also aims to compare the rate of clinically significant adverse events after RV5 immunization to the standard 2-month shot series and to historical controls who were not...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0039-1698455
更新日期:2019-11-18 00:00:00
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journal_title:American journal of perinatology
pub_type: 临床试验,杂志文章
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更新日期:1993-07-01 00:00:00
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journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-999271
更新日期:1992-09-01 00:00:00
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journal_title:American journal of perinatology
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journal_title:American journal of perinatology
pub_type: 杂志文章
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更新日期:1987-07-01 00:00:00
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journal_title:American journal of perinatology
pub_type: 杂志文章,随机对照试验
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更新日期:2009-10-01 00:00:00
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journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0036-1581079
更新日期:2016-07-01 00:00:00
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journal_title:American journal of perinatology
pub_type: 杂志文章
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journal_title:American journal of perinatology
pub_type: 杂志文章
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更新日期:2018-11-01 00:00:00
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journal_title:American journal of perinatology
pub_type: 杂志文章
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更新日期:2020-07-03 00:00:00
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journal_title:American journal of perinatology
pub_type: 杂志文章
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更新日期:1994-05-01 00:00:00
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journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0039-1679914
更新日期:2019-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:2015-02-01 00:00:00
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journal_title:American journal of perinatology
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:American journal of perinatology
pub_type: 临床试验,杂志文章
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journal_title:American journal of perinatology
pub_type: 杂志文章,多中心研究
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journal_title:American journal of perinatology
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更新日期:2012-08-01 00:00:00
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journal_title:American journal of perinatology
pub_type: 杂志文章
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更新日期:2004-01-01 00:00:00
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journal_title:American journal of perinatology
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journal_title:American journal of perinatology
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