A Genome-Wide Analysis of Clinical Chorioamnionitis among Preterm Infants.

Abstract:

OBJECTIVE:To identify single nucleotide polymorphisms (SNPs) associated with clinical chorioamnionitis among preterm infants. STUDY DESIGN:We reanalyzed a genome-wide association study (GWAS) from preterm newborns at less than 30 weeks' gestation. Cases and control definitions were determined using administrative records. There were 213 clinical chorioamnionitis cases and 707 clinically uninfected controls. We compared demographic and clinical outcomes of cases and controls. We performed a GWAS and compared the distribution of SNPs from the background genes and from the immunome genes. We used a Wilcoxon's rank-sum test to compare the SNPs normalized odds ratio and used odds ratios and p-values to determine candidate genes. RESULTS:Infants affected by clinical chorioamnionitis were more likely to have periventricular leukomalacia, high-grade retinopathy, and high-grade intraventricular hemorrhage (IVH). Although a GWAS did not identify SNPs associated with clinical chorioamnionitis at the genome-wide significance level, a direct test on the exonic variants in the human immunome revealed their significant increase of risk in clinical chorioamnionitis. CONCLUSION:Among very preterm infants, clinical chorioamnionitis was associated with periventricular leukomalacia, high-grade retinopathy, and IVH. Our analysis of variants in the human immunome indicates an association with clinical chorioamnionitis in very preterm pregnancies.

journal_name

Am J Perinatol

authors

Spiegel AM,Li J,Oehlert JW,Mayo JA,Quaintance CC,Girsen AI,Druzin ML,El-Sayed YY,Shaw GM,Stevenson DK,Gibbs RS

doi

10.1055/s-0038-1677503

subject

Has Abstract

pub_date

2019-12-01 00:00:00

pages

1453-1458

issue

14

eissn

0735-1631

issn

1098-8785

journal_volume

36

pub_type

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