Abstract:
:Aim To determine the challenges, if any, in translating the benefits of surfactant replacement therapy (SRT) to a resource-limited setting. Method This was a retrospective descriptive study comparing the outcome of 75 cases who received surfactant and 69 controls who did not at the University Hospital of the West Indies during the period 2001 to 2011. Descriptive analyses were performed. Statistical significance was taken at the level p < 0.05. Results Only 13% of neonates with respiratory distress syndrome received surfactant therapy. The median time of surfactant administration was 16.5 hours (interquartile range: 6-37 hours). The mean ± standard deviation time between repeat doses was 19.1 ± 14 hours. There was no difference in mortality between cases (67%) and controls (59%) (p = 0.32). However, the cases who survived were less mature (28.3 ± 2 weeks) and less clinically stable (CRIB II [Clinical Risk Index for Babies] score: 8.2 ± 3) than their controls who survived (30.0 ± 2 weeks; CRIB II score: 6.0 ± 3) (p = 0.01). There was no difference in mean gestational age or CRIB II scores between nonsurviving cases and controls. A high incidence of sepsis, pneumothoraces, and pulmonary hemorrhage was noted in both cases and controls. Conclusion SRT did not improve the overall outcome in preterm neonates treated with RDS. Challenges encountered in optimizing SRT included affordability and accessibility of surfactant, supportive equipment, and supportive therapies, as well as a high incidence of complications related to prematurity.
journal_name
Am J Perinatoljournal_title
American journal of perinatologyauthors
Hamilton N,Trotman Hdoi
10.1055/s-0036-1598023subject
Has Abstractpub_date
2017-07-01 00:00:00pages
742-748issue
8eissn
0735-1631issn
1098-8785journal_volume
34pub_type
杂志文章abstract::Objective To compare maternal birth complications early versus late in the academic year and to evaluate the impact of resident work hour limitation on the "July effect." Study Design We conducted a retrospective, population-based cohort study of 628,414 singleton births in Washington State from 1987 to 2012 measuring...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0037-1598244
更新日期:2017-07-01 00:00:00
abstract:PURPOSE:We hypothesized that surgical energy could be used to create hysterotomies in open fetal surgery. STUDY DESIGN:Initial studies compared the LigaSure Impact and Harmonic ACE + 7 Shears in the efficiency of hysterotomy and thermal damage. Pregnant ewes at an estimated gestational age (EGA) of 116 to 120 days (te...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0038-1673664
更新日期:2019-06-01 00:00:00
abstract::Brucellosis represents a rare cause of neonatal infection. In this article we report a very unusual case of congenital infection due to BRUCELLA MELITENSIS in a term neonate presenting after birth with severe respiratory distress and radiological manifestations (lobar consolidation and diffuse interstitial infiltratio...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-984407
更新日期:2007-08-01 00:00:00
abstract::Our objective was to describe the change in the level of troponin I in patients who undergo a vaginal or cesarean delivery. We obtained troponin I levels on admission and 1 hour after delivery in women undergoing vaginal and cesarean deliveries. Exclusion criteria included <37 weeks' gestation, a history of cardiac di...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2004-820507
更新日期:2004-01-01 00:00:00
abstract::Objective The objective of this study was to study the temporal profile of pulmonary hypertension (PH) in preterm infants. Study Design Infants < 28 weeks were screened for early PH at 10 to 14 days of life. Infants with early PH (n = 10) and gestationally matched controls (n = 18) underwent serial echocardiography ev...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0036-1581079
更新日期:2016-07-01 00:00:00
abstract::We present an unusual complication of midtrimester genetic amniocentesis of a monochorionic twin gestation in which prolonged fetal bradycardia of 60 to 80 beats per minute sustained over two hours was associated with multiple subsequent fetal anomalies. These included: microcephaly, bilateral closed-lip schizencephal...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-994354
更新日期:1996-08-01 00:00:00
abstract:OBJECTIVE:The aim of the article is to review the effectiveness of neonatal noninvasive high-frequency ventilation (NIHFV) in preventing endotracheal mechanical ventilation. STUDY DESIGN:Retrospective case series including all 79 instances of NIHFV use at four participating centers between July 2010 and September 2012...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0034-1381317
更新日期:2015-02-01 00:00:00
abstract::The objective of this paper is to evaluate the efficacy of various magnetic resonance imaging (MRI) sequences and the general usefulness of prenatal MRI in determining the position of the fetal liver and visualizing lung tissue in fetuses who have congenital diaphragmatic hernia (CDH). This was a retrospective review ...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-1999-6821
更新日期:1999-01-01 00:00:00
abstract::Tuberous sclerosis complex (TSC) is an autosomal-dominant phakomatosis that can result in cardiac and central nervous system lesions and may adversely impact fetal and maternal health. We report a case of a 19-year-old primagravida with TSC whose pregnancy was complicated by preeclampsia, preterm labor, and fetal demi...
journal_title:American journal of perinatology
pub_type: 杂志文章,评审
doi:10.1055/s-2005-861572
更新日期:2005-02-01 00:00:00
abstract:BACKGROUND:Neonatal presentation of vein of Galen aneurysmal malformations (VGAMs) complicated by cardiac failure and pulmonary hypertension is frequently associated with a poor prognosis. Interventional neuroradiology with embolization can offer a chance for survival, although neurological damage can represent a limit...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0038-1666813
更新日期:2019-01-01 00:00:00
abstract::This is the first reported case in which a Logothetopulos pack was utilized to achieve pelvic hemostasis in a patient requiring a cesarean hysterectomy for placenta accreta with postpartum hemorrhage. The Logothetopulos pack is an easily constructed gauze tamponade method that proved to be life-saving in this case. ...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-999514
更新日期:1990-10-01 00:00:00
abstract:OBJECTIVE: The purpose of this study was to compare the nulliparous-term-singleton-vertex (NTSV) and the Society of Maternal-Fetal Medicine (SMFM) cesarean birth metrics as tools for quality improvement efforts based on hospital size. MATERIALS AND METHODS: Cesarean birth rates from 275 hospitals from six states were ...
journal_title:American journal of perinatology
pub_type: 杂志文章,多中心研究
doi:10.1055/s-0037-1607985
更新日期:2018-03-01 00:00:00
abstract:OBJECTIVE:The Misgav-Ladach technique is recommended worldwide to perform cesarean sections but there is no consensus about the appropriate technique to use in patients with previous cesarean sections. This study evaluated the feasibility of the Misgav-Ladach technique in patients with previous cesarean sections. STUD...
journal_title:American journal of perinatology
pub_type: 临床试验,杂志文章
doi:10.1055/s-0032-1323580
更新日期:2013-03-01 00:00:00
abstract::The objective of this article is to prospectively investigate the efficacy of amnioinfusion as a means to reduce febrile morbidity in pregnancies complicated by chorioamnionitis. All laboring patients with a temperature > or =100.1 degrees F were approached for study participation. Exclusion criteria included amnionit...
journal_title:American journal of perinatology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1055/s-2007-994085
更新日期:1998-01-01 00:00:00
abstract:INTRODUCTION:Many tertiary neonatal units employ a restricted visiting policy. Webcams have previously been implemented in the neonatal unit setting in several countries. OBJECTIVES:This study aims to determine the views from parents, physicians, and nursing staff before implementation of a webcam system. METHODS:A q...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0034-1376388
更新日期:2015-02-01 00:00:00
abstract::While treatment of respiratory distress syndrome (RDS) with surfactant in premature neonates is well established, evidence for its use in non-RDS conditions, especially in the term neonate, has been less abundant. The last published review on a PubMed search was in 2001. In this review, we comprehensively and critical...
journal_title:American journal of perinatology
pub_type: 杂志文章,评审
doi:10.1055/s-0035-1556883
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:Buprenorphine (BUP) is commonly used for opioid maintenance therapy in pregnancy. Our goal was to determine whether liver dysfunction related to hepatitis C virus (HCV) infection impacts BUP dosing requirements in pregnancy. STUDY DESIGN:This was a retrospective cohort study of pregnant women with antenatal ...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0039-1698838
更新日期:2020-01-01 00:00:00
abstract:: ...
journal_title:American journal of perinatology
pub_type: 社论
doi:10.1055/s-0038-1676585
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVE: This study aimed to assess risk for fetal acidemia, low Apgar scores, and hypoxic ischemic encephalopathy based on decision-to-incision time interval in the setting of emergency cesarean delivery. STUDY DESIGN: This unplanned secondary analysis of the Maternal-Fetal Medicine Units prospective observational ...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0040-1717068
更新日期:2020-09-21 00:00:00
abstract:OBJECTIVE:The aim of this study was to evaluate the association between neonatal seizure and neurodevelopmental impairment (NDI) at 18 to 24 months in extremely preterm neonates. The association between anticonvulsants use and NDI was also assessed. STUDY DESIGN:In this retrospective cohort study of infants born at <2...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0038-1667107
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVE: The objective of this study was to compare national guidelines on the prevention of RhD alloimmunization. STUDY DESIGN: We performed a review of four national guidelines on prevention of alloimmunization from the American Congress of Obstetricians and Gynecologists, Royal College of Obstetricians and Gynaec...
journal_title:American journal of perinatology
pub_type: 杂志文章,评审
doi:10.1055/s-0037-1606609
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVES:The purpose of this article is to review all randomized control trials (RCTs) that have looked at the health effects of yoga on pregnancy, and to present their evidence on the specific ways in which pregnant women, and their infants can benefit from yoga intervention. The purpose is also to determine whether...
journal_title:American journal of perinatology
pub_type: 杂志文章,评审
doi:10.1055/s-0034-1396701
更新日期:2015-05-01 00:00:00
abstract::Presented are three cases of fetal death, all of which occurred within 3 days of a normal biophysical profile. Despite the excellent record of this antepartum test in predicting fetal well-being, there is a low incidence of false-negative tests; increasing the frequency of testing will not prevent all false-negative t...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-999352
更新日期:1991-03-01 00:00:00
abstract:OBJECTIVE:To investigate the effect of pretreatment with obestatin (OB), an endogenous hormone also found in mother's milk, in experimental necrotizing enterocolitis (NEC). STUDY DESIGN:Pups were randomized into four groups: control, OB-control, NEC, and OB-NEC. NEC was induced by asphyxia and hypothermia in the NEC a...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0038-1676491
更新日期:2019-09-01 00:00:00
abstract::A fiber-enriched diabetic diet that contained a modest increase in dietary fiber and a commercially available fiber supplement was studied in pregnant diabetic women for its potential glucose-lowering effects. Noninsulin-requiring gestational diabetic patients were placed on a fiber-enriched diet of increasing fiber c...
journal_title:American journal of perinatology
pub_type: 临床试验,杂志文章
doi:10.1055/s-2007-994738
更新日期:1993-07-01 00:00:00
abstract::The most frequently used set of gestational age-birth weight curves in the United States is the Colorado (C) standard published in 1963. To investigate the usefulness of this standard in an urban population at sea level, we examined the birth weight vs gestational age data from 56,675 singleton liveborn infants born b...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-999785
更新日期:1987-07-01 00:00:00
abstract:OBJECTIVE: Potentially avoidable maternity complications (PAMCs) have been validated as an indicator of access to quality prenatal care. African-American mothers have exhibited a higher incidence of PAMCs, which has been attributed to unequal health coverage. The objective of this study was to assess if racial disparit...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0040-1701195
更新日期:2020-01-27 00:00:00
abstract:OBJECTIVE:Preterm infants are at risk of encountering oral feeding difficulties which impede on the transition to independent oral feeds. The objective of this study was to identify a pivotal period where regressions are most likely to occur during their oral feeding progression. STUDY DESIGN:This is a retrospective s...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0038-1669947
更新日期:2019-04-01 00:00:00
abstract:OBJECTIVE:To examine the change in body mass index (BMI) categories between pregnancies and its effect on adverse pregnancy outcomes. STUDY DESIGN:We performed a retrospective cohort study of women with two consecutive deliveries from 2005 to 2010. Analysis was limited to women with BMI recorded at <24 weeks for both ...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0038-1670634
更新日期:2019-04-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to evaluate obstetric outcomes in relation to the extent of donor sperm exposure with and without egg donation. MATERIALS AND METHODS:This is a retrospective cohort study in a single tertiary care center. All women with a singleton pregnancy who conceived following sperm donation (S...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0038-1667029
更新日期:2019-01-01 00:00:00