Abstract:
:The pregnant woman with idiopathic thrombocytopenic purpura (ITP) and her fetus-neonate present a number of challenging issues for both the perinatologist and neonatologist. A review of these issues within a single format is helpful because of the widely scattered nature of the pertinent information in the medical literature. Maternal ITP is described herein as chronic, idiopathic, immune thrombocytopenic purpura, and the multiple interactions between ITP and pregnancy are detailed. The chief effect of maternal ITP on the fetus-neonate is thrombocytopenia, which occurs in approximately 37% of infants born to mothers with ITP. Using available literature, the pathophysiology, natural course, and therapy for maternal ITP-induced neonatal thrombocytopenia are described. Because affected infants may be severely thrombocytopenic at birth and at risk for hemorrhagic symptoms secondary to the stress of vaginal delivery, cesarean section is advocated as the preferred route of delivery for mothers with ITP. This approach is controversial, however, principally because many cesarean sections are productive of unaffected or mildly affected neonates. The predelivery use of fetal blood sampling and the presence of maternal circulating (unbound) antiplatelet antibody in this setting may provide the perinatologist guidance as to the appropriate delivery route for the at-risk thrombocytopenic infant.
journal_name
Am J Perinatoljournal_title
American journal of perinatologyauthors
Beck Rdoi
10.1055/s-2007-1000014subject
Has Abstractpub_date
1984-04-01 00:00:00pages
251-8issue
3eissn
0735-1631issn
1098-8785journal_volume
1pub_type
杂志文章,评审abstract:OBJECTIVE:Prediction of gestational latency after placement of physical exam indicated cerclage (PEIC) is limited. Uterocervical angle (UCA) has been associated with spontaneous preterm delivery in the general population. Our objective was to examine whether UCA is associated with gestational latency in women with PEIC...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0037-1621734
更新日期:2018-07-01 00:00:00
abstract:OBJECTIVE: It is well established that women with a previous vaginal delivery have higher success rates in relation to vaginal birth after cesarean than those without. The aim of this study was to examine the effect of past mode of delivery on contractile parameters of human myometrium in vitro. STUDY DESIGN: Myometri...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0039-1694980
更新日期:2021-01-01 00:00:00
abstract::We report a case with spontaneous rupture of the renal pelvis during pregnancy. A 34-year-old Japanese woman was referred at 20 weeks' gestation because of sudden severe right flank pain. She had severe colic pain radiating to the right lower abdomen with percussion tenderness at the right costovertebral angle and was...
journal_title:American journal of perinatology
pub_type: 杂志文章,评审
doi:10.1055/s-2002-28489
更新日期:2002-05-01 00:00:00
abstract:PURPOSE:We hypothesized that surgical energy could be used to create hysterotomies in open fetal surgery. STUDY DESIGN:Initial studies compared the LigaSure Impact and Harmonic ACE + 7 Shears in the efficiency of hysterotomy and thermal damage. Pregnant ewes at an estimated gestational age (EGA) of 116 to 120 days (te...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0038-1673664
更新日期:2019-06-01 00:00:00
abstract:OBJECTIVE: In 2015, Neonatal Resuscitation Program (NRP) recommended laryngeal mask airway (LMA) as an alternative to the endotracheal tube (ETT) in situations where the provider is "unable to intubate and unable to ventilate." LMA insertion is being taught in the NRP routinely. However, endotracheal intubation is the ...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0040-1721379
更新日期:2020-11-29 00:00:00
abstract::Two cases of inadvertent third trimester amniocenteses occurring during attempted spinal tap and culdocentesis are presented. These hitherto undescribed occurrences stress potential complications of these invasive diagnostic procedures in the gravid woman. ...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-994618
更新日期:1993-11-01 00:00:00
abstract::The combination of multicystic kidney and crossed ectopia is very rare. In most of the affected children, diagnosis has been made postnatally by ultrasonographic examination to evaluate a palpated abdominal mass. We describe the third male newborn reported in the literature with a prenatally diagnosed crossed ectopic ...
journal_title:American journal of perinatology
pub_type: 杂志文章,评审
doi:10.1055/s-2007-994073
更新日期:1998-08-01 00:00:00
abstract::The aim of this study was to evaluate neutrophil chemotaxis and random migration in healthy newborn infants and septic neonates with similar gestational and postnatal age. Possible relationships between chemotactic activity, random migration, causative microorganisms, and clinical course of septic infants were also in...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2000-9507
更新日期:2000-01-01 00:00:00
abstract::It is well established that ultrasound measurement of femur length and biparietal diameter are comparably accurate estimators of gestational age when obtained in the first half of pregnancy. Both estimators, however, become less accurate later in pregnancy. The present study compares the relative accuracy of these est...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-999837
更新日期:1986-04-01 00:00:00
abstract::The manifestations of fetal varicella syndrome usually involve several organ systems, including skin, ocular, neurologic, gastrointestinal, and genitourinary. Although ocular anomalies have been reported to be as high as 68%, manifestations limited to the eyes is extremely rare. Herein we report the case of fetal vari...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-994493
更新日期:1995-09-01 00:00:00
abstract:OBJECTIVE:The aim of the study is to determine if umbilical cord serum concentrations of interleukin-6 (IL-6), C-reactive protein (CRP), and myeloperoxidase (MPO), in pregnancies at risk for preterm birth (PTB), are associated with neonatal morbidities and/or altered neurodevelopmental outcomes in the children. STUDY ...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0033-1359723
更新日期:2014-09-01 00:00:00
abstract::We present a case of congenital midgut volvulus detected by prenatal sonography and ultrafast magnetic resonance (MR) imaging. At 34 weeks of gestation, enlarged hyperechogenic loops without peristalsis was identified by sonographic examination. On ultrafast T2-weighted single-shot fast-spin echo MR imaging, enlarged ...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2001-18794
更新日期:2001-12-01 00:00:00
abstract:OBJECTIVE:Preterm infants are at risk of encountering oral feeding difficulties which impede on the transition to independent oral feeds. The objective of this study was to identify a pivotal period where regressions are most likely to occur during their oral feeding progression. STUDY DESIGN:This is a retrospective s...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0038-1669947
更新日期:2019-04-01 00:00:00
abstract::Cord blood gas determinations were made on arterial and venous blood from 78 babies weighing less than 2000 gm at birth, including 52 weighing 1500 gm or less. Correlations were made with Apgar scores and intrapartum events as well as with birthweight (BW) and gestational age (GA). Significant differences were seen be...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-999925
更新日期:1985-04-01 00:00:00
abstract::Rh disease has largely disappeared as a result of prophylaxis with anti-D. However, the cases that remain are more complicated with a combination of novel challenges with regard to in utero management with transfusion and its effects on the course of the neonate, both early and late. Thrombocytopenia in the neonate ca...
journal_title:American journal of perinatology
pub_type: 杂志文章,评审
doi:10.1055/s-2003-45392
更新日期:2003-11-01 00:00:00
abstract::The most frequently used set of gestational age-birth weight curves in the United States is the Colorado (C) standard published in 1963. To investigate the usefulness of this standard in an urban population at sea level, we examined the birth weight vs gestational age data from 56,675 singleton liveborn infants born b...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-999785
更新日期:1987-07-01 00:00:00
abstract::Two cases of fetal myocardial calcification confirmed postnatally are reported. In contrast to other reports, both infants survived with resolution of calcification by 6 and 12 months. Diagnostic investigations failed to confirm the presence of congenital infection. Both pregnancies were complicated by early cocaine u...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2008-1040740
更新日期:1994-05-01 00:00:00
abstract::Objective The objective of this study was to study the temporal profile of pulmonary hypertension (PH) in preterm infants. Study Design Infants < 28 weeks were screened for early PH at 10 to 14 days of life. Infants with early PH (n = 10) and gestationally matched controls (n = 18) underwent serial echocardiography ev...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0036-1581079
更新日期:2016-07-01 00:00:00
abstract:OBJECTIVE:Advances in neonatology have made possible the survival of neonates with lower gestational ages and birth weights. Nevertheless, findings remain of a sex difference in mortality for premature and low birth weight (LBW) neonates with male sex often associated with poorer outcome (the "male disadvantage"). Thro...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0037-1608876
更新日期:2018-07-01 00:00:00
abstract::The Advisory Committee on Immunization Practices of the Centers for Disease Control and Prevention recommends influenza vaccination for women who will be in the second or third trimester of pregnancy during the influenza season. We analyzed hospital admissions with principal diagnoses of influenza or pneumonia and inf...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2004-831888
更新日期:2004-08-01 00:00:00
abstract::Antihistamines are commonly used to treat nausea and vomiting of pregnancy (NVP). We re-analyzed the 24 primary studies cited in a 1997 meta-analysis that concluded antihistamine use for NVP was safe as they had been studied in more than 200,000 participating women and the pooled odds ratio for congenital malformation...
journal_title:American journal of perinatology
pub_type: 杂志文章,meta分析
doi:10.1055/s-0033-1358772
更新日期:2014-09-01 00:00:00
abstract::Caffeine is commonly used in the treatment of apnea of prematurity. The skin of preterm infants varies considerably in its level of maturity. To understand skin absorption in low birthweight infants (less than 1500 gm) with gestational age between 26 and 34 weeks, a group of 56 preterm babies was studied after percuta...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-999282
更新日期:1992-09-01 00:00:00
abstract::In insulin dependent diabetic (IDDM) gestations, fetal pulmonary maturity is delayed in the presence of suboptimal glycemic control. Serum glycosylated hemoglobin (HbA1c) provides a means of assessing glycemic control. We evaluated maternal HbA1c in IDDM pregnancies at term undergoing amniocentesis for lung maturity t...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-993868
更新日期:1999-01-01 00:00:00
abstract:OBJECTIVE:We sought to determine if maternal prepregnancy body mass index (BMI) is a risk factor for neonatal respiratory morbidity and to determine if increasing BMI decreased the efficacy of betamethasone (BMZ). STUDY DESIGN:This was a secondary analysis of the Antenatal Late Preterm Steroids trial, double-blind, ra...
journal_title:American journal of perinatology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1055/s-0039-1696644
更新日期:2020-03-01 00:00:00
abstract:BACKGROUND:Neonatal presentation of vein of Galen aneurysmal malformations (VGAMs) complicated by cardiac failure and pulmonary hypertension is frequently associated with a poor prognosis. Interventional neuroradiology with embolization can offer a chance for survival, although neurological damage can represent a limit...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0038-1666813
更新日期:2019-01-01 00:00:00
abstract::We investigated the correlation of fetal heart rate patterns and fetal acid-base findings with the occurrence of early periventricular/intraventricular hemorrhage and variants. Ninety-five consecutive singleton neonates with birthweights less than or equal to 2000 gm were investigated. One-third of them showed early p...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-999819
更新日期:1986-01-01 00:00:00
abstract::Disulfiram has been used effectively to deter alcohol consumption in patients with a history of alcohol abuse. Its use in reproductive age women has become increasingly common in recent years, intensifying the risk of fetal exposure. Nonspecific but significant abnormalities have been described in the infants of women...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-994688
更新日期:1993-01-01 00:00:00
abstract::We sought (1) to identify risk factors for meconium aspiration syndrome (MAS) among infants born to women whose labors were complicated by thick-consistency meconium-stained amniotic fluid (MSAF), and (2) to determine whether risk factors and infant prognosis differ according to the time of onset of respiratory distre...
journal_title:American journal of perinatology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1055/s-0029-1241740
更新日期:2010-04-01 00:00:00
abstract::Community-acquired pneumonia (CAP) is the leading cause of death in children < 5 years of age worldwide. It is also one of the most frequent infectious diseases in children, leading to large antibiotic use and hospitalization even in the industrialized countries. However, the optimal management of CAP in children is s...
journal_title:American journal of perinatology
pub_type: 杂志文章,评审
doi:10.1055/s-0039-1691801
更新日期:2019-07-01 00:00:00
abstract::Pregnant patients with severe acute respiratory syndrome coronavirus 2, the virus responsible for the clinical condition newly described in 2019 as coronavirus disease 2019 (COVID-19) and illness severity to warrant intensive care have a complex disease process that must involve multiple disciplines. Guidelines from v...
journal_title:American journal of perinatology
pub_type: 杂志文章,评审
doi:10.1055/s-0040-1713121
更新日期:2020-08-01 00:00:00