Abstract:
:The objective of this study was to identify the most efficient and cost-effective nebulizer device for delivery of albuterol aerosol as a bronchodilator in ventilated preterm infants. Bronchodilators are frequently used as part of the therapeutic regimen of ventilated preterm infants. This can be delivered by different types of nebulizers like the Jet or metered dose inhaler (MDI) spacer device. Fifty-three premature infants being ventilated for RDS (24 to 34 weeks of gestation) were studied just prior to extubation. Twenty-four of them received standard doses of albuterol aerosol via Jet nebulizer and 29 via MDI-spacer. Heart rate, respiratory rate, oxygen saturation, lung compliance, and airway resistance were monitored prior and 15 minutes after albuterol delivery. There were significant changes in the parameters studied between pre- and postnebulizer treatment. In both groups, there was a significant improvement in lung function as evidenced by 13-24% decreased airway resistance (RAWE) and 3-7% increased lung compliance (CDYN). There was also a beneficial clinical response as demonstrated by increased oxygen saturations. These findings suggest that both MDI-spacer and Jet nebulizer are equally effective in delivering the albuterol aerosol to the lower respiratory tract. Since a small dose of albuterol delivered via the MDI-spacer improved lung function as effectively as a higher dose via the Jet nebulizer, the MDI-spacer would be the preferred mode of aerosol administration, especially because it takes only 2 minutes to deliver it. Furthermore, it was also cost-effective as one MDI-spacer treatment costs 2 cents, while a Jet treatment costs 10 cents in our neonatal intensive care unit (NICU).
journal_name
Am J Perinatoljournal_title
American journal of perinatologyauthors
Khalaf MN,Hurley JF,Bhandari Vdoi
10.1055/s-2001-14526subject
Has Abstractpub_date
2001-05-01 00:00:00pages
169-74issue
3eissn
0735-1631issn
1098-8785journal_volume
18pub_type
临床试验,杂志文章,随机对照试验abstract::The purpose of this study was to examine the maternal risk factors associated with early onset Group B streptococcus (GBS) sepsis and determine the potential impact of intrapartum chemoprophylaxis using these risk factors. Using a computerized perinatal database, 26,525 deliveries over a five-year period (1989 to 1994...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-994433
更新日期:1996-11-01 00:00:00
abstract:OBJECTIVE:To review developmental outcomes of neonates with mild hypoxic-ischemic encephalopathy (HIE) treated with therapeutic hypothermia (TH). STUDY DESIGN:Neonates ≥35 weeks' gestation with mild HIE/TH (TH group, n = 30) were matched with healthy term-born infants (control group, n = 30) and reviewed for the prese...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0038-1676973
更新日期:2019-11-01 00:00:00
abstract:OBJECTIVE:This study aimed to examine whether labor before cesarean affects the risk of placenta accreta spectrum (PAS) disorders in a subsequent pregnancy. STUDY DESIGN:This is a secondary analysis of the Cesarean Registry, a prospective cohort study of women undergoing cesarean between 1999 and 2002. Women with one ...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0039-1685449
更新日期:2020-05-01 00:00:00
abstract:OBJECTIVE:To evaluate the role of first-trimester uterine artery Doppler in the prediction of recurrent preeclampsia (PE). METHODS:Uterine artery pulsatility index (UtPI) was measured at 11 to 13 weeks' gestation in 1,810 women with singleton pregnancies who had developed PE in a previous pregnancy. They were categori...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0033-1338172
更新日期:2014-02-01 00:00:00
abstract::Chorioamnionitis has generally been thought to be a contraindication to attempting a delayed interval delivery in a multiple gestation. We present a twin gestation in which a delay of 88 days between the birth of the two infants occurred. Chorioamnionitis observed immediately after the delivery of Twin A was successfu...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-993962
更新日期:1998-06-01 00:00:00
abstract::Mixoploidy is rare chromosomal disorder characterized by multiple cell lines, usually including triploidy, within tissues. Pregnancy outcome has generally been considered poor with congenital anomalies and developmental delay reported in postnatally diagnosed cases. We report on two cases of abnormal midtrimester ultr...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0030-1249361
更新日期:2010-09-01 00:00:00
abstract::Objective To compare maternal birth complications early versus late in the academic year and to evaluate the impact of resident work hour limitation on the "July effect." Study Design We conducted a retrospective, population-based cohort study of 628,414 singleton births in Washington State from 1987 to 2012 measuring...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0037-1598244
更新日期:2017-07-01 00:00:00
abstract::We compared short-term neonatal outcomes between premature infants with spontaneous preterm birth (s-PTB) and those delivered due to preeclampsia (PEC). Data were collected from women with singleton pregnancies admitted with spontaneous preterm labor (PTL) (2002 to 2005) and PEC (2005 to 2007). Patients delivering 24 ...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0029-1234036
更新日期:2010-02-01 00:00:00
abstract:OBJECTIVE:Our aim was to estimate the incidence of unintentional hysterotomy extension at the time of cesarean delivery and to identify associated risk factors and maternal morbidity. STUDY DESIGN:We conducted a secondary analysis of a randomized controlled trial evaluating chlorhexidine-alcohol versus iodine-alcohol ...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0038-1676112
更新日期:2019-08-01 00:00:00
abstract:OBJECTIVE:To evaluate the association between adequacy of prenatal care utilization and risk of fetal and neonatal mortality and adverse outcomes. METHODS:We conducted a population-based cohort study using the Center for Disease Control and Prevention's Linked Birth-Infant Death and Fetal Death data on all deliveries ...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0032-1316439
更新日期:2012-11-01 00:00:00
abstract:OBJECTIVE:To determine whether 17-α-hydroxyprogesterone caproate (17P) reduces the incidence of preterm birth in women with a history-indicated cerclage. STUDY DESIGN:Retrospective cohort study of women who received a cerclage for a prior preterm birth, analyzed based on exposure to 17P. The primary outcome variable w...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0032-1332799
更新日期:2013-10-01 00:00:00
abstract::I developed a single equation that simulated previously published growth charts for very low-birth-weight infants, using birth weight as the only variable. The intent of this study was to validate the equation using infants admitted to our neonatal intensive care unit (NICU) and to determine if this equation could be ...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-993914
更新日期:1998-02-01 00:00:00
abstract:OBJECTIVE:This study aims to determine if transabdominal (TA) cervical length may be used to rule out a short cervix on transvaginal (TV) ultrasound. STUDY DESIGN:We conducted a prospective cohort study of women undergoing routine anatomic survey at 17 to 23 weeks gestation. TA and TV cervical length measurements were...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0035-1566308
更新日期:2016-04-01 00:00:00
abstract::The manifestations of fetal varicella syndrome usually involve several organ systems, including skin, ocular, neurologic, gastrointestinal, and genitourinary. Although ocular anomalies have been reported to be as high as 68%, manifestations limited to the eyes is extremely rare. Herein we report the case of fetal vari...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-994493
更新日期:1995-09-01 00:00:00
abstract:OBJECTIVE:The aim of this study is to examine the hypothesis that prolonged rupture of membranes (PROM) is associated with increased cord blood erythropoietin (EPO) concentrations, proportional to the duration of ruptured membranes. STUDY DESIGN:This study is a prospective, cross-sectional, observational (nonintervent...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0034-1384643
更新日期:2015-03-01 00:00:00
abstract::Arteriovenous malformations of the Vein of Galen continue to present diagnostic and therapeutic challenges in the neonatal period. Approximately 40-50% of all malformations of the Vein of Galen present in the neonatal period, usually with congestive heart failure. These neonates represent the most severe cases and are...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2000-13456
更新日期:2000-01-01 00:00:00
abstract::We investigated body mass index (BMI) and weight gain among pregnant women (ages 14 to 25) and assessed the relationship of BMI and weight gain on birth outcomes. We performed a secondary analysis of 841 women enrolled in a randomized controlled trial receiving prenatal care in two university-affiliated clinics. Almos...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0028-1110088
更新日期:2009-05-01 00:00:00
abstract::The antioxidant enzyme paraoxonase 1 is a marker of oxidative stress and has been implicated in the pathogenesis of preeclampsia. Our objective was to determine if an association exists between low paraoxonase 1 activity at midgestation and the development of preeclampsia. We conducted a case-control study of 50 women...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0029-1236438
更新日期:2010-03-01 00:00:00
abstract::We compared lymphocyte subsets and cytokine responses to bacteria among term, preterm infants, and adults. Lymphocyte subset percentages in cord blood (22 preterm, 27 term neonates) and peripheral blood from 21 adults and cytokine/chemokine interleukin (IL)-6, IL-8, IL-10, IL-12, interferon gamma (IFN gamma) responses...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0029-1220788
更新日期:2009-10-01 00:00:00
abstract:OBJECTIVE:We assessed the utility of plasma B-type natriuretic peptide (BNP) in infants with persistent pulmonary hypertension of the newborn (PPHN) in the prediction of inhaled nitric oxide (iNO) requirement. METHODS:This prospective study involved neonates (gestational age ≥ 34 weeks) with PPHN and confirmatory echo...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0035-1548540
更新日期:2015-09-01 00:00:00
abstract:OBJECTIVE: This work aimed to study perinatal, maternal, and neonatal characteristics of birth tourism (BT) mother-baby dyads and the rate of neonatal intensive care unit (NICU) admissions of BT infants. STUDY DESIGN: Retrospective study at a regional perinatal center comparing BT mother-baby dyads to all dyads. BT in...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0040-1719117
更新日期:2020-11-09 00:00:00
abstract:OBJECTIVE: The aim of the study is to model amplitude-integrated electroencephalography (aEEG) utility to diagnose seizures in common clinical scenarios. STUDY DESIGN: Using reported neonatal seizure prevalence and aEEG sensitivities and specificities, likelihood ratios (LRs) and post-test probabilities were calculate...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0040-1721711
更新日期:2020-12-15 00:00:00
abstract:OBJECTIVE:We sought to determine if maternal prepregnancy body mass index (BMI) is a risk factor for neonatal respiratory morbidity and to determine if increasing BMI decreased the efficacy of betamethasone (BMZ). STUDY DESIGN:This was a secondary analysis of the Antenatal Late Preterm Steroids trial, double-blind, ra...
journal_title:American journal of perinatology
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2020-03-01 00:00:00
abstract::Meningitis is the major pathologic manifestation of Listeria monocytogenes in the United States. Despite the fact that this organism has a well-known predilection for individuals who are pregnant or immunocompromised, to date, maternal listeric meningitis remains an unreported entity in the English literature. The aut...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-1000029
更新日期:1984-07-01 00:00:00
abstract::Objective To assess the additive value of prenatal chromosomal microarray analysis (CMA) for all indications and the likelihood of detecting pathologic copy number variations (CNVs) based on specific indications. Methods A retrospective analysis was performed on amniocentesis and chorionic villi sampling results obtai...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0036-1586501
更新日期:2017-03-01 00:00:00
abstract:OBJECTIVE:To determine the accuracy of clinically estimated fetal weight (CEFW) in patients with gestational diabetes (GDM), pregestational diabetes (DM), and obesity. STUDY DESIGN:This is a retrospective analysis of Consortium of Safe Labor data. Subjects were classified into six groups: DM, DM and obese, GDM, GDM an...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0033-1334450
更新日期:2014-01-01 00:00:00
abstract::Our objective was to compare the incidence of recurrent spontaneous preterm delivery (SPTD) in patients with cervical cerclage treated with weekly 17 alpha-hydroxyprogesterone caproate (17P) injections versus daily outpatient nursing surveillance (ONS) without 17P. Included in this retrospective cohort study were sing...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2008-1064935
更新日期:2008-05-01 00:00:00
abstract:AIM:The main purpose of this article is to assess trends in cytomegalovirus (CMV) infection reported among infants in California neonatal intensive care units (NICUs) during 2005 to 2016. STUDY DESIGN:The California Perinatal Quality Care Collaborative collects data on all very low birth weight (VLBW, birth weight ≤ 1...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0039-1683958
更新日期:2020-01-01 00:00:00
abstract:AIMS:Detection and careful stratification of fetal heart rate (FHR) is extremely important in all pregnancies. The most lethal cardiac rhythm disturbances occur during apparently normal pregnancies where FHR and rhythm are regular and within normal or low-normal ranges. These hidden depolarization and repolarization ab...
journal_title:American journal of perinatology
pub_type: 杂志文章,评审
doi:10.1055/s-0034-1372430
更新日期:2014-08-01 00:00:00
abstract:OBJECTIVE:Buprenorphine (BUP) is commonly used for opioid maintenance therapy in pregnancy. Our goal was to determine whether liver dysfunction related to hepatitis C virus (HCV) infection impacts BUP dosing requirements in pregnancy. STUDY DESIGN:This was a retrospective cohort study of pregnant women with antenatal ...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0039-1698838
更新日期:2020-01-01 00:00:00