Abstract：
OBJECTIVE:To evaluate the role of first-trimester uterine artery Doppler in the prediction of recurrent preeclampsia (PE). METHODS:Uterine artery pulsatility index (UtPI) was measured at 11 to 13 weeks' gestation in 1,810 women with singleton pregnancies who had developed PE in a previous pregnancy. They were categorized into three subgroups according to UtPI multiple of median (MoM): < 1.0, 1.0 to 1.49, and ≥ 1.50 MoM. The rate of early onset PE (< 34 weeks), intermediate PE (34 to 36 weeks), late PE (≥ 37 weeks), perinatal death, and small-for-gestational-age outcome (SGA; below the 5th percentile) were compared between each subgroup. RESULTS:The median mean UtPI decreased with advancing crown-rump length (CRL) from 1.77 at CRL of 45 to 54 mm to 1.52 at CRL of 75 to 84 mm. UtPI < 1.0 MoM was associated with a low-risk of early PE (0.2%), intermediate PE (0.3%), perinatal death (0.3%), and SGA (3.3%). The risk for these complications increases with UtPI of 1.0 to 1.4 MoM or ≥ 1.5 MoM (early PE 2.8 and 14.3%, respectively, p < 0.001; intermediate PE 2.1 and 5.4%, p < 0.001; perinatal death 1.3 and 6.8%, p < 0.001; and SGA 8.0 and 20.9%, p < 0.001). CONCLUSION:In women with previous PE, first-trimester UtPI discriminates women at high and low risk for recurrence of PE and adverse pregnancy outcomes.
journal_name
Am J Perinatoljournal_title
American journal of perinatologyauthors
Demers S,Bujold E,Arenas E,Castro A,Nicolaides KHdoi
10.1055/s-0033-1338172subject
Has Abstractpub_date
2014-02-01 00:00:00pages
99-104issue
2eissn
0735-1631issn
1098-8785journal_volume
31pub_type
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journal_title：American journal of perinatology
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journal_title：American journal of perinatology
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journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-2007-994638
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pub_type： 杂志文章,多中心研究
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