Abstract：
OBJECTIVE:This study aims to evaluate vaginal microbiota differences by bacterial vaginosis (BV), birth timing, and race, and to estimate parameters to power future vaginal microbiome studies. METHODS:Previously, vaginal swabs were collected at 21 to 25 weeks (stored at -80°C), and vaginal smears evaluated for BV (Nugent criteria). In a blinded fashion, 40 samples were selected, creating 8 equal-sized groups stratified by race (black/white), BV (present/absent), and birth timing (preterm/term). Samples were thawed, DNA extracted, and prepared. Polymerase chain reaction (PCR) with primers targeting the 16S rDNA V4 region was used to prepare an amplicon library. PCR products were sequenced and analyzed using quantitative insight into microbial ecology; taxonomy was assigned using ribosomal database program classifier (threshold 0.8) against the modified Greengenes database. RESULTS:After quality control, 97,720 sequences (mean) per sample, single-end 250 base-reads, were analyzed. BV samples had greater microbiota diversity (p < 0.05)-with BVAB1, Prevotella, and unclassified genus, Bifidobacteriaceae family (all p < 0.001) more abundant; there was minimal content of Gardnerella or Mobiluncus. Microbiota did not differ by race or birth timing, but there was an association between certain microbial clusters and preterm birth (p = 0.07). To evaluate this difference, 159 patients per group are needed. CONCLUSIONS:There are differences in the vaginal microbiota between patients with and without BV. Larger studies should assess the relationship between microbiota composition and preterm birth.
journal_name
Am J Perinatoljournal_title
American journal of perinatologyauthors
Subramaniam A,Kumar R,Cliver SP,Zhi D,Szychowski JM,Abramovici A,Biggio JR,Lefkowitz EJ,Morrow C,Edwards RKdoi
10.1055/s-0035-1565919subject
Has Abstractpub_date
2016-03-01 00:00:00pages
401-8issue
4eissn
0735-1631issn
1098-8785journal_volume
33pub_type
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journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-2007-999592
更新日期：1989-07-01 00:00:00
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journal_title：American journal of perinatology
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doi：10.1055/s-2001-15504
更新日期：2001-06-01 00:00:00
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journal_title：American journal of perinatology
pub_type： 杂志文章,评审
doi：10.1055/s-2001-12940
更新日期：2001-01-01 00:00:00
abstract：OBJECTIVE:Our objective was to evaluate the efficacy of perioperative multimodal pain management in reducing opioid use after elective cesarean delivery (CD). STUDY DESIGN:A single-center, double-blinded, placebo-controlled randomized trial of women undergoing elective CD. Participants were allocated 1:1 to receive th...
journal_title：American journal of perinatology
pub_type： 杂志文章,随机对照试验
doi：10.1055/s-0039-1681096
更新日期：2019-09-01 00:00:00
abstract：:This case-controlled study reviewed 26 cases of uterine rupture at an academic medical center. Controls were selected in a 2:1 design by reviewing the immediate successful vaginal birth after cesarean delivery (VBAC) before and after each case of uterine rupture. At less than 2 hours before delivery or acute uterine r...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-2007-981433
更新日期：2007-05-01 00:00:00
abstract：:The objective of this study was to determine if the rate of preeclampsia is increased in triplet as compared to twin gestations. Fifty-three triplet pregnancies between 1986 and 1993 at The New York Hospital-Cornell Medical Center were reviewed. These were matched for maternal age, parity, and race to twin gestations ...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-2007-994140
更新日期：1997-05-01 00:00:00
abstract：:Objective To determine the association between birthweight extremes and risk of adverse neonatal and childhood outcomes following preterm premature rupture of membranes (PPROM). Study Design This is a secondary analysis of data from the Beneficial Effects of Antenatal Magnesium Sulfate Trial. Women with nonanomalous s...
journal_title：American journal of perinatology
pub_type： 杂志文章,多中心研究
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更新日期：2016-10-01 00:00:00
abstract：OBJECTIVE: This study aimed to determine whether outcomes differed between infants enrolled in the PREMOD2 trial and those otherwise eligible but not enrolled, and whether the use of waiver effected these differences. STUDY DESIGN: The multicenter PREMOD2 (PREmature infants receiving Milking Or Delayed cord clamping) ...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-0040-1719184
更新日期：2020-11-03 00:00:00
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journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-0034-1395483
更新日期：2015-07-01 00:00:00
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journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-2007-994533
更新日期：1994-01-01 00:00:00
abstract：:The findings of hyperechoic and enlarged fetal kidneys on routine antenatal ultrasonography is a non-specific finding that alerts the physician to a differential diagnosis of various genetic and non-genetic disorders, including fetal polycystic disease and Beckwith-Wiedeman syndrome. Detection of fetal or neonatal pol...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-2007-994309
更新日期：1996-04-01 00:00:00
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journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-0039-1693988
更新日期：2020-12-01 00:00:00
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journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-0034-1381317
更新日期：2015-02-01 00:00:00
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journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-2007-993918
更新日期：1998-03-01 00:00:00
abstract：:With more than 20,000 fetal deaths occurring annually in the United States, accurate epidemiological data concerning fetal death offer the potential to develop interventions aimed at saving a considerable number of fetuses. Currently, fetal death rates are determined by dividing the number of deaths by total births. T...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-2007-994589
更新日期：1994-07-01 00:00:00
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journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-0040-1716481
更新日期：2020-09-07 00:00:00
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journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-2007-999261
更新日期：1992-09-01 00:00:00
abstract：:We studied Stem cell factor (SCF) levels in 15 mother-newborn pairs, 15 healthy adult controls, and 16 newborn with bacterial sepsis. SCF levels were also determined in six newborns with sepsis before and after completion of treatment. SCF levels (pg/mL) were found to be 2141 +/- 529 in cord blood, 1385 +/- 314 in mot...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-2007-993970
更新日期：1998-07-01 00:00:00
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journal_title：American journal of perinatology
pub_type： 杂志文章,评审
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journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-2007-999375
更新日期：1991-05-01 00:00:00
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journal_title：American journal of perinatology
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doi：10.1055/s-0039-1694980
更新日期：2021-01-01 00:00:00
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journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-2007-999564
更新日期：1989-04-01 00:00:00
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journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-0032-1304819
更新日期：2012-06-01 00:00:00
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journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-0034-1370348
更新日期：2014-11-01 00:00:00
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journal_title：American journal of perinatology
pub_type： 杂志文章,随机对照试验
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更新日期：2019-07-01 00:00:00
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journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-2007-993903
更新日期：1998-02-01 00:00:00
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journal_title：American journal of perinatology
pub_type： 杂志文章,评审
doi：10.1055/s-2007-999616
更新日期：1989-07-01 00:00:00
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journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-0035-1565917
更新日期：2016-03-01 00:00:00
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journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-0039-1683958
更新日期：2020-01-01 00:00:00
abstract：:The aim of this study was to compare the pregnancy outcome and delivery complications in women 40 years or older (cases) to that of women 20 to 30 years old (controls). Over a 5-year period, 319 cases had a singleton delivery in our institution. These women were compared with 326 controls. Parity was significantly hig...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-2002-20175
更新日期：2002-01-01 00:00:00
