The Impact of Hepatitis C Virus Infection on Buprenorphine Dose in Pregnancy.

Abstract:

OBJECTIVE:Buprenorphine (BUP) is commonly used for opioid maintenance therapy in pregnancy. Our goal was to determine whether liver dysfunction related to hepatitis C virus (HCV) infection impacts BUP dosing requirements in pregnancy. STUDY DESIGN:This was a retrospective cohort study of pregnant women with antenatal exposure to BUP to compare dosing between individuals positive versus negative for HCV infection. Spearman correlation tests were used to assess the relationship between BUP dose and HCV status. RESULTS:HCV infection was present in 103 (39%) of the patients. Patients with HCV infection required lower dose increases of BUP throughout pregnancy (p = 0.02). HCV viral load was positively correlated with the liver enzymes aspartate transaminase (r = 0.30, p = 0.003) and alanine transaminase (r = 0.25, p = 0.01). There was a negative correlation between HCV viral load and BUP dose during the second trimester (r = -0.27, p = 0.01) and third trimester (r = -0.20, p = 0.04). CONCLUSION:Women with HCV infection required less of an increase in BUP dose throughout pregnancy compared with women without HCV infection. Severity of HCV infection, as measured by viral load and liver enzymes, was also associated with BUP dosing.

journal_name

Am J Perinatol

authors

McDowell ML,Tonismae TR,Slaven JE,Abernathy MP,Shanks AL,Benjamin TD,Quinney SK

doi

10.1055/s-0039-1698838

subject

Has Abstract

pub_date

2020-01-01 00:00:00

pages

73-78

issue

1

eissn

0735-1631

issn

1098-8785

journal_volume

37

pub_type

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