Abstract：
OBJECTIVE:To quantify the potential cost savings if azithromycin is substituted for erythromycin in women with preterm premature rupture of membranes (PPROM). STUDY DESIGN:Secondary analysis of a multicentered study investigating magnesium sulfate for the prevention of cerebral palsy in premature infants. All patients with PPROM who received antibiotics for prophylaxis were included in the analysis. The number of expected doses each patient would have received was calculated for erythromycin, multidose azithromycin, and single-dose azithromycin regimens accounting for latency from PPROM to delivery. The wholesale acquisition cost was used to calculate the expected cost of each regimen. RESULTS:There were 981 PPROM patients who received a penicillin class antibiotic and erythromycin. Patients would have received 7,528 intravenous doses and 10,194 oral doses of erythromycin at a combined cost of $357,169. In comparison, patients would have received 6,422 and 3,942 doses at a cost of $15,669 and $9,574 for the multidose and single-dose azithromycin regimens respectively, which represents a more than 95% cost reduction for either regimen compared with erythromycin. CONCLUSION:The use of azithromycin substituted for erythromycin in the standard antibiotic regimen of women with PPROM represents a potential for substantial cost reduction.
journal_name
Am J Perinatoljournal_title
American journal of perinatologyauthors
Finneran MM,Smith DD,Buhimschi CSdoi
10.1055/s-0038-1667369subject
Has Abstractpub_date
2019-01-01 00:00:00pages
105-110issue
1eissn
0735-1631issn
1098-8785journal_volume
36pub_type
杂志文章,多中心研究,随机对照试验abstract：:Chorioamnionitis contributes to neonatal and maternal morbidity and mortality. We aimed to evaluate of the impact of clinical and histological chorioamnionitis on mortality and morbidity of preterm infants. Maternal and neonatal data were collected in a retrospective cohort of preterm infants less than 30 weeks' gesta...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-0032-1321501
更新日期：2013-01-01 00:00:00
abstract：:The significance and management of prepartum bradycardia is not well established in prepartum fetal assessment. The incidence of prolonged bradycardia was 3.5% (45 per 1284), defined as a decrease of greater than or equal to 40 beats per minute of the fetal heart rate (FHR) below the baseline for at least 2 minutes. T...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-2007-999972
更新日期：1985-10-01 00:00:00
abstract：:Seven sociodemographic and behavioral factors that may explain the increased risk of preterm deliveries among black women were examined using data from a national sample of 5823 married mothers who responded to the 1980 National Natality Survey (NNS) Questionnaire. There was a twofold increase in the rate of preterm d...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-2007-999412
更新日期：1991-09-01 00:00:00
abstract：:We studied the effect of antenatal corticosteroids on the incidence of respiratory disorders in singleton neonates born between 34 and 36 weeks of gestation. Retrospective analysis was conducted of the incidence of respiratory distress syndrome (RDS) and other respiratory disorders (need for mechanical ventilation, co...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-2007-1022470
更新日期：2008-02-01 00:00:00
abstract：:Cord blood gas determinations were made on arterial and venous blood from 78 babies weighing less than 2000 gm at birth, including 52 weighing 1500 gm or less. Correlations were made with Apgar scores and intrapartum events as well as with birthweight (BW) and gestational age (GA). Significant differences were seen be...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-2007-999925
更新日期：1985-04-01 00:00:00
abstract：:Major akinesia with arthrogryposis and craniosynostosis at birth mimics irreversible disorders of the nervous system of pejorative outcome. In this context, the early detection of anti-acetylcholine fetal receptor antibodies in the mother may allow rapid diagnosis of transient neonatal myasthenia of favorable prognosi...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-2002-34468
更新日期：2002-08-01 00:00:00
abstract：OBJECTIVE:This article compares hemodynamic characteristics of neonates with hypoxic ischemic encephalopathy (HIE) receiving therapeutic hypothermia (TH) with normal versus abnormal brain magnetic resonance imaging (MRI). METHODS:Serial echocardiography (echo) was performed within 24 hours, after 48 to 72 hours of coo...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-0038-1629900
更新日期：2018-08-01 00:00:00
abstract：OBJECTIVE:This study aimed to evaluate temporal trends in opioid use disorder (OUD) during antepartum and postpartum hospitalizations. STUDY DESIGN:This repeated cross-sectional analysis analyzed data from the National (Nationwide) Inpatient Sample. Women aged 15 to 54 years admitted antepartum or postpartum were iden...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-0039-1694725
更新日期：2020-12-01 00:00:00
abstract：:The objective of this study is to review the safety and success of a trial of labor after cesarean in a group of patients managed by a solo practitioner in a rural community. This was a retrospective review of all deliveries performed over an 11-year period by a single practitioner in a rural community. Standard contr...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-2003-38317
更新日期：2003-02-01 00:00:00
abstract：OBJECTIVE: Transient tachypnoea of the newborn (TTN) is one of the most common causes of neonatal respiratory distress (RD) during the newborn period. Chest radiography (CXR) is commonly used to rule out the diagnosis, but TTN is often misdiagnosed as neonatal respiratory distress syndrome (NRDS) on the basis of CXR al...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-0040-1721134
更新日期：2020-11-26 00:00:00
abstract：:To study a possible relation between the use of postnatal glucocorticoids and the incidence and severity of retinopathy of prematurity (ROP), we conducted a retrospective study over a 4-year period that compared data of 161 preterm infants treated with hydrocortisone for bronchopulmonary dysplasia (BPD) with the data ...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-2000-13437
更新日期：2000-01-01 00:00:00
abstract：:Managing preterm rupture of membranes (PPROM) is a balance between benefits of prolonging gestation and the risks of perinatal infection. This study evaluates a real-time polymerase chain reaction (PCR) for the detection of amniotic fluid infection and neonatal complications by amniocentesis following PPROM. A total o...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-0030-1271212
更新日期：2011-08-01 00:00:00
abstract：OBJECTIVE:The aim of this article is to evaluate the accuracy, precision, and safety of transcutaneous carbon dioxide tension (TcPCO2) monitoring at different electrode temperatures in preterm infants in the early postnatal period. STUDY DESIGN:A total of 26 neonates with a median birth weight of 974 g (432-1,694 g) a...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-0033-1352485
更新日期：2014-05-01 00:00:00
abstract：:We examined the prevalence of cesarean delivery (CD) among women with morbid obesity and extreme morbid obesity. Using Kentucky birth certificate data, a cross-sectional analysis of nulliparous singleton gestations at term was performed. We examined the prevalence of CD by body mass index (BMI; in kg/m2) using the Nat...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-0031-1280852
更新日期：2011-10-01 00:00:00
abstract：OBJECTIVE:This study aims to identify risk factors for cesarean delivery (CD) surgical site infection (SSI). study design: Retrospective analysis of 2,739 CDs performed at the University of Pittsburgh in 2011. CD SSIs were defined using National Healthcare Safety Network (NHSN) criteria. Chi-square test and t-test were...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-0035-1563548
更新日期：2016-01-01 00:00:00
abstract：OBJECTIVE: This study aimed to review the feasibility of nasal high-frequency oscillatory ventilation (NHFOV) in preventing reintubation in preterm infants STUDY DESIGN: This is a retrospective cohort study of all premature newborn infants placed on NHFOV in a single-center neonatal intensive care unit. RESULTS: Twen...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-0040-1718738
更新日期：2020-10-19 00:00:00
abstract：:Although mother's milk is the optimal nutrition for preterm infants, the amount of protein, calcium, and phosphorus become inadequate for the growth of preterm infants, such that fortification is recommended when enteral feeding is established. Recently, intestinal obstruction due to calcium soap formation has been re...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-0031-1295659
更新日期：2012-04-01 00:00:00
abstract：:Diagnosis of fetal pulmonary hypoplasia could be of great benefit to the obstetrician in the management of those pregnancies complicated by prolonged preterm ruptured membranes. Ultrasonography and magnetic resonance imaging were employed for fetal diagnosis of pulmonary hypoplasia and we were unable to predict accura...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-2007-994689
更新日期：1993-01-01 00:00:00
abstract：:We report a case that presents clear evidence of an intrauterine infection of twin fetuses with an enterovirus. The mother had signs and symptoms of chorioamniotitis at 34 weeks' gestation. Coxsackie virus, group B type 1 (CVB1), was cultured from amniotic fluid obtained by transabdominal amniocentesis when the membra...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-2007-994407
更新日期：1995-03-01 00:00:00
abstract：:The objective of this article is to report obstetric outcomes of human immunodeficiency virus-1 (HIV-1)-serodiscordant couples who underwent in vitro fertilization and embryo transfer (IVF-ET) with intracytoplasmic sperm injection (ICSI) at a tertiary care center. We reviewed the outcomes of seronegative women after I...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-2003-42694
更新日期：2003-08-01 00:00:00
abstract：OBJECTIVE:To identify characteristics predictive of survival of patients with congenital diaphragmatic hernia (CDH). STUDY DESIGN:Retrospective analysis of clinical characteristics including severity of lung disease measured by oxygenation index (OI) associated with single-center survival in CDH patients (n = 81) from...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-0032-1304817
更新日期：2012-05-01 00:00:00
abstract：:The purpose of this study was to examine the maternal risk factors associated with early onset Group B streptococcus (GBS) sepsis and determine the potential impact of intrapartum chemoprophylaxis using these risk factors. Using a computerized perinatal database, 26,525 deliveries over a five-year period (1989 to 1994...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-2007-994433
更新日期：1996-11-01 00:00:00
abstract：OBJECTIVE:To analyze outcomes after second-stage labor beyond 3 hours and determine if prolonged second stages were intentional. STUDY DESIGN:Retrospective cohort analysis of maternal and neonatal outcomes in nulliparous women based on second-stage duration. Medical records were reviewed for management decisions in wo...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-0032-1314894
更新日期：2012-10-01 00:00:00
abstract：:Phosphatidylglycerol (PG) in amniotic fluid was quantitatively measured by thin-layer chromatography (TLC) in 941 amniotic fluid samples and related to the presence or absence of respiratory distress syndrome (RDS) in neonates born within 7 days of the amniocentesis. In 639 case tests with PG 1 nmol/ml or more of amni...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-2007-994666
更新日期：1992-01-01 00:00:00
abstract：AIMS:Detection and careful stratification of fetal heart rate (FHR) is extremely important in all pregnancies. The most lethal cardiac rhythm disturbances occur during apparently normal pregnancies where FHR and rhythm are regular and within normal or low-normal ranges. These hidden depolarization and repolarization ab...
journal_title：American journal of perinatology
pub_type： 杂志文章,评审
doi：10.1055/s-0034-1372430
更新日期：2014-08-01 00:00:00
abstract：OBJECTIVE: Women with placenta accreta spectrum (PAS) having an unplanned delivery may have worse outcome compared with women with a planned delivery. The primary objective of this study was to compare severe maternal morbidity among women with PAS who had a planned scheduled delivery versus an unplanned delivery. Seco...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-0040-1714676
更新日期：2020-07-23 00:00:00
abstract：OBJECTIVE:This article assesses the degree of variability in the current practice of skin antiseptics used in Canadian neonatal intensive care units (NICUs) and different experiences related to each antiseptic used. METHODS:An anonymous survey was distributed to a clinical representative of each of the 124 Canadian le...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-0038-1661406
更新日期：2019-01-01 00:00:00
abstract：:The Diabetes in Pregnancy Study Group of North America (DPSG-NA) was founded in 1997 in San Antonio, Texas, out of the recognition that the field of maternal-fetal medicine should support and conduct research to address the specialized needs of pregnant women with type 1, type 2, or gestational diabetes mellitus. Sinc...
journal_title：American journal of perinatology
pub_type： 历史文章,杂志文章
doi：10.1055/s-0036-1585082
更新日期：2016-11-01 00:00:00
abstract：:Surfactants have been routinely used since 1990 for the treatment of respiratory distress syndrome (RDS). The use of surfactant has coincided with a decrease in mortality in infants due to RDS. This review focuses on clinical aspects of surfactant use. New information, particularly effects of ventilatory styles on sur...
journal_title：American journal of perinatology
pub_type： 杂志文章,评审
doi：10.1055/s-2000-13445
更新日期：2000-01-01 00:00:00
abstract：OBJECTIVE:This study was aimed to evaluate the prevalence of sonographic markers for placenta accreta spectrum (PAS) in pregnancies at low-risk for PAS. STUDY DESIGN:Pregnant women at low-risk for PAS presenting for routine second trimester ultrasound who enrolled in the study were evaluated prospectively for sonograp...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-0038-1676488
更新日期：2019-07-01 00:00:00
