Abstract:
OBJECTIVE:This article compares hemodynamic characteristics of neonates with hypoxic ischemic encephalopathy (HIE) receiving therapeutic hypothermia (TH) with normal versus abnormal brain magnetic resonance imaging (MRI). METHODS:Serial echocardiography (echo) was performed within 24 hours, after 48 to 72 hours of cooling, within 24 hours of normothermia, and after starting feeds. Pulmonary hemodynamics, cardiac output, and ventricular function were evaluated. All neonates underwent brain MRI (day 4-5), per clinical standard of care. Clinical cardiovascular and echocardiography characteristics were compared between patients with normal versus abnormal MRI. Cardiovascular changes during TH and after rewarming were identified. RESULTS:Twenty neonates at median gestation and birth weight of 40 weeks (interquartile range [IQR]: 39, 41) and 3,410 g (IQR: 2,885, 4,093), respectively, were enrolled. Increased median left ventricular output (LVO) (106-159 mL/kg/min, p < 0.001) and reduced isovolumic relaxation time (IVRT) (48-42 ms, p < 0.001) were seen after rewarming. Echocardiography evidence of pulmonary hypertension (PH) was identified in five neonates. Eight neonates (40%) had brain injury identified on MRI (watershed [n = 4], basal ganglia [n = 4]); this subgroup were more likely to have echo evidence of PH at 24 hours. CONCLUSION:Longitudinal changes in cardiac output were noted in neonates with HIE during TH and rewarming. Echocardiography evidence of PH, however, was associated with abnormal MRI brain. The prognostic relevance of these physiologic changes requires more comprehensive delineation.
journal_name
Am J Perinatoljournal_title
American journal of perinatologyauthors
More KS,Sakhuja P,Giesinger RE,Ting JY,Keyzers M,Sheth JN,Lapointe A,Jain A,Moore AM,Miller SP,McNamara PJdoi
10.1055/s-0038-1629900subject
Has Abstractpub_date
2018-08-01 00:00:00pages
979-989issue
10eissn
0735-1631issn
1098-8785journal_volume
35pub_type
杂志文章abstract::Rh disease has largely disappeared as a result of prophylaxis with anti-D. However, the cases that remain are more complicated with a combination of novel challenges with regard to in utero management with transfusion and its effects on the course of the neonate, both early and late. Thrombocytopenia in the neonate ca...
journal_title:American journal of perinatology
pub_type: 杂志文章,评审
doi:10.1055/s-2003-45392
更新日期:2003-11-01 00:00:00
abstract::Cimetidine therapy used for the treatment of gastric bleeding due to tolazoline therapy in a newborn infant was temporally associated with episodes of severe hypoxemia. It appears likely that the histamine H2 receptor blocked by cimetidine obviated the pulmonary vasodilator effect of tolazoline therapy. ...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-994346
更新日期:1996-07-01 00:00:00
abstract:OBJECTIVE:To compare obstetric and neonatal outcomes between human immunodeficiency virus (HIV) positive (HIV+) and HIV negative (HIV-) women and to determine if racial disparities exist among pregnancies complicated by HIV infection. STUDY DESIGN:This was a retrospective analysis of data from the Consortium of Safe L...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0033-1354565
更新日期:2014-06-01 00:00:00
abstract::We sought to describe a case series and literature review of uterine rupture in the absence of a previous cesarean delivery. In addition to four cases in our institution, a search of the literature from 1994 to 2008 identified cases of uterine rupture unrelated to a prior cesarean. Uterine rupture in the absence of a ...
journal_title:American journal of perinatology
pub_type: 杂志文章,评审
doi:10.1055/s-0029-1223287
更新日期:2009-11-01 00:00:00
abstract:AIM:The main purpose of this article is to assess trends in cytomegalovirus (CMV) infection reported among infants in California neonatal intensive care units (NICUs) during 2005 to 2016. STUDY DESIGN:The California Perinatal Quality Care Collaborative collects data on all very low birth weight (VLBW, birth weight ≤ 1...
journal_title:American journal of perinatology
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journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0038-1675621
更新日期:2019-07-01 00:00:00
abstract::Diagnostic ultrasonography has given us the opportunity to diagnose several congenital malformations in utero. Skeletal dysplasias is a heterogeneous group of disorders of the skeleton. Although disorders of bone growth are often diagnosed in utero, it is usually a general diagnosis because the exact syndrome cannot b...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-994638
更新日期:1993-03-01 00:00:00
abstract::The most common mechanism of fetal tachycardia is orthodromic reciprocating tachycardia utilizing an accessory atrioventricular connection, however, data regarding accessory connection location in patients with fetal tachycardia is limited. To investigate the location of accessory connections in fetal tachycardia, pos...
journal_title:American journal of perinatology
pub_type: 临床试验,杂志文章
doi:10.1055/s-2003-40014
更新日期:2003-04-01 00:00:00
abstract::A case of congenital left-sided diaphragmatic hernia complicated by formation of gastropleural fistula and Candida tropicalis empyema is presented. The possibility of pleural fistula should be considered in any undiagnosed case of pleural effusion, pneumothorax, empyema, hemothorax, or hydropneumothorax. ...
journal_title:American journal of perinatology
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journal_title:American journal of perinatology
pub_type: 杂志文章,多中心研究
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更新日期:2015-10-01 00:00:00
abstract::Serial ultrasound measurements of the fetus under investigation is an important indicator of fetal growth, and thus fetal health. To assess how reliable those measurements are, a videotape was made, and, utilizing an ultrasound machine that allowed the placement of callipers on the videotape, the dispersion of the mea...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-999271
更新日期:1992-09-01 00:00:00
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journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0039-3400309
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE: Transient tachypnoea of the newborn (TTN) is one of the most common causes of neonatal respiratory distress (RD) during the newborn period. Chest radiography (CXR) is commonly used to rule out the diagnosis, but TTN is often misdiagnosed as neonatal respiratory distress syndrome (NRDS) on the basis of CXR al...
journal_title:American journal of perinatology
pub_type: 杂志文章
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更新日期:2020-11-26 00:00:00
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journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0040-1722328
更新日期:2021-01-04 00:00:00
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journal_title:American journal of perinatology
pub_type: 临床试验,杂志文章
doi:10.1055/s-2007-994738
更新日期:1993-07-01 00:00:00
abstract:BACKGROUND:Postnatal assessment of disease severity is critical for analysis of mortality rates and development of future interventions in congenital diaphragmatic hernia (CDH). OBJECTIVE:The objective of this study was to stratify the risk of mortality based on arterial Paco 2. METHODS:Retrospective analysis of infa...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0034-1368088
更新日期:2014-11-01 00:00:00
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journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0032-1321497
更新日期:2013-01-01 00:00:00
abstract::Two cases of inadvertent third trimester amniocenteses occurring during attempted spinal tap and culdocentesis are presented. These hitherto undescribed occurrences stress potential complications of these invasive diagnostic procedures in the gravid woman. ...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-994618
更新日期:1993-11-01 00:00:00
abstract::Anti-Cw is an uncommon cause of clinically significant hemolytic disease of the newborn (HDN). We report an unusually severe case of HDN due to anti-Cw that required phototherapy and exchange transfusion. We also describe a novel PCR-RFLP method for Cw typing of fetal genomic DNA that was used for prenatal diagnosis i...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-993872
更新日期:1999-01-01 00:00:00
abstract::This case-controlled study reviewed 26 cases of uterine rupture at an academic medical center. Controls were selected in a 2:1 design by reviewing the immediate successful vaginal birth after cesarean delivery (VBAC) before and after each case of uterine rupture. At less than 2 hours before delivery or acute uterine r...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-981433
更新日期:2007-05-01 00:00:00
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journal_title:American journal of perinatology
pub_type: 杂志文章
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更新日期:2009-05-01 00:00:00
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journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0038-1673651
更新日期:2019-05-01 00:00:00
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journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0034-1376388
更新日期:2015-02-01 00:00:00
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journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-993914
更新日期:1998-02-01 00:00:00
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journal_title:American journal of perinatology
pub_type: 杂志文章,随机对照试验
doi:10.1055/s-0031-1274509
更新日期:2011-05-01 00:00:00
abstract::Seven sociodemographic and behavioral factors that may explain the increased risk of preterm deliveries among black women were examined using data from a national sample of 5823 married mothers who responded to the 1980 National Natality Survey (NNS) Questionnaire. There was a twofold increase in the rate of preterm d...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-999412
更新日期:1991-09-01 00:00:00
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journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0032-1324701
更新日期:2013-05-01 00:00:00
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journal_title:American journal of perinatology
pub_type: 杂志文章,评审
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更新日期:2019-07-01 00:00:00
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journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-994064
更新日期:1998-01-01 00:00:00
abstract::The findings of hyperechoic and enlarged fetal kidneys on routine antenatal ultrasonography is a non-specific finding that alerts the physician to a differential diagnosis of various genetic and non-genetic disorders, including fetal polycystic disease and Beckwith-Wiedeman syndrome. Detection of fetal or neonatal pol...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-994309
更新日期:1996-04-01 00:00:00