The Acylcarnitine Profile in Dried Blood Spots is Affected by Hematocrit: A Study of Newborn Screening Samples in Very-Low-Birth-Weight Infants.


OBJECTIVE: The acylcarnitine profile is analyzed in dried blood spots (DBS) to screen for inborn errors of metabolism. Hematocrit (Ht) is known to affect the result of quantitative analyses of DBS samples; however, the effects of Ht on the acylcarnitine profiles in DBS have not been studied in actual samples from newborns. STUDY DESIGN: The acylcarnitine profiles in DBS for newborn screening tests and Ht levels of very-low-birth-weight infants were obtained from medical records. We investigated the relationship between Ht and each acylcarnitine using Pearson's correlation coefficient (r). RESULTS: We examined 77 newborns in this study. There was a significantly positive correlation between Ht and C0, C2, C12, C16, C18, C18:1, and C18:1-OH, respectively (p < 0.0025). The correlation was the greatest on C2 (r = 0.59). CONCLUSION: This study clarifies that Ht and C0, C2, C12, C16, C18, C18:1, and C18:1-OH are significantly correlated in DBS, which is consistent with previous studies. Hence, the effect of Ht should be considered when interpreting the results of acylcarnitine profiles in DBS. KEY POINTS:· Acylcarnitine profile in dried blood spots (DBS) is affected by the hematocrit (Ht) of the sample.. · There are positive correlations between Ht and C0, C2, C12, C16, C18, and C18:1-OH in DBS.. · We should be aware of the effects of Ht on acylcarnitine profiles in DBS..


Am J Perinatol


Haga M,Isobe M,Kawabata K,Shimizu M,Mochizuki H




Has Abstract


2020-12-29 00:00:00






  • Equation for predicting weight gain in very low-birth-weight infants.

    abstract::I developed a single equation that simulated previously published growth charts for very low-birth-weight infants, using birth weight as the only variable. The intent of this study was to validate the equation using infants admitted to our neonatal intensive care unit (NICU) and to determine if this equation could be ...

    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Meetze WH

    更新日期:1998-02-01 00:00:00

  • Noninvasive measurement of cardiac output in healthy preterm and term newborn infants.

    abstract::Although values for cardiac output in the newborn infant have been reported previously, the methods utilized have been invasive. To assess if cardiac output could be determined noninvasively in the neonate, we measured mean ascending aortic blood flow velocity (VAo) in well newborns using a portable 5MHz, range gated,...

    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Alverson DC,Eldridge MW,Johnson JD,Aldrich M,Angelus P,Berman W Jr

    更新日期:1984-01-01 00:00:00

  • Hypertrophic cardiomyopathy in infants of diabetic mothers: an update.

    abstract::Infants of diabetic mothers (IDMs) are at known risk for developing a hypertrophic type of cardiomyopathy. The severity of IDM cardiomyopathy can vary from an incidental finding on echocardiography to an infant with severe symptoms of congestive heart failure. The purpose of this article is to review the pathophysiolo...

    journal_title:American journal of perinatology

    pub_type: 杂志文章,评审


    authors: Reller MD,Kaplan S

    更新日期:1988-10-01 00:00:00

  • Meconium plugs and intussusception in a premature infant.

    abstract::Neonatal intussusception in premature infants is uncommon and may mimic other abdominal disorders. We present a case of intussusception in a very low birthweight neonate. Presenting signs initially suggested necrotizing enterocolitis and meconium disease, and the diagnosis was confirmed at laparotomy. ...

    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Glick B,Alpan G,Vinograd I,Udassin R,Mogle P,Eyal F

    更新日期:1985-04-01 00:00:00

  • The significance of antiphospholipid antibodies in pregnant women with chronic hypertension.

    abstract::The objective of this study was to perform antiphospholipid antibody screening in women with chronic hypertension to assess whether the presence of such antibodies is associated with adverse pregnancy outcome. Serum for anticardiolipin antibodies and lupus anticoagulant was obtained in pregnant women with chronic hype...

    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Zeeman GG,Alexander JM,McIntire DD,Leveno KJ

    更新日期:2004-07-01 00:00:00

  • The Impact of the New Hypertension Guidelines to Low-Dose Aspirin Prophylaxis Eligibility for the Prevention of Preeclampsia: A Cost-Benefit Analysis.

    abstract:OBJECTIVE: American College of Cardiology and American Heart Association (ACC/AHA) published new guidelines which lower the cut-off for hypertension. We sought to evaluate the impact of these guidelines to cost and benefit of various low-dose aspirin prophylaxis approaches. STUDY DESIGN: Decision tree analysis was cre...

    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Putra M,Balasooriya MM,Boscia AL,Dalkiran E,Sokol RJ

    更新日期:2019-10-11 00:00:00

  • Effective prenatal care decreases the incidence of low birthweight.

    abstract::In Finland a nationwide free prenatal care system was mandated by law in 1944. At present, 99.9% of Finland's pregnant women use it. The primary aim is to provide advice and care to all women in local centers and to identify pregnant women exhibiting risk factors and refer them to specialized prenatal units located in...

    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Hakala TH,Ylikorkala O

    更新日期:1989-04-01 00:00:00

  • Fetal death after normal biophysical profile.

    abstract::Presented are three cases of fetal death, all of which occurred within 3 days of a normal biophysical profile. Despite the excellent record of this antepartum test in predicting fetal well-being, there is a low incidence of false-negative tests; increasing the frequency of testing will not prevent all false-negative t...

    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Watson WJ,Katz VL,Bowes WA Jr

    更新日期:1991-03-01 00:00:00

  • Altered mRNA expression pattern of placental epidermal growth factor receptor (EGFR) in pregnancies complicated by preeclampsia and/or intrauterine growth retardation.

    abstract::Placental pathology in preeclampsia (PE) and intrauterine growth retardation (IUGR) is associated with alterations of the placental epidermal growth factor receptor (EGFR). It is encoded by a single gene, which gives rise to two different full-length transcripts and one putative truncated transcript in the placenta. T...

    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Faxén M,Nasiell J,Blanck A,Nisell H,Lunell NO

    更新日期:1998-01-01 00:00:00

  • Does perinatal phenobarbital exposure affect developmental outcome at age 2?

    abstract::The objective of this paper is to determine if phenobarbital exposure during pregnancy affects developmental outcome at age 2 years. Between 1991 and 1994, 401 pregnant patients at risk for delivery prior to 34 weeks' gestation were invited to participate; 48 mothers declined entry. Before delivery, pharmacy randomize...

    journal_title:American journal of perinatology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Thorp JA,O'Connor M,Jones AM,Hoffman EL,Belden B

    更新日期:1999-01-01 00:00:00

  • Successful Treatment of Preterm Labor in Association with Acute COVID-19 Infection.

    abstract::Novel coronavirus disease 2019 (COVID-19) infection occurring during pregnancy is associated with an increased risk of preterm delivery. This case report describes successful treatment of preterm labor during acute COVID-19 infection. Standard treatment for preterm labor may allow patients with acute COVID-19 infectio...

    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Browne PC,Linfert JB,Perez-Jorge E

    更新日期:2020-06-01 00:00:00

  • Normal Cervical Effacement in Term Labor.

    abstract:OBJECTIVE:To estimate the natural history of cervical effacement in labor. STUDY DESIGN:This is a retrospective cohort study of term, vertex, singletons who reached 10 cm of cervical dilation from 2010 to 2014. Interval-censored regression was used to estimate the median number of hours between changes in effacement (...

    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Rhoades JS,Stout MJ,Woolfolk C,Tuuli MG,Macones GA,Cahill AG

    更新日期:2019-01-01 00:00:00

  • Association between Breast Milk and Bronchopulmonary Dysplasia: A Single Center Observational Study.

    abstract::Introduction Bronchopulmonary dysplasia (BPD) is a frequent, long-term complication in very low-birth-weight (VLBW) newborns. Its etiology is multifactorial and the oxidative stress is one of its main causes. Breast milk (BM) reduces oxidative stress and provides antioxidant protection, therefore, BM may have a protec...

    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Fonseca LT,Senna DC,Silveira RC,Procianoy RS

    更新日期:2017-02-01 00:00:00

  • Sonographic diagnosis of intrauterine growth retardation using the postnatal ponderal index and the crown-heel length as standards of diagnosis.

    abstract::One hundred twenty-one patients underwent an ultrasound examination within 48 hours of delivery to assess prospectively the reliability of the diagnosis of intrauterine growth retardation. Sonographic parameters examined included the abdominal circumference, sonographic estimate of fetal weight, the head to abdominal ...

    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Weiner CP,Robinson D

    更新日期:1989-10-01 00:00:00

  • Birth weight and gestational age standards based on regional perinatal network data: an analysis of risk factors.

    abstract::The most frequently used set of gestational age-birth weight curves in the United States is the Colorado (C) standard published in 1963. To investigate the usefulness of this standard in an urban population at sea level, we examined the birth weight vs gestational age data from 56,675 singleton liveborn infants born b...

    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Raju TN,Winegar A,Seifert L,Miller S

    更新日期:1987-07-01 00:00:00

  • The use of 17 alpha-hydroxyprogesterone caproate (17p) in women with cervical cerclage.

    abstract::Our objective was to compare the incidence of recurrent spontaneous preterm delivery (SPTD) in patients with cervical cerclage treated with weekly 17 alpha-hydroxyprogesterone caproate (17P) injections versus daily outpatient nursing surveillance (ONS) without 17P. Included in this retrospective cohort study were sing...

    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Rebarber A,Cleary-Goldman J,Istwan NB,Rhea DJ,Desch C,Russo-Stieglitz K,Saltzman DH

    更新日期:2008-05-01 00:00:00

  • Risk Factors and Maternal Morbidity Associated with Unintentional Hysterotomy Extension at the Time of Cesarean Delivery.

    abstract:OBJECTIVE:Our aim was to estimate the incidence of unintentional hysterotomy extension at the time of cesarean delivery and to identify associated risk factors and maternal morbidity. STUDY DESIGN:We conducted a secondary analysis of a randomized controlled trial evaluating chlorhexidine-alcohol versus iodine-alcohol ...

    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Bligard KH,Durst JK,Stout MJ,Martin S,Cahill AG,Macones GA,Tuuli MG

    更新日期:2019-08-01 00:00:00

  • Femur length versus biparietal diameter for estimating gestational age in the third trimester.

    abstract::It is well established that ultrasound measurement of femur length and biparietal diameter are comparably accurate estimators of gestational age when obtained in the first half of pregnancy. Both estimators, however, become less accurate later in pregnancy. The present study compares the relative accuracy of these est...

    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Egley CC,Seeds JW,Cefalo RC

    更新日期:1986-04-01 00:00:00

  • Necrotizing enterocolitis in a premature infant as the presenting symptom of familial dysautonomia in the neonatal period: case report and review of the literature.

    abstract::We present a case of a premature infant with early-onset necrotizing enterocolitis as the presenting symptom of familial dysautonomia. The diagnosis of familial dysautonomia in the neonatal period is usually rare and difficult, because many of the symptoms may be mild or nonspecific, whereas other characteristic signs...

    journal_title:American journal of perinatology

    pub_type: 杂志文章,评审


    authors: Barak S,Riskin A,Kugelman A,Abend-Weinger M,Chistyakov I,Bader D

    更新日期:2005-10-01 00:00:00

  • Glycemic Control and Pregnancy Outcomes in Women with Type 2 Diabetes Treated with Oral Hypoglycemic Agents.

    abstract::Objective There is limited data regarding the use of oral hypoglycemic agents (OHAs) in pregnant women with type 2 diabetes mellitus (T2DM). Study Design This was a retrospective cohort study of women with T2DM who were treated with OHA or insulin from the first trimester onward. Bivariate and multivariate logistic re...

    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Feghali MN,Caritis SN,Catov JM,Scifres CM

    更新日期:2017-06-01 00:00:00

  • Evaluating Fundal Dominant Contractions on Spatiotemporal Electrohysterography as a Marker for Effective Labor Contractions.

    abstract:OBJECTIVE:To evaluate if fundal (F) dominance of the electrohysterogram is associated with vaginal delivery and lack of F dominance is associated with cesarean for labor dystocia. STUDY DESIGN:We conducted a prospective cohort study of nulliparous women in spontaneous labor at ≥36 weeks. Clinicians were blinded to ele...

    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Edwards RK,Euliano NR,Singh S,LeDuke RC,Andrews WW,Jauk V,Subramaniam A,Szychowski JM

    更新日期:2019-07-01 00:00:00

  • Erratum to: A Double-Blind, Randomized, Placebo-Controlled Trial of 17 Alpha-hydroxyprogesterone Caproate in the Management of Preterm Premature Rupture of Membranes.

    abstract:: ...

    journal_title:American journal of perinatology

    pub_type: 杂志文章,已发布勘误


    authors: Langen ES,Sit A,Sherwin K,Lyell DJ,Blumenfeld YJ,El-Sayed YY

    更新日期:2018-07-01 00:00:00

  • Comparison of the Miller Laryngoscope and Videolaryngoscope for Tracheal Intubation by Novice Doctors during Neonatal Cardiopulmonary Resuscitation: A Randomized Crossover Simulation Trial.

    abstract:OBJECTIVE:Recent guidelines for neonatal cardiopulmonary resuscitation emphasize the importance of adequate ventilation. In cases of failed resuscitation with positive pressure ventilation, tracheal intubation and chest compressions are recommended. The present study compared the utility of the Miller laryngoscope (Mil...

    journal_title:American journal of perinatology

    pub_type: 杂志文章,随机对照试验


    authors: Komasawa N,Ueki R,Kaminoh Y,Nishi S

    更新日期:2015-07-01 00:00:00

  • The prognosis of Rh-affected pregnancies: an exception to the usual rule.

    abstract::A patient with a homozygous marital partner had three progressively less seriously involved RH-positive babies after a fetal demise due to erythroblastosis. Only the first of the three required fetal transfusions. All were Rh genotypically identical. The case is presented for interest and to illustrate an exception to...

    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Perkins RP

    更新日期:1988-01-01 00:00:00

  • Severe neutrophilia in an infant with persistent pulmonary hypertension of the newborn.

    abstract::We report the case of a term male infant with severe persistent pulmonary hypertension of the newborn, who developed massive neutrophilia of unknown etiology. An extensive evaluation failed to disclose an obvious cause for his neutrophilia. A bone marrow aspirate was performed and was consistent with a leukemoid react...

    journal_title:American journal of perinatology

    pub_type: 杂志文章,评审


    authors: Engmann C,Donn SM

    更新日期:2003-10-01 00:00:00

  • Using the Probability of Cesarean from a Validated Cesarean Prediction Calculator to Predict Labor Length and Morbidity.

    abstract:OBJECTIVE:To determine if increasing predicted risk of cesarean was associated with longer labor length and increased morbidity among women undergoing induction with an unfavorable cervix. STUDY DESIGN:Using a publically available database, we evaluated whether a previously validated prediction model for cesarean deli...

    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Hamm RF,Downes KL,Srinivas SK,Levine LD

    更新日期:2019-05-01 00:00:00

  • Are maternal serum troponin I levels affected by vaginal or cesarean delivery?

    abstract::Our objective was to describe the change in the level of troponin I in patients who undergo a vaginal or cesarean delivery. We obtained troponin I levels on admission and 1 hour after delivery in women undergoing vaginal and cesarean deliveries. Exclusion criteria included <37 weeks' gestation, a history of cardiac di...

    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Koscica KL,Bebbington M,Bernstein PS

    更新日期:2004-01-01 00:00:00

  • Role of Cord Blood Carboxyhemoglobin in Detecting Significant Hyperbilirubinemia in Term Neonates with ABO Alloimmunization.

    abstract:OBJECTIVE: This study aimed to assess whether cord blood carboxyhemoglobin (COHb) levels in jaundiced term neonates with and without a positive direct Coombs test (DCT) and in healthy controls could be used as a predictor of severe hyperbilirubinemia. The percentage of cord blood COHb should be higher among neonates wi...

    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Tıraş M,Can E,Hamilçıkan Ş

    更新日期:2021-01-04 00:00:00

  • Mixoploidy: perinatal diagnosis and pregnancy outcome.

    abstract::Mixoploidy is rare chromosomal disorder characterized by multiple cell lines, usually including triploidy, within tissues. Pregnancy outcome has generally been considered poor with congenital anomalies and developmental delay reported in postnatally diagnosed cases. We report on two cases of abnormal midtrimester ultr...

    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Jadhav AR,Dildy GA,Belfort MA,Lacassie Y,Carey JC

    更新日期:2010-09-01 00:00:00

  • A review of studies with chlorhexidine applied directly to the umbilical cord.

    abstract::Infection-related neonatal mortality due to omphalitis in developing country home births is an important public health problem. Three cluster randomized trials of 4% chlorhexidine applied to the umbilical cord stump from once to multiple times in the days following a home birth have evaluated this intervention compare...

    journal_title:American journal of perinatology

    pub_type: 杂志文章,评审


    authors: Goldenberg RL,McClure EM,Saleem S

    更新日期:2013-09-01 00:00:00