Abstract:
OBJECTIVE: The acylcarnitine profile is analyzed in dried blood spots (DBS) to screen for inborn errors of metabolism. Hematocrit (Ht) is known to affect the result of quantitative analyses of DBS samples; however, the effects of Ht on the acylcarnitine profiles in DBS have not been studied in actual samples from newborns. STUDY DESIGN: The acylcarnitine profiles in DBS for newborn screening tests and Ht levels of very-low-birth-weight infants were obtained from medical records. We investigated the relationship between Ht and each acylcarnitine using Pearson's correlation coefficient (r). RESULTS: We examined 77 newborns in this study. There was a significantly positive correlation between Ht and C0, C2, C12, C16, C18, C18:1, and C18:1-OH, respectively (p < 0.0025). The correlation was the greatest on C2 (r = 0.59). CONCLUSION: This study clarifies that Ht and C0, C2, C12, C16, C18, C18:1, and C18:1-OH are significantly correlated in DBS, which is consistent with previous studies. Hence, the effect of Ht should be considered when interpreting the results of acylcarnitine profiles in DBS. KEY POINTS:· Acylcarnitine profile in dried blood spots (DBS) is affected by the hematocrit (Ht) of the sample.. · There are positive correlations between Ht and C0, C2, C12, C16, C18, and C18:1-OH in DBS.. · We should be aware of the effects of Ht on acylcarnitine profiles in DBS..
journal_name
Am J Perinatoljournal_title
American journal of perinatologyauthors
Haga M,Isobe M,Kawabata K,Shimizu M,Mochizuki Hdoi
10.1055/s-0040-1721849subject
Has Abstractpub_date
2020-12-29 00:00:00eissn
0735-1631issn
1098-8785pub_type
杂志文章abstract:OBJECTIVE: This study aimed to compare attitudes of providers regarding perinatal management and outcomes for periviable newborns of caregivers at centers with higher resuscitation (HR) and lower resuscitation (LR) rates in the delivery room. STUDY DESIGN: All obstetric and neonatal clinical providers at six U.S. site...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0040-1709128
更新日期:2020-04-15 00:00:00
abstract::A case is presented of a primigravida with transient diabetes insipidus, gestational hypertension, and multiple seizures resistant to magnesium sulfate and diazepam. After addition of phenytoin, no further seizures occurred. Transient diabetes insipidus in pregnancy has been previously associated with hypertension, li...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-999504
更新日期:1990-07-01 00:00:00
abstract:OBJECTIVE:This study aimed to evaluate temporal trends in opioid use disorder (OUD) during antepartum and postpartum hospitalizations. STUDY DESIGN:This repeated cross-sectional analysis analyzed data from the National (Nationwide) Inpatient Sample. Women aged 15 to 54 years admitted antepartum or postpartum were iden...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0039-1694725
更新日期:2020-12-01 00:00:00
abstract:OBJECTIVE:Systemic lupus erythematosus (SLE) increases the risk of complications in pregnancy. Hydroxychloroquine (HCQ) decreases flares and neonatal lupus syndrome. Limited evidence suggests that HCQ also reduces preeclampsia and preterm birth in SLE pregnancies. We studied whether HCQ was associated with lower odds o...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0039-3402752
更新日期:2020-07-01 00:00:00
abstract:OBJECTIVE:To identify the variables associated with sepsis-associated mortality, as well as to develop a severity risk score to predict death in very low-birth-weight (VLBW) neonates affected by nosocomial sepsis. STUDY DESIGN:Retrospective cohort study. Infants weighing ≤ 1500 g with neonatal sepsis of nosocomial ori...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0032-1324701
更新日期:2013-05-01 00:00:00
abstract::With more than 20,000 fetal deaths occurring annually in the United States, accurate epidemiological data concerning fetal death offer the potential to develop interventions aimed at saving a considerable number of fetuses. Currently, fetal death rates are determined by dividing the number of deaths by total births. T...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-994589
更新日期:1994-07-01 00:00:00
abstract:OBJECTIVES:This article prospectively examines the use of ultrasound for antenatal detection of abnormal placental cord insertion (PCI) and compares the antenatal classification with delivered placental classification. STUDY DESIGN:This prospective cohort study examined 277 singleton pregnancies in a tertiary center. ...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0039-3400309
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE: It is well established that women with a previous vaginal delivery have higher success rates in relation to vaginal birth after cesarean than those without. The aim of this study was to examine the effect of past mode of delivery on contractile parameters of human myometrium in vitro. STUDY DESIGN: Myometri...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0039-1694980
更新日期:2021-01-01 00:00:00
abstract::The aim of this study is to identify clinical, etiologic, and laboratory factors that potentiate adverse outcome of hyperbilirubinemia among term and late preterm neonates in logistic regression analysis. A retrospective cohort of infants with total serum bilirubin (TSB) ≥ 20 mg/dL from 1995 to 2007 was surveyed. Eigh...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0031-1274506
更新日期:2011-05-01 00:00:00
abstract:OBJECTIVE:Normal initial blood glucose values in healthy newborns are not well defined and are subject to controversy. Despite substantive research, there is no single initial value of glucose that can be used with certainty of safety in newborns, and thus various protocols and cutoffs have been proposed. STUDY DESIGN...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0038-1667293
更新日期:2019-01-01 00:00:00
abstract::Placental pathology in preeclampsia (PE) and intrauterine growth retardation (IUGR) is associated with alterations of the placental epidermal growth factor receptor (EGFR). It is encoded by a single gene, which gives rise to two different full-length transcripts and one putative truncated transcript in the placenta. T...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-993890
更新日期:1998-01-01 00:00:00
abstract:OBJECTIVE:This study assessed the impact of a nurse simulation training program on perception of kangaroo mother care (KMC) value and transfer skill competency. STUDY DESIGN:An 8-item Likert scale skill survey tool and a 24-item Likert developmental care survey tool were used in a prospective cohort study to analyze p...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0034-1371359
更新日期:2014-11-01 00:00:00
abstract:OBJECTIVE: This study was aimed to describe continuous labor curves, including second stage, based on fetal head station. STUDY DESIGN: We performed a prospective multicenter cohort study. The inclusion criteria were women with singleton uncomplicated cephalic term pregnancies in labor, who delivered vaginally. We use...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0040-1702989
更新日期:2020-03-02 00:00:00
abstract:OBJECTIVE:We have previously shown a decrease in the overall stillbirth rate at our institution in women receiving the seasonal influenza vaccine during pregnancy. The goal of this study was to ascertain factors associated with this decrease. STUDY DESIGN:This was a retrospective cohort study examining the stillbirth ...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0034-1544046
更新日期:2015-05-01 00:00:00
abstract::We investigated the correlation of fetal heart rate patterns and fetal acid-base findings with the occurrence of early periventricular/intraventricular hemorrhage and variants. Ninety-five consecutive singleton neonates with birthweights less than or equal to 2000 gm were investigated. One-third of them showed early p...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-999819
更新日期:1986-01-01 00:00:00
abstract::Liposomal amphotericin B L-Amp B, a novel formulation of Amp B, is effective for the treatment of invasive fungal infections in children and adults and is associated with less toxicity than the conventional preparation. Data on the use of L-Amp B in neonates is scarce. We describe the clinical course of two premature ...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-994337
更新日期:1997-10-01 00:00:00
abstract::The ability of vibratory acoustic stimulation to shorten the duration of antepartum fetal heart rate monitoring was investigated by a randomized controlled trial. Vibratory acoustic stimulation did not shorten the overall duration of testing. This failure to improve the performance of antepartum monitoring appeared to...
journal_title:American journal of perinatology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1055/s-2007-999489
更新日期:1990-07-01 00:00:00
abstract::Ehlers-Danlos syndrome type IV (EDS IV) is a rare but serious disorder of connective tissue that is characterized by the abnormal production or secretion of type III collagen. Experience with pregnant patients exhibiting this syndrome is limited. This report describes the successful management of a pregnancy in a woma...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-999756
更新日期:1987-04-01 00:00:00
abstract::Periventricular leukomalacia (PVL) is a complication of prematurity that carries a high risk of long-term neurologic morbidity. We report the first case, to our knowledge, of unexpected PVL associated with in utero methamphetamine exposure in a 30-week gestation premature infant with a benign hospital course, who subs...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-970079
更新日期:2007-02-01 00:00:00
abstract::Extremely preterm infants often develop chronic lung disease (CLD) characterized by heterogeneous aeration; poorly supported, floppy airways; and air trapping. High-frequency jet ventilation (HFJV) with high end-expiratory pressure (optimal lung volume strategy [OLVS]) may improve airway patency, lead to better gas di...
journal_title:American journal of perinatology
pub_type: 临床试验,杂志文章
doi:10.1055/s-2006-954821
更新日期:2006-11-01 00:00:00
abstract::The purpose of this study was to examine factors that were associated with uterine rupture in patients attempting vaginal birth after cesarean delivery. We analyzed the results of all patients attempting vaginal birth after cesarean delivery between September 1996 to December 1999 at a single institution using a conte...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2004-828608
更新日期:2004-05-01 00:00:00
abstract:OBJECTIVE: This work aimed to study perinatal, maternal, and neonatal characteristics of birth tourism (BT) mother-baby dyads and the rate of neonatal intensive care unit (NICU) admissions of BT infants. STUDY DESIGN: Retrospective study at a regional perinatal center comparing BT mother-baby dyads to all dyads. BT in...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0040-1719117
更新日期:2020-11-09 00:00:00
abstract::Obstetrical antiphospholipid syndrome (APS) is associated with maternal and fetal morbidity and mortality. Standard treatment with low-dose acetylsalicylic acid and unfractionated heparin has achieved up to a 70 to 80% likelihood of success. Conversely, up to 30% of women with APS will have further pregnancy losses, d...
journal_title:American journal of perinatology
pub_type: 杂志文章,评审
doi:10.1055/s-2006-931805
更新日期:2006-02-01 00:00:00
abstract:OBJECTIVES:This study aims to compare women with early (13-16 years), late teenage (17-19 years), and adult (25-29 years) pregnancies regarding pregnancy risk factors and reproductive outcomes. METHODS:An observational study, utilizing medical charts and direct interview, conducted in an academic hospital during Janua...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0035-1565917
更新日期:2016-03-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to assess whether the location of the trocar insertion site for laser treatment of twin-twin transfusion syndrome was associated with preterm-premature rupture of membranes (PPROM) and preterm birth (PTB). STUDY DESIGN:In this study trocar location was documented in the operat...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0037-1620268
更新日期:2018-07-01 00:00:00
abstract::Discordancy in twins is generally described as a weight difference between the fetuses of 15 to 25% and its prevalence in normal twin gestations is estimated at 15 to 29%. The present study was performed in order to determine the frequency of discordant newborns in uncomplicated triplet gestations. One hundred and fou...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-994724
更新日期:1993-05-01 00:00:00
abstract::We sought to evaluate the effectiveness of daily oral micronized progesterone (MP) in preventing recurrent spontaneous preterm birth (RSPB) and whether MP increases maternal serum progesterone. We performed a pilot, single-center, randomized, double-blind, placebo-controlled trial in women with a prior preterm birth a...
journal_title:American journal of perinatology
pub_type: 杂志文章,随机对照试验
doi:10.1055/s-0031-1274509
更新日期:2011-05-01 00:00:00
abstract::Oxygenation instability is a very common problem in the premature infant that manifests as intermittent hypoxemia episodes (HEs). These are particularly frequent in premature infants who are on mechanical ventilation beyond the first weeks after birth. However, they can also occur in spontaneously breathing infants. S...
journal_title:American journal of perinatology
pub_type: 杂志文章,评审
doi:10.1055/s-0038-1637760
更新日期:2018-05-01 00:00:00
abstract:OBJECTIVE: This study aimed to review the feasibility of nasal high-frequency oscillatory ventilation (NHFOV) in preventing reintubation in preterm infants STUDY DESIGN: This is a retrospective cohort study of all premature newborn infants placed on NHFOV in a single-center neonatal intensive care unit. RESULTS: Twen...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0040-1718738
更新日期:2020-10-19 00:00:00
abstract::To determine the accuracy of antenatal renal pelvis measurement as a screening tool for renal anomalies we reviewed the antenatal ultrasounds performed at our institution over 1 year. Renal pelvis dilation was found in 3.8% of pregnancies followed by our obstetrics department. In nine (17.6%) infants renal anomalies w...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-993918
更新日期:1998-03-01 00:00:00