Abstract:
:We sought to evaluate the effectiveness of daily oral micronized progesterone (MP) in preventing recurrent spontaneous preterm birth (RSPB) and whether MP increases maternal serum progesterone. We performed a pilot, single-center, randomized, double-blind, placebo-controlled trial in women with a prior preterm birth and current singleton gestation at 16 to 20 weeks ( N = 33). The primary outcome was the rate of RSPB. Subjects were given either daily MP (400 mg) or placebo from 16 to 34 weeks. Serum progesterone was obtained at enrollment and in the late second/early third trimester. Pregnancy outcome data were collected. RSPB occurred in 5/19 (26.3%) in the MP group versus 8/14 (57.1%) in placebo group ( P = 0.15). The mean age at delivery was 37.0 ± 2.7 weeks for the MP group versus 35.9 ± 2.6 weeks for the placebo ( P = 0.3). Mean serum progesterone at 28 weeks was 122.6 ± 61.8 pg/mL for MP group versus 90.1 ± 38.7 pg/mL for placebo ( P = 0.19). MP was associated with a trend toward a reduction in RSPB and an increase in the maternal serum progesterone. Although the primary outcome in this pilot study did not reach statistical significance, the results suggest a favorable trend meriting further investigation.
journal_name
Am J Perinatoljournal_title
American journal of perinatologyauthors
Glover MM,McKenna DS,Downing CM,Smith DB,Croom CS,Sonek JDdoi
10.1055/s-0031-1274509subject
Has Abstractpub_date
2011-05-01 00:00:00pages
377-81issue
5eissn
0735-1631issn
1098-8785journal_volume
28pub_type
杂志文章,随机对照试验abstract::Neonatal alloimmune thrombocytopenia (NAIT) is the most common cause of severe thrombocytopenia in an otherwise healthy newborn. The most serious complication is intracranial hemorrhage, which can occur either in the fetus or the newborn. Despite the known serious sequelae, both antenatal management and neonatal treat...
journal_title:American journal of perinatology
pub_type: 杂志文章,评审
doi:10.1055/s-0030-1263296
更新日期:2011-02-01 00:00:00
abstract::Amniocentesis to guide the management of preterm pregnancies complicated by premature rupture of the membranes (PROM) has been adopted at several centers. The purpose of this study was to evaluate this practice prospectively among comparable groups of patients, which has not previously been reported. Forty-seven patie...
journal_title:American journal of perinatology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1055/s-2007-1000031
更新日期:1984-07-01 00:00:00
abstract::We have examined the trend in the incidence and mortality of intraventricular hemorrhage (IVH) in low birthweight infants from 1981 through 1984. During this time we admitted 407 infants in the first week of life with a birthweight less than or equal to 1500 gm in whom a cranial ultrasonogram or autopsy had been perfo...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-999896
更新日期:1986-10-01 00:00:00
abstract::Managing preterm rupture of membranes (PPROM) is a balance between benefits of prolonging gestation and the risks of perinatal infection. This study evaluates a real-time polymerase chain reaction (PCR) for the detection of amniotic fluid infection and neonatal complications by amniocentesis following PPROM. A total o...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0030-1271212
更新日期:2011-08-01 00:00:00
abstract:OBJECTIVE:To identify single nucleotide polymorphisms (SNPs) associated with clinical chorioamnionitis among preterm infants. STUDY DESIGN:We reanalyzed a genome-wide association study (GWAS) from preterm newborns at less than 30 weeks' gestation. Cases and control definitions were determined using administrative reco...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0038-1677503
更新日期:2019-12-01 00:00:00
abstract::Exposure to immunosuppressant agents during gestation can affect the fetal immune system. The aim of this study was to evaluate the immune function of infants whose mothers were administered immunosuppressants during pregnancy for the treatment of autoimmune disorders. Circulating lymphocyte subsets and in vitro immun...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-986679
更新日期:2007-09-01 00:00:00
abstract::We sought to determine the detection (clinical or sonographic) rate of macrosomic newborns (at least 4000 g) and the peripartum factors among those who were or were not identified accurately. We retrospectively reviewed all deliveries over 1 year and all maternal and neonatal charts of macrosomic newborns delivered du...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0028-1095187
更新日期:2009-02-01 00:00:00
abstract::With more than 20,000 fetal deaths occurring annually in the United States, accurate epidemiological data concerning fetal death offer the potential to develop interventions aimed at saving a considerable number of fetuses. Currently, fetal death rates are determined by dividing the number of deaths by total births. T...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-994589
更新日期:1994-07-01 00:00:00
abstract::In 18 women with gestational diabetes the variables of an oral glucose tolerance test (fasting and 2-hour blood glucose values and area under the blood glucose curve) performed in the last trimester of pregnancy correlated significantly with the urinary C-peptide excretion during the first 12 hours of the life (r = 0....
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-999674
更新日期:1988-04-01 00:00:00
abstract::The Roberts-SC phocomelia syndrome (pseudothalidomide syndrome) is a rare, usually lethal condition involving short limbs and occasional hydrocephalus. Presented is a case in which prenatal sonographic findings were highly suggestive of this syndrome, although not definite. In this fetus, findings of hydrocephalus, sh...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-999392
更新日期:1991-07-01 00:00:00
abstract::Cimetidine therapy used for the treatment of gastric bleeding due to tolazoline therapy in a newborn infant was temporally associated with episodes of severe hypoxemia. It appears likely that the histamine H2 receptor blocked by cimetidine obviated the pulmonary vasodilator effect of tolazoline therapy. ...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-994346
更新日期:1996-07-01 00:00:00
abstract::We studied the effect of antenatal corticosteroids on the incidence of respiratory disorders in singleton neonates born between 34 and 36 weeks of gestation. Retrospective analysis was conducted of the incidence of respiratory distress syndrome (RDS) and other respiratory disorders (need for mechanical ventilation, co...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-1022470
更新日期:2008-02-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to evaluate the association between neonatal seizure and neurodevelopmental impairment (NDI) at 18 to 24 months in extremely preterm neonates. The association between anticonvulsants use and NDI was also assessed. STUDY DESIGN:In this retrospective cohort study of infants born at <2...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0038-1667107
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVE: The aim of the study is to investigate factors affecting total sleep time (TST) during infant polysomnography (PSG) and assess if <4 hours of TST is sufficient for accurate interpretation. STUDY DESIGN: Overall, 242 PSGs performed in 194 infants <6 months of chronological age between March 2013 and December...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0040-1718948
更新日期:2020-10-27 00:00:00
abstract::The aim of this study is to identify clinical, etiologic, and laboratory factors that potentiate adverse outcome of hyperbilirubinemia among term and late preterm neonates in logistic regression analysis. A retrospective cohort of infants with total serum bilirubin (TSB) ≥ 20 mg/dL from 1995 to 2007 was surveyed. Eigh...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0031-1274506
更新日期:2011-05-01 00:00:00
abstract::Discordancy in twins is generally described as a weight difference between the fetuses of 15 to 25% and its prevalence in normal twin gestations is estimated at 15 to 29%. The present study was performed in order to determine the frequency of discordant newborns in uncomplicated triplet gestations. One hundred and fou...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-994724
更新日期:1993-05-01 00:00:00
abstract::We present an unusual case in which sonographic assessment at 33 weeks' gestation, 5 weeks following a normal fetal anatomical survey and biometry, demonstrated a large, irregular-shaped, echogenic, suprasellar midline intracranial mass occupying the anterior and middle fossas. Associated severe obstructive hydrocepha...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-994064
更新日期:1998-01-01 00:00:00
abstract::Liposomal amphotericin B L-Amp B, a novel formulation of Amp B, is effective for the treatment of invasive fungal infections in children and adults and is associated with less toxicity than the conventional preparation. Data on the use of L-Amp B in neonates is scarce. We describe the clinical course of two premature ...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-994337
更新日期:1997-10-01 00:00:00
abstract:OBJECTIVE:The aim of this study is to evaluate the impact of multiple pregnancies, maternal obesity, and preeclampsia on the effect of antenatal steroids on neonatal respiratory distress syndrome (RDS). STUDY DESIGN:The retrospective cohort study was performed in a level III maternity ward. Population was composed of ...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0035-1548537
更新日期:2015-09-01 00:00:00
abstract::Objective There is limited data regarding the use of oral hypoglycemic agents (OHAs) in pregnant women with type 2 diabetes mellitus (T2DM). Study Design This was a retrospective cohort study of women with T2DM who were treated with OHA or insulin from the first trimester onward. Bivariate and multivariate logistic re...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0036-1597625
更新日期:2017-06-01 00:00:00
abstract::Hepatoblastoma accounts for less than 1% of all pediatric malignancies. However, it remains the most common malignant tumor of the liver in newborns. Less than 10% of hepatoblastoma cases are diagnosed in the neonatal period. The diagnosis can be very difficult due to the wide spectrum of presentation and differences ...
journal_title:American journal of perinatology
pub_type: 杂志文章,评审
doi:10.1055/s-2005-872592
更新日期:2005-11-01 00:00:00
abstract::We describe the neuropathologic procedure utilized in the Stillbirth Collaborative Research Network (SCRN), focusing on the examination of central nervous system (CNS) in stillbirth (SB). The SCRN was organized to perform a case-control study to determine the scope and causes of SB. Pathologists at all the participati...
journal_title:American journal of perinatology
pub_type: 杂志文章,多中心研究
doi:10.1055/s-0031-1284229
更新日期:2011-12-01 00:00:00
abstract:OBJECTIVE:To compare the efficacy of similar buccal and vaginal misoprostol doses for induction of labor. STUDY DESIGN:Retrospective chart review of 207 consecutive women undergoing term induction of labor with misoprostol. Misoprostol route and dosing were collected. Time to delivery and other labor outcomes (e.g., v...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0038-1675219
更新日期:2019-06-01 00:00:00
abstract:UNLABELLED:We evaluated the effectiveness of oral misoprostol for outpatient cervical ripening and labor induction in prolonged pregnancies. We performed a randomized, double-blind, placebo-controlled study of women at 40 to 42 weeks' gestation with well-dated pregnancies, singleton gestations, Bishop scores less than ...
journal_title:American journal of perinatology
pub_type: 杂志文章,随机对照试验
doi:10.1055/s-0029-1220790
更新日期:2009-10-01 00:00:00
abstract:OBJECTIVES:This study aims to compare women with early (13-16 years), late teenage (17-19 years), and adult (25-29 years) pregnancies regarding pregnancy risk factors and reproductive outcomes. METHODS:An observational study, utilizing medical charts and direct interview, conducted in an academic hospital during Janua...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0035-1565917
更新日期:2016-03-01 00:00:00
abstract:OBJECTIVE:To determine the risk of gestational diabetes mellitus (GDM) and insulin resistance (IR) in obesity defined by body mass index (BMI), waist-to-hip ratio (WHR), or both combined. METHODS:Secondary analysis of a randomized multicenter trial of antioxidant supplementation versus placebo in nulliparous low-risk ...
journal_title:American journal of perinatology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1055/s-0035-1562928
更新日期:2016-01-01 00:00:00
abstract::We compared short-term neonatal outcomes between premature infants with spontaneous preterm birth (s-PTB) and those delivered due to preeclampsia (PEC). Data were collected from women with singleton pregnancies admitted with spontaneous preterm labor (PTL) (2002 to 2005) and PEC (2005 to 2007). Patients delivering 24 ...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0029-1234036
更新日期:2010-02-01 00:00:00
abstract::Limited research in young adults and immature animals suggests a detrimental effect of tobacco on bone during growth. We aimed to determine the adverse effects of maternal nicotine exposure during pregnancy and lactation on neonatal rat bone development, and to determine a protective effect of ascorbic acid. Gravid ra...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2006-951287
更新日期:2006-10-01 00:00:00
abstract::The objective of this article is to prospectively investigate the efficacy of amnioinfusion as a means to reduce febrile morbidity in pregnancies complicated by chorioamnionitis. All laboring patients with a temperature > or =100.1 degrees F were approached for study participation. Exclusion criteria included amnionit...
journal_title:American journal of perinatology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1055/s-2007-994085
更新日期:1998-01-01 00:00:00
abstract::The present study of 466 consecutive liveborn preterm singleton deliveries included 238 cases of spontaneous preterm labor and delivery, 175 cases with premature rupture of membranes, 13 cases of nonhypertensive abruption, 18 cases of preeclampsia, and 22 cases of placenta previa. Placental infarction, chronic villiti...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-999318
更新日期:1992-05-01 00:00:00