Abstract：
OBJECTIVE:This article identifies the prevalence and associated factors of hypophosphatemia (HP) in very low birth weight (VLBW) infants in the first week of life. STUDY DESIGN:Prospective exploratory cohort study of 106 consecutive VLBW infants admitted to neonatal intensive care at Foothills Hospital, Calgary, Canada. HP was defined as at least one measurement of serum phosphate < 1.5 mmol/L (4.5 mg/dL). RESULTS:Seventy-seven percent (82/106) of the VLBW infants had HP, with significantly higher prevalence in infants < 1,000 g (94%) compared to infants ≥ 1,000 g (61%) (p < 0.001). Hypophosphatemic infants had lower birth weight (p < 0.001), gestational age (p < 0.001), and their increase in phosphate intake was slower (p = 0.003). Respiratory distress syndrome (RDS) (p = 0.002), intraventricular hemorrhage (IVH) ≥ grade III (p = 0.020), and hyperglycemia (p = 0.013) were more frequent among hypophosphatemic infants, especially among those < 1,000 g. Mortality, seizures, arrhythmias, and need for transfusion were not different between groups. Birth weight modified the association between RDS, IVH, hyperglycemia, and HP. CONCLUSION:HP was ubiquitous among infants < 1,000 g and highly prevalent among those weighing 1,000 to 1,500 g. While the direction of effect was not clear, RDS, IVH, and hyperglycemia were associated with HP. Prevention of HP in these physiologically immature neonates might improve neonatal outcomes.
journal_name
Am J Perinatoljournal_title
American journal of perinatologyauthors
Al-Wassia H,Lyon AW,Rose SM,Sauve RS,Fenton TRdoi
10.1055/s-0039-1677713subject
Has Abstractpub_date
2019-11-01 00:00:00pages
1412-1419issue
13eissn
0735-1631issn
1098-8785journal_volume
36pub_type
杂志文章abstract：:Periventricular leukomalacia (PVL) is a complication of prematurity that carries a high risk of long-term neurologic morbidity. We report the first case, to our knowledge, of unexpected PVL associated with in utero methamphetamine exposure in a 30-week gestation premature infant with a benign hospital course, who subs...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-2007-970079
更新日期：2007-02-01 00:00:00
abstract：:This article evaluates the role of alpha-fetoprotein (AFP) testing in the diagnosis of ruptured membranes in the preterm patient. AFP is normally found in amniotic fluid and is not present in vaginal secretions. Testing for AFP in vaginal fluid was compared with nitrazine evaluation and ferning in two groups of preter...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-2007-999500
更新日期：1990-07-01 00:00:00
abstract：:We describe the neuropathologic procedure utilized in the Stillbirth Collaborative Research Network (SCRN), focusing on the examination of central nervous system (CNS) in stillbirth (SB). The SCRN was organized to perform a case-control study to determine the scope and causes of SB. Pathologists at all the participati...
journal_title：American journal of perinatology
pub_type： 杂志文章,多中心研究
doi：10.1055/s-0031-1284229
更新日期：2011-12-01 00:00:00
abstract：:Objective The objective of this study was to study the temporal profile of pulmonary hypertension (PH) in preterm infants. Study Design Infants < 28 weeks were screened for early PH at 10 to 14 days of life. Infants with early PH (n = 10) and gestationally matched controls (n = 18) underwent serial echocardiography ev...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-0036-1581079
更新日期：2016-07-01 00:00:00
abstract：:A hospital-based case-controlled study was undertaken to determine maternal and neonatal characteristics associated with fractured clavicle. A total of 11,604 consecutive vaginal deliveries of liveborn infants in vertex presentation at the Mount Sinai Hospital from 1988 to 1990 were reviewed. Maternal and neonatal cha...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-2007-994546
更新日期：1994-09-01 00:00:00
abstract：:Objective We aimed to evaluate which patient-level factors influence mode of delivery among candidates for operative vaginal delivery. Study Design Cross-sectional study of candidates for operative vaginal delivery from 18 hospitals over 8 years. Probabilities of mode of delivery were estimated using hierarchical logi...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-0037-1601441
更新日期：2017-08-01 00:00:00
abstract：OBJECTIVE:To analyze outcomes after second-stage labor beyond 3 hours and determine if prolonged second stages were intentional. STUDY DESIGN:Retrospective cohort analysis of maternal and neonatal outcomes in nulliparous women based on second-stage duration. Medical records were reviewed for management decisions in wo...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-0032-1314894
更新日期：2012-10-01 00:00:00
abstract：:The purpose of this study was to examine the association between intrapair birthweight discordance and fetal and neonatal mortality. This was a historical cohort study, using the Statistics Canada linked birth-infant death file. Twin births in Canada (excluding Ontario) for the period 1986-1997 were studied. Outcome m...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-2005-870899
更新日期：2005-07-01 00:00:00
abstract：OBJECTIVE: This study aimed to assess whether cord blood carboxyhemoglobin (COHb) levels in jaundiced term neonates with and without a positive direct Coombs test (DCT) and in healthy controls could be used as a predictor of severe hyperbilirubinemia. The percentage of cord blood COHb should be higher among neonates wi...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-0040-1722328
更新日期：2021-01-04 00:00:00
abstract：:End-stage renal disease complicates only a small percentage of pregnancies, but, of these, virtually all become anemic due to a deficiency in erythropoietin. Erythropoietin has been shown to correct anemia due to renal disease in nonpregnant patients. We report two cases of erythropoietin use during pregnancy complica...
journal_title：American journal of perinatology
pub_type： 杂志文章,评审
doi：10.1055/s-2007-994392
更新日期：1995-01-01 00:00:00
abstract：:In studying the effects of amniotic fluid on bacterial growth in a laboratory model, we noted that the pH of the fluid appeared to exert an independent effect. This study was designed to test the ability to control the growth of Escherichia coli in amniotic fluid simply by controlling two important growth conditions, ...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-2007-994674
更新日期：1992-03-01 00:00:00
abstract：:The objective of this study was to evaluate the diagnostic accuracy of different single ultrasonographic parameters in predicting intrauterine growth-restricted (IUGR) babies as defined by Ponderal index at birth. Study sample composed of two sets of data from Iran and Australia. The Iranian sample consisted of 296 Ir...
journal_title：American journal of perinatology
pub_type： 杂志文章,多中心研究
doi：10.1055/s-2001-17856
更新日期：2001-09-01 00:00:00
abstract：:The ability of vibratory acoustic stimulation to shorten the duration of antepartum fetal heart rate monitoring was investigated by a randomized controlled trial. Vibratory acoustic stimulation did not shorten the overall duration of testing. This failure to improve the performance of antepartum monitoring appeared to...
journal_title：American journal of perinatology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1055/s-2007-999489
更新日期：1990-07-01 00:00:00
abstract：:We sought to validate center-specific published medians and estimate the effects of sonologist and Doppler measurement techniques on middle cerebral artery (MCA) peak systolic velocity (PSV) values. We studied 154 gravidas with normal singletons who underwent MCA PSV measurement at 18 to 35 weeks' gestation by one of ...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-0030-1249365
更新日期：2010-09-01 00:00:00
abstract：OBJECTIVE:To evaluate the association between adequacy of prenatal care utilization and risk of fetal and neonatal mortality and adverse outcomes. METHODS:We conducted a population-based cohort study using the Center for Disease Control and Prevention's Linked Birth-Infant Death and Fetal Death data on all deliveries ...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-0032-1316439
更新日期：2012-11-01 00:00:00
abstract：:Carbamoyl phosphate synthetase deficiency is a type of an inborn error of metabolism with a poor prognosis. Carbamoyl phosphate synthetase is a liver-specific enzyme, and its deficiency can only be diagnosed by enzyme assay using liver biopsy specimens. A pregnant woman at risk for carbamoyl phosphate synthetase defic...
journal_title：American journal of perinatology
pub_type： 杂志文章,评审
doi：10.1055/s-2007-994579
更新日期：1994-03-01 00:00:00
abstract：OBJECTIVE:To evaluate whether tocolysis with nifedipine can be omitted in women with symptoms of preterm labor, a shortened cervix, and negative fetal fibronectin test. STUDY DESIGN:A randomized noninferiority trial was performed in all Dutch perinatal centers. Women with symptoms of preterm labor between 24 and 34 we...
journal_title：American journal of perinatology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1055/s-0034-1390346
更新日期：2015-04-01 00:00:00
abstract：:We describe a case of transient hyperinsulinism in an asphyxiated newborn infant with hypoglycemia. Although hypoglycemia in birth asphyxiated infants is generally attributed to depletion of glycogen stores, we observed severe hyperinsulinism associated with the hypoglycemia. The hypoglycemia was refractory to high gl...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-2001-15504
更新日期：2001-06-01 00:00:00
abstract：:Aplasia cutis congenita (ACC) is the clinical manifestation of an uncommon group of skin disorders. One postulated etiology is disseminated intravascular coagulation from release of thrombogenic maternal arising from placental injury or fetal demise. This leads to disruption of the ectodermal blood supply responsible ...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-1999-7279
更新日期：1999-01-01 00:00:00
abstract：OBJECTIVE:Prediction of gestational latency after placement of physical exam indicated cerclage (PEIC) is limited. Uterocervical angle (UCA) has been associated with spontaneous preterm delivery in the general population. Our objective was to examine whether UCA is associated with gestational latency in women with PEIC...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-0037-1621734
更新日期：2018-07-01 00:00:00
abstract：:We present a case of congenital midgut volvulus detected by prenatal sonography and ultrafast magnetic resonance (MR) imaging. At 34 weeks of gestation, enlarged hyperechogenic loops without peristalsis was identified by sonographic examination. On ultrafast T2-weighted single-shot fast-spin echo MR imaging, enlarged ...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-2001-18794
更新日期：2001-12-01 00:00:00
abstract：:This study considers whether admission to the hospital of a patient diagnosed with a short cervix delayed delivery, prevented preterm delivery, and/or decreased the rate of change in the cervical length (CL) on follow-up measurements. The design was a retrospective cohort study of women carrying singleton pregnancies ...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-2006-958164
更新日期：2007-01-01 00:00:00
abstract：:Periventricular leukomalacia, a condition characterized by hpoxic-ischemic infarction of deep cerebral white matter, can now be recognized by cranial sonography. The case presented here demonstrates the association of periventricular leukomalacia present at birth with intrauterine paroxysmal supraventricular tachycard...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-2007-999826
更新日期：1986-01-01 00:00:00
abstract：OBJECTIVE:This study aims to evaluate vaginal microbiota differences by bacterial vaginosis (BV), birth timing, and race, and to estimate parameters to power future vaginal microbiome studies. METHODS:Previously, vaginal swabs were collected at 21 to 25 weeks (stored at -80°C), and vaginal smears evaluated for BV (Nug...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-0035-1565919
更新日期：2016-03-01 00:00:00
abstract：:This study was conducted to examine the potential effects of expanded Medicaid coverage for low income women. Statewide birth data for 1983 to 1985 were examined to determine the relationship between prenatal care and admissions to neonatal intensive care units (NICUs) and the costs of this care. An NICU sample was co...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-2007-994790
更新日期：1992-07-01 00:00:00
abstract：:Elevated serum transaminase levels can have many different etiologies, especially in the pregnant patient. Hypoxic hepatitis is a distinct syndrome caused by decreased hepatic blood flow that presents with a marked, but transient, increase in liver enzymes. A 28-year-old woman, gravida 3, para 2 with history of gastri...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-0028-1085065
更新日期：2008-09-01 00:00:00
abstract：:Preeclampsia is uncommon prior to 24 weeks gestation and has been associated with partial and complete hydatidiform moles. We present an unusual case in which a patient was diagnosed with preeclampsia at 17 weeks gestation. Ultrasound findings were consistent with a partial hydatidiform mole. Within 24 hours of the on...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-2006-934093
更新日期：2006-04-01 00:00:00
abstract：:Small- to moderate-sized aortic thrombi in the sick newborn are frequently demonstrated, however, severe aortic thrombosis is rarely encountered. We report two newborn infants presenting with signs of decreased lower limb perfusion shortly after birth. An occlusive infrarenal aortic thrombus was demonstrated in both i...
journal_title：American journal of perinatology
pub_type： 杂志文章,评审
doi：10.1055/s-2000-9975
更新日期：2000-01-01 00:00:00
abstract：:Conventional interval dosing (CID) and extended interval dosing (EID) of gentamicin were compared in preterm infants. Gentamicin peak and trough levels, serum creatinine, urine output, and hearing screens were obtained in 40 preterm infants. Results suggest that EID is safe, provides gentamicin levels in desirable ran...
journal_title：American journal of perinatology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1055/s-2004-820515
更新日期：2004-02-01 00:00:00
abstract：:The Advisory Committee on Immunization Practices of the Centers for Disease Control and Prevention recommends influenza vaccination for women who will be in the second or third trimester of pregnancy during the influenza season. We analyzed hospital admissions with principal diagnoses of influenza or pneumonia and inf...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-2004-831888
更新日期：2004-08-01 00:00:00
