Role of Cord Blood Carboxyhemoglobin in Detecting Significant Hyperbilirubinemia in Term Neonates with ABO Alloimmunization.


OBJECTIVE: This study aimed to assess whether cord blood carboxyhemoglobin (COHb) levels in jaundiced term neonates with and without a positive direct Coombs test (DCT) and in healthy controls could be used as a predictor of severe hyperbilirubinemia. The percentage of cord blood COHb should be higher among neonates with Coombs-positive ABO hemolytic disease than among those with Coombs-negative ABO incompatibility and higher than that of ABO-compatible control neonates. STUDY DESIGN: This cross-sectional descriptive study of 198 term neonates comprised three subgroups: group I featured 68 DCT-positive ABO-incompatible neonates (ABO + DCT), group II featured 60 DCT-negative ABO-incompatible neonates with hyperbilirubinemia (ABO-DCT), and group III featured 70 healthy controls. COHb was determined by an OSM3 hemoximeter. RESULTS: Group I differed from groups II and III for cord blood bilirubin, cord blood hemoglobin, and cord blood hematocrit. Groups I and II had higher mean total serum bilirubin (TSB) levels than group III, while there was no difference in the mean TSB levels between groups I and II. There was no significant difference between the COHb group means for groups I, II, and III (p = 0.98). The area under the receiver operating characteristic curve calculated for group I/group III and group II/group III were found to be 0.62 and 0.54, respectively. CONCLUSION: COHb levels did not prove to be superior to the DCT for predicting the risk of developing severe hyperbilirubinemia in term neonates. KEY POINTS:· COHb levels do not predict the risk of developing severe hyperbilirubinemia in term neonates.. · COHb levels may predict that ABO incompatibility in early life.. · COHb levels did not prove to be superior to the direct coombs test..


Am J Perinatol


Tıraş M,Can E,Hamilçıkan Ş




Has Abstract


2021-01-04 00:00:00






  • Factors that Influence Longitudinal Growth from Birth to 18 Months of Age in Infants with Gastroschisis.

    abstract:OBJECTIVE:This study aimed to investigate factors that influence growth in infants with gastroschisis. STUDY DESIGN:Growth parameters at birth, discharge, 6, 12, and 18 months of age were collected from 42 infants with gastroschisis. RESULTS:The mean z-scores for weight, length, and head circumference were below norm...

    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Nair N,Merhar S,Wessel J,Hall E,Kingma PS

    更新日期:2020-12-01 00:00:00

  • Prevention of RhD Alloimmunization: A Comparison of Four National Guidelines.

    abstract:OBJECTIVE: The objective of this study was to compare national guidelines on the prevention of RhD alloimmunization. STUDY DESIGN: We performed a review of four national guidelines on prevention of alloimmunization from the American Congress of Obstetricians and Gynecologists, Royal College of Obstetricians and Gynaec...

    journal_title:American journal of perinatology

    pub_type: 杂志文章,评审


    authors: Sperling JD,Dahlke JD,Sutton D,Gonzalez JM,Chauhan SP

    更新日期:2018-01-01 00:00:00

  • Prophylactic pelvic artery catheterization and embolization in women with placenta accreta: can it prevent cesarean hysterectomy?

    abstract::We present the outcome of a relatively large cohort of women with suspected placenta accreta who underwent prophylactic pelvic artery catheterization prior to cesarean section. All pregnant women with suspected placenta accreta who delivered in one tertiary center were included in this retrospective study. All patient...

    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Sivan E,Spira M,Achiron R,Rimon U,Golan G,Mazaki-Tovi S,Schiff E

    更新日期:2010-06-01 00:00:00

  • Resolving polyhydramnios. A sign of improved fetal status.

    abstract::Four cases of transient polyhydramnios are reviewed. It is proposed that by taking note of changes in amniotic fluid volume, one can more accurately assess a fetal-maternal unit that is affected by a number of specific disease processes. ...

    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Hill LM

    更新日期:1988-01-01 00:00:00

  • Treatment Utility of Postpartum Antibiotics in Chorioamnionitis Study.

    abstract::Objective To determine if postpartum antibiotics are necessary for patients with chorioamnionitis after a cesarean delivery (CD). Study Design Multicenter randomized controlled trial. Laboring patients with singleton gestations and chorioamnionitis who underwent CD were eligible. Patients were treated with ampicillin ...

    journal_title:American journal of perinatology

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Shanks AL,Mehra S,Gross G,Colvin R,Harper LM,Tuuli MG

    更新日期:2016-07-01 00:00:00

  • Surgical Site Infection following Cesarean Delivery: Patient, Provider, and Procedure-Specific Risk Factors.

    abstract:OBJECTIVE:This study aims to identify risk factors for cesarean delivery (CD) surgical site infection (SSI). study design: Retrospective analysis of 2,739 CDs performed at the University of Pittsburgh in 2011. CD SSIs were defined using National Healthcare Safety Network (NHSN) criteria. Chi-square test and t-test were...

    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Shree R,Park SY,Beigi RH,Dunn SL,Krans EE

    更新日期:2016-01-01 00:00:00

  • Effect of active management on latent phase labor.

    abstract::The effect of active management on latent phase labor was assessed in 197 consecutive nulliparous women. Active management resulted in a significant shortening of the latent phase but had no effect on active phase labor. Patients undergoing induction of labor had latent phases that were almost identical to the accepte...

    journal_title:American journal of perinatology

    pub_type: 临床试验,杂志文章


    authors: Boylan PC,Parisi VM

    更新日期:1990-10-01 00:00:00

  • Misdiagnosis of a normal fetal platelet count after coagulation of intrapartum scalp samples in autoimmune thrombocytopenic purpura.

    abstract::Intrapartum fetal scalp sampling for platelet counts in maternal autoimmune thrombocytopenia has been advocated for determining route of delivery. We report a case in which two coagulated scalp samples were believed to indicate a normal fetal platelet count. As a result, vaginal delivery of a severely thrombocytopenic...

    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Moise KJ Jr,Patton DE,Cano LE

    更新日期:1991-09-01 00:00:00

  • Sudden unexpected death in a neonate.

    abstract::A sudden and unexpected death, at 26 hours of age, of a term infant with no identifiable risk factors either in the prenatal or in the immediate neonatal period is described. The most remarkable postmortem findings were confined to the lungs, which had many areas of aspirated amniotic fluid, as well as extensive areas...

    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Imaizumi SO,Balsara GR

    更新日期:1989-07-01 00:00:00

  • Nasogastric versus Orogastric Bolus Tube Feeding in Preterm Infants: Pilot Randomized Clinical Trial.

    abstract:OBJECTIVE: According to the most recent metanalysis, the best way to establish safe enteral feeding in preterm babies using nasogastric or orogastric tubes is still not well understood. This study aimed to determine the effects of bolus nasal tubes versus bolus orogastric tubes on the time required to reach full entera...

    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Badran AT,Hashish M,Ali A,Shokeir M,Shabaan A

    更新日期:2020-07-03 00:00:00

  • The Performance of First-Trimester Anatomy Scan: A Decision Analysis.

    abstract::Introduction First-trimester ultrasound (US) for anatomy assessment may improve anomaly detection, but it may also increase overall US utilization. We sought to assess the utility of first-trimester US for evaluation of fetal anatomy. Materials and Methods A decision analytic model was created to compare first- plus s...

    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Harper LM,Wood SL,Jenkins SM,Owen J,Biggio JR

    更新日期:2016-08-01 00:00:00

  • Outcome and Feasibility after 7 Years of Therapeutic Hypothermia in Southern Brazil.

    abstract:OBJECTIVE:This study aimed to describe the experience with a protocol of therapeutic hypothermia (TH) in southern Brazil. STUDY DESIGN:Newborns with gestational age > 35 weeks with evidence of perinatal asphyxia plus moderate or severe encephalopathy were recruited between March 2011 and November 2017. Whole-body hypo...

    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Procianoy RS,Corso AL,Schoenardie BO,de Oliveira GPF,Longo MG,Silveira RC

    更新日期:2020-07-01 00:00:00

  • Ultrasonically measured biparietal diameter and abdominal circumference: intra- and interobserver variation in the third trimester.

    abstract::Serial ultrasound measurements of the fetus under investigation is an important indicator of fetal growth, and thus fetal health. To assess how reliable those measurements are, a videotape was made, and, utilizing an ultrasound machine that allowed the placement of callipers on the videotape, the dispersion of the mea...

    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Vine DG,Cooperberg PL,Dansereau J

    更新日期:1992-09-01 00:00:00

  • Screening for intrauterine growth restriction in uncomplicated pregnancies: time for action.

    abstract::A randomized clinical trial (RCT) noted that sonographic examination in the third trimester, in conjunction with delivery at term for abnormalities of fetal growth, significantly decreased the likelihood of small-for-gestational-age (SGA) neonates in uncomplicated pregnancies. We identified 15 characteristics of scree...

    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Chauhan SP,Rouse DJ,Ananth CV,Magann EF,Chang E,Dahlke JD,Abuhamad AZ

    更新日期:2013-01-01 00:00:00

  • Are maternal serum troponin I levels affected by vaginal or cesarean delivery?

    abstract::Our objective was to describe the change in the level of troponin I in patients who undergo a vaginal or cesarean delivery. We obtained troponin I levels on admission and 1 hour after delivery in women undergoing vaginal and cesarean deliveries. Exclusion criteria included <37 weeks' gestation, a history of cardiac di...

    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Koscica KL,Bebbington M,Bernstein PS

    更新日期:2004-01-01 00:00:00

  • Pleural effusion with parenteral nutrition solution: an unusual complication of an "appropriately" placed umbilical venous catheter.

    abstract::Pleural effusion is not an uncommon complication of percutaneous intravenous catheters in neonates. Umbilical venous catheters (UVCs) are associated with pleural effusion following abnormal placement in the left atrium or pulmonary veins due to venous obstruction. We report for the first time a case of right-sided ple...

    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Pabalan MJ,Wynn RJ,Reynolds AM,Ryan RM,Youssfi M,Manja V,Lakshminrusimha S

    更新日期:2007-11-01 00:00:00

  • Emergency cerclages: a review of 40 consecutive procedures.

    abstract::This report describes 40 consecutive emergency cerclages on dilated and effaced cervices prior to 26 weeks' gestation. These "emergency" cerclages were associated with a mean extension of gestational age of 12 weeks (range, 3 days to 20.5 weeks). Thirty-one of 40 pregnancies were carried to 28 weeks' gestation and 23 ...

    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Mitra AG,Katz VL,Bowes WA Jr,Carmichael S

    更新日期:1992-05-01 00:00:00

  • The risk for preterm labor in women receiving 17 alpha-hydroxyprogesterone caproate prophylaxis for preterm birth prevention.

    abstract::We sought to identify maternal or clinical characteristics of women likely to develop preterm labor (PTL) at <34 weeks' gestation while receiving 17 alpha-hydroxyprogesterone caproate (17P) prophylaxis. Current singleton gestations with prior preterm delivery enrolled for outpatient 17P administration at <27 weeks' ge...

    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Joy S,Rhea DJ,Istwan NB,Desch CN,Stanziano G

    更新日期:2010-04-01 00:00:00

  • Does preincubation with prostaglandin E1 or prostaglandin E2 enhance oxytocin-induced myometrial contractility in vitro?

    abstract:OBJECTIVE:To determine if preincubation with prostaglandin E1 (PGE1) and E2 (PGE2) enhances oxytocin-induced myometrial contractility in vitro. STUDY DESIGN:Myometrial strips from 13 women were incubated with PGE1 (10-5 mol/L or 10-6 mol/L), PGE2 (10-5 mol/L or 10-6 mol/L) or solvent before adding cumulative concentra...

    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Chiossi G,Reed LC,Costantine MM,Hankins GD,Saade GR,Longo M

    更新日期:2013-09-01 00:00:00

  • Obstetric Recommendations in American Congress of Obstetricians and Gynecologists Practice Bulletins versus UpToDate: a comparison.

    abstract:OBJECTIVE:To compare the obstetric recommendations in American Congress of Obstetricians and Gynecologists (ACOG) practice bulletins (PB) with similar topics in UpToDate (UTD). STUDY DESIGN:We accessed all obstetric PB and cross-searched UTD (May 1999-May 2013). We analyzed only the PB which had corresponding UTD chap...

    journal_title:American journal of perinatology

    pub_type: 杂志文章,评审


    authors: Myer EN,Too GT,Hammad IA,Babbar S,Martin CE,Hill JB,Blackwell SB,Chauhan SP

    更新日期:2015-04-01 00:00:00

  • Birth Tourism Is Associated with Fewer Neonatal Intensive Care Unit Admissions: A Healthy Migrant Effect?

    abstract:OBJECTIVE: This work aimed to study perinatal, maternal, and neonatal characteristics of birth tourism (BT) mother-baby dyads and the rate of neonatal intensive care unit (NICU) admissions of BT infants. STUDY DESIGN: Retrospective study at a regional perinatal center comparing BT mother-baby dyads to all dyads. BT in...

    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Lim J,Sun WD,Zhang L,Mikhael M

    更新日期:2020-11-09 00:00:00

  • Preventing Preterm Birth with Progesterone in Women with a Short Cervical Length from a Low-Risk Population: A Multicenter Double-Blind Placebo-Controlled Randomized Trial.

    abstract:OBJECTIVE:The objective of this study was to evaluate the effectiveness of vaginal progesterone in reducing adverse neonatal outcome due to preterm birth (PTB) in low-risk pregnant women with a short cervical length (CL). STUDY DESIGN:Women with a singleton pregnancy without a history of PTB underwent CL measurement a...

    journal_title:American journal of perinatology

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: van Os MA,van der Ven AJ,Kleinrouweler CE,Schuit E,Kazemier BM,Verhoeven CJ,de Miranda E,van Wassenaer-Leemhuis AG,Sikkema JM,Woiski MD,Bossuyt PM,Pajkrt E,de Groot CJ,Mol BW,Haak MC

    更新日期:2015-08-01 00:00:00

  • The Association between Shirodkar Cerclage and Preterm Premature Rupture of Membranes in Singleton Pregnancies.

    abstract:OBJECTIVE: The aim of this study was to estimate if preterm premature rupture of membranes in women with cerclage is due to the cerclage itself or rather the underlying risk factors for preterm birth in this population. STUDY DESIGN: This was a retrospective cohort study of singleton pregnancies who underwent Shirodka...

    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Muniz Rodriguez A,Pastor A,Fox NS

    更新日期:2020-05-23 00:00:00

  • Severe aortic thrombosis in the neonate--successful treatment with low-molecular-weight heparin: two case reports and review of the literature.

    abstract::Small- to moderate-sized aortic thrombi in the sick newborn are frequently demonstrated, however, severe aortic thrombosis is rarely encountered. We report two newborn infants presenting with signs of decreased lower limb perfusion shortly after birth. An occlusive infrarenal aortic thrombus was demonstrated in both i...

    journal_title:American journal of perinatology

    pub_type: 杂志文章,评审


    authors: Klinger G,Hellmann J,Daneman A

    更新日期:2000-01-01 00:00:00

  • Gestational Weight Gain and Pregnancy Outcomes among Nulliparous Women.

    abstract:OBJECTIVE: To determine the association between total gestational weight gain and perinatal outcomes. STUDY DESIGN: Data from the Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-To-Be (NuMoM2b) study were used. Total gestational weight gain was categorized as inadequate, adequate, or excessive based on the 20...

    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Dude AM,Grobman W,Haas D,Mercer BM,Parry S,Silver RM,Wapner R,Wing D,Saade G,Reddy U,Iams J,Kominiarek MA

    更新日期:2021-01-01 00:00:00

  • Neonatal cord blood subsets and cytokine response to bacterial antigens.

    abstract::We compared lymphocyte subsets and cytokine responses to bacteria among term, preterm infants, and adults. Lymphocyte subset percentages in cord blood (22 preterm, 27 term neonates) and peripheral blood from 21 adults and cytokine/chemokine interleukin (IL)-6, IL-8, IL-10, IL-12, interferon gamma (IFN gamma) responses...

    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Peoples JD,Cheung S,Nesin M,Lin H,Tatad AM,Hoang D,Perlman JM,Cunningham-Rundles S

    更新日期:2009-10-01 00:00:00

  • Acyclovir treatment of primary herpes in pregnancy complicated by second trimester preterm premature rupture of membranes with term delivery: case report.

    abstract::Primary genital herpes simplex virus (HSV) infection in pregnancy is associated with an increased risk of vertical transmission to the fetus, especially with rupture of membranes. Two cases of primary herpes and two cases of recurrent herpes in pregnancy with preterm premature rupture of membranes and expectant manage...

    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Dietrich YM,Napolitano PG

    更新日期:2002-07-01 00:00:00

  • Association of midgestational paraoxonase 1 activity with pregnancies complicated by preeclampsia.

    abstract::The antioxidant enzyme paraoxonase 1 is a marker of oxidative stress and has been implicated in the pathogenesis of preeclampsia. Our objective was to determine if an association exists between low paraoxonase 1 activity at midgestation and the development of preeclampsia. We conducted a case-control study of 50 women...

    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Baker AM,Klein RL,Haeri S,Moss KL,Boggess KA

    更新日期:2010-03-01 00:00:00

  • Recombinant human Clara cell secretory protein treatment increases lung mRNA expression of surfactant proteins and vascular endothelial growth factor in a premature lamb model of respiratory distress syndrome.

    abstract::Infant respiratory distress syndrome (IRDS) can lead to impaired alveolarization and dysmorphic vascularization of bronchopulmonary dysplasia. Clara cell secretory protein (CC10) has anti-inflammatory properties but is deficient in the premature infant. Because surfactant and vascular endothelial growth factor (VEGF) ...

    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Wolfson MR,Funanage VL,Kirwin SM,Pilon AL,Shashikant BN,Miller TL,Shaffer TH

    更新日期:2008-11-01 00:00:00

  • A clinical scoring system to predict the development of bronchopulmonary dysplasia.

    abstract:OBJECTIVE:This study aims to develop a scoring system for the prediction of bronchopulmonary dysplasia (BPD). METHODS:Medical records of 652 infants whose gestational age and birth weight were below 32 weeks and 1,500 g, respectively, and who survived beyond 28th postnatal day were reviewed retrospectively. Logistic r...

    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Gursoy T,Hayran M,Derin H,Ovali F

    更新日期:2015-06-01 00:00:00