Abstract：
OBJECTIVE:Adding azithromycin to standard antibiotic prophylaxis for unscheduled cesarean delivery has been shown to reduce postcesarean infections. Because wound infection with ureaplasmas may not be overtly purulent, we assessed the hypothesis that azithromycin-based extended-spectrum antibiotic prophylaxis also reduces wound complications that are identified as noninfectious. STUDY DESIGN:This is a secondary analysis of the C/SOAP (Cesarean Section Optimal Antibiotic Prophylaxis) randomized controlled trial, which enrolled women with singleton pregnancies ≥24 weeks who were undergoing nonelective cesarean. Women were randomized to adjunctive azithromycin or identical placebo up to 1 hour preincision. All wound complications occurring within 6 weeks were adjudicated into infection and noninfectious wound complications (seroma, hematoma, local cellulitis, and other noninfectious wound breakdown). The primary outcome for this analysis is the composite of noninfectious wound complications. RESULTS:At a total of 14 sites, 2,013 women were randomized to adjunctive azithromycin (n = 1,019) or placebo (n = 994). Groups were similar at baseline. Although there was a lower rate of noninfectious wound complications in the azithromycin group compared with placebo (2.9 vs. 3.8%), this was not statistically significant (p = 0.22). CONCLUSION:While adding azithromycin to usual antibiotic prophylaxis for nonelective cesarean delivery does reduce the risk of postcesarean infections, it did not significantly reduce the risk of postcesarean noninfectious wound complications.
journal_name
Am J Perinatoljournal_title
American journal of perinatologyauthors
Ausbeck EB,Jauk VC,Boggess KA,Saade GR,Longo S,Clark EAS,Esplin S,Cleary K,Wapner R,Letson K,Owens M,Abramovici A,Ambalavanan N,Szychowski JM,Andrews W,Tita ATN,Cesarean Section Optimal Antibiotic Prophylaxis Trial Consordoi
10.1055/s-0039-1679914subject
Has Abstractpub_date
2019-07-01 00:00:00pages
886-890issue
9eissn
0735-1631issn
1098-8785journal_volume
36pub_type
杂志文章abstract：:The present study of 466 consecutive liveborn preterm singleton deliveries included 238 cases of spontaneous preterm labor and delivery, 175 cases with premature rupture of membranes, 13 cases of nonhypertensive abruption, 18 cases of preeclampsia, and 22 cases of placenta previa. Placental infarction, chronic villiti...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-2007-999318
更新日期：1992-05-01 00:00:00
abstract：INTRODUCTION:Many tertiary neonatal units employ a restricted visiting policy. Webcams have previously been implemented in the neonatal unit setting in several countries. OBJECTIVES:This study aims to determine the views from parents, physicians, and nursing staff before implementation of a webcam system. METHODS:A q...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-0034-1376388
更新日期：2015-02-01 00:00:00
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journal_title：American journal of perinatology
pub_type： 杂志文章
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journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-2007-994140
更新日期：1997-05-01 00:00:00
abstract：:The numbers of ectopic pregnancies have increased because of the popularization of assisted reproductive techniques. However, the retroperitoneal space is an exceptional location for ectopic pregnancy because the entrance to the retroperitoneal space is unknown. A woman 31 years of age who had received bilateral salpi...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-2007-1004829
更新日期：2008-01-01 00:00:00
abstract：OBJECTIVE:To determine epidemiology and clinical characteristics of infants with methicillin-susceptible (MSSA) and -resistant Staphylococcus aureus (MRSA) in a level III neonatal intensive care unit (NICU). STUDY DESIGN:All NICU admissions (2001 to 2008) with any positive S. aureus culture were included as cases. Cas...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-0032-1304819
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abstract：:Introduction Our aim was to survey clinicians to assess awareness and utilization of the NICHD Neonatal Research Network outcomes estimator, which allows clinicians to use multiple factors to better estimate the likelihood that intensive care will benefit the delivered neonate. Study Design The survey tool included a ...
journal_title：American journal of perinatology
pub_type： 杂志文章
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journal_title：American journal of perinatology
pub_type： 杂志文章,评审
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更新日期：2018-05-01 00:00:00
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journal_title：American journal of perinatology
pub_type： 杂志文章
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journal_title：American journal of perinatology
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journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-0033-1347363
更新日期：2014-03-01 00:00:00
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journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-2007-994618
更新日期：1993-11-01 00:00:00
abstract：:Objective To assess the additive value of prenatal chromosomal microarray analysis (CMA) for all indications and the likelihood of detecting pathologic copy number variations (CNVs) based on specific indications. Methods A retrospective analysis was performed on amniocentesis and chorionic villi sampling results obtai...
journal_title：American journal of perinatology
pub_type： 杂志文章
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更新日期：2017-03-01 00:00:00
abstract：OBJECTIVE:This study aimed to investigate factors that influence growth in infants with gastroschisis. STUDY DESIGN:Growth parameters at birth, discharge, 6, 12, and 18 months of age were collected from 42 infants with gastroschisis. RESULTS:The mean z-scores for weight, length, and head circumference were below norm...
journal_title：American journal of perinatology
pub_type： 杂志文章
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更新日期：2020-12-01 00:00:00
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journal_title：American journal of perinatology
pub_type： 杂志文章,多中心研究,随机对照试验
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更新日期：2010-04-01 00:00:00
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journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-2007-993903
更新日期：1998-02-01 00:00:00
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journal_title：American journal of perinatology
pub_type： 杂志文章
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journal_title：American journal of perinatology
pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：American journal of perinatology
pub_type： 杂志文章
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journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-2007-993970
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journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-2007-994346
更新日期：1996-07-01 00:00:00
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journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-0040-1716481
更新日期：2020-09-07 00:00:00
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更新日期：2019-03-01 00:00:00
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journal_title：American journal of perinatology
pub_type： 杂志文章,随机对照试验
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更新日期：2013-11-01 00:00:00
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更新日期：2009-11-01 00:00:00
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journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-2007-999866
更新日期：1986-07-01 00:00:00
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journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-2007-994649
更新日期：1993-03-01 00:00:00
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journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-2007-999726
更新日期：1987-01-01 00:00:00
abstract：OBJECTIVE:The aim of the study is to conduct an initial pilot trial evaluating the feasibility, safety, and efficacy of bupropion for smoking cessation in pregnancy. STUDY DESIGN:A randomized, double-blind, parallel-group pilot study of bupropion versus placebo with 50 pregnant smokers was planned. Eligibility criteri...
journal_title：American journal of perinatology
pub_type： 杂志文章,随机对照试验
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更新日期：2015-03-01 00:00:00
