Risk factors for early and late onset of respiratory symptoms in babies born through meconium.

Abstract:

:We sought (1) to identify risk factors for meconium aspiration syndrome (MAS) among infants born to women whose labors were complicated by thick-consistency meconium-stained amniotic fluid (MSAF), and (2) to determine whether risk factors and infant prognosis differ according to the time of onset of respiratory distress. We performed a secondary analysis of a multicenter randomized trial of amnioinfusion (AI) for the prevention of MAS among women with thick-consistency MSAF. MAS was defined as onset of respiratory distress requiring oxygen supplementation within the first 4 hours of life. Patients with respiratory symptoms with onset at >or=4 hours were treated as a separate outcome category, "late-onset respiratory distress." We developed peripartum and intrapartum regression models to identify the risk of MAS and its subgroups. A tracing with marked abnormalities was a significant risk factor for moderate/severe MAS, but not for mild MAS or for late-onset respiratory distress. Meconium below the vocal cords and need for resuscitation immediately after birth were risk factors for mild and moderate/severe MAS as well as for late-onset respiratory distress. The risk of nonrespiratory comorbidities varied directly according to the severity of the respiratory distress. Late-onset respiratory distress shares several risk factors with MAS, as defined by Rossi et al. The two conditions may represent different manifestations of the same disease process.

journal_name

Am J Perinatol

authors

Xu H,Calvet M,Wei S,Luo ZC,Fraser WD,Amnioinfusion Study Group.

doi

10.1055/s-0029-1241740

subject

Has Abstract

pub_date

2010-04-01 00:00:00

pages

271-8

issue

4

eissn

0735-1631

issn

1098-8785

journal_volume

27

pub_type

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