Abstract:
OBJECTIVE:To determine if preincubation with prostaglandin E1 (PGE1) and E2 (PGE2) enhances oxytocin-induced myometrial contractility in vitro. STUDY DESIGN:Myometrial strips from 13 women were incubated with PGE1 (10-5 mol/L or 10-6 mol/L), PGE2 (10-5 mol/L or 10-6 mol/L) or solvent before adding cumulative concentrations of oxytocin (10-10 to 10-6 mol/L). The area under the contraction curve was calculated after addition of each agent. One- and two-way analysis of variance was used for comparison (significance p < 0.05). RESULTS:PGE2 10-5 mol/L reduced response to oxytocin 10-9 to 10-6 mol/L (p < 0.05). PGE2 reduced spontaneous myometrial contractility as compared with PGE1 (p < 0.05). A dose-dependent negative effect of prostaglandins was detected on oxytocin 10-8 mol/L (10-5 mol/L > 10-6 mol/L; p < 0.05). CONCLUSION:Contrary to the hypothesis, neither PGE1 nor PGE2 enhanced oxytocin-induced myometrial contractility; in fact, PGE2 decreased contractility.
journal_name
Am J Perinatoljournal_title
American journal of perinatologyauthors
Chiossi G,Reed LC,Costantine MM,Hankins GD,Saade GR,Longo Mdoi
10.1055/s-0032-1329696subject
Has Abstractpub_date
2013-09-01 00:00:00pages
649-54issue
8eissn
0735-1631issn
1098-8785journal_volume
30pub_type
杂志文章abstract:: ...
journal_title:American journal of perinatology
pub_type: 社论
doi:10.1055/s-0038-1676585
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journal_title:American journal of perinatology
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journal_title:American journal of perinatology
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journal_title:American journal of perinatology
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journal_title:American journal of perinatology
pub_type: 临床试验,杂志文章
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journal_title:American journal of perinatology
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journal_title:American journal of perinatology
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journal_title:American journal of perinatology
pub_type: 杂志文章
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journal_title:American journal of perinatology
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journal_title:American journal of perinatology
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journal_title:American journal of perinatology
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journal_title:American journal of perinatology
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journal_title:American journal of perinatology
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journal_title:American journal of perinatology
pub_type: 杂志文章,评审
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journal_title:American journal of perinatology
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journal_title:American journal of perinatology
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journal_title:American journal of perinatology
pub_type: 杂志文章
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journal_title:American journal of perinatology
pub_type: 杂志文章,多中心研究
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journal_title:American journal of perinatology
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