Does preincubation with prostaglandin E1 or prostaglandin E2 enhance oxytocin-induced myometrial contractility in vitro?

Abstract:

OBJECTIVE:To determine if preincubation with prostaglandin E1 (PGE1) and E2 (PGE2) enhances oxytocin-induced myometrial contractility in vitro. STUDY DESIGN:Myometrial strips from 13 women were incubated with PGE1 (10-5 mol/L or 10-6 mol/L), PGE2 (10-5 mol/L or 10-6 mol/L) or solvent before adding cumulative concentrations of oxytocin (10-10 to 10-6 mol/L). The area under the contraction curve was calculated after addition of each agent. One- and two-way analysis of variance was used for comparison (significance p < 0.05). RESULTS:PGE2 10-5 mol/L reduced response to oxytocin 10-9 to 10-6 mol/L (p < 0.05). PGE2 reduced spontaneous myometrial contractility as compared with PGE1 (p < 0.05). A dose-dependent negative effect of prostaglandins was detected on oxytocin 10-8 mol/L (10-5 mol/L > 10-6 mol/L; p < 0.05). CONCLUSION:Contrary to the hypothesis, neither PGE1 nor PGE2 enhanced oxytocin-induced myometrial contractility; in fact, PGE2 decreased contractility.

journal_name

Am J Perinatol

authors

Chiossi G,Reed LC,Costantine MM,Hankins GD,Saade GR,Longo M

doi

10.1055/s-0032-1329696

subject

Has Abstract

pub_date

2013-09-01 00:00:00

pages

649-54

issue

8

eissn

0735-1631

issn

1098-8785

journal_volume

30

pub_type

杂志文章
  • Society for Maternal-Fetal Medicine's Fellow Research Series 2018: Manuscripts of the Year.

    abstract:: ...

    journal_title:American journal of perinatology

    pub_type: 社论

    doi:10.1055/s-0038-1676585

    authors: Metz TD,Gill L,Silver RM,Society for Maternal-Fetal Medicine Fellowship Affairs Committee.

    更新日期:2019-01-01 00:00:00

  • B-type natriuretic peptide: biomarker of persistent pulmonary hypertension of the newborn?

    abstract:OBJECTIVE:We assessed the utility of plasma B-type natriuretic peptide (BNP) in infants with persistent pulmonary hypertension of the newborn (PPHN) in the prediction of inhaled nitric oxide (iNO) requirement. METHODS:This prospective study involved neonates (gestational age ≥ 34 weeks) with PPHN and confirmatory echo...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-0035-1548540

    authors: Shah N,Natarajan G,Aggarwal S

    更新日期:2015-09-01 00:00:00

  • Accurate ultrasonic estimation of fetal weight.

    abstract::The accuracy of eight ultrasonic fetal weight formulas were analyzed in 1099 fetuses who underwent real-time ultrasound examination within 72 hours prior to delivery. Shepard's formula was most consistently found to give the lowest systematic and random errors throughout all weight categories, though Deter's formula h...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-2007-999944

    authors: Ott WJ,Doyle S,Flamm S

    更新日期:1985-07-01 00:00:00

  • Neonatal effects of magnesium sulfate given to the mother.

    abstract:OBJECTIVE:Magnesium historically has been used for treatment and/or prevention of eclampsia or preterm labor. More recently, antepartum magnesium sulfate has been suggested for prevention of cerebral palsy in preterm infants. Although adverse effects and toxicity of magnesium in pregnant women are well known, the fetal...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-0032-1316440

    authors: Abbassi-Ghanavati M,Alexander JM,McIntire DD,Savani RC,Leveno KJ

    更新日期:2012-11-01 00:00:00

  • Hypoxemia associated with cimetidine therapy in a newborn infant.

    abstract::Cimetidine therapy used for the treatment of gastric bleeding due to tolazoline therapy in a newborn infant was temporally associated with episodes of severe hypoxemia. It appears likely that the histamine H2 receptor blocked by cimetidine obviated the pulmonary vasodilator effect of tolazoline therapy. ...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-2007-994346

    authors: Kuint J,Linder N,Reichman B

    更新日期:1996-07-01 00:00:00

  • Fetal myocardial calcification associated with maternal cocaine use.

    abstract::Two cases of fetal myocardial calcification confirmed postnatally are reported. In contrast to other reports, both infants survived with resolution of calcification by 6 and 12 months. Diagnostic investigations failed to confirm the presence of congenital infection. Both pregnancies were complicated by early cocaine u...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-2008-1040740

    authors: Yap TE,Diana D,Herson V,Chameides L,Rowe JC

    更新日期:1994-05-01 00:00:00

  • First trimester disulfiram exposure: report of two cases.

    abstract::Disulfiram has been used effectively to deter alcohol consumption in patients with a history of alcohol abuse. Its use in reproductive age women has become increasingly common in recent years, intensifying the risk of fetal exposure. Nonspecific but significant abnormalities have been described in the infants of women...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-2007-994688

    authors: Helmbrecht GD,Hoskins IA

    更新日期:1993-01-01 00:00:00

  • Immune system development in infants born to mothers with autoimmune disease, exposed in utero to immunosuppressive agents.

    abstract::Exposure to immunosuppressant agents during gestation can affect the fetal immune system. The aim of this study was to evaluate the immune function of infants whose mothers were administered immunosuppressants during pregnancy for the treatment of autoimmune disorders. Circulating lymphocyte subsets and in vitro immun...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-2007-986679

    authors: Motta M,Ciardelli L,Marconi M,Tincani A,Gasparoni A,Lojacono A,Chirico G

    更新日期:2007-09-01 00:00:00

  • Do fiber-enriched diabetic diets have glucose-lowering effects in pregnancy?

    abstract::A fiber-enriched diabetic diet that contained a modest increase in dietary fiber and a commercially available fiber supplement was studied in pregnant diabetic women for its potential glucose-lowering effects. Noninsulin-requiring gestational diabetic patients were placed on a fiber-enriched diet of increasing fiber c...

    journal_title:American journal of perinatology

    pub_type: 临床试验,杂志文章

    doi:10.1055/s-2007-994738

    authors: Reece EA,Hagay Z,Caseria D,Gay LJ,DeGennaro N

    更新日期:1993-07-01 00:00:00

  • Remifentanil analgesia during laser treatment for retinopathy of prematurity: a practical approach in neonatal intensive care unit.

    abstract:BACKGROUND:Retinopathy of prematurity (ROP) is a significant cause of childhood blindness. AIM:The aim of this study is to determine the feasibility of remifentanil analgesia during laser treatment of ROP performed in the neonatal intensive care unit (NICU). PATIENTS AND METHODS:Remifentanil was infused continuously ...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-0034-1370348

    authors: Demirel N,Bas AY,Kavurt S,Celik IH,Yucel H,Turkbay D,Hekimoğlu E,Koc O

    更新日期:2014-11-01 00:00:00

  • Birth Tourism and Neonatal Intensive Care: A Children's Hospital Experience.

    abstract::Objective The aim of this article is to examine characteristics of birth tourism (BT) neonates admitted to a neonatal intensive care unit (NICU). Methods This was a retrospective review over 3 years; BT cases were identified, and relevant perinatal, medical, social, and financial data were collected and compared with ...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-0036-1584139

    authors: Mikhael M,Cleary JP,Dhar V,Chen Y,Nguyen DV,Chang AC

    更新日期:2016-12-01 00:00:00

  • Accurate gestational dating: revisited.

    abstract::Using first trimester fetal crown-rump length (CRL) measurements as the criterion for gestational dating, rather than menstrual history or neonatal gestational age evaluation after birth, may be a more accurate way of evaluating the accuracy of second or third trimester ultrasonic measurements for gestational age esti...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-2007-994606

    authors: Ott WJ

    更新日期:1994-11-01 00:00:00

  • Transvaginal sonography at 5 to 14 weeks' gestation: fetal stomach, abnormal cord insertion, and yolk sac.

    abstract::Transvaginal ultrasound evaluation of the fetal digestive system was performed on 1000 fetuses at 5 to 14 weeks' gestation. The normal physiologic process of the midgut herniation into the cord as well as the embryonal connection between the yolk sac and fetus were detected. Peristalsis of the stomach was noted as ear...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-2007-999261

    authors: Bronshtein M,Yoffe N,Zimmer EZ

    更新日期:1992-09-01 00:00:00

  • Oxygenation of the human fetus as a function of hemoglobulin concentration.

    abstract::We studied the relationships between fetal hemoglobin concentration, acid base status, and lactate concentration in umbilical venous and fetal heart blood in 157 fetuses affected by blood group incompatibility who had been exposed for 214 fetal blood sampling procedures (cordocentesis in 153 and intracardiac puncture ...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-2007-994524

    authors: Westgren M,Lingman G,Stangenberg M

    更新日期:1994-01-01 00:00:00

  • Fractured clavicle in the neonate: a retrospective three-year review.

    abstract::A hospital-based case-controlled study was undertaken to determine maternal and neonatal characteristics associated with fractured clavicle. A total of 11,604 consecutive vaginal deliveries of liveborn infants in vertex presentation at the Mount Sinai Hospital from 1988 to 1990 were reviewed. Maternal and neonatal cha...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-2007-994546

    authors: Brown BL,Lapinski R,Berkowitz GS,Holzman I

    更新日期:1994-09-01 00:00:00

  • Respiratory Instability and Hypoxemia Episodes in Preterm Infants.

    abstract::Oxygenation instability is a very common problem in the premature infant that manifests as intermittent hypoxemia episodes (HEs). These are particularly frequent in premature infants who are on mechanical ventilation beyond the first weeks after birth. However, they can also occur in spontaneously breathing infants. S...

    journal_title:American journal of perinatology

    pub_type: 杂志文章,评审

    doi:10.1055/s-0038-1637760

    authors: Bancalari E,Claure N

    更新日期:2018-05-01 00:00:00

  • Intrapartum chemoprophylaxis for group B streptococcus infection to prevent neonatal disease: who should be treated?

    abstract::The purpose of this study was to examine the maternal risk factors associated with early onset Group B streptococcus (GBS) sepsis and determine the potential impact of intrapartum chemoprophylaxis using these risk factors. Using a computerized perinatal database, 26,525 deliveries over a five-year period (1989 to 1994...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-2007-994433

    authors: Philipson EH,Herson VC

    更新日期:1996-11-01 00:00:00

  • Prenatal diagnosis of midgut volvulus by sonography and magnetic resonance imaging.

    abstract::We present a case of congenital midgut volvulus detected by prenatal sonography and ultrafast magnetic resonance (MR) imaging. At 34 weeks of gestation, enlarged hyperechogenic loops without peristalsis was identified by sonographic examination. On ultrafast T2-weighted single-shot fast-spin echo MR imaging, enlarged ...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-2001-18794

    authors: Miyakoshi K,Ishimoto H,Tanigaki S,Minegishi K,Tanaka M,Miyazaki T,Yoshimura Y

    更新日期:2001-12-01 00:00:00

  • Outpatient oral misoprostol for prolonged pregnancies: a pilot investigation.

    abstract:UNLABELLED:We evaluated the effectiveness of oral misoprostol for outpatient cervical ripening and labor induction in prolonged pregnancies. We performed a randomized, double-blind, placebo-controlled study of women at 40 to 42 weeks' gestation with well-dated pregnancies, singleton gestations, Bishop scores less than ...

    journal_title:American journal of perinatology

    pub_type: 杂志文章,随机对照试验

    doi:10.1055/s-0029-1220790

    authors: Gaffaney CA,Saul LL,Rumney PJ,Morrison EH,Thomas S,Nageotte MP,Wing DA

    更新日期:2009-10-01 00:00:00

  • Fetal polycystic kidney disease associated with glutaric aciduria type II: an inborn error of energy metabolism.

    abstract::The findings of hyperechoic and enlarged fetal kidneys on routine antenatal ultrasonography is a non-specific finding that alerts the physician to a differential diagnosis of various genetic and non-genetic disorders, including fetal polycystic disease and Beckwith-Wiedeman syndrome. Detection of fetal or neonatal pol...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-2007-994309

    authors: Whitfield J,Hurst D,Bennett MJ,Sherwood WG,Hogg R,Gonsoulin W

    更新日期:1996-04-01 00:00:00

  • Unusual misplacement sites of percutaneous central venous lines in the very low birth weight neonate.

    abstract::Percutaneously placed central venous lines have become an intricate part of the medical management of the very low birth weight infant. It is critically important that health care providers involved with the placement of these catheters be familiar with the possible subtle sites for catheter misplacement. We present t...

    journal_title:American journal of perinatology

    pub_type: 杂志文章,评审

    doi:10.1055/s-2007-994099

    authors: Lussky RC,Trower N,Fisher D,Engel R,Cifuentes R

    更新日期:1997-02-01 00:00:00

  • Teenage Pregnancies: Risk Factors and Associated Neonatal Outcomes in an Eastern-European Academic Perinatal Care Center.

    abstract:OBJECTIVES:This study aims to compare women with early (13-16 years), late teenage (17-19 years), and adult (25-29 years) pregnancies regarding pregnancy risk factors and reproductive outcomes. METHODS:An observational study, utilizing medical charts and direct interview, conducted in an academic hospital during Janua...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-0035-1565917

    authors: Suciu LM,Pasc AL,Cucerea M,Bell EF

    更新日期:2016-03-01 00:00:00

  • Percutaneous Inserted Venous Catheter via Femoral Vein in Extremely Low-Birth-Weight Infants: A Single-Center Experience.

    abstract:OBJECTIVE:This study aimed to assess the applicability of the insertion of small diameter catheters through the femoral vein in extremely low-birth-weight (ELBW) infants. STUDY DESIGN:All femoral small diameter catheters (Silastic or femoral arterial catheter [FAC]) inserted in ELBW infants in a tertiary level neonata...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-0039-1693718

    authors: Bergón-Sendín E,Soriano-Ramos M,Méndez-Marín MD,De Miguel-Moya M,Fontiveros-Escalona D,Diezma-Godino M,Pallás-Alonso CR,Moral-Pumarega MT

    更新日期:2020-12-01 00:00:00

  • Trichosporon beigelii, a new neonatal pathogen.

    abstract::Trichosporon beigelii is an uncommon cause of sepsis in low-birth-weight infants. We present two cases of neonatal trichosporonosis and two cases of neonatal trichosporon colonization to familiarize neonatologists with this entity and to discuss management considerations. A 23-week-gestation male developed clinical ev...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-2007-994109

    authors: Yoss BS,Sautter RL,Brenker HJ

    更新日期:1997-02-01 00:00:00

  • The Impact of the New Hypertension Guidelines to Low-Dose Aspirin Prophylaxis Eligibility for the Prevention of Preeclampsia: A Cost-Benefit Analysis.

    abstract:OBJECTIVE: American College of Cardiology and American Heart Association (ACC/AHA) published new guidelines which lower the cut-off for hypertension. We sought to evaluate the impact of these guidelines to cost and benefit of various low-dose aspirin prophylaxis approaches. STUDY DESIGN: Decision tree analysis was cre...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-0039-1697588

    authors: Putra M,Balasooriya MM,Boscia AL,Dalkiran E,Sokol RJ

    更新日期:2019-10-11 00:00:00

  • Cervical Length as a Predictor of Preterm Delivery in an Unselected Cohort of Women with Twin Pregnancies.

    abstract:OBJECTIVE:To determine the risk of spontaneous preterm delivery (SPTD) associated with transvaginal cervical length (TVCL) in an unselected cohort. STUDY DESIGN:This is a retrospective study of serial TVCLs in unselected twin gestations. Receiver operator curves for SPTD were constructed from TVCLs at 18, 20, 22, and ...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-0038-1676484

    authors: Brock CO,Moroz LA,Gyamfi-Bannerman C

    更新日期:2019-10-01 00:00:00

  • Large fetomaternal hemorrhage: prenatal predictive factors for perinatal outcome.

    abstract::We sought to identify prenatal predictive factors for perinatal outcome and to estimate fetal hemoglobin (Hb) levels in large fetomaternal hemorrhages (transfused blood volume [TBV] > 20 mL) by performing a case-series study ( N = 32). Perinatal outcome was favorable (F group, N = 22) and poor (P group, N = 10: four f...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-0028-1103150

    authors: Huissoud C,Divry V,Dupont C,Gaspard M,Rudigoz RC

    更新日期:2009-03-01 00:00:00

  • A rapid and safe method to detect fetal parvovirus B19 infection in amniotic fluid by polymerase chain reaction: report of a case.

    abstract::Molecular amplification of parvovirus B19 DNA in an amniotic fluid sample was used to confirm the etiologic agent of a case with fetal hydrops. The polymerase chain reaction (PCR) method used is easy and fast to perform. We have a 2-year experience on its use in clinical parvovirus B19 diagnosis. The results are avail...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-2007-994518

    authors: Nikkari S,Ekblad U

    更新日期:1995-11-01 00:00:00

  • Midpregnancy Cervical Length in Nulliparous Women and its Association with Postterm Delivery and Intrapartum Cesarean Delivery.

    abstract:OBJECTIVE:To evaluate the association between midpregnancy cervical length and postterm delivery and cesarean delivery during labor. STUDY DESIGN:In a multicenter cohort study, cervical length was measured in low-risk singleton pregnancies between 16 and 22 weeks of gestation. From this cohort, we identified nulliparo...

    journal_title:American journal of perinatology

    pub_type: 杂志文章,多中心研究

    doi:10.1055/s-0035-1556067

    authors: van der Ven AJ,van Os MA,Kleinrouweler CE,Verhoeven CJ,de Miranda E,Bossuyt PM,de Groot CJ,Haak MC,Pajkrt E,Mol BW,Kazemier BM

    更新日期:2016-01-01 00:00:00

  • Current Practices of Antiseptic Use in Canadian Neonatal Intensive Care Units.

    abstract:OBJECTIVE:This article assesses the degree of variability in the current practice of skin antiseptics used in Canadian neonatal intensive care units (NICUs) and different experiences related to each antiseptic used. METHODS:An anonymous survey was distributed to a clinical representative of each of the 124 Canadian le...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-0038-1661406

    authors: McCord H,Fieldhouse E,El-Naggar W

    更新日期:2019-01-01 00:00:00