Serum unconjugated estriols in insulin-dependent diabetic pregnancies: normative data and clinical relevance.

Abstract:

:The purpose of this study was to establish normative reference values for serum unconjugated estriol (E3) concentrations in insulin-dependent diabetic pregnancy. There were 1973 samples analyzed in 63 diabetic pregnancies not complicated by fetal distress and/or neonatal asphyxia. These samples were compared with 867 samples collected in 25 pregnancies complicated by fetal distress and/or neonatal asphyxia and 103 samples collected in seven nondiabetic, uncomplicated pregnancies. E3 values were found to be significantly higher in diabetic compared with nondiabetic healthy gravid women, correlating with infant birthweight. The percent change of daily E3 values from the highest previous 3 days mean (maximum mean) was 1 +/- 27% (mean +/- SD). The 95% confidence limit for this percent change indicates that a decrease of 52% or more is theoretically seen in 2.5% of the observations. Using the traditional decrease of 40% currently used in the literature, there were false-negative and false-positive predictions of fetal distress and/or neonatal asphyxia at rates unacceptable for patient management. The use of E3 determinations in combination with nonstress test-contraction stress test did not improve the predictability of this latter test. Serum E3 determinations are of little clinical value in the management of insulin-dependent diabetic pregnant women.

journal_name

Am J Perinatol

authors

Miodovnik M,Mimouni F,Hertzberg VS,Siddiqi TA,Tsang RC

doi

10.1055/s-2007-999718

subject

Has Abstract

pub_date

1988-10-01 00:00:00

pages

327-33

issue

4

eissn

0735-1631

issn

1098-8785

journal_volume

5

pub_type

杂志文章
  • Vaginal birth after cesarean delivery in a small rural community with a solo practice.

    abstract::The objective of this study is to review the safety and success of a trial of labor after cesarean in a group of patients managed by a solo practitioner in a rural community. This was a retrospective review of all deliveries performed over an 11-year period by a single practitioner in a rural community. Standard contr...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-2003-38317

    authors: Upadhyaya CD,Upadhyaya DM,Carlan SJ

    更新日期:2003-02-01 00:00:00

  • Predictive value of late decelerations for fetal acidemia in unselective low-risk pregnancies.

    abstract::We evaluated the clinical significance of late decelerations (LD) of intrapartum fetal heart rate (FHR) monitoring to detect low pH (< 7.1) in low-risk pregnancies. We selected two secondary and two tertiary-level institutions where 10,030 women delivered. Among them, 5522 were low-risk pregnancies. The last 2 hours o...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-2004-837272

    authors: Sameshima H,Ikenoue T

    更新日期:2005-01-01 00:00:00

  • Length of Neuromuscular Re-education Therapy and Growth Parameters in Premature Infants.

    abstract:OBJECTIVE: Neuromuscular re-education (NMRE) therapy including bracing, containment, facilitation techniques, joint compression, weight (WT) bearing, and myofascial release has been shown to improve neurodevelopmental maturation in premature infants. This study aimed to examine the association of NMRE with growth param...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-0040-1716492

    authors: Leone M,Alsofrom J,Kane M,Laryea S,Abdelatif D,Mohamed MA

    更新日期:2020-09-11 00:00:00

  • Fetal and neonatal mortality among twin gestations in a Canadian population: the effect of intrapair birthweight discordance.

    abstract::The purpose of this study was to examine the association between intrapair birthweight discordance and fetal and neonatal mortality. This was a historical cohort study, using the Statistics Canada linked birth-infant death file. Twin births in Canada (excluding Ontario) for the period 1986-1997 were studied. Outcome m...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-2005-870899

    authors: Wen SW,Fung KF,Huang L,Demissie K,Joseph KS,Allen AC,Kramer MS,Fetal and Infant Health Group of the Canadian Perinatal Surveillance System.

    更新日期:2005-07-01 00:00:00

  • Glycosylated hemoglobin as a predictor of fetal pulmonic maturity in insulin-dependent diabetes at term.

    abstract::In insulin dependent diabetic (IDDM) gestations, fetal pulmonary maturity is delayed in the presence of suboptimal glycemic control. Serum glycosylated hemoglobin (HbA1c) provides a means of assessing glycemic control. We evaluated maternal HbA1c in IDDM pregnancies at term undergoing amniocentesis for lung maturity t...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-2007-993868

    authors: Heimberger CM,Ghidini A,Lewis KM,Spong CY

    更新日期:1999-01-01 00:00:00

  • Association of paroxysmal supraventricular tachycardia and periventricular leukomalacia.

    abstract::Periventricular leukomalacia, a condition characterized by hpoxic-ischemic infarction of deep cerebral white matter, can now be recognized by cranial sonography. The case presented here demonstrates the association of periventricular leukomalacia present at birth with intrauterine paroxysmal supraventricular tachycard...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-2007-999826

    authors: Donn SM,Bowerman RA

    更新日期:1986-01-01 00:00:00

  • Multimodal Pain Management for Cesarean Delivery: A Double-Blinded, Placebo-Controlled, Randomized Clinical Trial.

    abstract:OBJECTIVE:Our objective was to evaluate the efficacy of perioperative multimodal pain management in reducing opioid use after elective cesarean delivery (CD). STUDY DESIGN:A single-center, double-blinded, placebo-controlled randomized trial of women undergoing elective CD. Participants were allocated 1:1 to receive th...

    journal_title:American journal of perinatology

    pub_type: 杂志文章,随机对照试验

    doi:10.1055/s-0039-1681096

    authors: Hadley EE,Monsivais L,Pacheco L,Babazade R,Chiossi G,Ramirez Y,Ellis V,Simon M,Saade GR,Costantine M

    更新日期:2019-09-01 00:00:00

  • Using the Probability of Cesarean from a Validated Cesarean Prediction Calculator to Predict Labor Length and Morbidity.

    abstract:OBJECTIVE:To determine if increasing predicted risk of cesarean was associated with longer labor length and increased morbidity among women undergoing induction with an unfavorable cervix. STUDY DESIGN:Using a publically available database, we evaluated whether a previously validated prediction model for cesarean deli...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-0038-1675625

    authors: Hamm RF,Downes KL,Srinivas SK,Levine LD

    更新日期:2019-05-01 00:00:00

  • Society for Maternal-Fetal Medicine's Fellow Research Series 2018: Manuscripts of the Year.

    abstract:: ...

    journal_title:American journal of perinatology

    pub_type: 社论

    doi:10.1055/s-0038-1676585

    authors: Metz TD,Gill L,Silver RM,Society for Maternal-Fetal Medicine Fellowship Affairs Committee.

    更新日期:2019-01-01 00:00:00

  • Risks of Preterm Premature Rupture of Membranes and Preterm Birth Post Fetoscopy Based on Location of Trocar Insertion Site.

    abstract:OBJECTIVE:The objective of this study was to assess whether the location of the trocar insertion site for laser treatment of twin-twin transfusion syndrome was associated with preterm-premature rupture of membranes (PPROM) and preterm birth (PTB). STUDY DESIGN:In this study trocar location was documented in the operat...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-0037-1620268

    authors: Chmait RH,Chon AH,Korst LM,Llanes A,Kontopoulos EV,Quintero RA

    更新日期:2018-07-01 00:00:00

  • Altered mRNA expression pattern of placental epidermal growth factor receptor (EGFR) in pregnancies complicated by preeclampsia and/or intrauterine growth retardation.

    abstract::Placental pathology in preeclampsia (PE) and intrauterine growth retardation (IUGR) is associated with alterations of the placental epidermal growth factor receptor (EGFR). It is encoded by a single gene, which gives rise to two different full-length transcripts and one putative truncated transcript in the placenta. T...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-2007-993890

    authors: Faxén M,Nasiell J,Blanck A,Nisell H,Lunell NO

    更新日期:1998-01-01 00:00:00

  • Remifentanil analgesia during laser treatment for retinopathy of prematurity: a practical approach in neonatal intensive care unit.

    abstract:BACKGROUND:Retinopathy of prematurity (ROP) is a significant cause of childhood blindness. AIM:The aim of this study is to determine the feasibility of remifentanil analgesia during laser treatment of ROP performed in the neonatal intensive care unit (NICU). PATIENTS AND METHODS:Remifentanil was infused continuously ...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-0034-1370348

    authors: Demirel N,Bas AY,Kavurt S,Celik IH,Yucel H,Turkbay D,Hekimoğlu E,Koc O

    更新日期:2014-11-01 00:00:00

  • Clinical Indicators of Late-Onset Sepsis Workup in Very Low-Birth-Weight Infants in the Neonatal Intensive Care Unit.

    abstract::Background Late-onset sepsis (LOS) in very low-birth-weight (VLBW) infants is associated with significant morbidity and mortality. Objectives To determine the incidence of LOS workup, association, and predictive value of clinical indicators leading to culture-positive versus culture-negative sepsis workup. Methods All...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-0036-1579648

    authors: Das A,Shukla S,Rahman N,Gunzler D,Abughali N

    更新日期:2016-07-01 00:00:00

  • Sudden unexpected death in a neonate.

    abstract::A sudden and unexpected death, at 26 hours of age, of a term infant with no identifiable risk factors either in the prenatal or in the immediate neonatal period is described. The most remarkable postmortem findings were confined to the lungs, which had many areas of aspirated amniotic fluid, as well as extensive areas...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-2007-999592

    authors: Imaizumi SO,Balsara GR

    更新日期:1989-07-01 00:00:00

  • Necrotizing enterocolitis in the asphyxiated full-term infant.

    abstract::Five full term infants with necrotizing enterocolitis, confirmed histologically, presented in the first five days of life. All passed grossly bloody stools and three mucosal casts. Severe perinatal asphyxia with accompanying secondary hyperammonemia was present in all, and abnormal liver function studies were present ...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-2007-1000050

    authors: Goldberg RN,Thomas DW,Sinatra FR

    更新日期:1983-10-01 00:00:00

  • Midpregnancy Cervical Length in Nulliparous Women and its Association with Postterm Delivery and Intrapartum Cesarean Delivery.

    abstract:OBJECTIVE:To evaluate the association between midpregnancy cervical length and postterm delivery and cesarean delivery during labor. STUDY DESIGN:In a multicenter cohort study, cervical length was measured in low-risk singleton pregnancies between 16 and 22 weeks of gestation. From this cohort, we identified nulliparo...

    journal_title:American journal of perinatology

    pub_type: 杂志文章,多中心研究

    doi:10.1055/s-0035-1556067

    authors: van der Ven AJ,van Os MA,Kleinrouweler CE,Verhoeven CJ,de Miranda E,Bossuyt PM,de Groot CJ,Haak MC,Pajkrt E,Mol BW,Kazemier BM

    更新日期:2016-01-01 00:00:00

  • Equation for predicting weight gain in very low-birth-weight infants.

    abstract::I developed a single equation that simulated previously published growth charts for very low-birth-weight infants, using birth weight as the only variable. The intent of this study was to validate the equation using infants admitted to our neonatal intensive care unit (NICU) and to determine if this equation could be ...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-2007-993914

    authors: Meetze WH

    更新日期:1998-02-01 00:00:00

  • The effect of filtration of amniotic fluid on the growth of Chlamydia trachomatis and Escherichia coli.

    abstract::There is increasing concern about Chlamydia trachomatis infection during pregnancy, because of reports of increased maternal, fetal, and neonatal risks. Amniotic fluid is known to possess antibacterial activity and has recently been shown to inhibit formation of chlamydial inclusions in McCoy cell culture. To further ...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-2007-999341

    authors: Ismail MA,Salti GI,Block BS,Moawad AH

    更新日期:1991-01-01 00:00:00

  • Neurodevelopmental Impairment at Two Years in Premature Infants with Prolonged Patency of Ductus Arteriosus after a Conservative Approach.

    abstract:OBJECTIVE: The study aims to assess the impact on neurodevelopmental outcomes of a prolonged hemodynamically significant patent ductus arteriosus (PDA) after a conservative treatment. STUDY DESIGN: This involves the study of two cohorts of preterm infants 23 to 29 weeks gestation, before (n = 29) and after (n = 54) a ...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-0039-1697674

    authors: Aldecoa-Bilbao V,García-Catalán MJ,Gaixa M,Clotet Caba J,Teodoro S,Figaró Voltà C

    更新日期:2019-10-10 00:00:00

  • The value of the leukocyte esterase test in diagnosing intra-amniotic infection.

    abstract::This communication examines the diagnostic value of the leukocyte esterase activity (LEA) test in the detection of intra-amniotic infection. Amniotic fluid from 171 consecutive patients with premature rupture of membranes (n = 149) and preterm labor (n = 22) was obtained through amniocentesis. Gram stain, bacterial an...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-2007-999657

    authors: Romero R,Emamian M,Wan M,Yarkoni S,McCormack W,Mazor M,Hobbins JC

    更新日期:1988-01-01 00:00:00

  • Listeria meningitis during pregnancy.

    abstract::Meningitis is the major pathologic manifestation of Listeria monocytogenes in the United States. Despite the fact that this organism has a well-known predilection for individuals who are pregnant or immunocompromised, to date, maternal listeric meningitis remains an unreported entity in the English literature. The aut...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-2007-1000029

    authors: Boucher M,Yonekura ML

    更新日期:1984-07-01 00:00:00

  • Accuracy of clinically estimated fetal weight in pregnancies complicated by diabetes mellitus and obesity.

    abstract:OBJECTIVE:To determine the accuracy of clinically estimated fetal weight (CEFW) in patients with gestational diabetes (GDM), pregestational diabetes (DM), and obesity. STUDY DESIGN:This is a retrospective analysis of Consortium of Safe Labor data. Subjects were classified into six groups: DM, DM and obese, GDM, GDM an...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-0033-1334450

    authors: Drassinower D,Timofeev J,Huang CC,Benson JE,Driggers RW,Landy HJ

    更新日期:2014-01-01 00:00:00

  • Role of Cord Blood Carboxyhemoglobin in Detecting Significant Hyperbilirubinemia in Term Neonates with ABO Alloimmunization.

    abstract:OBJECTIVE: This study aimed to assess whether cord blood carboxyhemoglobin (COHb) levels in jaundiced term neonates with and without a positive direct Coombs test (DCT) and in healthy controls could be used as a predictor of severe hyperbilirubinemia. The percentage of cord blood COHb should be higher among neonates wi...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-0040-1722328

    authors: Tıraş M,Can E,Hamilçıkan Ş

    更新日期:2021-01-04 00:00:00

  • Conservative versus aggressive management of preterm rupture of membranes. A randomized trial of amniocentesis.

    abstract::Amniocentesis to guide the management of preterm pregnancies complicated by premature rupture of the membranes (PROM) has been adopted at several centers. The purpose of this study was to evaluate this practice prospectively among comparable groups of patients, which has not previously been reported. Forty-seven patie...

    journal_title:American journal of perinatology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1055/s-2007-1000031

    authors: Cotton DB,Gonik B,Bottoms SF

    更新日期:1984-07-01 00:00:00

  • Tocolysis in advanced preterm labor: impact on neonatal outcome.

    abstract::Chart review of 73 patients with 3.5 cm or more dilation, intact membranes, and regular contractions at less than 36 weeks. Forty-four (group A) received tocolysis with magnesium sulfate, and 13 of the 44 also received indomethacin. Twenty-nine (group B) received no tocolysis. Obstetric and neonatal outcomes were comp...

    journal_title:American journal of perinatology

    pub_type: 临床试验,杂志文章

    doi:10.1055/s-2007-994478

    authors: de Veciana M,Porto M,Major CA,Barke JI

    更新日期:1995-07-01 00:00:00

  • Impact of advanced maternal age on pregnancy outcome.

    abstract::The aim of this study was to compare the pregnancy outcome and delivery complications in women 40 years or older (cases) to that of women 20 to 30 years old (controls). Over a 5-year period, 319 cases had a singleton delivery in our institution. These women were compared with 326 controls. Parity was significantly hig...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-2002-20175

    authors: Seoud MA,Nassar AH,Usta IM,Melhem Z,Kazma A,Khalil AM

    更新日期:2002-01-01 00:00:00

  • The Stillbirth Collaborative Research Network neuropathologic examination protocol.

    abstract::We describe the neuropathologic procedure utilized in the Stillbirth Collaborative Research Network (SCRN), focusing on the examination of central nervous system (CNS) in stillbirth (SB). The SCRN was organized to perform a case-control study to determine the scope and causes of SB. Pathologists at all the participati...

    journal_title:American journal of perinatology

    pub_type: 杂志文章,多中心研究

    doi:10.1055/s-0031-1284229

    authors: Pinar H,Koch MA,Hawkins H,Heim-Hall J,Shehata B,Thorsten VR,Chin S,Willinger M,dela Monte S

    更新日期:2011-12-01 00:00:00

  • Gestational Weight Gain and Postpartum Depression in Women with Class III Obesity.

    abstract:OBJECTIVE:We investigated the association between gestational weight gain (GWG) and postpartum depression (PPD) in women with class III obesity. STUDY DESIGN:This is a retrospective cohort of women with body mass index (BMI) ≥ 40 kg/m2 at entry to care, first prenatal visit ≤14 weeks gestation, with singleton, nonanom...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-0039-1693989

    authors: Adkins LD,Tucker A,Gatta LA,Siegel AM,Reiff E,Brown HL,Dotters-Katz SK

    更新日期:2020-01-01 00:00:00

  • B-type natriuretic peptide: biomarker of persistent pulmonary hypertension of the newborn?

    abstract:OBJECTIVE:We assessed the utility of plasma B-type natriuretic peptide (BNP) in infants with persistent pulmonary hypertension of the newborn (PPHN) in the prediction of inhaled nitric oxide (iNO) requirement. METHODS:This prospective study involved neonates (gestational age ≥ 34 weeks) with PPHN and confirmatory echo...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-0035-1548540

    authors: Shah N,Natarajan G,Aggarwal S

    更新日期:2015-09-01 00:00:00

  • Can Transabdominal Cervical Length Measurement Exclude Short Cervix?

    abstract:OBJECTIVE:This study aims to determine if transabdominal (TA) cervical length may be used to rule out a short cervix on transvaginal (TV) ultrasound. STUDY DESIGN:We conducted a prospective cohort study of women undergoing routine anatomic survey at 17 to 23 weeks gestation. TA and TV cervical length measurements were...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-0035-1566308

    authors: Rhoades JS,Park JM,Stout MJ,Macones GA,Cahill AG,Tuuli MG

    更新日期:2016-04-01 00:00:00