Abstract:
:Seventy premature infants (birthweight 1.75 kg or less, gestational age 33 weeks or less) with hemoglobin less than 10 g/dL and hematocrit less than 30% were studied and randomly divided into three groups. All of them received oral elemental iron 3 mg/kg/day and vitamin E 5 mg/kg/day during the study period. Recombinant human erythropoietin (rHuEPO) 150 U/kg was administered intravenously twice a week for 4 weeks in group A (26 infants). Infants in group A received a total of 4 erythrocyte transfusions because of frequent apnea. Infants in group B (25 infants) received erythrocyte transfusion when their hemoglobin levels was less than 10 g/dL with signs and symptoms (including tachycardia, tachypnea, poor feeding, apnea, poor weight gain) attributed to anemia or who had a hemoglobin less than 8 g/dL even if asymptomatic. Infants in group B received a total of 36 erythrocyte transfusions. Infants in group C (19 infants) were assigned to a non-rHuEPO and nontransfusion group. Three of the 19 premature infants in group C received erythrocyte transfusions later because of frequent and prolonged apneic episodes and were excluded from this study. Our data revealed that reticulocyte and serum erythropoietin values were higher (p < 0.01) in rHuEPO-treated group than transfusion group and hemoglobin and hematocrit values were lower in group C than the other two groups during the rHuEPO treatment period. No significant difference (p > 0.05) was found in neutrophil and platelet counts among these three groups. Serum ferritin values were found lower in the rHuEPO-treated group than the other two groups. Lower weight gain was found in infants in group C. We conclude that rHuEPO administration can reduce the need for blood transfusion. Poor weight gain can be found in infants with anemia of prematurity who do not receive rHuEPO or blood transfusion therapy.
journal_name
Am J Perinatoljournal_title
American journal of perinatologyauthors
Chen JY,Wu TS,Chanlai SPdoi
10.1055/s-2007-994483subject
Has Abstractpub_date
1995-09-01 00:00:00pages
314-8issue
5eissn
0735-1631issn
1098-8785journal_volume
12pub_type
临床试验,杂志文章,随机对照试验abstract:OBJECTIVE:To assess the association between altitudes of neonatal intensive care units (NICU) and the rate of bronchopulmonary dysplasia (BPD) and BPD/death in very preterm infants. STUDY DESIGN:Data from infants born at <33 weeks' gestation admitted to Canadian Neonatal Network during 2008 and 2009 were analyzed. The...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0032-1329690
更新日期:2013-08-01 00:00:00
abstract::The aim of this study is to identify clinical, etiologic, and laboratory factors that potentiate adverse outcome of hyperbilirubinemia among term and late preterm neonates in logistic regression analysis. A retrospective cohort of infants with total serum bilirubin (TSB) ≥ 20 mg/dL from 1995 to 2007 was surveyed. Eigh...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0031-1274506
更新日期:2011-05-01 00:00:00
abstract:: ...
journal_title:American journal of perinatology
pub_type: 社论
doi:10.1055/s-0038-1676585
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVE:To evaluate to what extent indicators of placenta insufficiency are associated with low concentrations of insulin-like growth factor 1 (IGF-1) and IGF-1-binding protein-1 (IGFBP-1) in neonatal blood, and to what extent the concentrations of these growth factors are associated with concentrations of proteins w...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0038-1677472
更新日期:2019-12-01 00:00:00
abstract::This prospective study was performed to determine a way to improve conventional transcutaneous bilirubinometry results in healthy term newborn infants. In 118 infants during phototherapy (group A), and in 118 infants without phototherapy (group B), bilirubin determinations were done in duplicate using the Minolta AirS...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2005-867087
更新日期:2005-05-01 00:00:00
abstract::The Roberts-SC phocomelia syndrome (pseudothalidomide syndrome) is a rare, usually lethal condition involving short limbs and occasional hydrocephalus. Presented is a case in which prenatal sonographic findings were highly suggestive of this syndrome, although not definite. In this fetus, findings of hydrocephalus, sh...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-999392
更新日期:1991-07-01 00:00:00
abstract::The use of transabdominal vibroacoustic stimulation has been shown to improve the efficiency of antepartum fetal surveillance. The ability of the fetus to habituate to such a stimulus has also been suggested as a means of assessing the function of the central nervous system. The purpose of this blinded prospective inv...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-999420
更新日期:1991-11-01 00:00:00
abstract::The novel coronavirus disease 2019 (COVID-19) pandemic has resulted in changes to perinatal and neonatal care, concentrating on minimizing risks of transmission to the newborn and health care staff while ensuring medical care is not compromised for both mother and infant. Current recommendations on infant care and fee...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0040-1716506
更新日期:2020-11-01 00:00:00
abstract:OBJECTIVE:This study aimed to assess the applicability of the insertion of small diameter catheters through the femoral vein in extremely low-birth-weight (ELBW) infants. STUDY DESIGN:All femoral small diameter catheters (Silastic or femoral arterial catheter [FAC]) inserted in ELBW infants in a tertiary level neonata...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0039-1693718
更新日期:2020-12-01 00:00:00
abstract::Background It is unclear how adherence to the Institute of Medicine's (IOM) guidelines for weight gain affects pregnancy outcomes. Objective We investigated how weight gain outside the IOM's recommendations affects the risks of adverse pregnancy outcomes. Study Design We performed a secondary analysis of a prospective...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0036-1584583
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVE:The definition of postpartum hemorrhage (PPH) was developed more than 50 years ago. Since then, the obstetric population has changed dramatically. We sought to determine how well we estimated blood loss (EBL) and find thresholds predicting need for transfusion. STUDY DESIGN:We performed a prospective cohort ...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0035-1552940
更新日期:2015-11-01 00:00:00
abstract::Objective To assess the additive value of prenatal chromosomal microarray analysis (CMA) for all indications and the likelihood of detecting pathologic copy number variations (CNVs) based on specific indications. Methods A retrospective analysis was performed on amniocentesis and chorionic villi sampling results obtai...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0036-1586501
更新日期:2017-03-01 00:00:00
abstract:OBJECTIVE:Adding azithromycin to standard antibiotic prophylaxis for unscheduled cesarean delivery has been shown to reduce postcesarean infections. Because wound infection with ureaplasmas may not be overtly purulent, we assessed the hypothesis that azithromycin-based extended-spectrum antibiotic prophylaxis also redu...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0039-1679914
更新日期:2019-07-01 00:00:00
abstract:OBJECTIVE: Women with placenta accreta spectrum (PAS) having an unplanned delivery may have worse outcome compared with women with a planned delivery. The primary objective of this study was to compare severe maternal morbidity among women with PAS who had a planned scheduled delivery versus an unplanned delivery. Seco...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0040-1714676
更新日期:2020-07-23 00:00:00
abstract:OBJECTIVE:This study aims to identify risk factors for cesarean delivery (CD) surgical site infection (SSI). study design: Retrospective analysis of 2,739 CDs performed at the University of Pittsburgh in 2011. CD SSIs were defined using National Healthcare Safety Network (NHSN) criteria. Chi-square test and t-test were...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0035-1563548
更新日期:2016-01-01 00:00:00
abstract::The purpose of this study was to examine the maternal risk factors associated with early onset Group B streptococcus (GBS) sepsis and determine the potential impact of intrapartum chemoprophylaxis using these risk factors. Using a computerized perinatal database, 26,525 deliveries over a five-year period (1989 to 1994...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-994433
更新日期:1996-11-01 00:00:00
abstract:OBJECTIVE: Transient tachypnoea of the newborn (TTN) is one of the most common causes of neonatal respiratory distress (RD) during the newborn period. Chest radiography (CXR) is commonly used to rule out the diagnosis, but TTN is often misdiagnosed as neonatal respiratory distress syndrome (NRDS) on the basis of CXR al...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0040-1721134
更新日期:2020-11-26 00:00:00
abstract::The objective of this article is to report obstetric outcomes of human immunodeficiency virus-1 (HIV-1)-serodiscordant couples who underwent in vitro fertilization and embryo transfer (IVF-ET) with intracytoplasmic sperm injection (ICSI) at a tertiary care center. We reviewed the outcomes of seronegative women after I...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2003-42694
更新日期:2003-08-01 00:00:00
abstract::Arteriovenous malformations of the Vein of Galen continue to present diagnostic and therapeutic challenges in the neonatal period. Approximately 40-50% of all malformations of the Vein of Galen present in the neonatal period, usually with congestive heart failure. These neonates represent the most severe cases and are...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2000-13456
更新日期:2000-01-01 00:00:00
abstract::The findings of hyperechoic and enlarged fetal kidneys on routine antenatal ultrasonography is a non-specific finding that alerts the physician to a differential diagnosis of various genetic and non-genetic disorders, including fetal polycystic disease and Beckwith-Wiedeman syndrome. Detection of fetal or neonatal pol...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-994309
更新日期:1996-04-01 00:00:00
abstract::We studied 16 women, at 32 weeks' or more gestation who required magnesium sulfate (MgSO4) therapy for preterm labor or preeclampsia. A 60-minute Doppler fetal heart rate (FHR) tracing, analyzed by the Oxford Sonicaid System 8000, was obtained for 1 hour before and 2 hours after each patient received intravenous MgSO4...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-994468
更新日期:1995-07-01 00:00:00
abstract::The objective of this study was to perform antiphospholipid antibody screening in women with chronic hypertension to assess whether the presence of such antibodies is associated with adverse pregnancy outcome. Serum for anticardiolipin antibodies and lupus anticoagulant was obtained in pregnant women with chronic hype...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2004-829870
更新日期:2004-07-01 00:00:00
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journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0034-1381317
更新日期:2015-02-01 00:00:00
abstract::Pulmonary hypoplasia is lethal in its most severe form; in less severe cases the clinical course is protracted, usually resulting in chronic lung disease. A case of unexpected survival of an infant with clinical and radiologic evidence of pulmonary hypoplasia, in whom dexamethasone was administered, is presented. Poss...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-999375
更新日期:1991-05-01 00:00:00
abstract:OBJECTIVE:Prediction of gestational latency after placement of physical exam indicated cerclage (PEIC) is limited. Uterocervical angle (UCA) has been associated with spontaneous preterm delivery in the general population. Our objective was to examine whether UCA is associated with gestational latency in women with PEIC...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0037-1621734
更新日期:2018-07-01 00:00:00
abstract::Two cases of fetal myocardial calcification confirmed postnatally are reported. In contrast to other reports, both infants survived with resolution of calcification by 6 and 12 months. Diagnostic investigations failed to confirm the presence of congenital infection. Both pregnancies were complicated by early cocaine u...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2008-1040740
更新日期:1994-05-01 00:00:00
abstract:OBJECTIVE:To estimate the natural history of cervical effacement in labor. STUDY DESIGN:This is a retrospective cohort study of term, vertex, singletons who reached 10 cm of cervical dilation from 2010 to 2014. Interval-censored regression was used to estimate the median number of hours between changes in effacement (...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0038-1645858
更新日期:2019-01-01 00:00:00
abstract::Cimetidine therapy used for the treatment of gastric bleeding due to tolazoline therapy in a newborn infant was temporally associated with episodes of severe hypoxemia. It appears likely that the histamine H2 receptor blocked by cimetidine obviated the pulmonary vasodilator effect of tolazoline therapy. ...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-994346
更新日期:1996-07-01 00:00:00
abstract::The effect of active management on latent phase labor was assessed in 197 consecutive nulliparous women. Active management resulted in a significant shortening of the latent phase but had no effect on active phase labor. Patients undergoing induction of labor had latent phases that were almost identical to the accepte...
journal_title:American journal of perinatology
pub_type: 临床试验,杂志文章
doi:10.1055/s-2007-999524
更新日期:1990-10-01 00:00:00
abstract::Four hundred sixty-four fetuses underwent real time ultrasound examination within 72 hours before birth to evaluate other factors than the weight formula itself that might influence the accuracy of ultrasound weight estimation. The results indicated that fetal sex had no effect on weight estimation accuracy, but that ...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-999866
更新日期:1986-07-01 00:00:00