Abstract：
:Using infrared and Raman microspectroscopy, the authors examined the interaction of cold atmospheric plasma with the skin's built-in protective cushion, the outermost skin layer stratum corneum. Following a spectroscopic analysis, the authors could identify four prominent chemical alterations caused by plasma treatment: (1) oxidation of disulfide bonds in keratin leading to a generation of cysteic acid; (2) formation of organic nitrates as well as (3) of new carbonyl groups like ketones, aldehydes and acids; and (4) reduction of double bonds in the lipid matter lanolin, which resembles human sebum. The authors suggest that these generated acidic and NO-containing functional groups are the source of an antibacterial and regenerative environment at the treatment location of the stratum corneum. Based upon the author's results, the authors propose a mechanistic view of how cold atmospheric plasmas could modulate the skin chemistry to produce positive long-term effects on wound healing: briefly, cold atmospheric plasmas have the potential to transform the skin itself into a therapeutic resource.
journal_name
Biointerphasesjournal_title
Biointerphasesauthors
Kartaschew K,Mischo M,Baldus S,Bründermann E,Awakowicz P,Havenith Mdoi
10.1116/1.4919610subject
Has Abstractpub_date
2015-06-06 00:00:00pages
029516issue
2eissn
1934-8630issn
1559-4106journal_volume
10pub_type
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