Abstract:
:The articular cartilage, once injured, has a limited capacity for intrinsic repair. Preparation of functionally biocartilage substitutes in vitro for cartilage repair is an attractive concept with the recent advances in tissue engineering. In this study, adipose-derived adult stem cells (ADAS) and chondrocytes (Ch) were cocultured in different population ratios on the surface of hyaluronan-grafted chitosan (CS-HA) membranes. The two types of cells could self-assemble into cospheroids with different morphologies. In particular, when ADAS and Ch were cocultured at an initial ratio of 7:3 on CS-HA surface, the expression of chondrogenic markers was upregulated, leading to preferred chondrogenesis of the cospheroids. Therefore, using the ADAS/Ch 7:3 cospheroids derived on CS-HA surface instead of using only a single type of cells may be favorable for future therapeutic applications.
journal_name
Biointerphasesjournal_title
Biointerphasesauthors
Yeh HY,Hsieh FY,Hsu SHdoi
10.1116/1.4942754subject
Has Abstractpub_date
2016-03-25 00:00:00pages
011011issue
1eissn
1934-8630issn
1559-4106journal_volume
11pub_type
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