Growth hormone secretion and ultradian rhythms in growth-retarded rats with dorsomedial hypothalamic lesions.

Abstract:

:Rats with lesions of the dorsomedial nucleus of the hypothalamus (DMN-L) are hypophagic and have reduced linear growth and body weight, but normal body composition. Male Sprague-Dawley rats (170-190 g) housed individually under a 12:12 L:D schedule with lights out at 1430 hr received jugular cannulas, and on return to precannulation body weight (4.2 +/- 0.6 days), they received bilateral electrolytic DMN-L or sham-operations (SHAM). Rats with DMN-L (n = 8) were hypophagic postsurgery and weight less (p less than 0.05) than SHAM at six days postlesion surgery. The difference in body weight between the two groups continued to expand over the next four weeks. Six days postsurgery, the rats were bled (RBC's returned in 10% BSA-saline) every 15 minutes between 0600-1215 hr and growth hormone (GH) subsequently assayed. The total GH secretion, as computed from the area under each rat's ultradian pattern, was similar in both groups (DMN-L versus SHAM, 2952.2 +/- 346.5 versus 2950.4 +/- 337.5). Using the PULSAR computer program, the baseline secretion (12.2 +/- 4.0 versus 11.8 +/- 2.7 ng/ml), total number of peaks (2.4 +/- 0.4 versus 2.4 +/- 0.2), and interpeak interval (2.8 +/- 0.5 versus 2.7 +/- 0.4, hr) were not significantly different between the DMN-L and SHAM rats, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)

journal_name

Physiol Behav

journal_title

Physiology & behavior

authors

Byrd SL,Bellinger LL

doi

10.1016/0031-9384(89)90268-0

subject

Has Abstract

pub_date

1989-08-01 00:00:00

pages

279-83

issue

2

eissn

0031-9384

issn

1873-507X

pii

0031-9384(89)90268-0

journal_volume

46

pub_type

杂志文章
  • Preloads of corn oil inhibit independent ingestion on postnatal day 15 in rats.

    abstract::The ontogenetic development of postingestive inhibitory control of ingestion by an oil preload was examined in preweaning rats. Gastric preloads (5% b.wt) of water, mineral oil or corn oil were administered 5 min before a 30-min intake test in which pups licked milk from the floor of a test chamber. Preloads of corn o...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/s0031-9384(97)00256-4

    authors: Weller A,Gispan IH,Armony-Sivan R,Ritter RC,Smith GP

    更新日期:1997-10-01 00:00:00

  • Dose-related stimulation of feeding by systemic injections of monosodium glutamate.

    abstract::Monosodium glutamate (MSG) is an excitotoxin capable of both stimulating and lesioning neurons in circumventricular organs (CVOs) after systemic administration. In this study, MSG and equiosmotic concentrations of NaCl were administered subcutaneously to adult rats in order to observe the effects on food and water int...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(86)90412-9

    authors: Reddy VM,Meharg SS,Ritter S

    更新日期:1986-10-01 00:00:00

  • Seasonal energetics of the Hottentot golden mole at 1500 m altitude.

    abstract::Winter is an energetically stressful period for small mammals as increasing demands for thermoregulation are often coupled with shortages of food supply. In sub-tropical savannah, Hottentot golden moles (Ambysomus hottentottus longiceps) forage throughout the year and for long periods of each day. This may enable them...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2005.02.022

    authors: Scantlebury M,Oosthuizen MK,Speakman JR,Jackson CR,Bennett NC

    更新日期:2005-04-13 00:00:00

  • The pineal affects life span in hamsters with heart disease.

    abstract::Cardiomyopathic hamsters (CMH) develop heart disease early in life which leads to congestive heart failure and death as these hamsters age. We have previously shown that living in constant light or other non-24-h light-dark (LD) cycles can increase longevity in these hamsters, and the current experiment examined poten...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/s0031-9384(97)00250-3

    authors: Natelson BH,Ottenweller JE,Tapp WN,Heung S,Beldowicz D

    更新日期:1997-11-01 00:00:00

  • Morus alba L. Diminishes visceral adiposity, insulin resistance, behavioral alterations via regulation of gene expression of leptin, resistin and adiponectin in rats fed a high-cholesterol diet.

    abstract::Ethanolic extract of leaves of Morus alba L. (M. alba), known as white mulberry, was orally administered (100 mg/kg b.wt) for 8 weeks to female Wistar rats that were fed a high-cholesterol diet (HCD), to investigate the potential of M. alba leaves in attenuation of obesity, dyslipidemia, insulin resistance, and defici...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2018.12.010

    authors: Metwally FM,Rashad H,Mahmoud AA

    更新日期:2019-03-15 00:00:00

  • Autonomic blockade does not prevent learned heart rate attenuation during exercise.

    abstract::Each of three monkeys was operantly conditioned to slow its heart, to exercise (lift weights) and to attenuate the tachycardia of exercise by combining these two skills. Each was further tested during beta-adrenergic blockade (atenolol), combined alpha-adrenergic blockade (prazosin) and beta-adrenergic blockade, or ch...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(91)90058-v

    authors: Engel BT,Talan MI

    更新日期:1991-02-01 00:00:00

  • Copulatory thrusting pattern in the male rat after acute treatment with GABA transaminase inhibitors.

    abstract::It has previously been found that the GABA transaminase inhibitors gamma-acetylen GABA (GAG) and sodium valproate reduced intromission behavior in male rats without affecting mounting behavior. These effects were obtained, however, only in doses that also impaired motor execution. The purpose of the present study was ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(90)90148-w

    authors: Agmo A,Contreras JL

    更新日期:1990-02-01 00:00:00

  • Socio-sexual behavior in male rats after lesions of the dorsolateral tegmentum.

    abstract::The medial preoptic area of the anterior hypothalamus (MPOA/AH) and the dorsolateral tegmentum (DLT) play an important role in the control of sexual behavior. Unilateral lesions of the MPOA/AH (medial preoptic area of the anterior hypothalamus) combined with unilateral lesions of the contralateral DLT result in defici...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/s0031-9384(98)00146-2

    authors: Giordano M,Güemes M,López-Arias V,Paredes RG

    更新日期:1998-08-01 00:00:00

  • Postweaning social experience and adult aggression in rats.

    abstract::One group of male rats was reared continuously in small, stable colonies of three animals each during a ten-week period beginning when they were 46 days old. A second group of animals was also reared in small groups of three animals each but membership within these colonies was randomly changed at weekly intervals. Th...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(84)90373-1

    authors: Lore RK,Stipo-Flaherty A

    更新日期:1984-10-01 00:00:00

  • Examinations of the reward comparison hypothesis: The modulation of gender and footshock.

    abstract::The reward comparison hypothesis suggests that drugs of abuse-induced conditioned saccharin suppression intake is due to the reward value of drugs of abuse that outweighs that of a saccharin solution dissociating from the aversive LiCl-induced conditioned taste aversion (CTA). Huang and Hsiao (2008) provided some conf...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2015.07.022

    authors: Huang AC,Wang CC,Wang S

    更新日期:2015-11-01 00:00:00

  • REM sleep deprivation affects extinction of cued but not contextual fear conditioning.

    abstract::Previous research has demonstrated that rapid eye movement (REM), or paradoxical, sleep deprivation can interfere with the retention of certain types of learning tasks, particularly spatial learning. The present study investigated the effects of 6 h of REM sleep deprivation on the retention and extinction of both cued...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2004.11.011

    authors: Silvestri AJ

    更新日期:2005-03-16 00:00:00

  • Lead effects on food competition and predatory aggression in Binghamton HET mice.

    abstract::The ubiquity of lead in our environment, its toxic nature and its potential to alter behavior of humans and animals has stimulated much research. In addition to the well known, but complex, changes in activity and performance of learned tasks following exposure to lead, an increasing body of literature suggests that c...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(91)90014-f

    authors: Hahn ME,Burright RG,Donovick PJ

    更新日期:1991-10-01 00:00:00

  • Antioxidant enzyme activities in the lymphoid organs and muscles of rats fed fatty acids-rich diets subjected to prolonged physical exercise-training.

    abstract::Rats weighing 45-50 g were fed 3 diets for 8 wk: a balanced control diet (CD) consisting of 4% fat (polyunsaturated/saturated fatty acids [P/S] ratio 2.9/1) and two fat-rich diets: polyunsaturated (UD)--P/S 7.6/1 and saturated (SD) P/S 0.3/1. After 8 wk feeding on the respective diets, rats were subjected to swimming ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(94)90342-5

    authors: Pereira B,Rosa LF,Safi DA,Guimarães AR,Bechara EJ,Curi R

    更新日期:1994-11-01 00:00:00

  • Elevated plus-maze behavior in adult offspring of selectively bred rats.

    abstract::Animals sampled from the third generation (S3) of selective breeding of N:NIH strain rats based on ultrasonic vocalization (USV) rates in infancy (High, Low, and Random lines) were tested as adults on the elevated plus maze, a well-validated test of anxiety. Results showed that the Low line spent a greater percent of ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(95)02222-8

    authors: Dichter GS,Brunelli SA,Hofer MA

    更新日期:1996-07-01 00:00:00

  • Spices and energy balance.

    abstract::The sensory properties of foods and beverages are primary determinants of food choice. Some flavor components have an inherent hedonic valence that influences ingestive behavior. However, these hedonic impressions may be modified and others newly formed through their association with the post-ingestive consequences of...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2011.10.028

    authors: Mattes RD

    更新日期:2012-11-05 00:00:00

  • Effects of ethanol in an open field apparatus: modification by U50488H and WIN 44441-3.

    abstract::The effects of U50488H, a kappa agonist, and WIN 44441-3, a kappa antagonist, and their modification of the effects of ethanol, on the behavior of rats in a modified open field apparatus, was examined. Crossover activity was increased by U50488H. Headpoke activity was decreased by WIN 44441-3 and increased by U50488H....

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(89)90129-7

    authors: Pohorecky LA,Patel V,Roberts P

    更新日期:1989-02-01 00:00:00

  • Peripheral administration of a corticotropin-releasing factor antagonist increases the vocalizing and locomotor activity of isolated guinea pig pups.

    abstract::Guinea pig pups vocalized more and were more active during a 60-min period of isolation in a novel environment when injected SC with 50 micrograms of the corticotropin-releasing factor (CRF) antagonist, [D-Phe]CRF12-41, than when injected with saline vehicle only. More pups exhibited eye closing and extensive piloerec...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(96)00091-1

    authors: McInturf SM,Hennessy MB

    更新日期:1996-09-01 00:00:00

  • Plasma catecholamine responses during a personalized physical stress as a dynamic characterization of essential hypertension.

    abstract::High performance liquid chromatography (HPLC) with electrochemical detection proves to be a reliable method for determination of plasma catecholamines (CA) to assess the possible role of the sympathetic nervous system (SNS) in essential hypertension (EH). The present investigation in a group of 15 normotensive (N) and...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(91)90302-5

    authors: Tosti-Croce C,Lucarelli C,Betto P,Floridi A,Rinaldi R,Salvati A,Taggi F,Sciarra F

    更新日期:1991-04-01 00:00:00

  • The type of implicit motive enactment is modulated by sex hormones in naturally cycling women.

    abstract::Sex hormones have been reported to dynamically modulate the expression of implicit motives, a concept that has previously been thought to be relatively stable over time. This study investigates to what extent the need for affiliation, power, and achievement, as well as the form of enactment of these needs as measured ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2013.09.016

    authors: Ball A,Wolf CC,Ocklenburg S,Brüne M,Wolf OT,Güntürkün O,Pinnow M

    更新日期:2014-01-17 00:00:00

  • Gustatory processing differences in PTC tasters and non-tasters: a reaction time analysis.

    abstract::The present study examined differences in gustatory processing for tasters and non-tasters of phenylthiocarbamide (PTC) by assessing intensity judgment reaction times in these two groups. After prescreening for sensitivity to PTC, subjects were asked to judge whether solutions of sucrose, sodium chloride, quinine sulf...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(85)90343-9

    authors: Frank RA,Korchmar DL

    更新日期:1985-08-01 00:00:00

  • Comparison of two isometric handgrip protocols on sympathetic arousal in women.

    abstract::Isometric handgrip is commonly used in stress research because the task reliably increases sympathetic arousal. Various handgrip protocols have been used; they vary in handgrip strength, duration of grip, and the number of cycles of handgrip and rest. However, most protocols require the calibration of a maximum volunt...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2015.01.031

    authors: Nielsen SE,Mather M

    更新日期:2015-04-01 00:00:00

  • Feeding cycles in smokers, exsmokers and nonsmokers.

    abstract::Smokers, exsmokers and nonsmokers showed 50 to 150 minute cycles of consummatory behavior (eating and drinking) that appear to reflect a biological rhythm of oral drive. Smokers and exsmokers had significantly shorter cycles, i.e., more frequent consummatory peaks, than nonsmokers. If a greater frequency of consummato...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(86)90480-4

    authors: Green J,Tapp WN

    更新日期:1986-01-01 00:00:00

  • Effect of cage size on ultradian locomotor rhythms of laboratory mice.

    abstract::The effect of cage size on spontaneous locomotor rhythms of laboratory mice was studied under simulated light-dark (12:12) cycles. On-line image analysis of bodily displacement yielded a locomotor signal over a period of 3 days. Continuous wavelet transform was applied to the signal, and ensemble averaging of eight mi...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/s0031-9384(97)00305-3

    authors: Poon AM,Wu BM,Poon PW,Cheung EP,Chan FH,Lam FK

    更新日期:1997-12-01 00:00:00

  • Histamine plays no part in schedule-induced polydipsia in the rat.

    abstract::Twelve Sprague-Dawley male albino rats were tested with or without combined antagonism of peripheral H1 (using 2 mg/kg dexbrompheniramine IP) and H2 (using 32 mg/kg cimetidine IP) receptors for histamine prior to (a) drinking after 2.5 mg/kg histamine SC, (b) drinking after 24-hr water deprivation, and (c) drinking du...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(85)90385-3

    authors: Kraly FS,Coogan LA,Mashkuri PL,Kellman SA

    更新日期:1985-05-01 00:00:00

  • Impairment of thermoregulatory cooling behavior by single cortical spreading depression in the rat.

    abstract::Effects of single waves of unilateral cortical spreading depression (CSD) on skin-cooling operant behavior were studied in the rat with and without unilateral lesion in the preoptic and anterior hypothalamus (PO/AH). The skin-cooling behavior was severely suppressed for 6 min, with a resulting rise in rectal temperatu...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(83)90227-5

    authors: Shibata M,Hori T,Kiyohara T,Nakashima T,Osaka T

    更新日期:1983-04-01 00:00:00

  • Neonatal infection modulates behavioral flexibility and hippocampal activation on a Morris Water Maze task.

    abstract::Neonatal infection has enduring effects on the brain, both at the cellular and behavioral levels. We determined the effects of peripheral infection with Escherichia coli at postnatal day (P) 4 in rats on a water maze task in adulthood, and assessed neuronal activation in the dentate gyrus (DG) following the memory tes...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2014.02.033

    authors: Williamson LL,Bilbo SD

    更新日期:2014-04-22 00:00:00

  • Medial and lateral amygdalectomy differentially influences consummatory negative contrast.

    abstract::Rats shifted from a 32% to 4% sucrose solution consume substantially less 4% sucrose than unshifted animals that experience only the 4% solution. This negative contrast effect was found to be attenuated by lesions of the lateral aspects of the amygdala (basolateral, lateral, and basomedial nuclei) and eliminated by le...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(84)90035-0

    authors: Becker HC,Jarvis MF,Wagner GC,Flaherty CF

    更新日期:1984-11-01 00:00:00

  • Functional relationship between the hypothalamic vigilance area and PAG vigilance area.

    abstract::The vigilance reaction is characterized by a large bradycardia, a pressor response, and inspiratory apnea in anesthetized rabbits and the inhibition of movement in conscious rabbits. This affective response pattern can be elicited by electrical stimulation of the dorsolateral hypothalamus (the hypothalamic vigilance a...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/s0031-9384(97)00004-8

    authors: Duan YF,Winters R,McCabe PM,Green EJ,Huang Y,Schneiderman N

    更新日期:1997-09-01 00:00:00

  • The effect of photoperiod on development of sexual behavior and fertility in golden hamsters.

    abstract::Male hamsters were raised on short (SD) or long (LD) photoperiods from birth, and the expression of sexual behavior at 6, 7, 10, and 14 weeks was compared. Neither mounting, intromissions, ejaculations, nor ultrasonic vocalizations differed in the two groups until 14 weeks of age, when these behaviors were performed m...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(87)90383-0

    authors: Cherry JA

    更新日期:1987-01-01 00:00:00

  • The effects of early dietary experience on subsequent protein selection in the rat.

    abstract::Two series of experiments were designed to investigate the effects of protein composition of the first solid food consumed by young rat pups on their subsequent protein intake after weaning. In the first series of experiments, pups were allowed access to the maternal diet between 17 and 21 days of age, then weaned to ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(86)90015-6

    authors: Morris P,Anderson GH

    更新日期:1986-01-01 00:00:00