Y-body study in bone marrow precursors, peripheral blood cells and alveolar macrophages for demonstration of haemopoietic engraftment in allogeneic bone marrow transplantation.

abstract：OBJECTIVES AND METHODS:We conducted a retrospective analysis to evaluate the outcomes of 28 heavily pretreated (median 3 (2-6) treatment lines, sixteen (57%) allotransplanted) relapsed/refractory acute myeloid leukemia patients who had failed salvage venetoclax-based therapies. RESULTS:The median age was 59 years (20-...

journal_title：European journal of haematology

authors： Zucenka A,Pileckyte R,Trociukas I,Peceliunas V,Vaitekenaite V,Maneikis K,Davainis L,Zvirblis T,Stoskus M,Gineikiene E,Norvilas R,Dirse V,Surauciute A,Zucenkiene E,Griskevicius L

更新日期：2021-01-01 00:00:00

abstract：:Haemophilia remains a complex disorder to diagnose and manage, requiring close cooperation between multidisciplinary healthcare professionals. There are still many unmet challenges in haemophilia care. The first Team Haemophilia Education (THE) meeting, held on 7-8 May 2015 in Amsterdam, The Netherlands, aimed to prom...

journal_title：European journal of haematology

authors： Berntorp E,Hart D,Mancuso ME,d'Oiron R,Perry D,O'Mahony B,Kaczmarek R,Crato M,Pasi J,Miners A,Carlsson KS,Kitchen S,Boehlen F,Giangrande P,Cebura E,Uitslager N,Osooli M,Janeckova D,Haldon R,Rivolta GF

更新日期：2016-07-01 00:00:00

abstract：:In March 1981, a 53-year-old man presented with itching and was diagnosed as having myelofibrosis. There was gradual enlargement of the spleen over the following 5 yr. His spleen had to be removed in February 1986 because of physical discomfort. 3 months post-splenectomy he became polycythaemic. Bone marrow examinatio...

journal_title：European journal of haematology

authors： Dokal I,Pagliuca A,Deenmamode M,Mufti GJ,Lewis SM

更新日期：1989-01-01 00:00:00

abstract：:All-trans retinoic acid (ATRA) has been shown to inhibit in vitro growth of multiple myeloma (MM) cells, and this effect can be further potentiated by the addition of Dexamethasone (DEX). We here extended this study by testing the activity of 9-cis retinoic acid (9-cis RA) and 13-cis retinoic acid (13-cis RA), both al...

journal_title：European journal of haematology

authors： Tosi P,Pellacani A,Visani G,Ottaviani E,Ronconi S,Zamagni E,Benni M,Cavo M,Tura S

更新日期：1999-03-01 00:00:00

abstract：:The present trial was designed to test the effects of G-CSF on the duration of the second phase of induction chemotherapy in children with newly diagnosed acute lymphoblastic leukemia (ALL). A total of 32 patients were assigned randomly to a group that received (14 patients; group A) or a group that did not receive (1...

journal_title：European journal of haematology

authors： Dibenedetto SP,Ragusa R,Ippolito AM,Lo Nigro L,Di Cataldo A,D'Amico S,Miraglia V

更新日期：1995-08-01 00:00:00

abstract：:Immune thrombocytopenic purpura (ITP) is an autoimmune disorder, and high-dose dexamethasome (HD-DXM) has been used as a first-line therapy for patients with ITP. However, little is known about the role of dendritic cells (DCs) and CD4(+)Foxp3(+) regulatory T (Treg) cells in the pathogenesis of chronic ITP and the eff...

journal_title：European journal of haematology

authors： Ling Y,Cao X,Yu Z,Ruan C

更新日期：2007-10-01 00:00:00

abstract：:Little is known about the S100B⁺ lymphocytes, which are unique human peripheral blood lymphocytes (PBL) containing the S100B protein. It has recently been shown that S100B is released from various types of S100B⁺ cells and exhibits varied cytokine-like activities. In this study, we precisely characterized the S100B⁺ l...

journal_title：European journal of haematology

authors： Miki Y,Gion Y,Mukae Y,Hayashi A,Sato H,Yoshino T,Takahashi K

更新日期：2013-02-01 00:00:00

abstract：:The aim of this study was to evaluate the usefulness of serum osteocalcin (OC) levels in multiple myeloma (MM) in order to assess its significance and activity, and to predict its course. Serum OC was measurement in 117 patients with MM and 116 healthy controls matched for age and sex. Serum OC levels were weakly corr...

journal_title：European journal of haematology

authors： Mejjad O,Le Loët X,Basuyau JP,Ménard JF,Jego P,Grisot C,Daragon A,Grosbois B,Euller-Ziegler L,Monconduit M

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND:Abnormal coagulation parameters have been reported in COVID-19-infected patients. Although the underlying mechanism of COVID-19 coagulopathy remains unknown, it has been suggested to be a form of disseminated intravascular coagulation (DIC). OBJECTIVES:The aim of our study was to analyze the coagulation par...

journal_title：European journal of haematology

authors： Martín-Rojas RM,Pérez-Rus G,Delgado-Pinos VE,Domingo-González A,Regalado-Artamendi I,Alba-Urdiales N,Demelo-Rodríguez P,Monsalvo S,Rodríguez-Macías G,Ballesteros M,Osorio-Prendes S,Díez-Martín JL,Pascual Izquierdo C

更新日期：2020-12-01 00:00:00

abstract：:We investigated whether depressed plasma antithrombin and protein C activity, considered as a specific finding of disseminated intravascular coagulation (DIC), is due to consumption coagulopathy in septic patients with DIC. An analysis of hemostatic parameters was performed in 139 septic patients (68 with DIC and 71 w...

journal_title：European journal of haematology

authors： Asakura H,Ontachi Y,Mizutani T,Kato M,Ito T,Saito M,Morishita E,Yamazaki M,Aoshima K,Takami A,Yoshida T,Suga Y,Miyamoto K,Nakao S

更新日期：2001-09-01 00:00:00

abstract：OBJECTIVES:Here, we tested the hypothesis that human M-CSF (hM-CSF) overexpressed in cord blood (CB) CD34+ cells would induce differentiation and survival of monocytes and osteoclasts in vitro and in vivo. METHODS:Human M-CSF was overexpressed in cord blood CD34+ cells using a lentiviral vector. RESULTS:We show that ...

journal_title：European journal of haematology

authors： Montano Almendras CP,Thudium CS,Löfvall H,Moscatelli I,Schambach A,Henriksen K,Richter J

更新日期：2017-05-01 00:00:00

abstract：:This single-center retrospective study reported the outcome of 19 children treated with a reduced-intensity conditioning (RIC) regimen prior to allogeneic stem cell transplantation (allo-SCT), for hematologic malignancies (n = 17), bone marrow failure (n = 1), and neuroblastoma (n = 1). Children were ineligible for st...

journal_title：European journal of haematology

authors： Strullu M,Rialland F,Cahu X,Brissot E,Corradini N,Thomas C,Blin N,Rialland X,Méchinaud F,Mohty M

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND:Non-Hodgkin lymphoma patients have a 25% increased risk of secondary primary neoplasms (SPNs). Regarding the controversy about the increased risk of SPN in patients exposed to radioimmunotherapy (RIT), we have analyzed this issue in a cohort of follicular lymphoma (FL) patients treated with/without RIT. PAT...

journal_title：European journal of haematology

authors： Andrade-Campos MM,Liévano P,Espinosa-Lara N,Soro-Alcubierre G,Grasa-Ulrich JM,López-Gómez L,Baringo T,Giraldo P

更新日期：2016-12-01 00:00:00

abstract：:Immune reconstitution may be delayed after CD34-selected compared with unmanipulated autologous peripheral blood stem cell transplantation (PBSCT), resulting in a theoretically increased risk of infections. In a case-control matched study we compared the incidence of infection in 25 recipients of CD34-selected PBSC (C...

journal_title：European journal of haematology

authors： Frère P,Pereira M,Fillet G,Beguin Y

更新日期：2006-02-01 00:00:00

abstract：:This study was conducted in order to assess myocardial and liver iron concentrations (LICs) using serial magnetic resonance imaging (MRI) scans in patients with beta-thalassaemia major, over a 4-yr period, and consequently to compare the effectiveness of different chelation regimens. Fifty children and young adults wi...

journal_title：European journal of haematology

authors： Christoforidis A,Haritandi A,Tsatra I,Tsitourides I,Karyda S,Athanassiou-Metaxa M

更新日期：2007-01-01 00:00:00

abstract：:In recent years, several direct-acting oral anticoagulants (DOAC) have become available for use in Europe and other regions in indications related to prophylaxis and treatment of venous and arterial thromboembolism. They include the oral direct thrombin inhibitor dabigatran etexilate (Pradaxa, Boehringer Ingelheim) an...

journal_title：European journal of haematology

authors： Gómez-Outes A,Suárez-Gea ML,Lecumberri R,Terleira-Fernández AI,Vargas-Castrillón E

更新日期：2015-11-01 00:00:00

abstract：:Multiple myeloma (MM) is considered to be an essentially incurable haematological malignant disease, probably because of the existence of resistant clonal precursor cell with self-renewal capacity. Recent data have indicated that the myeloma cell hierarchy includes circulating clonal memory B cells, which differ consi...

journal_title：European journal of haematology

authors： Björkstrand B,Rasmussen T,Remes K,Gruber A,Pelliniemi TT,Johnsen HE

更新日期：2003-06-01 00:00:00

abstract：OBJECTIVE:To assess the outcome of the measurement of apoptotic index in myeloma patients treated by conventional chemotherapy and novel drugs with biological mechanism of action, thalidomide and bortezomib. PATIENTS AND METHODS:In a cohort of 189 patients with newly diagnosed multiple myeloma from November 1997 throu...

journal_title：European journal of haematology

authors： Minarik J,Scudla V,Ordeltova M,Bacovsky J,Pika T,Langova K

更新日期：2009-12-01 00:00:00

abstract：:Twenty-nine consecutive cases with a t(8;21)(q22;q22) in the bone marrow (BM) karyotype were retrospectively studied concerning clinical, morphological and cytogenetic data. All had been diagnosed as acute myeloid leukaemia (AML), 27 FAB subtype M2 and two M1, comprising 5% of all cytogenetically analysed AML during 1...

journal_title：European journal of haematology

authors： Billström R,Johansson B,Fioretos T,Garwicz S,Malm C,Zettervall O,Mitelman F

更新日期：1997-07-01 00:00:00

abstract：:A consecutive material of 111 untreated patients with non-Hodgkin's lymphoma was studied with respect to fraction of S-phase cells in blood mononuclear cells in relation to presence of monoclonal B cells in blood (MBCB). Fraction of S-phase cells was determined by flow cytometry and estimation of MBCB was performed by...

journal_title：European journal of haematology

authors： Lindh J,Jonsson H,Lenner P,Roos G

更新日期：1989-04-01 00:00:00

abstract：OBJECTIVES:Invasive Aspergillosis (IA) is a serious problem among hematological patients and it is associated with high mortality. This situation can worsen at times of hospital construction, however there are several preventive measures available. This work aims to define the cost-effectiveness of some of these interv...

journal_title：European journal of haematology

authors： Combariza JF,Toro LF,Orozco JJ,Arango M

更新日期：2018-02-01 00:00:00

abstract：:In addition to BCR, various rare fusion partners for the ABL1 gene have been reported in leukemia. We have identified the fusion gene SNX2-ABL1 in a pediatric case of acute lymphoblastic leukemia (ALL), which has only once previously been reported in an adult patient. Cytogenetic analysis detected this fusion gene ari...

journal_title：European journal of haematology

authors： Masuzawa A,Kiyotani C,Osumi T,Shioda Y,Iijima K,Tomita O,Nakabayashi K,Oboki K,Yasuda K,Sakamoto H,Ichikawa H,Hata K,Yoshida T,Matsumoto K,Kiyokawa N,Mori T

更新日期：2014-03-01 00:00:00

abstract：:We have studied the kinetics of plasma levels of circulating (c)selectins in 8 patients undergoing bone marrow or stem cell transplantation to gain estimates for the distribution and half-life of (c)selectins and to potentially identify an endothelial source of cP-selectin in patients who are deprived of platelets and...

journal_title：European journal of haematology

authors： Jilma B,Eichler HG,Becherer A,Brugger S,Kalhs P,Stohlawetz P,Kapiotis S,Kapiotis S

更新日期：1998-07-01 00:00:00

abstract：:Myeloperoxidase (MPO), a heme protein, is a major component of azurophilic granules of neutrophils. Optimal oxygen-dependent microbicidal activity depends on MPO as the critical enzyme for the generation of hypochlorous acid and other toxic oxygen products. MPO is synthesized during the promyelocytic stage of myeloid ...

journal_title：European journal of haematology

authors： Nauseef WM,Olsson I,Arnljots K

更新日期：1988-02-01 00:00:00

abstract：OBJECTIVES:As new, effective therapies emerge for acute lymphoblastic leukaemia (ALL), the results of clinical trials need to relate to standard of care. METHODS:We used the population-based Swedish ALL Registry to evaluate characteristics, treatment and long-term outcome in 933 patients with diagnosis between 1997 an...

journal_title：European journal of haematology

authors： Lennmyr E,Karlsson K,Ahlberg L,Garelius H,Hulegårdh E,Izarra AS,Joelsson J,Kozlowski P,Moicean A,Tomaszewska-Toporska B,Lübking A,Hallböök H,Swedish Adult Acute Lymphoblastic Leukaemia Group (SVALL).

更新日期：2019-08-01 00:00:00

abstract：:A murine cultured cell line (MKM-O) was established from a tumor of a BALB/C (nu/nu) mouse that had been subcutaneously inoculated with human hepatoma tissue fragments in the same location. The MKM-O cell line was proven to be of endothelial origin by morphological examinations and positive staining with fluorescein-l...

journal_title：European journal of haematology

authors： Yoshimura T,Miyanomae T,Tanaka M,Iwai Y,Mayumi M,Mikawa H

更新日期：1987-08-01 00:00:00

abstract：:MALT lymphoma is usually described in association with Helicobacter pylori, HCV, HHV8, Campylobacter jejuni or in a setting of overreactive immunity. In HIV(+) patients, MALT lymphoma is most commonly described in children. We describe here an original case of HIV(+) MALT lymphoma with bronchial, conjuctival and laryn...

journal_title：European journal of haematology

authors： Girard T,Luquet-Besson I,Baran-Marszak F,Raphaël M,Boué F

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVE:Diffuse large B-cell lymphoma (DLBCL) can be classified as germinal center B cell-like (GCB) or activated B cell-like (ABC)/non-GCB based on cell-of-origin (COO) classification. This study evaluated the prognostic significance of COO classification in 250 patients diagnosed with de novo DLBCL who received R-C...

journal_title：European journal of haematology

authors： Xu J,Liu JL,Medeiros LJ,Huang W,Khoury JD,McDonnell TJ,Tang G,Schlette E,Yin CC,Bueso-Ramos CE,Lin P,Li S

更新日期：2020-04-01 00:00:00

abstract：OBJECTIVES:Vitamin E has antioxidant and immunomodulatory effects that might influence the development of acute graft-versus-host disease (GvHD). We investigated the association between plasma vitamin E levels and acute GvHD. METHODS:We studied 115 adults who underwent myeloablative allogeneic hematopoietic cell trans...

journal_title：European journal of haematology

authors： Gjaerde LK,Ostrowski SR,Minculescu L,Andersen NS,Friis LS,Kornblit B,Petersen SL,Schjødt I,Sengeløv H

更新日期：2020-12-12 00:00:00

abstract：:We evaluated the serum/plasma levels of cytokines [interleukin (IL)-6, vascular endothelial growth factor (VEGF), transforming growth factor (TGF)-beta2] and markers of coagulation, fibrinolysis, endothelial and platelet activation during the first 4 wk of treatment with the thalidomide analogue Actimid (CC-4047) in 1...

journal_title：European journal of haematology

authors： Streetly M,Hunt BJ,Parmar K,Jones R,Zeldis J,Schey S

更新日期：2005-04-01 00:00:00