Abstract：
:Mevalonate (MVA) is a key compound of living organisms including bacteria, plants, and humans. MVA and mevalonolactone (MVL), a lactonized form of MVA, are important for pharmaceutical, cosmeceutical, and biotechnological applications. Although (R, S)-MVA with 50% enantiomeric purity is mainly produced by chemical synthesis, recently, microbial fermentation processes for MVA production have been considered as an alternative to the chemical synthesis because of high enantiomeric purity [(R)-MVA] and high titer. In the present study, bio-MVA produced by a fermentative process was decolorized by a charcoal-based method and then chemically transformed into bio-MVL without byproducts by means of phosphoric acid as an acid catalyst. The final bio-MVL was (R)-MVL with over 99% enantiomeric purity according to 1H NMR analysis.
journal_name
J Biotechnoljournal_title
Journal of biotechnologyauthors
Kim JW,Yoon HC,Kwon SJ,Lee BY,Lee PCdoi
10.1016/j.jbiotec.2017.08.017subject
Has Abstractpub_date
2017-10-10 00:00:00pages
46-49eissn
0168-1656issn
1873-4863pii
S0168-1656(17)31620-6journal_volume
259pub_type
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