Abstract:
:The inflammation of chronic wounds generally causes delaying their healing process. The present work aims to formulate a wound dressing polyelectrolyte membrane based on chitosan (Ch) and sodium hyaluronate (HA) loaded with glutathione (GSH). The membrane types (Ch/HA and Ch/HA/GSH) were examined by Fourier transform infrared spectroscopy (FT-IR). The material properties were further investigated using thermal gravimetric analysis (TGA) and scanning electron microscopy (SEM). Physical characteristics of the prepared membranes, such as wettability, surface roughness, and mechanical properties were determined by standard experimental methods. In vitro assays were used to evaluate the haemocompatibility, thrombogenicity, and cytotoxicity of the membranes. The wound healing examined using a standard rat model exhibited a progress at exploiting the Ch/HA/GSH-type membranes compared to a bicomponent Ch/HA membrane or a "dry" healing wound. Histological examination of the recovered skin confirmed the visual observations. In conclusion, in vivo study results assert that Ch/HA/GSH is a proper wound-dressing for healing the chronic skin wounds.
journal_name
J Biotechnoljournal_title
Journal of biotechnologyauthors
Tamer TM,Hassan MA,Valachová K,Omer AM,El-Shafeey MEA,Mohy Eldin MS,Šoltés Ldoi
10.1016/j.jbiotec.2020.02.002subject
Has Abstractpub_date
2020-02-20 00:00:00pages
103-113eissn
0168-1656issn
1873-4863pii
S0168-1656(20)30029-8journal_volume
310pub_type
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