Imaging features of myeloproliferative neoplasms.

Abstract:

:Myeloproliferative neoplasms (MPNs) are a heterogeneous group of haematological disorders including polycythaemia vera (PV), essential thrombocythaemia (ET), primary myelofibrosis (PMF), and chronic myeloid leukaemia (CML). These disorders show large overlap in genetic and clinical presentations, and can have many different imaging manifestations. Unusual thromboses, embolic events throughout the systemic or pulmonary vasculature, or osseous findings can often be clues to the underlying disease. There is limited literature about the imaging features of these disorders, and this may result in under-diagnosis. Multiple treatments are available for symptom control, and the development of multiple new pharmacological inhibitors has significantly improved morbidity and prognosis. Knowledge of these conditions may enable the radiologist to suggest an MPN as a possible underlying cause for certain imaging findings, particularly unexplained splanchnic venous thrombosis, i.e. in the absence of chronic liver disease or pancreatitis. The aim of the present review is to outline using examples the different categories of MPN and illustrate the variety of radiological findings associated with these diseases.

journal_name

Clin Radiol

journal_title

Clinical radiology

authors

Murphy IG,Mitchell EL,Raso-Barnett L,Godfrey AL,Godfrey EM

doi

10.1016/j.crad.2017.05.014

subject

Has Abstract

pub_date

2017-10-01 00:00:00

pages

801-809

issue

10

eissn

0009-9260

issn

1365-229X

pii

S0009-9260(17)30206-4

journal_volume

72

pub_type

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