Abstract:
AIM:To evaluate the early treatment response to chemotherapy in patients with lung cancer using dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI). MATERIALS AND METHODS:Twenty-two patients with lung cancer underwent DCE-MRI before chemotherapy and 1 week after the start of the first course of chemotherapy. Pharmacokinetic parameters (Ktrans, Kep, and Ve) derived from DCE MRI were generated using the post-processing platform. These parameters and corresponding changes were compared between responders and non-responders after treatment using Student's t or Mann-Whitney U-tests. Diagnostic efficiency of kinetic parameters in differentiating responders from non-responders after 1 week of chemotherapy was also investigated. RESULTS:Thirteen responders after 1 week of chemotherapy had a significant decrease in Ktrans and Ve compared with the pretreatment value (p<0.05), and had no significant changes in Kep (p>0.05). Nine non-responders had no significant changes in Ktrans, Kep, and Ve compared with the pretreatment value (p>0.05). Changes in Ktrans (ΔKtrans) were significantly larger in responders than that in non-responders (p<0.05). Changes in Ve and Kep (ΔVe andΔKep) were without statistical significance after treatment between responders and non-responders (p>0.05). The cut-off value of ΔKtrans in best predicting tumour's chemotherapeutic response was 0.032/min and the corresponding AUC (area under the curve), sensitivity, specificity, and accuracy were 0.821, 84.62%, 77.78%, and 81.82%, respectively. CONCLUSION:DCE MRI may be useful for evaluating the early response to chemotherapy in patients with lung cancer, but larger, more definitive studies are needed.
journal_name
Clin Radioljournal_title
Clinical radiologyauthors
Xu J,Mei L,Liu L,Wang K,Zhou Z,Zheng Jdoi
10.1016/j.crad.2018.02.013subject
Has Abstractpub_date
2018-07-01 00:00:00pages
625-631issue
7eissn
0009-9260issn
1365-229Xpii
S0009-9260(18)30094-1journal_volume
73pub_type
杂志文章abstract::Mycobacterial infection is re-emerging as a major health care concern. Although Mycobacterium tuberculosis(MTB) is still the most important pathogen, atypical mycobacterium (AMB) infections are becoming increasingly common. We present a pictorial review of the imaging features of these infections in the chest, abdomen...
journal_title:Clinical radiology
pub_type: 杂志文章,评审
doi:10.1053/crad.2001.0755
更新日期:2001-07-01 00:00:00
abstract::Magnetic resonance imaging (MRI) depicts in exquisite detail the supporting structures of the posteromedial corner of the knee. This musculoligamentous unit plays a central role as a dynamic stabilizer of the knee joint and the recognition of injury to the posteromedial corner carries important implications in terms o...
journal_title:Clinical radiology
pub_type: 杂志文章,评审
doi:10.1016/j.crad.2006.11.024
更新日期:2007-06-01 00:00:00
abstract::Biliary tract visualisation in 50 patients examined by infusion of methylglucamine iodipamide was compared, by double-blind technique, to cholangiograms obtained in 50 other patients by a single bolus injection. The infusion technique did not give better results than the single bolus method. In another group of 20 pat...
journal_title:Clinical radiology
pub_type: 临床试验,杂志文章
doi:10.1016/s0009-9260(76)80156-0
更新日期:1976-04-01 00:00:00
abstract:INTRODUCTION:Conventional CT demonstrates pathology of the thoracic aorta. This study aimed to evaluate the additional contributions to surgical planning of multiplanar reformatting, maximum intensity projections and three-dimensional (3-D) reconstruction. DESIGN:Retrospective. SUBJECT AND METHODOLOGY: Fifty-three pat...
journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/s0009-9260(98)80100-1
更新日期:1998-03-01 00:00:00
abstract::Musculoskeletal infection involving the pelvis has rarely been reported in infants. When such infections involve the pelvic muscles they are generally believed to result from secondary spread from adjacent structures. We report five cases of primary pelvic musculoskeletal infection affecting infants <1 year, all of wh...
journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/s0009-9260(97)80160-2
更新日期:1997-10-01 00:00:00
abstract:AIM:To quantify the dose reduction and ensure that the use of a split-bolus protocol provided sufficient vascular enhancement. MATERIALS AND METHODS:Between 1 January 2014 and 31 May 2014, both split bolus and traditional two-phase scans were performed on a single CT scanner (SOMATOM Definition AS+, Siemens Healthcare...
journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/j.crad.2015.05.014
更新日期:2015-10-01 00:00:00
abstract:AIM:To undertake a meta-analysis of the diagnostic performance of abbreviated (ABB) magnetic resonance imaging (MRI) and full diagnostic protocol MRI (FDP-MRI) in breast cancer. MATERIALS AND METHODS:This meta-analysis was performed using the Preferred Reporting Items for Systematic Reviews and Meta-Analysis for Diagn...
journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/j.crad.2020.08.036
更新日期:2021-02-01 00:00:00
abstract:AIM:To determine the prevalence and association of mesenteric panniculitis (MP) in a group of patients with non-Hodgkin's lymphoma (NHL) compared to control group. MATERIALS AND METHODS:We retrospectively evaluated computed tomography (CT) and combined positron-emission tomography (PET) with CT examinations of a total...
journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/j.crad.2017.05.008
更新日期:2017-10-01 00:00:00
abstract::Craniosynostosis, caused by premature fusion of the sutures, may be syndromic or non-syndromic. Radiology has an important role to play in the assessment, management and follow-up of these patients. Initial investigations may often be undertaken within general radiology departments. An understanding of the terminology...
journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1053/crad.2001.0836
更新日期:2002-02-01 00:00:00
abstract::Duplex Doppler imaging was used to study the effect of pancreatic and bile duct tumours on portal vein and hepatic artery blood flow and the specific Doppler signals recorded from these tumours. Chaotic portal vein flow occurred in 35% (14) of pancreatic and 20% (6) of biliary tumours and complete portal vein occlusio...
journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/s0009-9260(05)80637-3
更新日期:1992-03-01 00:00:00
abstract:AIM:To determine the level of confidence general practitioners (GPs) have in radiology reports provided by neuroradiologists and to elicit the preferences of GPs regarding report format and level of detail. MATERIALS AND METHODS:Electronic surveys comprising anonymised neuroradiology reports were sent to GP practices ...
journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/j.crad.2018.06.013
更新日期:2018-11-01 00:00:00
abstract::We have retrospectively assessed the computed tomography (CT) findings in 92 patients suffering severe blunt abdominal trauma. Surgical findings and clinical follow-up were correlated with the CT findings. In nine patients CT was first used after emergency surgery and provided baseline data which was useful for furthe...
journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/s0009-9260(05)80373-3
更新日期:1992-11-01 00:00:00
abstract:AIM:To evaluate the usage, safety, and efficacy of high-dose intravenous metoprolol for heart rate reduction in computer tomographic (CT) coronary angiography. MATERIALS AND METHODS:As this was retrospective analysis of anonymous data, medical ethics committee approval was waived by the regional health research author...
journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/j.crad.2014.03.003
更新日期:2014-07-01 00:00:00
abstract:AIM:To differentiate uric acid from non-uric acid renal stones based on their spectral attenuation values. MATERIALS AND METHODS:The present study was approved by the institutional review board and the need for informed consent was waived. Thirty-three consecutive patients (21 men, 12 women; mean age 55 years) with sy...
journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/j.crad.2017.01.018
更新日期:2017-06-01 00:00:00
abstract::A case of granular cell tumour (GCT) of the biliary tree is reported with the first published sonographic images of this tumour. The difficulty in distinguishing this tumour from cholelithiasis is illustrated. ...
journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/s0009-9260(05)81753-2
更新日期:1994-07-01 00:00:00
abstract:AIM:To evaluate the feasibility of using air as intraluminal contrast medium in magnetic resonance (MR) colonography. MATERIALS AND METHODS:Twenty-two patients underwent MR colonography (MRC) using air before colonoscopy. All patients were imaged in prone and supine positions. Each colon was divided into five segments...
journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/s0009-9260(03)00126-0
更新日期:2003-07-01 00:00:00
abstract:AIM:To explore possible correlations between tumour apparent diffusion coefficient (ADC), morphological tumour volume, and clinical and histological characteristics in endometrial carcinomas and to evaluate interobserver agreement for preoperative staging by MRI and for ADC measurements. MATERIALS AND METHODS:Preopera...
journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/j.crad.2014.12.016
更新日期:2015-05-01 00:00:00
abstract::Sixty-four patients (37 stage I and 27 stage II) with low grade non-Hodgkin's lymphoma were treated by surgical excision alone (two patients) or with radiotherapy (53 patients), chemotherapy (five patients) or both (four patients). Actuarial survival was 80.7% at 5 years and 77.9% at 10 years. Actuarial recurrence-fre...
journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/s0009-9260(88)80537-3
更新日期:1988-05-01 00:00:00
abstract::Uncommon liver lesions pose a diagnostic challenge because of unfamiliar imaging findings. For simplification, these lesions can be divided into four broad categories based on the dominant imaging feature in each: hypervascular, hypovascular, fat-containing, or cystic lesions. In this review, we profile the radiologic...
journal_title:Clinical radiology
pub_type: 杂志文章,评审
doi:10.1016/j.crad.2017.07.016
更新日期:2018-02-01 00:00:00
abstract:AIM:To investigate the feasibility of using a low-concentration test bolus in abdominal aorta computed tomography (CT) angiography (CTA). MATERIALS AND METHODS:In 10 patients referred for CTA of the abdominal aorta with a body mass index (BMI) ≤28 kg/m2, a standard test bolus of 10 ml contrast medium (CM; 350 mg iodin...
journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/j.crad.2016.08.008
更新日期:2016-12-01 00:00:00
abstract::A randomized prospective trial was undertaken to compare the relative effectiveness of two commonly used bowel preparations (senna tablets and sodium picosulphate powder) administered to patients before they underwent out-patient intravenous urography. Their 'control' films were compared with plain 'kidneys, ureters, ...
journal_title:Clinical radiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0009-9260(05)81271-1
更新日期:1991-11-01 00:00:00
abstract::Healthcare expenditure is continually increasing and projected to accelerate in the future, with an increasing proportion being spent on interventional radiology. The role of cost effectiveness studies in ensuring the best allocation of resources is discussed, and the role of National Institute of Health and Care Exce...
journal_title:Clinical radiology
pub_type: 杂志文章,评审
doi:10.1016/j.crad.2020.09.017
更新日期:2020-10-17 00:00:00
abstract:AIM:To evaluate whether a simple pre-treatment regimen of sinus node inhibition by ivabradine taken at home for only 1 day resulted in a lower pre-scanning heart rate (HR) and reduced the need for intravenous beta-blockers (BB) prior to coronary computed tomography angiography (CTA). MATERIALS AND METHODS:The pre-trea...
journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/j.crad.2013.05.005
更新日期:2013-10-01 00:00:00
abstract::Pelvic phleboliths were demonstrated in 1000 subjects aged 16--79 years (mean 42.1, s.d. 12.7). They occurred in 44.2% of the subjects, in 37.3% of the males and 50.1% of the females. Among subjects between the ages of 35 and 54, phleboliths occurred more frequently in the females than in the males. In addition the ol...
journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/s0009-9260(80)80095-x
更新日期:1980-01-01 00:00:00
abstract:AIM:To identify characteristic high-resolution computed tomography (CT) findings for individual collagen vascular disease (CVD)-related interstitial pneumonias (IPs). MATERIALS AND METHODS:The HRCT findings of 187 patients with CVD, including 55 patients with rheumatoid arthritis (RA), 50 with systemic sclerosis (SSc)...
journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/j.crad.2018.04.017
更新日期:2018-09-01 00:00:00
abstract::Intestinal failure (IF) is the inability of the alimentary tract to digest and absorb sufficient nutrition to maintain normal fluid balance, growth, and health. It commonly arises from disease affecting the mesenteric root. Although severe IF is usually managed in specialized units, it lies at the end of a spectrum wi...
journal_title:Clinical radiology
pub_type: 杂志文章,评审
doi:10.1016/j.crad.2010.01.011
更新日期:2010-05-01 00:00:00
abstract:AIM:To assess the current practice of scaphoid fracture imaging (where initial scaphoid radiographs are normal) in the UK. MATERIALS AND METHODS:A survey monkey questionnaire was sent to 140 eligible NHS trusts derived from the NHS England database following exclusion of all non-acute and specialist centres. Four ques...
journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/j.crad.2019.02.016
更新日期:2019-06-01 00:00:00
abstract::Four patients with cervical spine trauma were examined by computerised tomography in addition to standard radiography and additional useful information was thereby gained. The axial projection is particularly useful in studying the cervical spinal canal and neural arch. The examination may be performed rapidly without...
journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/s0009-9260(79)80162-2
更新日期:1979-03-01 00:00:00
abstract::Thyroglossal fistulography is poorly documented in the radiological literature. An illustrative case is presented, highlighting the technique employed and the significance of its findings. The taste of contrast medium as it spills over the tongue is a useful additional sign in the successful demonstration of a fistulo...
journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/s0009-9260(05)80017-0
更新日期:1992-04-01 00:00:00
abstract:AIM:To present the clinical and radiological results of coil embolization in internal carotid artery (ICA) bifurcation aneurysms (BA). MATERIALS AND METHODS:The records of 65 patients with 66 ICA BA were retrieved from data prospectively accrued between September 1999 and July 2013. Clinical and morphological outcomes...
journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/j.crad.2014.01.017
更新日期:2014-06-01 00:00:00