Abstract：
:Sodium picosulphate (Picolax) is widely used for bowel preparation prior to colonic investigation or surgery. The most troublesome side effect reported is headache, which has been thought to be due to dehydration. In a prospective randomized study we investigated the incidence of adverse effects in patients given Picolax prior to barium enema examination, and assessed the incidence of adverse effects with different oral fluid regimens. A total of 197 outpatients were allocated to one of five fluid regimens on the day prior to the enema: (a) 4 pints of Dioralyte (glucose and electrolyte solution); (b) 4 pints of half-strength Dioralyte; (c) 4 pints of water; (d) 6 pints of water; and (e) free fluids. In a questionnaire, 36% of patients had no headache (graded 0/5), while 38% had a significant headache (graded 3/5 or greater). Sixteen per cent had significant abdominal pain, 42% had dry mouths, 43% thirst and 34% tiredness or irritability. There was no correlation between headache and fluid regimen. Furthermore, we have found no evidence of dehydration. None of the five fluid regimens was shown to offer any advantage, and we therefore recommend that patients be allowed to drink according to thirst when taking Picolax.
journal_name
Clin Radioljournal_title
Clinical radiologyauthors
Lawrance JA,Massoud TF,Creasy TS,Shatwell W,Mason A,Nolan DJdoi
10.1016/s0009-9260(05)82911-3subject
Has Abstractpub_date
1994-01-01 00:00:00pages
35-7issue
1eissn
0009-9260issn
1365-229Xjournal_volume
49pub_type
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更新日期：2009-01-01 00:00:00
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pub_type： 杂志文章,多中心研究,随机对照试验
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