Abstract：
:Thirteen adult patients with biochemically proven congenital adrenal hyperplasia (CAH) were examined by computed tomography (CT). Six patients had never received glucocorticoid therapy. In three of those six patients, CT revealed a tumorous transformation in one of the hyperplastic adrenal glands. In the seven patients with CAH who were treated since childhood, no mass could be demonstrated on CT. The development of an adrenocortical tumour due to chronic adrenal cortical stimulation by excessive adreno-cortico-trophic hormone (ACTH) production in adult patients with untreated CAH may not be a rare occurrence, as is demonstrated in this series. It is important not to confuse this entity with a primary virilizing adrenal tumour which requires a different form of treatment. In case of tumorous transformation in untreated adults with CAH, suppressive therapy with CT control should be favoured over surgery, as long as the tumour is ACTH-dependent. Moreover, these observations illustrate the desirability of lifelong glucocorticoid therapy in patients with CAH, including adult males who biochemically may not require suppression of steroid androgen excess.
journal_name
Clin Radioljournal_title
Clinical radiologyauthors
Falke TH,van Seters AP,Schaberg A,Moolenaar AJdoi
10.1016/s0009-9260(86)80389-0subject
Has Abstractpub_date
1986-03-01 00:00:00pages
155-60issue
2eissn
0009-9260issn
1365-229Xjournal_volume
37pub_type
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journal_title：Clinical radiology
pub_type： 杂志文章,评审
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更新日期：2010-07-01 00:00:00
abstract：AIM:To prospectively analyse the occurrence of right coronary artery (RCA) artefact and assess its relationship with patient heart rate (HR) and HR variability (HRV) in order to determine the most appropriate parameters for high-pitch cardiovascular computed tomography (CT) acquisition, minimize the likelihood of artef...
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journal_title：Clinical radiology
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journal_title：Clinical radiology
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pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：Clinical radiology
pub_type： 杂志文章
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更新日期：2000-12-01 00:00:00
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journal_title：Clinical radiology
pub_type： 杂志文章
doi：10.1016/s0009-9260(88)80211-3
更新日期：1988-09-01 00:00:00
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更新日期：2019-05-01 00:00:00
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journal_title：Clinical radiology
pub_type： 杂志文章
doi：10.1016/s0009-9260(89)80183-7
更新日期：1989-05-01 00:00:00
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journal_title：Clinical radiology
pub_type： 杂志文章
doi：10.1016/s0009-9260(05)81237-1
更新日期：1993-11-01 00:00:00
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journal_title：Clinical radiology
pub_type： 杂志文章
doi：10.1016/s0009-9260(89)80214-4
更新日期：1989-05-01 00:00:00
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journal_title：Clinical radiology
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1994-01-01 00:00:00
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journal_title：Clinical radiology
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1987-07-01 00:00:00
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journal_title：Clinical radiology
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doi：10.1016/j.crad.2010.03.002
更新日期：2010-06-01 00:00:00
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journal_title：Clinical radiology
pub_type： 杂志文章
doi：10.1016/s0009-9260(82)80308-5
更新日期：1982-07-01 00:00:00
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doi：10.1016/s0009-9260(05)80648-8
更新日期：1992-03-01 00:00:00
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journal_title：Clinical radiology
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更新日期：2005-02-01 00:00:00
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journal_title：Clinical radiology
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doi：10.1016/s0009-9260(05)80007-8
更新日期：1992-04-01 00:00:00
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更新日期：2012-05-01 00:00:00
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journal_title：Clinical radiology
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更新日期：2001-06-01 00:00:00
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journal_title：Clinical radiology
pub_type： 杂志文章,评审
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更新日期：2012-06-01 00:00:00
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