Bone marrow changes on MRI in children with acute lymphoblastic leukaemia 5 years after treatment.

Abstract:

:T1-weighted magnetic resonance imaging (MRI) of the lower extremities was performed 5 years after the cessation of therapy on 25 children treated for acute lymphoblastic leukaemia (ALL). Signal intensity pathologies considered to be related with the leukaemia itself or the treatment of ALL were found in nine of 25 children (36%). Two of these children had findings of osteonecrosis, five had a patchy signal pattern, one had diffuse inhomogeneity of the bone marrow signal intensity in complete remission and one had diffusely decreased signal intensity preceding the diagnosis of relapse. MRI unexpectedly revealed many bone marrow pathologies in symptomless children successfully treated for ALL. Especially, osteonecrosis might cause significant disability, and the aetiology, clinical course and prognosis of this complication are not well known. The intensive dexamethasone medication included in the treatment protocols may be responsible for the development of osteonecrosis. However, the prognosis of osteonecrosis in the long run requires further studies.

journal_name

Clin Radiol

journal_title

Clinical radiology

authors

Ojala AE,Pääkkö E,Lanning FP,Harila-Saari AH,Lanning BM

doi

10.1016/s0009-9260(98)80060-3

subject

Has Abstract

pub_date

1998-02-01 00:00:00

pages

131-6

issue

2

eissn

0009-9260

issn

1365-229X

journal_volume

53

pub_type

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