Spectral CT imaging in the differential diagnosis of necrotic hepatocellular carcinoma and hepatic abscess.

Abstract:

AIM:To explore the value of CT spectral imaging in the differential diagnosis of necrotic hepatocellular carcinoma (nHCC) and hepatic abscess (HA) during the arterial phase (AP) and portal venous phase (PP). MATERIALS AND METHODS:Sixty patients with 36 nHCCs and 24 HAs underwent spectral CT during AP and PP. Iodine or water concentration were measured and the normalized iodine concentration (NIC) and lesion-normal parenchyma iodine concentration ratio (LNR) were calculated. The two-sample t-test was used to compare quantitative parameters. Two readers qualitatively assessed lesion types according to imaging features. Sensitivity and specificity were compared between the qualitative and quantitative studies. RESULTS:NIC and LNR in the AP for the wall of nHCC (0.14 ± 0.04 mg/ml; 2.77 ± 0.74) were higher than those of HA (0.13 ± 0.02 mg/ml; 1.4 ± 0.9). NIC and LNR in the PP for the wall of HA (0.66 ± 0.05 mg/ml; 1.2 ± 0.2) were higher than those of nHCC (0.5 ± 0.11 mg/ml; 0.94 ± 0.12). The differences in NIC in the AP were not significant but the differences in LNR in AP, and NIC and LNR in the PP were significant. The best quantitative parameter was LNR in AP, and a threshold of 1.52 would yield a sensitivity and specificity of 100% and 91.7%, respectively, for differentiating nHCC from HA. CONCLUSION:CT spectral imaging with quantitative iodine concentration analysis may help to increase the accuracy of differentiating nHCC from HA.

journal_name

Clin Radiol

journal_title

Clinical radiology

authors

Yu Y,Guo L,Hu C,Chen K

doi

10.1016/j.crad.2014.08.018

subject

Has Abstract

pub_date

2014-12-01 00:00:00

pages

e517-24

issue

12

eissn

0009-9260

issn

1365-229X

pii

S0009-9260(14)00412-7

journal_volume

69

pub_type

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