Abstract：
:The use of pyrethroids to control the human head louse, Pediculus humanus capitis De Geer (Anoplura: Pediculidae), has suffered considerable loss of efficacy due to the evolution of resistance. Thus, the development of efficiently insecticide delivery systems is imperative for the control of head lice. We studied the insecticidal activity of ivermectin-loaded lipid nanocapsules (IVM-LNC) against permethrin-resistant head lice from Argentina. The LNC, prepared by a phase inversion procedure, were characterized in terms of size, surface potential, and physical stability. These nanoparticles were nearly spherical with mean diameters of 55 nm and narrow size distribution (PI ≤ 0.2). The KT50 mortality values of head lice after exposure to two IVM-LNC formulations (0.11 and 0.28%) were significantly smaller (5 and 3 h, respectively) compared to those exposed only to LNC control group (8 h). This investigation showed the effectiveness in the encapsulation of ivermectin (IVM) into stable LNC dispersion with a potential clinical activity against head lice.
journal_name
Parasitol Resjournal_title
Parasitology researchauthors
Ullio-Gamboa G,Palma S,Benoit JP,Allemandi D,Picollo MI,Toloza ACdoi
10.1007/s00436-017-5510-2subject
Has Abstractpub_date
2017-08-01 00:00:00pages
2111-2117issue
8eissn
0932-0113issn
1432-1955pii
10.1007/s00436-017-5510-2journal_volume
116pub_type
杂志文章abstract：:Trypanosoma cruzi can modulate a large number of host intracellular responses during its invasion. GTPases such as RhoA, Rac1 and Cdc42 are examples of molecules that could be activated at this moment and trigger changes in the pattern of F-actin cytoskeleton leading to the formation of structures like stress fibers, ...
journal_title：Parasitology research
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journal_title：Parasitology research
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journal_title：Parasitology research
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更新日期：2017-01-01 00:00:00
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journal_title：Parasitology research
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