Abstract：
:Termination of early pregnancy by vacuum aspiration is a well-established technique. The procedure is highly effective and has a low complication rate, particularly when performed during the first few weeks after missed menses. However, this parasurgical method requires skilled health care personnel, and attempts have therefore been made to find medical alternatives. Prostaglandins were the first agents to be used successfully for this purpose, but the high incidence of mainly gastrointestinal side-effects has limited their widespread use. More recently, attention has focused on antiprogestational steroids, i.e., compounds that prevent the action of progesterone either by inhibiting its biosynthesis or by preventing it from binding to the cellular receptors in target organs. Current experience indicates that these compounds, particularly when used in combination with a low dose of a synthetic prostaglandin analogue, have the potential to become a safe, effective, and acceptable medical method for the termination of early pregnancy. :Vacuum aspiration is considered a very effective manner to terminate early pregnancies. This procedure carries a low rate of complications, particularly during the 1st few weeks after missed menses; however, it requires skilled health personnel. 2 methods have been developed as medical alternatives to vacuum aspiration: use of prostaglandins (PGs) and/or antiprogestational agents. Attention was focused on the use of PGs as a method of early termination of pregnancy because of their ability to stimulate uterine contraction. However, the use of PGs are also accompanied by frequent occurrences of gastrointestinal side effects and severe abdominal cramps. Despite these side effects, there is the possibility of reducing the dosage, thus reducing the side effects to little or nothing. Antiprogestational agents work to inhibit biosynthesis and also block the effect of progesterone on target cells. Administration of a low dosage progestin analogue in addition to the PG has prove to be a medically feasible approach to the early termination of a pregnancy.
journal_name
Bull World Health Organjournal_title
Bulletin of the World Health Organizationauthors
Van Look PF,Bygdeman Msubject
Has Abstractpub_date
1989-01-01 00:00:00pages
567-75issue
5eissn
0042-9686issn
1564-0604journal_volume
67pub_type
杂志文章,评审abstract：:A description is given of laboratory and field trials with a new molluscicide, Bayer 73. Following successful laboratory trials at one part per million, a river containing much vegetation and many semi-stagnant pools was treated at this dosage, the application resulting in a complete disappearance of snails and eggs f...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1960-01-01 00:00:00
abstract：:Vaccines constitute the single most important cost factor in the Expanded Programme on Immunization (EPI) in Mozambique and in view of future new disease-control initiatives, the proportional expenditure on vaccines will only increase. Airfreight may contribute up to at least 25% of the total cost of delivered vaccine...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1997-01-01 00:00:00
abstract：:As a result of extensive travel and temporary residence by people in areas where malaria is endemic, the disease is being reimported into countries from which it has been eradicated. Owing to the lack of experience of malaria on the part of present-day physicians and the atypical presentation of some forms of the dise...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1974-01-01 00:00:00
abstract：:The development of several DDT-resistant strains of Anopheles atroparvus is described. They were selected by larval treatment only (RL), selection of larval and adult females (RLAF), and selection of adult females and males (RAFM). Their rate of DDT-resistance was measured in the larval and adult states (mainly in the...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1959-01-01 00:00:00
abstract：:As culture filtrates of Mycobacterium tuberculosis have been shown by numerous workers to be antigenically heterogeneous, a series of experiments has been started to identify some of the different antigens likely to be useful in laboratory tests for measuring the antibodies in human blood. The work involves the fracti...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1955-01-01 00:00:00
abstract：:A simple grading system for trachoma, based on the presence or absence of five selected "key" signs, has been developed. The method was tested in the field and showed good observer agreement, the most critical point being the identification of severe cases of the disease. It is expected that the system will facilitate...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1987-01-01 00:00:00
abstract：OBJECTIVE:To assess government actions to improve the healthiness of food environments in New Zealand, based on the healthy food environment policy index. METHODS:A panel of 52 public health experts rated the extent of government implementation against international best practice for 42 indicators of food environment ...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：10.2471/BLT.14.145540
更新日期：2015-05-01 00:00:00
abstract：:This chapter presents the findings arrived at by applying the resource allocation model to tuberculosis control in the Republic of Korea. Optimum subprogrammes are obtained for the four objectives of the programme: reduction of disability, impairment, excess mortality, and economic loss. These subprogrammes are discus...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1973-01-01 00:00:00
abstract：:The risks and expected benefits from iodized oil, given orally or by injection, to pregnant women in areas of severe iodine deficiency where iodized salt is not available were evaluated. The conclusions, which were approved by the International Council for Control of Iodine Deficiency Disorders (ICCIDD), showed that f...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1996-01-01 00:00:00
abstract：Objective:To analyse the demographic and clinical characteristics of people attending physical rehabilitation centres run or supported by the International Committee of the Red Cross in countries and territories affected by conflict. Methods:Of 150 such rehabilitation centres worldwide, 38 use an electronic patient ma...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：10.2471/BLT.19.249060
更新日期：2020-09-01 00:00:00
abstract：:This paper describes the organization of an epidemiological survey, carried out by the Lipid Centre of the Institute of Experimental Medicine in Leningrad, particularly the ways in which subjects were recruited. The different methods of recruitment resulted in a total population response of 78.14%. A time index is int...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1981-01-01 00:00:00
abstract：:Several authors have reported an inverse correlation between death rates from cardiovascular diseases and local water hardness, but the significance of such a relationship is still debated. To investigate further this relationship, another indicator of water quality was used, namely, the alpha-radioactivity level of r...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1970-01-01 00:00:00
abstract：:Bringing together various disease-specific guidelines for sick children, WHO and UNICEF have developed an Integrated Management of Childhood Illness (IMCI) algorithm, one component of which (assess and classify) was tested in the outpatient department of a rural district hospital in western Uganda. Children aged 2-59 ...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1997-01-01 00:00:00
abstract：OBJECTIVE:To examine the prevalence of multiple types of maltreatment (MTM), potentially confounding factors and associations with depression, anxiety and self-esteem among adolescents in Viet Nam. METHODS:In 2006 we conducted a cross-sectional survey of 2591 students (aged 12-18 years; 52.1% female) from randomly-sel...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：10.2471/BLT.08.060061
更新日期：2010-01-01 00:00:00
abstract：OBJECTIVE:To investigate a new approach to calculating cause-related standardized mortality rates that involves assigning weights to each cause of death reported on death certificates. METHODS:We derived cause-related standardized mortality rates from death certificate data for France in 2010 using: (i) the classic me...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：10.2471/BLT.16.172189
更新日期：2016-12-01 00:00:00
abstract：:Viruses of various biological types are known to cause a wide range of acute respiratory infections, ranging from mild colds and catarrh to severe bronchiolitis and pneumonia. Bacteria also cause respiratory diseases including serious conditions such as otitis media and pneumonia. The whole situation is complex and to...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1980-01-01 00:00:00
abstract：:In 1961 the WHO Expert Committee on Biological Standardization asked the National Institute for Medical Research, London, to collect and study material to replace the first International Standard for Serum Gonadotrophin, stocks of which were running low. This paper describes the material that was contributed, its dist...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1966-01-01 00:00:00
abstract：:As in an earlier study, the authors have endeavoured to review the world incidence of poliomyelitis on the basis of the available statistical information (official notifications of cases and deaths) and to compare these data with data received from various sources regarding the prevailing viruses.It is certainly not y...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1956-01-01 00:00:00
abstract：:This paper is a report on an attempt to study seasonal variations in endemic cholera in West Bengal by statistical analysis of monthly mortality records over a 21-year period. The annual death-rates have been calculated for each month in each district and the average of the seven lowest rates in each district is plott...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1961-01-01 00:00:00
abstract：:The intrinsic qualities of influenza virus particles may be studied at the biological level from two points of view:(1) The surface structures associated with adsorption to the surface of the susceptible cell and entry into its substance are regarded as essentially somatic in character. Infection is possible only when...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1953-01-01 00:00:00
abstract：:Early identification of children at high risk of diarrhoea-associated dehydration would be of great value to health care workers in developing countries. To identify prognostic factors for life-threatening dehydration, we carried out a case-control study among under-2-year-olds in Porto Alegre, Brazil. Cases were 192 ...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
abstract：:For 164 days mature chickens received a daily diet containing 40 g of wheat treated with organomercurial fungicide and 80 g of untreated diet. A control group received 120 g of normal diet daily. The experimental group was then split - half receiving the same diet for a further 155 days, by which time all had been kil...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1976-01-01 00:00:00
abstract：:Studying the susceptibility of 189 Neisseria meningitidis strains to penicillin, amoxicillin, cefotaxime, ceftriaxone, chloramphenicol and rifampicin by determination of minimum inhibitory concentrations (MICs) by agar dilution (reference method), E-test and disc diffusion method on Mueller-Hinton agar at 37 degrees C...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1998-01-01 00:00:00
abstract：:New initiatives are aiming to reduce the global burden of schistosomiasis, mainly through the large-scale application of chemotherapy. To target chemotherapy effectively, rapid assessment procedures are needed for identifying high-risk communities that are foci for the disease. In this review, we examine the developme...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：2002-01-01 00:00:00
abstract：:This article presents a nomenclature system for allergens which has been officially recommended by the International Union of Immunological Societies (IUIS). The nomenclature is based on proposals of the IUIS Sub-Committee for Allergen Nomenclature and is applicable to highly purified, well-characterized allergens and...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1986-01-01 00:00:00
abstract：:Up-to-date information is given on the epidemiological situation of zoonotic visceral leishmaniasis (ZVL) in nine Mediterranean countries, and on drug regimens adopted in the management of ZVL patients in each country. Results of experimental and clinical trials on the efficacy and tolerability of liposomal amphoteric...
journal_title：Bulletin of the World Health Organization
pub_type： 临床试验,杂志文章,多中心研究
doi：
更新日期：1995-01-01 00:00:00
abstract：OBJECTIVE:To determine paediatric blood sample volume limits that are consistent with physiological "minimal risk." METHODS:A literature review was performed to search for evidence concerning the adverse effects of blood sampling in children and for guidelines on sampling volume in paediatric research. The search incl...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章,评审
doi：10.2471/BLT.10.080010
更新日期：2011-01-01 00:00:00
abstract：:The recommended procedures and criteria for T-cell receptor (TCR) designations are described. The officially adopted designations are for the TCR A, B, D and G loci and for V, D, J and C segments. ...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1993-01-01 00:00:00
abstract：:A WHO-coordinated study of the community control of hypertension in six countries (Cuba, Finland, France, Italy, Mongolia and Portugal) has shown that a comprehensive approach clearly improves the care of hypertensives in various populations. Hypertension control programmes were individually designed in each country a...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1988-01-01 00:00:00
abstract：:This article surveys the attitudes and perceptions of a random sample of the elderly population in three regions of Italy on the use and efficacy of influenza vaccine. The data were collected by direct interviews using a standard questionnaire. The results show that vaccination coverage against influenza is inadequate...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1999-01-01 00:00:00
