Abstract：
OBJECTIVE:To determine paediatric blood sample volume limits that are consistent with physiological "minimal risk." METHODS:A literature review was performed to search for evidence concerning the adverse effects of blood sampling in children and for guidelines on sampling volume in paediatric research. The search included Medline, EMBASE, other web-based and non-web-based sources and the bibliographies of the sources identified. Experts were also consulted. FINDINGS:Five studies and nine guidelines were identified. Existing guidelines specify paediatric blood sample volume limits ranging from 1% to 5% of total blood volume (TBV) over 24 hours and up to 10% of TBV over 8 weeks. The evidence available is limited and includes findings from non-randomized studies showing a minimal risk with one-off sampling of up to 5% of TBV. CONCLUSION:The evidence available is consistent with the conclusion that all identified guidelines are within the limits of "minimal risk." However, more and better evidence is required to draw firmer conclusions. Researchers and institutional review boards need to take into account the total sampling volume needed for both clinical care and research rather than for each alone. The child's general state of health should be considered and extra caution should be observed particularly with children whose illness can deplete blood volume or haemoglobin or hinder their replenishment. Local policies must also address the appropriateness and local acceptability of collection procedures and of the blood volumes drawn.
journal_name
Bull World Health Organjournal_title
Bulletin of the World Health Organizationauthors
Howie SRdoi
10.2471/BLT.10.080010subject
Has Abstractpub_date
2011-01-01 00:00:00pages
46-53issue
1eissn
0042-9686issn
1564-0604journal_volume
89pub_type
杂志文章,评审abstract：OBJECTIVE:In 2000, a referral hospital in the Gambia accepted a donation of oxygen concentrators to help maintain oxygen supplies. The concentrators broke down and were put into storage. A case study was done to find the reasons for the problem and to draw lessons to help improve both oxygen supplies and the success of...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：10.2471/blt.07.042994
更新日期：2008-01-01 00:00:00
abstract：Objective:To investigate multicontaminant air pollution in Chinese cities, to quantify the urban population affected and to explore the relationship between air pollution and urban population size. Methods:We obtained data for 155 cities with 276 million inhabitants for 2014 from China's air quality monitoring network...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：10.2471/BLT.17.195560
更新日期：2018-04-01 00:00:00
abstract：:The immunizing potency of liquid BCG vaccine prepared by the Tween 80 method was compared with that of control vaccine prepared by the usual grinding method. The former vaccine revealed higher immunizing properties than the latter although its inoculation dose was only one-fifth as great.With sodium glutamate as adjuv...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1957-01-01 00:00:00
abstract：:The authors present the results of a study carried out to determine the efficacy of chloroquine- and pyrimethamine-salt mixtures as a suppressive against sporozoite-induced vivax malaria (Chesson strain). The test subjects used in this study were volunteers of military age in the US Penitentiary at Atlanta, Ga. The su...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1958-01-01 00:00:00
abstract：:Although none of the currently available methods of contraception can be considered ideal for use by adolescents, many come reasonably close. The present article reviews the relative benefits and risks associated with each method. Oral contraceptives (OCs) appear to bear few specific risks for adolescents. Pills co...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1984-01-01 00:00:00
abstract：:A taxonomic approach using cluster analysis and principal component analysis has grouped the countries of the world in eight clusters, in an initial attempt to propose a worldwide spatial classification based on the following health-related indicators: (a) those directly related to the health status of the population;...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：:In the course of a village-scale trial of fenthion, carried out in a village near Lagos, Nigeria, 40% fenthion water-dispersible powder was used at a 3.75% concentration. This was applied by Galeazzi "OM" sprayers with constant-pressure assemblies. The target concentration was 1.5 g/m(2). Filter-papers were placed on ...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1963-01-01 00:00:00
abstract：:There is considerable exigency to take all necessary steps to cure tuberculosis cases and prevent further emergence of drug-resistant tuberculosis. The most important of these steps is to ensure that the treatment, particularly of sputum smear-positive cases, is adequate and that patients adhere to their treatment by ...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：2001-01-01 00:00:00
abstract：:Reports about recent famine victims and refugees have described the occurrence of xerophthalmia and resultant blindness related to severe vitamin A deficiency. These populations are subject to high prevalences of childhood protein-energy malnutrition and infectious diseases, pre-existing marginal vitamin A status, and...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1988-01-01 00:00:00
abstract：:Haemagglutination (HA) has been used frequently for the titration of tetanus antitoxin but published results have varied in relation to the "unitage" determined by the mouse toxin-neutralization test (TN). This report gives the results of the titration of a group of sera by haemagglutination and compares them with the...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1970-01-01 00:00:00
abstract：:When mice are immunized with radiation-attenuated sporozoites they are solidly protected against sporozoite challenge by an immune response that has been shown to require CD8+ lymphocytes in several strains of mice. The target of this CD8+ T-cell-dependent immunity has not been established. Immune BALB/c mice were sho...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1990-01-01 00:00:00
abstract：:Vaccines constitute the single most important cost factor in the Expanded Programme on Immunization (EPI) in Mozambique and in view of future new disease-control initiatives, the proportional expenditure on vaccines will only increase. Airfreight may contribute up to at least 25% of the total cost of delivered vaccine...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1997-01-01 00:00:00
abstract：:In laboratory experiments sterile males produced by crossing member species of the Anopheles gambiae complex competed very successfully with normal males for normal females and the latter when mated with sterile males laid sterile eggs.A field trial was arranged in a small isolated village near Bobo-Dioulasso, Upper V...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1970-01-01 00:00:00
abstract：:In view of the considerable and continuing public health significance of Mycobacterium bovis infection in humans and animals, WHO convened a meeting on zoonotic tuberculosis in Geneva in November 1993. The participants at the meeting reviewed the human and animal tuberculosis situation worldwide, discussed the zoonoti...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1994-01-01 00:00:00
abstract：:Doubts have been raised on theoretical grounds concerning the effect of BCG in tropical countries, where in most places a large proportion of the population have a naturally acquired tuberculin allergy of low strength and unknown (but almost certainly non-specific) origin. Furthermore, vaccinations in the tropics may ...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1964-01-01 00:00:00
abstract：OBJECTIVE:To describe mortality from neglected tropical diseases (NTDs) in Brazil, 2000-2011. METHODS:We extracted information on cause of death, age, sex, ethnicity and place of residence from the nationwide mortality information system at the Brazilian Ministry of Health. We selected deaths in which the underlying c...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：10.2471/BLT.15.152363
更新日期：2016-02-01 00:00:00
abstract：:James Chau talks to Ana Lesher Treviño about the challenges faced in communicating about public health. ...
journal_title：Bulletin of the World Health Organization
pub_type： 新闻
doi：10.2471/BLT.19.030819
更新日期：2019-08-01 00:00:00
abstract：:Described is a computer software package, EPIZOO, which has been developed specifically for undergraduate and postgraduate education, self-training, problem-solving, and simulation studies in veterinary epidemiology. The program is based on action-oriented animal population health/disease analyses and programming. EPI...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1995-01-01 00:00:00
abstract：:This is a classification of tumours of fibrous tissue, fat, muscle, blood and lymph vessels, and mast cells, irrespective of the region of the body in which they arise. Tumours of fibrous tissue are divided into fibroma, fibrosarcoma (including "canine haemangiopericytoma"), other sarcomas, equine sarcoid, and various...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1974-01-01 00:00:00
abstract：:In the past, several indices have been proposed to evaluate the threat of vectors to the community. Such indices, if accurately determined, could serve to assess the effectiveness of vector control campaigns. In this paper, a "risk of infection" index is introduced for the case of urban filariasis transmitted by Culex...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1967-01-01 00:00:00
abstract：OBJECTIVE:To estimate post-traumatic stress disorder (PTSD) symptoms in those injured and not injured by landmines or unexploded ordnance (UXO) in rural Lao People's Democratic Republic and to determine whether the perception of social support was associated with PTSD symptom severity. METHODS:A community survey was c...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：10.2471/BLT.12.115311
更新日期：2013-10-01 00:00:00
abstract：:The Haemosporidia, which comprise the malaria parasites, have probably evolved from Coccidia of the intestinal epithelium of the vertebrate host by adaptation first to some tissues of the internal organs and then to life in the circulating cells of the blood.The present opinion is that, among the malaria parasites of ...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1965-01-01 00:00:00
abstract：:Each of 87 strains of brucellae examined for its utilization of amino acid and carbohydrate substrates displayed a metabolic pattern that characterized it as to its species identity, irrespective of its serological and biochemical characters. Strains that displayed the metabolic pattern of Br. abortus were lysed by Br...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1962-01-01 00:00:00
abstract：OBJECTIVE:To measure the socioeconomic inequality in infant mortality in Iran (the Islamic Republic of Iran). METHODS:We analysed data from the provincially representative Demographic and Health Survey, which was done in Iran in 2000. We used a dichotomous hierarchical ordered probit model to develop an indicator of s...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：/S0042-96862005001100013
更新日期：2005-11-01 00:00:00
abstract：:Investigations of experimental schistosomiasis haematobia have suffered for want of satisfactory mammals in which schistosome infections would establish host-parasite situations more or less comparable with those seen in man. As a consequence, mammals representing different major groups have been exposed to infection ...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1971-01-01 00:00:00
abstract：:The frequency of man-biting by mosquitos depends upon the amount of contact between man and mosquito, which in turn depends upon the behaviour patterns of both. In order to examine these relationships in an area with a high incidence of malaria, a study was made in 1965 of the nocturnal movements and of mosquito bitin...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1968-01-01 00:00:00
abstract：:Tamiami virus produces a lethal encephalitis in suckling mice, and the illness is mediated, at least in part, by cellular immunity. Infection of extraneural organs, including lymphoid organs, is limited. The same virus produces a widespread infection in its natural host, the cotton rat, but neither symptomatic illness...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1975-01-01 00:00:00
abstract：:The dynamics of transmission of disease agents by vectors depends, in part, on the probability of host-vector contact, which can vary with fluctuations of both host and vector. As important as seasonal variations is 24-hour periodicity in activity. Periodicity in the landing of males and females of Aedes aegypti on ma...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1973-05-01 00:00:00
abstract：:The biological and molecular properties of both virulent and vaccine types of influenza virus strains are reviewed, including their analysis in laboratory animals and in organ tissue cultures, as well as studies of their genome peculiarities. Methods are discussed for obtaining attenuated donor strains of influenza vi...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1984-01-01 00:00:00
abstract：:Many global health institutions, including the World Health Organization, consider primary health care as the path towards achieving universal health coverage (UHC). However, there remain concerns about the feasibility and effectiveness of this approach in low-resource countries. Ethiopia has been implementing the pri...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：10.2471/BLT.19.248328
更新日期：2020-12-01 00:00:00
