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Overexpression and varied clinical significance of Th9 versus Th17 cells in distinct subtypes of oral lichen planus.

Abstract：

OBJECTIVE:Oral lichen planus (OLP) presents with large numbers of T lymphocytes accumulating beneath the epithelium of the oral mucosa; however, its aetiology remains obscure. A potential role for an emerging novel T cell subset, Th9, in OLP has recently been suggested but remains to be clarified. The current aim was to investigate the expression and potential clinical significance of Th9 cells in distinct subtypes of OLP. MATERIALS AND METHODS:Peripheral blood samples were collected from 41 OLP patients and 18 healthy controls (HCs). Flow cytometric analysis was used to detect the CD4+ T helper subset Th9 (IL-9+IL-17-CD4+ Th cells) and Th17 (IL-9-IL-17+CD4+ Th cells) expression levels. RESULTS:Flow cytometry results showed significantly elevated levels of Th9 cells in reticular and erosive OLP compared to HCs. Th9 expression in erosive OLP was less than in reticular OLP, indicating that Th9 but not Th17 cells may play a predominant role in reticular disease. However, in erosive OLP patients, we found much higher levels of Th17 cells compared to reticular OLP patients and HCs, indicating that Th17 dominates in erosive OLP. Statistical analysis showed positive correlations of Th9 cells and Th17 cells in patients with reticular or erosive OLP but none in HCs. CONCLUSIONS:Th9 and Th17 cells may take the predominant roles in reticular and erosive OLP respectively, and their numbers were positively correlated in reticular and erosive OLP patients. Elevated circulating Th9 cells may help maintain immune balance in OLP immunopathogenesis, which requires further investigation.

journal_name

Arch Oral Biol

journal_title

Archives of oral biology

authors

Wang H,Bai J,Luo Z,Fu J,Wang H,Sun Z

doi

10.1016/j.archoralbio.2017.04.003

subject

Has Abstract

pub_date

2017-08-01 00:00:00

pages

110-116

eissn

0003-9969

issn

1879-1506

pii

S0003-9969(17)30105-X

journal_volume

80

pub_type

杂志文章

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