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Overexpression of TP53 mutation-associated microRNA-182 promotes tumor cell proliferation and migration in head and neck squamous cell carcinoma.

Abstract：

OBJECTIVE:To investigate the functional mechanism of microRNA-182 (miR-182) in head and neck squamous cell carcinoma (HNSCC). DESIGN:HNSCC and normal samples were used to check both p53 and miR-182 expression. Two cancer cell lines with overexpression of miR-182 were used to check cell proliferation and migration. In vivo role of miR-182 was assessed using mouse xenograft tumor model. β-TrCP2 was found to be direct target of miR-182 by luciferase reporter assay. RESULTS:Overexpression of miR-182 was closely related with overproduction of p53 in HNSCC. Overexpression of miR-182 promoted cell proliferation and migration and its oncogenic effect was also confirmed in vivo. β-TrCP2 acted as direct target of miR-182 and its overexpression can reverse the miR-182 induced cell proliferation and migration. CONCLUSION:Overexpression of TP53 mutation-associated miR-182 may promote tumor cell proliferation and migration in HNSCC and suggest possible biomarker for the prediction of tumor recurrence.

journal_name

Arch Oral Biol

journal_title

Archives of oral biology

authors

Wang L,Jiang H,Li W,Jia C,Zhang H,Sun Y,Chen X,Song X

doi

10.1016/j.archoralbio.2016.09.012

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

105-112

eissn

0003-9969

issn

1879-1506

pii

S0003-9969(16)30273-4

journal_volume

73

pub_type

杂志文章

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