Abstract:
:Objective. The aim of the present study was to investigate whether pentraxin 3 (PTX3) can be a new noninvasive marker for prediction of liver fibrosis in patients with NAFLD. We also aimed to evaluate the relationship between PTX3 and atherosclerosis in patients with NAFLD. Method. Fifty-four male patients with biopsy-proven NAFLD and 20 apparently healthy male volunteers were included. PTX3 levels were determined, using an ELISA method (R&D Sysytems, Quantikine ELISA, USA). To detect the presence of subclinical atherosclerosis in NAFLD, measurements of CIMT, FMD, and cf-PWV levels were performed. Results. PTX3 levels in NAFLD patients with fibrosis were higher than both NAFLD patients without fibrosis and controls (P = 0.032 and P = 0.028, respectively), but there was no difference between controls and NAFLD patients without fibrosis in terms of PTX3 levels (P = 0.903). PTX3 levels were strongly correlated with cf-PWV (r = 0.359, P = 0.003), whereas no significant correlation was found with other atherosclerosis markers, CIMT and FMD. Conclusion. Elevated plasma PTX3 levels are associated with the presence of fibrosis in patients with NAFLD, independently of metabolic syndrome components. This study demonstrated that for the first time there is a close association between elevated PTX3 levels and increased arterial stiffness in patients with NAFLD.
journal_name
Gastroenterol Res Practjournal_title
Gastroenterology research and practiceauthors
Ozturk K,Kurt O,Dogan T,Ozen A,Demirci H,Yesildal F,Kantarcioglu M,Turker T,Guler AK,Karslioglu Y,Altun B,Uygun A,Bagci Sdoi
10.1155/2016/1417962subject
Has Abstractpub_date
2016-01-01 00:00:00pages
1417962eissn
1687-6121issn
1687-630Xjournal_volume
2016pub_type
杂志文章abstract:BACKGROUND:Preoperative chemoradiotherapy is the standard treatment for patients with locally advanced rectal cancer, although tumor responses vary widely; some patients may achieve a pathologic complete response rate (pCR) after chemoradiotherapy. Controversy exists with regard to the efficacy of different preoperativ...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章,评审
doi:10.1155/2017/1373092
更新日期:2017-01-01 00:00:00
abstract:Background/Aim:Endoscopic balloon dilation (EBD) has been effective for small-bowel strictures in patients with Crohn's disease (CD). However, its efficacy and indication for small-bowel strictures in non-CD patients have not been established. This study evaluated the clinical efficacy and safety of EBD for small-bowel...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2019/1262595
更新日期:2019-05-06 00:00:00
abstract::The rapid rise of obesity and type 2 diabetes poses a global threat to healthcare and is a major cause of mortality and morbidity. Bariatric surgery has revolutionised the treatment of both these conditions but is invasive and associated with an increased risk of complications. The EndoBarrier is a device placed endos...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章,评审
doi:10.1155/2018/7823182
更新日期:2018-07-26 00:00:00
abstract:Background:Both long-term proton pump inhibitor use and surgical fundoplication have potential drawbacks as treatments for chronic gastroesophageal reflux disease (GERD). Our aim was to investigate the potential efficacy of antireflux mucosectomy (ARMS) in porcine and determine the optimal circumference of resection in...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2019/3286738
更新日期:2019-02-24 00:00:00
abstract::Intestinal ischemia/reperfusion (I/R) injury is a significant problem that is associated with high morbidity and mortality in critical settings. This injury may be ameliorated using postconditioning protocol. In our study, we created a rabbit intestinal I/R injury model to analyze the effects of local ischemia postcon...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2016/2604032
更新日期:2016-01-01 00:00:00
abstract:Objective:The aim of our study was to investigate the expression of EGFR and PTEN in tissues and measure the serum platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) to evaluate the prognostic factors of patients with epithelioid malignant peritoneal mesothelioma (MPeM). Methods:33 patients of...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2019/7103915
更新日期:2019-02-04 00:00:00
abstract:Background:Critically ill patients can benefit from enteral nutrition with postpyloric feeding tubes, but the low success rate limits its wide use. Erythromycin could elevate the success rate of tube insertion, but its clinical efficiency still remains controversial. Methods:Included studies must be RCTs which assesse...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章,评审
doi:10.1155/2018/1671483
更新日期:2018-04-03 00:00:00
abstract::Alterations in gut microbiota are postulated to be an etiologic factor in the pathogenesis of irritable bowel syndrome (IBS). To determine whether IBS patients in China exhibited differences in their gut microbial composition, fecal samples were collected from diarrhea-predominant IBS (IBS-D) and healthy controls and ...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2018/6961783
更新日期:2018-06-05 00:00:00
abstract::Introduction. Preoperative malnutrition is a major risk factor for increased postoperative morbidity and mortality. Definition and diagnosis of malnutrition and its treatment is still subject for controversy. Furthermore, practical implementation of nutrition-related guidelines is unknown. Methods. A review of the ava...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2011/739347
更新日期:2011-01-01 00:00:00
abstract::Epstein-Barr virus (EBV) is an important DNA virus which establishes latent infection in human malignancies. Expression of EBV-encoded genes in the associated tumors is strongly modulated by promoter CpG methylation of EBV genome. This study aimed to explore the methylation status of the promoters of EBV BamHI-A right...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2017/3804146
更新日期:2017-01-01 00:00:00
abstract::Background/Aims. This study aimed to establish optimal propofol anesthesia for therapeutic endoscopy, which has not been established. Methodology. We retrospectively investigated data on 89 patients who underwent upper-GI endoscopic submucosal dissection or endoscopic mucosal resection under anesthesia with propofol. ...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2015/282149
更新日期:2015-01-01 00:00:00
abstract::Clostridium difficile toxin A is a colonic inflammatory agent that acts partially by activation of TRPV1 (transient receptor potential vanilloid type 1). Resiniferatoxin (RTX) is an excitotoxin that activates TRPV1 at low concentrations and defunctionalizes TRPV1 at high concentrations. RTX at various doses was inject...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2017/8438172
更新日期:2017-01-01 00:00:00
abstract::The objective of this study was to evaluate the possibility to undertake an ileocolic resection in complex Crohn's disease using a minimal open abdominal access using standard laparoscopic instruments. The incision was carried out over the previous McBurney scar, with a mean length of 6 cm. Seventy-two patients with c...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2020/6019435
更新日期:2020-02-28 00:00:00
abstract::The aim of this study was to use functional magnetic resonance imaging (BOLD-fMRI) to investigate the activated region associated with visceral pain in the brains of infant rats in a model of IBS. Sixteen newborn rats were randomized into an IBS model group and a control group. Those in the IBS group were separated fr...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2014/473846
更新日期:2014-01-01 00:00:00
abstract:Background:Nonselective β-blockers (NSBB) have been associated with increased incidence of paracentesis-induced circulatory dysfunction (PICD) and reduced survival in patients with cirrhosis and refractory ascites. Aim:To prospectively evaluate a hemodynamic response to NSBB in cirrhotics listed for liver transplantat...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2018/4098210
更新日期:2018-05-09 00:00:00
abstract::Obesity is nowadays a public health problem both in the industrialized world and developing countries. The different treatments to fight against obesity are not very successful with the exception of gastric surgery. The mechanism behind the achievement of this procedure remains unclear although the modifications in th...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章,评审
doi:10.1155/2015/560938
更新日期:2015-01-01 00:00:00
abstract::Hilar cholangiocarcinoma (HCCA) involves a complex anatomical region where bile ducts, arteries, and veins create a complex network. HCCA can lead to biliary strictures at the main hepatic confluence, involving the right and left radicles. Endoscopic drainage of jaundiced patients with HCCA is challenging and carries ...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章,评审
doi:10.1155/2019/5161350
更新日期:2019-11-04 00:00:00
abstract::Myeloproliferative neoplasms (MPNs) are the leading cause of Budd-Chiari syndrome (BCS), and the C allele of JAK2 rs4495487 was reported to be an additional candidate locus that contributed to MPNs. In the present study, we examined the role of JAK2 rs4495487 in the etiology and clinical presentation of Chinese BCS pa...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2015/807865
更新日期:2015-01-01 00:00:00
abstract::Objective. Balloon enteroscopy (BE) and capsule enteroscopy (CE) are enteroscopy methods that allow examination and treatment of the small bowel. Before the CE and BE era, the small intestine was difficult to access for investigation. Small intestinal tumours are infrequent conditions, but about half of them are malig...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2013/702536
更新日期:2013-01-01 00:00:00
abstract:Background:Patients with chronic liver disease (CLD) have extrahepatic manifestations and impaired health-related quality of life (HRQOL), and hepatitis C virus (HCV) infection is a leading cause of CLD, cirrhosis, and hepatocellular carcinoma (HCC). This study is aimed at assessing HRQOL in patients with HCV infection...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2020/6716103
更新日期:2020-01-07 00:00:00
abstract::This study was to investigate the association of psychological characteristics and functional dyspepsia treatment outcome. 109 patients who met the criteria for FD were enrolled. Eysenck Personality Questionnaire (EPQ), Symptom Checklist 90 (SCL90), and the Pittsburgh Sleep Quality Index (PSQI) were used to measure pe...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2016/5984273
更新日期:2016-01-01 00:00:00
abstract:Aim:This study is aimed at comparing gastric cancer T and N staging between virtual monochromatic energy images and fusion images generated by dual-source computed tomography (DSCT) dual-energy mode data acquisition prospectively while measuring the iodine concentration of gastric cancer and lymph nodes at different T ...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2018/5015202
更新日期:2018-12-04 00:00:00
abstract::The aim of the present study was to examine the influence of gastrectomy (GX) on cortical and cancellous bones in rats. Twenty male Sprague-Dawley rats were randomized into the two groups of 10 animals each: a sham operation (control) group and a GX group. Seven weeks after surgery, the bone mineral content and densit...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章,收录出版
doi:10.1155/2013/381616
更新日期:2013-01-01 00:00:00
abstract::Autophagy is a catabolic process by which a cell degrades its intracellular materials to replenish itself. Induction of autophagy under various cellular stress stimuli can lead to either cell survival or cell death via apoptotic and/or autophagic (nonapoptotic) pathways. The NSAID sulindac sulfide induces apoptosis in...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2012/897678
更新日期:2012-01-01 00:00:00
abstract::Pancreatic adenocarcinoma is an aggressive disease that has poor outcomes despite maximal traditional therapies. Thus, treatment of this cancer demands innovative strategies to be used in addition to standing therapies in order to provide new avenues of care. Here, we describe the technique of using endoscopic ultraso...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2013/207129
更新日期:2013-01-01 00:00:00
abstract::Purpose. Endoscopic ultrasound-guided biliary drainage (EUS-BD) has been increasingly reported worldwide. However, studies concerning EUS-BD from Mainland China are sporadic. This study aims to investigate the feasibility, efficacy, and safety of EUS-BD using SEMS in a single center from Mainland China. Methods. Betwe...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2017/6284094
更新日期:2017-01-01 00:00:00
abstract::Irritable bowel syndrome (IBS) is a gastrointestinal disorder linked to disturbances in the gut-brain axis. Visceral hypersensitivity and pain are hallmarks of IBS and linked to the physiological and psychological burden and to the nonadaptive coping with stress. Cognitive-behavioral therapy (CBT) for IBS has proven e...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2017/8915872
更新日期:2017-01-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) ranks second amongst all causes of cancer deaths globally. It is on a rise in Pakistan and might represent the most common cancer in adult males. Pakistan contributes significantly to global burden of hepatitis C, which is a known risk factor for HCC, and has one of the highest prevalenc...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章,评审
doi:10.1155/2016/5942306
更新日期:2016-01-01 00:00:00
abstract::Objective. This study compared the eradication rates of of Helicobacter pylori (HP) infection by a 7-day and 14-day anti-HP regimen. Materials and Methods. An open, randomized, prospective study was performed to evaluate the response to anti-HP treatment in adult HP-positive patients following a 7-day course (Regimen ...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2016/5061640
更新日期:2016-01-01 00:00:00
abstract:Background and Aim:Proximal sessile serrated adenomas (PSSA) leading to colorectal cancer (CRC) represent an alternate pathway for CRC development. In this study, we aim to determine the prevalence of PSSAs and the impact of patient, colonoscopy, and endoscopist-related factors on PSSA detection. Methods:Patients ≥ 50...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2017/6710931
更新日期:2017-01-01 00:00:00