Abstract:
:Hilar cholangiocarcinoma (HCCA) involves a complex anatomical region where bile ducts, arteries, and veins create a complex network. HCCA can lead to biliary strictures at the main hepatic confluence, involving the right and left radicles. Endoscopic drainage of jaundiced patients with HCCA is challenging and carries a high risk of infective complications. HCCA needs a careful multidisciplinary evaluation to assess the indication and purposes (preoperative/palliative) of the biliary drainage. Biliary drainage in HCCA needs to be planned by magnetic resonance cholangiography in order to study the biliary anatomy and perform a target drainage of the intrahepatic ducts above the malignant hilar stricture; all the opacified intrahepatic ducts above the hilar stricture must be drained to reduce septic complications. Drainage of >50% of the liver volume is important to obtain bilirubin reduction and less complications, but atrophic liver segments (identified by CT scan) do not require drainage due to the increased risk of cholangitis. When preoperative biliary drainage is planned, plastic stents must be inserted. Self-expandable metal stents are indicated for palliative purposes and should be placed only when a complete liver drainage is possible; only uncovered metal stents are indicated to drain malignant hilar strictures to avoid side-branch occlusion.
journal_name
Gastroenterol Res Practjournal_title
Gastroenterology research and practiceauthors
Tringali A,Boškoski I,Costamagna Gdoi
10.1155/2019/5161350subject
Has Abstractpub_date
2019-11-04 00:00:00pages
5161350eissn
1687-6121issn
1687-630Xjournal_volume
2019pub_type
杂志文章,评审abstract::Inflammatory bowel diseases (IBDs) comprising Crohn disease (CD) and ulcerative colitis (UC) are chronic inflammatory conditions with polygenic susceptibility. Interactions between TNF-alpha and TNF-alpha receptor play a fundamental role in inflammatory response. This study investigates the role that selected single n...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2009/591704
更新日期:2009-01-01 00:00:00
abstract:Objective:Fucosterol is derived from the brown alga Eisenia bicyclis and has various biological activities, including antioxidant, anticancer, and antidiabetic properties. The aim of this study was to investigate the protective effects of fucosterol pretreatment on Concanavalin A- (ConA-) induced acute liver injury in ...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2018/2824139
更新日期:2018-07-17 00:00:00
abstract::Irritable bowel syndrome (IBS) is a gastrointestinal disorder linked to disturbances in the gut-brain axis. Visceral hypersensitivity and pain are hallmarks of IBS and linked to the physiological and psychological burden and to the nonadaptive coping with stress. Cognitive-behavioral therapy (CBT) for IBS has proven e...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2017/8915872
更新日期:2017-01-01 00:00:00
abstract::Background. Previous studies have established norms of 24-hour gastric pH profiles for western countries. This study was designed to establish the pattern for a rural African population with a high incidence of oesophageal cancer. Methods. After lower oesophageal manometry a probe was placed 10 cm distal to the lower ...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2015/658106
更新日期:2015-01-01 00:00:00
abstract:Background and Aim:Proximal sessile serrated adenomas (PSSA) leading to colorectal cancer (CRC) represent an alternate pathway for CRC development. In this study, we aim to determine the prevalence of PSSAs and the impact of patient, colonoscopy, and endoscopist-related factors on PSSA detection. Methods:Patients ≥ 50...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2017/6710931
更新日期:2017-01-01 00:00:00
abstract:Background:The aim of this study was to evaluate the interobserver variability in diagnosing inflammatory bowel disease (IBD)-associated neoplasia among practicing pathologists from China using telepathology, a practice of remote diagnostic consultation increasingly used nationally and internationally, and its comparis...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2018/8715263
更新日期:2018-04-23 00:00:00
abstract::Gastric ectopic pancreas is an uncommon developmental anomaly and its histological diagnosis is usually difficult by using a conventional biopsy forceps. In the literature, most cases of gastric ectopic pancreas were usually diagnosed by gross pattern during endoscopic examination or features of endoscopic ultrasound....
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2014/160601
更新日期:2014-01-01 00:00:00
abstract::Background. Functional dyspepsia (FD) is a functional upper gastrointestinal disorder with significant morbidity and medical costs. Previous studies investigated the association of G-protein β3 (GNB3) genetic polymorphisms with FD but with inconsistent results. Therefore, we performed a meta-analysis to derive a preci...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章,评审
doi:10.1155/2016/5037254
更新日期:2016-01-01 00:00:00
abstract:Background/Objectives:This meta-analysis is aimed at investigating the prognostic roles of the inflammatory markers neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in patients with pancreatic cancer. Methods:The correlations between high inflammatory marker expression levels and prognosis i...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2018/9745601
更新日期:2018-06-07 00:00:00
abstract:Background and Aims:To date, there are no validated measures in IBD to assess the level of preparedness for transition into adult health care. The purpose of this study was to develop and assess the reliability and validity of a "Transition Readiness" (TR) measure for adolescents with IBD, as well as to evaluate the le...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2019/5062105
更新日期:2019-06-18 00:00:00
abstract:Aim:To describe the abnormalities at MR imaging and related complaints in patients with poor outcome after STARR procedure. Materials and Methods:The medical records of 21 symptomatic patients from centre 1, 31 patients from centre 2, and 63 patients from centre 3 were reviewed with regard to findings at MR defecograp...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2017/4392918
更新日期:2017-01-01 00:00:00
abstract:Objectives:To determine the prevalence and effect of dietary habits on functional constipation in preschool and early elementary school children in Japan. Study Design:A total of 3595 children aged 3 to 8 years from 28 nursery schools and 22 elementary schools in Yokohama City, Kanagawa Prefecture, Japan, were evaluat...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2018/3108021
更新日期:2018-02-27 00:00:00
abstract::Background. There is increasing evidence suggesting that the laparoscopic technique is the treatment of choice for large bowel resection, including for malignancy. The purpose of the study was to assess whether general surgeons, with particular skills in advanced laparoscopy, can adequately provide safe laparoscopic c...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2014/581523
更新日期:2014-01-01 00:00:00
abstract:Purpose:Patients with inflammatory bowel disease (IBD) frequently suffer from venous thromboembolic events, and the risk of thromboembolism increases along with disease activity. This study was conducted to discover novel thrombophilic markers using thromboelastography (TEG) and to evaluate the relation between the pre...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2020/3245657
更新日期:2020-05-20 00:00:00
abstract::Background. Since the incidence of adenocarcinoma of the oesophagus is rising, the prognosis is poor, and surveillance programs are expensive and mostly cost ineffective, there is a need to increase the knowledge of risk factors in Barrett's oesophagus and oesophageal cancer in order to be able to give attention to me...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2014/408470
更新日期:2014-01-01 00:00:00
abstract::Objective. In the present study, since PON1 is known as an HDL-associated antioxidant enzyme that inhibits the oxidative modification of LDL and oxidative stress plays a role in the pathogenesis of mesenteric ischemia, we investigated the changes in PON1 activity and lipid profile in an experimental ischemic colitis m...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2012/979506
更新日期:2012-01-01 00:00:00
abstract::Helicobacter pylori colonizes the stomachs of greater than 50% of the world's human population making it arguably one of the most successful bacterial pathogens. Chronic H. pylori colonization results in gastritis in nearly all patients; however in a subset of people, persistent infection with H. pylori is associated ...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章,评审
doi:10.1155/2016/3019362
更新日期:2016-01-01 00:00:00
abstract::This study was aimed at investigating the effect of baicalin on experimental cholesterol gallstones in mice. The mouse gallstone model was induced by feeding with a lithogenic diet, and cholesterol stones were found in the gallbladder. The lithogenic diet caused elevation of triglycerides, cholesterol, and low-density...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2020/1343969
更新日期:2020-04-21 00:00:00
abstract::Ovarian cancer peritoneal carcinomatosis requires a multimodal-treatment approach. Current treatment considerations are analyzed in this update and include the management of recurrent malignant ascites and the understanding of its pathophysiology, the role of peritoneal washing cytology in detecting peritoneal metasta...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章,评审
doi:10.1155/2018/5284814
更新日期:2018-04-05 00:00:00
abstract::Pancreatic adenocarcinoma is an aggressive disease that has poor outcomes despite maximal traditional therapies. Thus, treatment of this cancer demands innovative strategies to be used in addition to standing therapies in order to provide new avenues of care. Here, we describe the technique of using endoscopic ultraso...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2013/207129
更新日期:2013-01-01 00:00:00
abstract::Despite extensive research, alcohol remains one of the most common causes of liver disease in the United States. Alcoholic liver disease (ALD) encompasses a broad spectrum of disorders, including steatosis, steatohepatitis, and cirrhosis. Although many agents and approaches have been tested in patients with ALD and in...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章,评审
doi:10.1155/2016/5491465
更新日期:2016-01-01 00:00:00
abstract::Introduction. Preoperative malnutrition is a major risk factor for increased postoperative morbidity and mortality. Definition and diagnosis of malnutrition and its treatment is still subject for controversy. Furthermore, practical implementation of nutrition-related guidelines is unknown. Methods. A review of the ava...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2011/739347
更新日期:2011-01-01 00:00:00
abstract::Background. There has been an increasing interest in the use of volatile organic compounds (VOCs) as potential surrogate markers of gut dysbiosis in gastrointestinal disease. Gut dysbiosis occurs when pathological imbalances in gut bacterial colonies precipitate disease and has been linked to the dysmetabolism of bile...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章,评审
doi:10.1155/2015/398585
更新日期:2015-01-01 00:00:00
abstract::Background. Endoscopic-Ultrasonography- (EUS-) guided puncture and drainage of pancreatic pseudocyst is currently one of the most widely accepted nonsurgical treatments. To date, this technique has only been used for pancreatic pseudocysts adhesive to the gastric wall. This study introduces the technique of EUS-guided...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2013/785483
更新日期:2013-01-01 00:00:00
abstract:Background and Aim:As part of the EC-IBD prospective inception cohort study, we had unique opportunity to follow up our patients since diagnosis in the early 1990s. Patients and Methods:All patients from the greater Dublin area (n = 192) were followed up from inception between 1991 and 1993 until the 30 September 2009...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2017/4946068
更新日期:2017-01-01 00:00:00
abstract:Objectives:The incidence of gastrointestinal stromal tumors (GISTs) located in the colon is rare. Current studies mainly focus on case reports for colonic GISTs. Therefore, a population-based analysis was useful to guide the clinical treatment strategy. Methods:The patients were selected from 2000 to 2015 based on Sur...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2019/3849850
更新日期:2019-04-11 00:00:00
abstract::Distemonanthus benthamianus (Caesalpiniaceae) is a plant from the Cameroon pharmacopoeia very widely used in the treatment of many pathologies among which are gastrointestinal disorders. The main purpose of this study was to assess the healing properties of gastric ulcer from the methanolic extract of Distemonanthus b...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2020/8180323
更新日期:2020-11-28 00:00:00
abstract:Objective:To investigate and study the related risk factors of gastric cancer (GC) patients, to establish a high-risk scoring model of GC by multiple logistic regression analysis, and to explore the establishment of a GC screening mode with clinical opportunistic screening as the main method, and by using the pattern o...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2020/5609623
更新日期:2020-09-30 00:00:00
abstract::Aims. The association between Helicobacter pylori (H. pylori) infection and diarrhea-predominant irritable bowel syndrome (IBS-D) is still controversial. Here we performed a retrospective study to explore this issue. Methods. A total of 502 inpatients with Rome III confirmed IBS-D and known H. pylori status from 8 hos...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2016/3059201
更新日期:2016-01-01 00:00:00
abstract::Background. Fat affects gastric emptying (GE). 5-Hydroxythryptophan (5-HTP) is involved in central and peripheral satiety mechanisms. Influence of 5-HTP in addition to saturated or monounsaturated fatty acids (FA) on GE and hormone release was investigated. Subjects/Methods. 24 healthy individuals (12f : 12m, 22-29 ye...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2014/424503
更新日期:2014-01-01 00:00:00