Abstract：
BACKGROUND:Diversion colitis (DC) seems to be common in stoma patients, and the restoration of the continuity of the digestive tract is crucial for relief from the inflammatory process. No prospective studies of the late effects of DC on the lower gastrointestinal (GI) tract mucosa and the clinical condition of patients have been reported. METHODS:Data from 23 patients who underwent stoma creation were analysed during the reversal period (A) and at an average of 3 months (B1) and 5.6 years (B2) after restoration of GI tract continuity. Every monitoring visit included endoscopy, histology and assessment of the clinical condition of patients. RESULTS:Shortly after GI tract restoration (B1), a significant decrease in inflammation was observed. The Ki67 positivity percentage increased, but this was not significant. At an average of 5.6 years after restoration (group B2), the clinical symptoms were mild. More patients presented with endoscopically detected inflammation of the mucosa, but its severity was not significantly higher than that at 3 months after reversal. Histological inflammation was more common, and its severity was significantly higher than that shortly after reversal but similar to that before reversal. The Ki67 positivity percentage decreased at the last examination (B2). CONCLUSIONS:The results of this study show a complex recurrence of histological inflammation several years after GI tract restoration but without clinical and endoscopic inflammation and with good clinical condition. DC can potentially have a late influence on the rectal mucosa, even after stoma closure.
journal_name
Int J Colorectal Disjournal_title
International journal of colorectal diseaseauthors
Szczepkowski M,Banasiewicz T,Kobus Adoi
10.1007/s00384-017-2802-zsubject
Has Abstractpub_date
2017-08-01 00:00:00pages
1191-1196issue
8eissn
0179-1958issn
1432-1262pii
10.1007/s00384-017-2802-zjournal_volume
32pub_type
杂志文章abstract：INTRODUCTION:First degree relatives (FDR) of colorectal cancer (CRC) patients are at increased risk of CRC compared to the general population. However, screening colonoscopy rates amongst the FDRs remain dismal. The aim of the study was to explore the various issues amongst the patients and their FDR precluding their a...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-017-2818-4
更新日期：2017-07-01 00:00:00
abstract：BACKGROUND AND AIMS:This study determined correlations of clinical and manometric features with those of anal endosonography (AES). PATIENTS AND METHODS:Between 1996 and 1999 we examined 58 patients suffering from anal incontinence (AI) by AES using a linear probe and anorectal manometry following a standardized proto...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s003840100354
更新日期：2002-03-01 00:00:00
abstract：BACKGROUND:The prognostic significance of anti-53 autoantibody in colorectal cancer (CRC) patients is unclear due to measurement of overall rather than disease-specific survival and generally short follow-up periods in many studies. We aim to investigate prognostic significance of anti-p53 auto-antibodies in a study wi...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-008-0458-4
更新日期：2008-06-01 00:00:00
abstract：PURPOSE:The purpose of this study was to assess the effect of a structured hands-on workshop on the detection rate of obstetric anal sphincter injuries. METHODS:All physicians attending the delivery ward in our institution participated in a structured obstetric anal sphincter injury hands-on workshop developed by Dr. ...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-015-2365-9
更新日期：2016-01-01 00:00:00
abstract：PURPOSE:The aim of the study was to determine the spatiotemporal expression of Wnt5a during hindgut and anorectum development in human embryos and to explore the possible role of Wnt5a during the morphogenesis of the human hindgut and anorectum. MATERIALS AND METHODS:The embryos (n = 107) were sectioned serially and s...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-011-1191-y
更新日期：2011-08-01 00:00:00
abstract：BACKGROUND:Current guidelines support the use of adjuvant chemotherapy (CT) following neoadjuvant chemoradiotherapy (CTRT) and surgery to treat rectal cancer, although clinical trials have provided little evidence that it is effective. We performed a systematic review of published studies to assess whether adjuvant CT ...
journal_title：International journal of colorectal disease
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s00384-014-2082-9
更新日期：2015-04-01 00:00:00
abstract：INTRODUCTION:A simple quality of life questionnaire was designed to triage patients with faecal incontinence to the most appropriate level of support, investigation and treatment. METHOD:A questionnaire was developed to include a 'symptom' score, similar in content to St Mark's questionnaire and a 'bothersome' score. ...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-009-0769-0
更新日期：2009-10-01 00:00:00
abstract：:The aim of this collaborative prospective study was to verify the incidence of pelvic recurrence (PR) after radical surgery for cancer of the rectum and sigmoid. Very low anterior resection (VLAR) was usually performed, with the aim of preserving anal function and obtaining the maximum of radicality by means of en blo...
journal_title：International journal of colorectal disease
pub_type： 临床试验,杂志文章
doi：10.1007/BF00360353
更新日期：1992-09-01 00:00:00
abstract：BACKGROUND:Increasing the rate of pathological complete remissions after neoadjuvant chemoradiation of rectal cancer has become a strategy to further improve the long-term oncological outcome of patients. This report evaluates the influence of preoperative intensified radiochemotherapy on the rate and outcome of surgic...
journal_title：International journal of colorectal disease
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00384-007-0408-6
更新日期：2008-03-01 00:00:00
abstract：INTRODUCTION:When 'whole colonic imaging' is indicated, clinicians must decide between optical colonoscopy, barium enema and CT colonography (CTC). CTC is a relatively new technique which has become increasingly accessible in the UK over the past 5 years. As radiologists have gained experience and scanning parameters h...
journal_title：International journal of colorectal disease
pub_type： 杂志文章,评审
doi：10.1007/s00384-011-1178-8
更新日期：2011-08-01 00:00:00
abstract：PURPOSE:Colorectal cancer is a common malignancy and one of the major causes of cancer-related deaths worldwide. Similar to other human cancers, tumor metastasis is the biggest obstacle in the clinical treatment of colorectal cancer. In this study, we explored the functional role of SLIT2 in colon tumor metastasis and ...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-013-1641-9
更新日期：2013-07-01 00:00:00
abstract：PURPOSE:This paper aimed to study the long term follow-up of patients with primary rectal adenocarcinoma receiving neoadjuvant chemoradiotherapy who obtained a pathological complete response (pCR) and identify factors predicting complete response. METHODS:Retrospective review of notes, histology, pre-operative full bl...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-016-2712-5
更新日期：2017-03-01 00:00:00
abstract：INTRODUCTION:The transplantation of neural crest derived stem cells (NCSC) is a potent alternative for the treatment of Hirschsprung's disease (HSCR). Cells to be transplanted should find an appropriate microenvironment to survive and differentiate. Influences of HSCR-smooth-muscle-protein extracts upon isolated myente...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-012-1411-0
更新日期：2012-06-01 00:00:00
abstract：BACKGROUND AND AIMS:Pancreatic stellate cells (PSCs) play a key role in the development of pancreatic fibrosis. The molecular mechanisms underlying their activation in response to profibrogenic mediators, however, are largely unknown. Extending previous studies on the transcriptional regulation of PSC activation, we ha...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-003-0565-1
更新日期：2004-09-01 00:00:00
abstract：:Local therapy has been widely reported and accepted for benign tumours and carefully selected cancers of the rectum. Thirty-three patients with benign or malignant low rectal tumors have undergone a prospective evaluation after local resection with transanal electroresection as described by Faivre. Patients were divid...
journal_title：International journal of colorectal disease
pub_type： 临床试验,杂志文章
doi：10.1007/BF00341209
更新日期：1995-01-01 00:00:00
abstract：PURPOSE:Whether malignant colorectal obstruction (MCO) after one-stage curative surgery without preoperative decompression has a poor prognosis remains unclear. We assessed long-term outcomes of one-stage surgery without preoperative decompression for stage II/III MCO. METHODS:We retrospectively enrolled patients with...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-019-03413-z
更新日期：2019-11-01 00:00:00
abstract：PURPOSE:Circulating tumor cells (CTCs) represent an independent prognostic factor in metastatic colorectal cancer, while their significance in early stages is still an open issue. The aim of the study is to investigate the role of CTCs in rectal cancer patients undergoing neoadjuvant chemoradiotherapy (CT-RT). METHODS...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-014-1958-z
更新日期：2014-09-01 00:00:00
abstract：PURPOSE:Colon anastomotic leakage remains both a frequent and serious complication in gastrointestinal surgery. External coating of colonic anastomoses has been proposed as a means to lower the rate of this complication. The aim of this review was to evaluate existing studies on external coating of colonic anastomoses....
journal_title：International journal of colorectal disease
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s00384-012-1547-y
更新日期：2012-10-01 00:00:00
abstract：:Anal fissure is a common condition affecting young to middle-aged adults. It causes severe pain on defecation and rectal bleeding. The aetiology remains uncertain. Spasm of the internal anal sphincter is a constant feature. Nitric oxide (NO) is the major inhibitory neurotransmitter of the internal anal sphincter (IAS)...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-005-0757-y
更新日期：2006-10-01 00:00:00
abstract：BACKGROUND:Currently, many surgeons place a prophylactic drain in the abdominal or pelvic cavity after colorectal anastomosis as a conventional treatment. However, some trials have demonstrated that this procedure may not be beneficial to the patients. OBJECTIVE:To determine whether prophylactic placement of a drain i...
journal_title：International journal of colorectal disease
pub_type： 杂志文章,meta分析
doi：10.1007/s00384-016-2509-6
更新日期：2016-05-01 00:00:00
abstract：BACKGROUND:Gastrointestinal cancers belong to the most important causes of cancer death in the Western world. Because cure can be achieved only by complete surgical removal of the tumor, and most patients have metastasis at the time point of diagnosis, the majority of patients receive chemotherapy. DISCUSSION:Indicati...
journal_title：International journal of colorectal disease
pub_type： 杂志文章,评审
doi：10.1007/s00384-003-0496-x
更新日期：2003-11-01 00:00:00
abstract：BACKGROUND:MRI detected extramural vascular invasion (mrEMVI) is a poor prognostic factor in rectal cancer patients. The objectives of this study were to assess survival outcomes in patients with and without mrEMVI and to compare the prognostic value of mrEMVI with other rectal cancer features. METHODS:In a Dutch high...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-020-03632-9
更新日期：2020-10-01 00:00:00
abstract：BACKGROUND AND AIMS:We investigated expression of E-cadherin, beta-catenin, and c-erbB-2 in gastric cancer to identify molecular factor(s) relevant to development of liver metastasis, which is a frequent cause of mortality in gastric cancer patients. PATIENTS AND METHODS:We analyzed by immunohistochemistry and compare...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-002-0427-2
更新日期：2003-03-01 00:00:00
abstract：:Hidradenitis suppurativa (HS) is a chronic fistula- and abscess-forming disease of the cutis and subcutis of unknown etiology. Disease recurrence is frequent and may cause severe complications. We analyzed patients with HS who underwent surgery between 1976 and 1997. The operative procedures were divided into drainage...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s003840050159
更新日期：1998-01-01 00:00:00
abstract：BACKGROUND AND AIMS:Dextran sulfate sodium (DSS) induced colitis exhibits a predominantly NF-kappaB dependent proinflammatory cytokine profile and shares similarities with human inflammatory bowel disease (IBD). Lamina propria macrophages of IBD patients display elevated levels of NF-kappaB p65. Knowing the role of NF-...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-001-0366-3
更新日期：2002-07-01 00:00:00
abstract：:The mechanisms of the antineoplastic effect of nonsteroidal anti-inflammatory drugs (NSAIDs) still are unknown, but the induction of apoptosis is one of the possible mechanisms. We attempted to demonstrate the role of mitogen-activated protein (MAP) kinases, generally considered to be important mediators of proliferat...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s003840100301
更新日期：2001-06-01 00:00:00
abstract：PURPOSE:Kras mutations are negative predictors of anti-EGFR therapy, occurring in 40% of colorectal carcinomas (CRCs). Point substitutions in codon 12 or 13 are the most frequent mutations in Kras, but multiple mutations (MMs) in other codons can also develop. Few data exist on MMs with regard to their frequency and th...
journal_title：International journal of colorectal disease
pub_type： 杂志文章,评审
doi：10.1007/s00384-011-1238-0
更新日期：2011-10-01 00:00:00
abstract：:Recurrence of pilonidal sinus disease after surgical intervention is not a very rare problem although sophisticated reconstruction procedures have been developed. Recurrence is thought to be related to the anatomical status of the patients, i.e., depth of the intergluteal groove. Obese patients have deeper interglutea...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s003840000212
更新日期：2000-06-01 00:00:00
abstract：PURPOSE:This study was designed to examine the impact of an omentoplasty and its quality on pelviperineal morbidity after abdominoperineal resection (APR) for rectal cancer. METHODS:This was a retrospective single-centre study of consecutive patients undergoing APR for primary or recurrent rectal cancer between 2000 a...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-019-03412-0
更新日期：2019-11-01 00:00:00
abstract：OBJECTIVE:The objective of this study is to assess the value of metastatic lymph node ratio (LNR) in predicting disease-free survival (DFS) in patients with stage III adenocarcinoma of the colon. MATERIALS AND METHODS:From 1995 to 2003 inclusively, a total of 624 patients featuring stage III adenocarcinoma of the colo...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-009-0738-7
更新日期：2009-11-01 00:00:00
