Abstract:
:Biostatistics is an essential component in most original research studies in imaging. In this article we discuss five key statistical concepts for study design and analyses in modern imaging research: statistical hypothesis testing, particularly focusing on noninferiority studies; imaging outcomes especially when there is no reference standard; dealing with the multiplicity problem without spending all your study power; relevance of confidence intervals in reporting and interpreting study results; and finally tools for assessing quantitative imaging biomarkers. These concepts are presented first as examples of conversations between investigator and biostatistician, and then more detailed discussions of the statistical concepts follow. Three skeletal radiology examples are used to illustrate the concepts.
journal_name
Semin Musculoskelet Radioljournal_title
Seminars in musculoskeletal radiologyauthors
Obuchowski NA,Subhas N,Polster Jdoi
10.1055/s-0036-1597252subject
Has Abstractpub_date
2017-02-01 00:00:00pages
23-31issue
1eissn
1089-7860issn
1098-898Xjournal_volume
21pub_type
杂志文章,评审abstract::Computed tomography (CT) has gained multiplanar capability and submillimeter spatial resolution due to the development of spiral acquisition mode and multidetector row technology. Multidetector spiral CT arthrography of the knee is a valuable imaging modality for the assessment of lesions of the meniscus, anterior cru...
journal_title:Seminars in musculoskeletal radiology
pub_type: 杂志文章,评审
doi:10.1055/s-2002-23163
更新日期:2002-03-01 00:00:00
abstract::Balancing mobility and stability, the biomechanics of the shoulder provides optimal use of the thumb and hand. More than a glenohumeral joint, the shoulder complex consists of four joints and numerous muscles and ligaments. Injuries to the shoulder result from overuse, extremes of motion, and excessive forces. This re...
journal_title:Seminars in musculoskeletal radiology
pub_type: 杂志文章,评审
doi:10.1055/s-2003-41081
更新日期:2003-03-01 00:00:00
abstract::This article provides a brief review of the normal osseous, ligamentous, muscular, and neurovascular imaging anatomy of the elbow. Special attention is paid to the normal structures that may simulate pathology, as well as anatomical variants that may lead to pathology. This review will help clarify distinctions betwee...
journal_title:Seminars in musculoskeletal radiology
pub_type: 杂志文章,评审
doi:10.1055/s-0030-1263254
更新日期:2010-09-01 00:00:00
abstract::Magnetic resonance imaging (MRI) is widely used in the clinical setting as well as for research applications. Since its inception, technical development has broadly progressed as a response to challenges in both the clinical and research settings. Higher magnetic field strength and advances in hardware and software ha...
journal_title:Seminars in musculoskeletal radiology
pub_type: 杂志文章,评审
doi:10.1055/s-0037-1599209
更新日期:2017-04-01 00:00:00
abstract::Degenerative disease may lead to spinal canal stenosis and long-lasting pain. It is among the leading cause of disability that may affect the ability to work. It has become more common in an increasingly aging population. MRI is the most comprehensive imaging modality and provides detailed morphologic information. A s...
journal_title:Seminars in musculoskeletal radiology
pub_type: 杂志文章,评审
doi:10.1055/s-0034-1375566
更新日期:2014-07-01 00:00:00
abstract::In rheumatoid arthritis (RA), due to its superior contrast resolution and tomographic nature, magnetic resonance (MR) imaging can depict soft tissue and joint involvement better than plain radiography. Active synovitis and pannus are shown by a wide variety of contrast on T1- and T2-weighted images. They are markedly ...
journal_title:Seminars in musculoskeletal radiology
pub_type: 杂志文章
doi:10.1055/s-2001-15674
更新日期:2001-06-01 00:00:00
abstract::Disorders of ligaments and tendons at the midfoot are less common than those around the ankle and at the hindfoot. Nevertheless, disorders of the distal portions of the anterior and posterior tibialis tendons (ATT and PTT) and the spring ligament complex have an important clinical impact and can be treated with surger...
journal_title:Seminars in musculoskeletal radiology
pub_type: 杂志文章,评审
doi:10.1055/s-2005-921939
更新日期:2005-09-01 00:00:00
abstract::Three-dimensional (3D) turbo-spin echo (TSE) sequences have outgrown the stage of mere sequence optimization and by now are clinically applicable. Image blurring and acquisition times have been reduced, and contrast for T1-, T2-, and moderately T2-weighted (or intermediate-weighted) fat-suppressed variants has been op...
journal_title:Seminars in musculoskeletal radiology
pub_type: 杂志文章,评审
doi:10.1055/s-0035-1563732
更新日期:2015-09-01 00:00:00
abstract::Early diagnosis, followed by early initiation and optimal adjustments of aggressive therapies, are acknowledged as essential to optimize long-term clinical and radiological outcome in rheumatoid arthritis (RA). This requires sensitive methods for detection and monitoring of the primary feature of RA--the synovitis. In...
journal_title:Seminars in musculoskeletal radiology
pub_type: 杂志文章,评审
doi:10.1055/s-2004-861576
更新日期:2004-12-01 00:00:00
abstract::End-stage ankle osteoarthritis often significantly impacts patients' quality of life. This can be managed surgically either by ankle arthrodesis or total ankle arthroplasty (TAA). Although ankle arthrodesis is considered by some as the standard-of-care surgical option for this condition, it restricts range of motion a...
journal_title:Seminars in musculoskeletal radiology
pub_type: 杂志文章,评审
doi:10.1055/s-0038-1677466
更新日期:2019-04-01 00:00:00
abstract::The evaluation of muscle diseases has traditionally integrated clinical with biochemical findings, occasionally resorting to muscle biopsy. This article reviews the role and imaging appearances of muscle diseases at MRI, specifically emphasising the role of WBMRI in global assessment of muscle abnormality, and in part...
journal_title:Seminars in musculoskeletal radiology
pub_type: 杂志文章,评审
doi:10.1055/s-0030-1248704
更新日期:2010-03-01 00:00:00
abstract::Ulnar-sided wrist pain is one of the most common symptoms in athletes of baseball, racket sports, golf, and wrestling where there is frequent use of the hands as well as in soccer and running, where hand use is minimal. Compared with all wrist injuries, ulnar-sided wrist injury is a relatively serious condition for at...
journal_title:Seminars in musculoskeletal radiology
pub_type: 杂志文章,评审
doi:10.1055/s-0032-1327006
更新日期:2012-09-01 00:00:00
abstract::In recent years significant advances have been made in imaging techniques. Dual-energy computed tomography has revolutionized the ability to detect and quantify gout. The key ultrasound features of gout have been defined. Magnetic resonance imaging is an excellent modality for demonstrating the extent and severity of ...
journal_title:Seminars in musculoskeletal radiology
pub_type: 杂志文章,评审
doi:10.1055/s-0038-1639484
更新日期:2018-04-01 00:00:00
abstract::There has been a renewed interest in the recent literature with regard to the normal anatomy of the distal biceps tendon. Cadaveric studies have demonstrated that a large percentage of individuals have two independent muscle bellies, the short and the long head, with two distinct separate tendons attaching at the radi...
journal_title:Seminars in musculoskeletal radiology
pub_type: 杂志文章,评审
doi:10.1055/s-0033-1333910
更新日期:2013-02-01 00:00:00
abstract::Shoulder ultrasound is a commonly performed imaging study that can accurately determine the presence of rotator cuff tendinosis and tears, as well as subacromial-subdeltoid bursal and long head of biceps tendon pathology. High accuracy depends on an awareness of imaging pitfalls that can be encountered and lead to ove...
journal_title:Seminars in musculoskeletal radiology
pub_type: 杂志文章,评审
doi:10.1055/s-0039-1693488
更新日期:2019-08-01 00:00:00
abstract::Over the last 2 decades, the definition of pathomechanical concepts that link osseous deformities to chondrolabral damage and expose young and active patients to the risk of early osteoarthritis has led to a tremendous increase in the number of joint-preserving surgeries performed. The rise in arthroscopic procedures ...
journal_title:Seminars in musculoskeletal radiology
pub_type: 杂志文章,评审
doi:10.1055/s-0039-1678729
更新日期:2019-06-01 00:00:00
abstract::Bisphosphonates have been widely used in the treatment of osteoporosis with well-documented long-term efficacy and safety, particularly in postmenopausal patients. But over the past decade, low-energy atypical subtrochanteric and proximal diaphyseal femoral fractures have emerged as an unexpected complication of prolo...
journal_title:Seminars in musculoskeletal radiology
pub_type: 杂志文章,评审
doi:10.1055/s-0036-1593766
更新日期:2016-09-01 00:00:00
abstract::Hydroxyapatite (HA) crystal deposition disease (HADD) is a well-recognized systemic disease of unknown etiology that is caused by para-articular and/or intra-articular deposition of HA crystals. The disease is clinically manifested by localized pain, swelling, and tenderness about the affected joint along with variabl...
journal_title:Seminars in musculoskeletal radiology
pub_type: 杂志文章,评审
doi:10.1055/s-2003-43229
更新日期:2003-09-01 00:00:00
abstract::The goal of this article is to present a concise review of the current concepts of shoulder instability. This chapter supplements the radiologic assessment of glenohumeral instability, which follows this section. ...
journal_title:Seminars in musculoskeletal radiology
pub_type: 杂志文章,评审
doi:10.1055/s-2005-867097
更新日期:2005-03-01 00:00:00
abstract::The treatment of articular cartilage injuries remains a challenge because cartilage has a limited capacity for spontaneous repair. Over the past decade, a number of surgical interventions have been developed to produce a durable repair. This article reviews the available treatment options, including their indications,...
journal_title:Seminars in musculoskeletal radiology
pub_type: 杂志文章,评审
doi:10.1055/s-2001-19044
更新日期:2001-12-01 00:00:00
abstract::This article provides a brief overview of the current state of hybrid single-photon emission computed tomography/computer tomography (SPECT/CT) imaging in musculoskeletal infections. SPECT/CT imaging, compared with conventional planar study and SPECT alone, provides improved anatomic localization of infection and more...
journal_title:Seminars in musculoskeletal radiology
pub_type: 杂志文章,评审
doi:10.1055/s-0034-1371020
更新日期:2014-04-01 00:00:00
abstract::This paper has been written to stimulate the radiologist to consider the various aspects of spinal steroid injections as therapeutic procedures. Special emphasis is placed on needle guidance, asepsis, and possible problems involved. It constitutes a highly practical and variously illustrated and informative guide for ...
journal_title:Seminars in musculoskeletal radiology
pub_type: 杂志文章
doi:10.1055/s-2008-1080142
更新日期:1997-01-01 00:00:00
abstract::Chronic musculoskeletal diseases such as arthritis, malignancy, chronic injury/ inflammation, and chronic musculoskeletal pain often pose challenges for current clinical imaging modalities. There is hope that a growing field, referred to as "molecular imaging," will shed new light on these chronic phenomenon as it aim...
journal_title:Seminars in musculoskeletal radiology
pub_type: 杂志文章,评审
doi:10.1055/s-2004-815679
更新日期:2003-12-01 00:00:00
abstract::Benign bone cysts (aneurysmal and unicameral) often require treatment to prevent pathological fractures. Percutaneous injections are less invasive than surgery. We describe the different percutaneous treatments available: local injection of steroids, calcitonin, or bone marrow in unicameral bone cysts, and Ethibloc(R)...
journal_title:Seminars in musculoskeletal radiology
pub_type: 杂志文章
doi:10.1055/s-2008-1080152
更新日期:1997-01-01 00:00:00
abstract::Painful skeletal and vertebral conditions caused by degeneration, fractures, infection, and neoplasm are common and associated with high morbidity and mortality. Since the introduction of modern orthopedic surgery these conditions have been treated with a multitude of techniques. Bone augmentation and grafting have em...
journal_title:Seminars in musculoskeletal radiology
pub_type: 杂志文章
doi:10.1055/s-2006-939029
更新日期:2006-06-01 00:00:00
abstract::In the musculoskeletal system, tumor-like lesions may present similar imaging findings as bone and soft tissue tumors and can be defined as tumors on radiologic examinations. Misinterpretation of the imaging findings can lead to inappropriate clinical management of the patient.There is still some debate regarding the ...
journal_title:Seminars in musculoskeletal radiology
pub_type: 杂志文章
doi:10.1055/s-0040-1721378
更新日期:2020-12-01 00:00:00
abstract::An increasingly aggressive therapeutic strategy, improved treatment options, and encouraging preliminary results have attracted growing attention to the potential of magnetic resonance imaging (MRI) in the diagnosis, prognostication, and monitoring of rheumatoid arthritis (RA). MRI offers multiplanar imaging with unpr...
journal_title:Seminars in musculoskeletal radiology
pub_type: 杂志文章,评审
doi:10.1055/s-2001-17543
更新日期:2001-09-01 00:00:00
abstract::Ankle ligament injuries are among the most common injuries in sports and recreational activities. Injuries of the medial collateral ligament or deltoid ligament complex account for ∼ 15% of ligamentous ankle trauma. They are usually associated with injuries of the lateral collateral ligaments and the tibiofibular synd...
journal_title:Seminars in musculoskeletal radiology
pub_type: 杂志文章,评审
doi:10.1055/s-0036-1580617
更新日期:2016-02-01 00:00:00
abstract::Congenital upper limb malformations represent complex pathologies because of their varied clinical presentations, imaging features, and etiologies. They can be divided into (1) failure of formation with transverse, intercalary, and longitudinal (preaxial, postaxial, and mesoaxial) deficiencies, (2) failure of differen...
journal_title:Seminars in musculoskeletal radiology
pub_type: 杂志文章,评审
doi:10.1055/s-0032-1311766
更新日期:2012-04-01 00:00:00
abstract::Muscle edema is commonly encountered in patients following extremity trauma. This article presents an overview of differential considerations in patients presenting with muscle edema, and while focusing on trauma outlines causes on the basis of mechanism, vasogenic, congestive, traumatic, and tumorigenic edema. ...
journal_title:Seminars in musculoskeletal radiology
pub_type: 杂志文章,评审
doi:10.1055/s-2007-971997
更新日期:2006-12-01 00:00:00