In vivo photoacoustic imaging of blood vessels using a homodyne interferometer with zero-crossing triggering.

abstract：:We present a study using a method able to assess tissue oxygenation, taking into account the absorption and the level of scattering in myocardial tissue using a calibrated fiber optic probe. With this method, interindividual comparisons of oxygenation can be made despite varying tissue optical properties during corona...

journal_title：Journal of biomedical optics

authors： Häggblad E,Lindbergh T,Karlsson MG,Casimir-Ahn H,Salerud EG,Strömberg T

更新日期：2008-09-01 00:00:00

abstract：:Nonmelanoma skin cancer is the most common form of human cancer, often resulting in high morbidity. Low visual contrast of these tumors makes their delineation a challenging problem. Employing a linearly polarized monochromatic light source and a wide-field CCD camera, we have developed a technique for fluorescence po...

journal_title：Journal of biomedical optics

authors： Yaroslavsky AN,Salomatina EV,Neel V,Anderson R,Flotte T

更新日期：2007-01-01 00:00:00

abstract：:We present unsupervised clustering methods for automatic grouping of human red blood cells (RBCs) extracted from RBC quantitative phase images obtained by digital holographic microscopy into three RBC clusters with regular shapes, including biconcave, stomatocyte, and sphero-echinocyte. We select some good features re...

journal_title：Journal of biomedical optics

authors： Ahmadzadeh E,Jaferzadeh K,Lee J,Moon I

更新日期：2017-07-01 00:00:00

abstract：:Collagen fiber orientation plays an important role in determining the structure and function of the articular cartilage. However, there is currently a lack of nondestructive means to image the fiber orientation from the cartilage surface. The purpose of this study is to investigate whether the newly developed optical ...

journal_title：Journal of biomedical optics

authors： Yao X,Wang Y,Ravanfar M,Pfeiffer FM,Duan D,Yao G

更新日期：2016-11-01 00:00:00

abstract：:A swept source (SS)-based circular-state (CS) polarization-sensitive optical coherence tomography (PS-OCT) constructed entirely with polarization-maintaining fiber optics components is proposed with the experimental verification. By means of the proposed calibration scheme, bulk quarter-wave plates can be replaced by ...

journal_title：Journal of biomedical optics

authors： Lin H,Kao MC,Lai CM,Huang JC,Kuo WC

更新日期：2014-02-01 00:00:00

abstract：:The effect of glucose on fluorescence of synthesized ZnCdS nanoparticles in the presence of glucose oxidase or in a mixture of glucose oxidase and peroxidase has been investigated. Behavior of fluorescence characteristics of ZnCdS nanoparticles with nonstabilized surface and coated with polymer shell is compared. It h...

journal_title：Journal of biomedical optics

authors： Kochubey VI,Volkova EK,Konyukhova JG

更新日期：2014-01-01 00:00:00

abstract：:Our aim is the development of a simple optical method for pulse wave profile, pulse wave delay time, and blood flow measurement. The method is based on recording the Doppler frequency shift related to a moving target--blood vessel walls or small particles. The Doppler signal is detected using the self-mixing that occu...

journal_title：Journal of biomedical optics

authors： Meigas K,Hinrikus H,Kattai R,Lass J

更新日期：2003-01-01 00:00:00

abstract：:Quantification of nicotinamide adenine dinucleotide (NADH) changes during functional brain activation and pathological conditions provides critical insight into brain metabolism. Of the different imaging modalities, two-photon laser scanning microscopy (TPLSM) is becoming an important tool for cellular-resolution meas...

journal_title：Journal of biomedical optics

authors： Baraghis E,Devor A,Fang Q,Srinivasan VJ,Wu W,Lesage F,Ayata C,Kasischke KA,Boas DA,Sakadzić S

更新日期：2011-10-01 00:00:00

abstract：:Photodynamic therapy (PDT) is an alternative to radical surgical resection for T1a or nonresectable carcinomas of the gastroesophageal junction. Besides the concentration of the photosensitizer, the light distribution in tissue is responsible for tumor destruction. For this reason, knowledge about the behavior of ligh...

journal_title：Journal of biomedical optics

authors： Holmer C,Lehmann KS,Wanken J,Reissfelder C,Roggan A,Mueller G,Buhr HJ,Ritz JP

更新日期：2007-01-01 00:00:00

abstract：SIGNIFICANCE:Photothermal optical coherence tomography (PT-OCT) has the promise to offer structural images coregistered with chemical composition information, which can offer a significant impact in early detection of diseases such as atherosclerosis. AIM:We take the first step in understanding the relation between PT...

journal_title：Journal of biomedical optics

authors： Salimi M,Villiger M,Tabatabaei N

更新日期：2020-12-01 00:00:00

abstract：:Spasticity is a motor disorder frequently present in individuals with cerebral palsy (CP). This study aimed to evaluate the effect of low-level laser therapy (LLLT) on the spasticity of the masseter and anterior temporal muscle fibers in children with CP over three weeks of intermittent laser exposures. The bite force...

journal_title：Journal of biomedical optics

authors： Santos MT,Diniz MB,Gouw-Soares SC,Lopes-Martins RA,Frigo L,Baeder FM

更新日期：2016-02-01 00:00:00

abstract：SIGNIFICANCE:The blood-brain barrier (BBB) is a major obstacle to detecting and treating brain tumors. Overcoming this challenge will facilitate the early and accurate detection of brain lesions and guide surgical resection of tumors. AIM:We generated an orthotopic brain tumor model that simulates the pathophysiology ...

journal_title：Journal of biomedical optics

authors： Habimana-Griffin L,Ye D,Carpenter J,Prior J,Sudlow G,Marsala L,Mixdorf M,Rubin J,Chen H,Achilefu S

更新日期：2020-02-01 00:00:00

abstract：SIGNIFICANCE:The potential of fluorescence lifetime imaging microscopy (FLIM) is recently being recognized, especially in biological studies. However, FLIM does not directly measure the lifetimes, rather it records the fluorescence decay traces. The lifetimes and/or abundances have to be estimated from these traces dur...

journal_title：Journal of biomedical optics

authors： Guo S,Silge A,Bae H,Tolstik T,Meyer T,Matziolis G,Schmitt M,Popp J,Bocklitz T

更新日期：2021-01-01 00:00:00

abstract：:We have developed a novel parallel-plate diffuse optical tomography (DOT) system for three-dimensional in vivo imaging of human breast tumor based on large optical data sets. Images of oxy-, deoxy-, and total hemoglobin concentration as well as blood oxygen saturation and tissue scattering were reconstructed. Tumor ma...

journal_title：Journal of biomedical optics

authors： Choe R,Konecky SD,Corlu A,Lee K,Durduran T,Busch DR,Pathak S,Czerniecki BJ,Tchou J,Fraker DL,Demichele A,Chance B,Arridge SR,Schweiger M,Culver JP,Schnall MD,Putt ME,Rosen MA,Yodh AG

更新日期：2009-03-01 00:00:00

abstract：:Colorectal cancer is one of the most aggressive cancers usually occurring in people above the age of 50 years. In the United States, colorectal cancer is the third most diagnosed cancer. The American Cancer Society has estimated 96,830 new cases of colon cancer and 40,000 new cases of rectal cancer in 2014 in the Unit...

journal_title：Journal of biomedical optics

authors： Salman A,Sebbag G,Argov S,Mordechai S,Sahu RK

更新日期：2015-07-01 00:00:00

abstract：:A photoacoustic imaging system that incorporates a commercial ultrasonic camera for real-time imaging of two-dimensional (2-D) projection planes in tissue at video rate (30 Hz) is presented. The system uses a Q-switched frequency-doubled Nd:YAG pulsed laser for photoacoustic generation. The ultrasonic camera consists ...

journal_title：Journal of biomedical optics

authors： Balogun O,Regez B,Zhang HF,Krishnaswamy S

更新日期：2010-03-01 00:00:00

abstract：:Intrauterine photoacoustic and ultrasound imaging are probe-based imaging modalities with translational potential for use in detecting endometrial diseases. This deep-tissue imaging probe design allows for the retrofitting of commercially available endometrial sampling curettes. The imaging probe presented here has a ...

journal_title：Journal of biomedical optics

authors： Miranda C,Barkley J,Smith B

更新日期：2018-04-01 00:00:00

abstract：:Coherent anti-Stokes Raman scattering (CARS) microscopy is used to determine the distribution and concentration of selected compounds in intact human hair. By generating images based on ratiometric CARS contrast, quantitative concentration maps of both water and externally applied d-glycine are produced in the cortex ...

journal_title：Journal of biomedical optics

authors： Zimmerley M,Lin CY,Oertel DC,Marsh JM,Ward JL,Potma EO

更新日期：2009-07-01 00:00:00

abstract：:Our purpose is to evaluate intramucosal gastric pH video imaging by 2('),7(')-bis(carboxyethyl)-5,6-carboxyfluorescein (BCECF) fluorescence ratio techniques. We use a video endoscopic imaging system and BCECF as the pH fluorescent probe. Systemic in vivo pH variations are studied in 10 pigs: five in the control group ...

journal_title：Journal of biomedical optics

authors： Rochon P,Jourdain M,Mangalaboyi J,Fourrier F,Soulié-Bégu S,Buys B,Dehlin G,Lesage JC,Chambrin MC,Mordon S

更新日期：2007-11-01 00:00:00

abstract：:Functional near-infrared spectroscopy is prone to contamination by motion artifacts (MAs). Motion correction algorithms have previously been proposed and their respective performance compared for evoked rain activation studies. We study instead the effect of MAs on "oscillation" data which is at the basis of functiona...

journal_title：Journal of biomedical optics

authors： Selb J,Yücel MA,Phillip D,Schytz HW,Iversen HK,Vangel M,Ashina M,Boas DA

更新日期：2015-05-01 00:00:00

abstract：:As molecular imaging moves towards lower detection limits, the elimination of endogenous background signals becomes imperative. We present a facile background-suppression technique that specifically segregates the signal from surface-enhanced Raman scattering (SERS)-active nanoparticles (NPs) from the tissue autofluor...

journal_title：Journal of biomedical optics

authors： Mallia RJ,McVeigh PZ,Veilleux I,Wilson BC

更新日期：2012-07-01 00:00:00

abstract：:In the present study, we evaluated the applicability of ex vivo photoacoustic imaging (PAI) on small animal organs. We used photoacoustic tomography (PAT) to visualize infarcted areas within murine hearts and compared these data to other imaging techniques [magnetic resonance imaging (MRI), micro-computed tomography] ...

journal_title：Journal of biomedical optics

authors： Holotta M,Grossauer H,Kremser C,Torbica P,Völkl J,Degenhart G,Esterhammer R,Nuster R,Paltauf G,Jaschke W

更新日期：2011-03-01 00:00:00

abstract：:Keratoconus is an eye disease in which the cornea progressively deforms due to loss of cornea mechanical rigidity, and thus causes deterioration of visual acuity. Techniques to characterize the mechanical characteristics of the cornea are important to better monitor changes and response to treatments. To investigate t...

journal_title：Journal of biomedical optics

authors： Ortega-Martinez A,Touchette G,Zhu H,Kochevar IE,Franco W

更新日期：2017-09-01 00:00:00

abstract：:This study investigates the precision and intraindividual variability of a clinical optical pachometer based on low-coherence reflectometry, which was used to measure the central thickness of a human cornea in vivo. The instrument, attached to a slit lamp, is a single mode fiber optic based Michelson interferometer wi...

journal_title：Journal of biomedical optics

authors： Bo Hnke M,Masters BR,Wa Lti R,Ballif JJ,Chavanne P,Gianotti R,Salathe RP

更新日期：1999-01-01 00:00:00

abstract：:Probing tissue with near-infrared radiation (NIR) simultaneously produces remitted fluorescence and Raman scattering (IE) plus Rayleigh∕Mie light scattering (EE) that noninvasively give chemical and physical information about the materials and objects within. We model tissue as a three-phase system: plasma and red blo...

journal_title：Journal of biomedical optics

authors： Chaiken J,Deng B,Goodisman J,Shaheen G,Bussjager RJ

更新日期：2011-09-01 00:00:00

abstract：:Sinus blockages are a common reason for physician visits, affecting one out of seven people in the United States, and often require medical treatment. Diagnosis in the primary care setting is challenging because symptom criteria (via detailed clinical history) plus objective imaging [computed tomography (CT) or endosc...

journal_title：Journal of biomedical optics

authors： Cerussi AE,Mishra N,You J,Bhandarkar N,Wong B

更新日期：2015-03-01 00:00:00

abstract：:Spatially resolved diffuse reflectance spectroscopy (srDRS) is a well-established technique for noninvasive, in vivo characterization of tissue optical properties toward diagnostic applications. srDRS has a potential for depth-resolved analysis of tissue, which is desired in various clinical situations. However, curre...

journal_title：Journal of biomedical optics

authors： Petitdidier N,Koenig A,Gerbelot R,Grateau H,Gioux S,Jallon P

更新日期：2018-11-01 00:00:00

abstract：:Functional near-infrared spectroscopy (fNIRS), acquired simultaneously with electroencephalography (EEG), allows the investigation of hemodynamic brain responses to epileptic activity. Because the presumed epileptogenic focus is patient-specific, an appropriate source/detector (SD) montage has to be reconfigured for e...

journal_title：Journal of biomedical optics

authors： Machado A,Marcotte O,Lina JM,Kobayashi E,Grova C

更新日期：2014-02-01 00:00:00

abstract：:The development of methods that allow microscale studies of complex biomaterials based on their molecular composition is of great interest to a wide range of research fields. We show that stimulated Raman scattering (SRS) microscopy is an excellent analytical tool to study distributions of different biomolecules in mu...

journal_title：Journal of biomedical optics

authors： Roeffaers MB,Zhang X,Freudiger CW,Saar BG,van Ruijven M,van Dalen G,Xiao C,Xie XS

更新日期：2010-11-01 00:00:00

abstract：:In the last decade, coherent anti-Stokes Raman scattering (CARS) microscopy has emerged as a powerful multiphoton imaging technique offering label-free chemical sensitivity and high three-dimensional resolution. However, its widespread application in the life sciences has been hampered by the use of costly pulsed lase...

journal_title：Journal of biomedical optics

authors： Li B,Borri P,Langbein W

更新日期：2013-06-01 00:00:00