当前位置： SCI文献检索 > Journal of Hepato-Biliary-Pancreatic Sciences期刊下所有文献 > Expression of Bcl-2 19-kDa interacting protein 3 predicts prognosis after ampullary carcinoma resection.

Expression of Bcl-2 19-kDa interacting protein 3 predicts prognosis after ampullary carcinoma resection.

Abstract：

BACKGROUND:An adequate management strategy for ampullary carcinoma (AC), a rare neoplasm, has yet to be determined. The aim of this study was to identify specific molecular markers allowing for the adequate management of AC. METHODS:The clinicopathological data of 41 patients who underwent curative resection of AC were reviewed retrospectively. The expression of thymidylate synthase (TS) and Bcl-2 19-kDa interacting protein 3 (BNIP3), two sensitive markers for S-1 and gemcitabine, respectively, was evaluated immunohistochemically. The relationship between the expression levels of these markers and the clinicopathological data were then investigated. RESULTS:The 5-year overall survival rate in the study population was 62%. In univariate and multivariate analyses, lymph node metastasis, neural invasion, lymphatic invasion, and the high-level BNIP3 expression were significant predictive factors for a poor postoperative prognosis. Neither TS nor BNIP3 expression were able to predict survival or the disease recurrence rate in patients who received postoperative adjuvant chemotherapy for AC. CONCLUSIONS:BNIP3 expression may serve as a prognostic marker for patients with AC, but neither TS nor BNIP3 contributes to the selection criteria for adjuvant chemotherapy for AC, at least with respect to current drug regimens.

journal_name

J Hepatobiliary Pancreat Sci

journal_title

Journal of hepato-biliary-pancreatic sciences

authors

Fujimoto T,Ohtsuka T,Date K,Kimura H,Matsunaga T,Mori Y,Miyasaka Y,Mochidome N,Oda Y,Nakamura M

doi

10.1002/jhbp.367

subject

Has Abstract

pub_date

2016-08-01 00:00:00

pages

489-96

issue

8

eissn

1868-6974

issn

1868-6982

journal_volume

23

pub_type

杂志文章

相关文献

Journal of Hepato-Biliary-Pancreatic Sciences文献大全
  • Recent advances in visualization, imaging, and navigation in hepatobiliary and pancreatic sciences.

    abstract：BACKGROUND/PURPOSE:Recent introduction of multi-detector CT (MDCT) and high-speed magnetic resonance (MR) imaging have dramatically advanced visualization and imaging technology in diagnostic and therapeutic strategy in hepatobiliary pancreatic disease. However, image diagnostics have progressed with a background of th...

    journal_title：Journal of hepato-biliary-pancreatic sciences

    pub_type： 杂志文章,评审

    doi：10.1007/s00534-009-0192-5

    authors： Sugimoto M

    更新日期：2010-09-01 00:00:00

  • Single HCC smaller than 2 cm: surgery or ablation: interventional oncologist's perspective.

    abstract：:In the EASL and AASLD guidelines, hepatic resection (HR) is considered the first option for patients in stage 0 (very early HCC). This statement was not based on randomized controlled trials (RCTs) versus other therapies, but on the oncological assumption that HR is the better procedure for obtaining complete tumor ab...

    journal_title：Journal of hepato-biliary-pancreatic sciences

    pub_type： 杂志文章,评审

    doi：10.1007/s00534-009-0244-x

    authors： Livraghi T

    更新日期：2010-07-01 00:00:00

  • Predictive performance of Blumgart T staging for perihilar cholangiocarcinoma in a Japanese center.

    abstract：BACKGROUND:The Blumgart system has been used for local tumor assessment in perihilar cholangiocarcinoma to predict resectability and survival, and T3 tumors are considered unresectable disease. The aim was to validate the predictive performance of this system using a Japanese cohort. METHODS:Medical records of consecu...

    journal_title：Journal of hepato-biliary-pancreatic sciences

    pub_type： 杂志文章

    doi：10.1002/jhbp.694

    authors： Ebata T,Mizuno T,Yokoyama Y,Igami T,Yamaguchi J,Onoe S,Watanabe N,Nagino M

    更新日期：2020-03-01 00:00:00

  • Propofol inhibits pancreatic cancer progress under hypoxia via ADAM8.

    abstract：BACKGROUND:To investigate the potential anti-tumoral properties of propofol in pancreatic cancer and elucidate the underlying mechanisms. METHODS:The relative expression of ADAM metallopeptidase domain 8 (ADAM8) in response to hypoxia in Panc1 cells was analyzed by western blotting. The enzymatic activity was determin...

    journal_title：Journal of hepato-biliary-pancreatic sciences

    pub_type： 杂志文章

    doi：10.1002/jhbp.624

    authors： Gao Y,Yu X,Zhang F,Dai J

    更新日期：2019-06-01 00:00:00

  • Left hepatectomy.

    abstract：:Left hepatectomy is one of the most common types of hepatectomy. In order to perform the procedure, surgeons need to possess all the basic skills for accomplishing any liver resection. The most important points to bear in mind in relation to left hepatectomy are: (1) a precise recognition of the surgical anatomy of th...

    journal_title：Journal of hepato-biliary-pancreatic sciences

    pub_type： 杂志文章

    doi：10.1007/s00534-011-0452-z

    authors： Kobayashi A,Miyagawa S

    更新日期：2012-01-01 00:00:00

  • Single-stage endoscopic treatment for mild to moderate acute cholangitis associated with choledocholithiasis: a multicenter, non-randomized, open-label and exploratory clinical trial.

    abstract：BACKGROUND:Two-stage treatment involving stone removal after drainage is recommended for mild to moderate acute cholangitis associated with choledocholithiasis. However, single-stage treatment has some advantages. We aimed to assess the efficacy and safety of single-stage endoscopic treatment for mild to moderate acute...

    journal_title：Journal of hepato-biliary-pancreatic sciences

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1002/jhbp.296

    authors： Eto K,Kawakami H,Haba S,Yamato H,Okuda T,Yane K,Hayashi T,Ehira N,Onodera M,Matsumoto R,Matsubara Y,Takagi T,Sakamoto N,Hokkaido Interventional EUS\/ERCP study (HONEST) group.

    更新日期：2015-12-01 00:00:00

  • Long-term outcomes and recurrence patterns of standard versus extended pancreatectomy for pancreatic head cancer: a multicenter prospective randomized controlled study.

    abstract：BACKGROUND:Our previous randomized controlled trial revealed no difference in 2-year overall survival (OS) between extended and standard resection for pancreatic adenocarcinoma. The present study evaluated the 5-year OS and recurrence patterns according to the extent of pancreatectomy. METHODS:Between 2006 and 2009, 1...

    journal_title：Journal of hepato-biliary-pancreatic sciences

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1002/jhbp.465

    authors： Jang JY,Kang JS,Han Y,Heo JS,Choi SH,Choi DW,Park SJ,Han SS,Yoon DS,Park JS,Yu HC,Kang KJ,Kim SG,Lee H,Kwon W,Yoon YS,Han HS,Kim SW

    更新日期：2017-07-01 00:00:00

  • Role of thrombospondin-1 expression in colorectal liver metastasis and its molecular mechanism.

    abstract：BACKGROUND:Thrombospondin-1 (THBS-1), a glycoprotein, is an endogenous inhibitor of angiogenesis and tumor growth. In this study, we investigated the clinical role and mechanism of THBS-1 expression in colorectal liver metastases, focusing on the relationships between its expression and tumor growth, epithelial-mesench...

    journal_title：Journal of hepato-biliary-pancreatic sciences

    pub_type： 杂志文章

    doi：10.1002/jhbp.376

    authors： Teraoku H,Morine Y,Ikemoto T,Saito Y,Yamada S,Yoshikawa M,Takasu C,Higashijima J,Imura S,Shimada M

    更新日期：2016-09-01 00:00:00

  • Basic knowledge of and a small trick for atraumatic needle driving in laparoscopic suturing.

    abstract：:Highlight Although recent advances in robotic surgery have enabled more precise movements of the needle driver, a sophisticated laparoscopic suturing technique is still desired. Honda and colleagues describe the basic knowledge of and a small but useful trick for atraumatic needle driving in laparoscopic suturing, bas...

    journal_title：Journal of hepato-biliary-pancreatic sciences

    pub_type： 杂志文章

    doi：10.1002/jhbp.814

    authors： Honda G,Ome Y,Yoshida N,Kawamoto Y

    更新日期：2020-10-01 00:00:00

  • New digital cholangiopancreatoscopy for diagnosis and therapy of pancreaticobiliary diseases (with videos).

    abstract：BACKGROUND:Recently, a new digital cholangiopancreatoscopy (DCPS) has been developed. The aim of this study is to retrospectively evaluate the utility of new DCPS in patients with pancreaticobiliary diseases. METHODS:Digital cholangiopancreatoscopy was used in 26 patients (16 men) with pancreaticobiliary diseases that...

    journal_title：Journal of hepato-biliary-pancreatic sciences

    pub_type： 杂志文章

    doi：10.1002/jhbp.328

    authors： Tanaka R,Itoi T,Honjo M,Tsuchiya T,Kurihara T,Tsuji S,Tonozuka R,Kamada K,Sofuni A,Mukai S

    更新日期：2016-04-01 00:00:00

  • Sex differences in outcomes of acute pancreatitis: Findings from a nationwide analysis.

    abstract：BACKGROUND:Sex is thought to play a significant role in predicting outcomes in numerous diseases. The role sex plays in acute pancreatitis (AP) remains limited. We sought to determine if sex is associated with hospitalization outcomes in this population, using a large national database. METHODS:This was a retrospectiv...

    journal_title：Journal of hepato-biliary-pancreatic sciences

    pub_type： 杂志文章

    doi：10.1002/jhbp.890

    authors： Sharma S,Weissman S,Aburayyan K,Acharya A,Aziz M,Systrom HK,Lew D,Vohra I,Feuerstein JD,Pandol SJ

    更新日期：2021-01-08 00:00:00

  • Surgical strategy of biliary papillomatosis in Western countries.

    abstract：:Surgical resection, considered the optimal treatment of biliary papillomatosis, often remains incomplete due to high risk of recurrence in view of positive margins or recurrence on the remnant bile duct because of its multifocality. Resection of the whole biliary tree by liver transplantation and duodenopancreatectomy...

    journal_title：Journal of hepato-biliary-pancreatic sciences

    pub_type： 杂志文章

    doi：10.1007/s00534-009-0151-1

    authors： Vibert E,Dokmak S,Belghiti J

    更新日期：2010-05-01 00:00:00

  • Multivariate logistic regression analysis for prediction of clinically relevant pancreatic fistula in the early phase after pancreaticoduodenectomy.

    abstract：BACKGROUND:Postoperative pancreatic fistula (PF) remains a major complication after pancreaticoduodenectomy (PD). We aimed to investigate the predictors of clinically relevant PF after PD. METHODS:We retrospectively analyzed the predictive factors of relevant grade B/C PF using logistic regression analysis of 100 cons...

    journal_title：Journal of hepato-biliary-pancreatic sciences

    pub_type： 杂志文章

    doi：10.1002/jhbp.11

    authors： Kosaka H,Kuroda N,Suzumura K,Asano Y,Okada T,Fujimoto J

    更新日期：2014-02-01 00:00:00

  • Recurrent intrahepatic cholangiocarcinoma: single-center experience using repeated hepatectomy and radiofrequency ablation.

    abstract：BACKGROUND:Intrahepatic cholangiocarcinoma (IHC) is a rare liver malignancy with a rising incidence worldwide. Since no standard treatment has been established so far, the aim of this study was to assess the safety and efficacy of repeated liver resection and/or radiofrequency ablation (RFA) in selected cases with recu...

    journal_title：Journal of hepato-biliary-pancreatic sciences

    pub_type： 杂志文章

    doi：10.1007/s00534-009-0256-6

    authors： Kamphues C,Seehofer D,Eisele RM,Denecke T,Pratschke J,Neumann UP,Neuhaus P

    更新日期：2010-07-01 00:00:00

  • Influence of duration of type 1 diabetes on long-term pancreatic transplant outcomes.

    abstract：BACKGROUND:There are no multicenter studies on the influence of diabetes duration on pancreatic transplant outcomes. Our study aimed to determine how type 1 diabetes duration influenced survival of pancreatic grafts. METHODS:The data of 8,139 patients who received pancreas transplants during 2006-2015 were extracted f...

    journal_title：Journal of hepato-biliary-pancreatic sciences

    pub_type： 杂志文章

    doi：10.1002/jhbp.677

    authors： Zhou J,Dong Y,Mei S,Gu Y,Li Z,Xiang J,Zheng H,Chen Z,Huang Z,Hu Z

    更新日期：2019-12-01 00:00:00

  • A phase II study of oral S-1 with concurrent radiotherapy followed by chemotherapy with S-1 alone for locally advanced pancreatic cancer.

    abstract：BACKGROUND/PURPOSE:S-1 is a new oral fluoropyrimidine anticancer agent shown to be effective for pancreatic cancer. In a previous phase I trial, we evaluated the safety of S-1 combined with radiotherapy to determine the maximum tolerated dose and dose-limiting toxicity in patients with unresectable pancreatic cancer. T...

    journal_title：Journal of hepato-biliary-pancreatic sciences

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00534-011-0400-y

    authors： Shinchi H,Maemura K,Mataki Y,Kurahara H,Sakoda M,Ueno S,Hiraki Y,Nakajo M,Natsugoe S,Takao S

    更新日期：2012-03-01 00:00:00

  • Usefulness of preoperative drip infusion cholangiography with computed tomography for predicting surgical difficulty during laparoscopic cholecystectomy.

    abstract：BACKGROUND:Drip infusion cholangiography with computed tomography (DIC-CT) is a major preoperative modality used for patients undergoing laparoscopic cholecystectomy (LC). METHODS:This study included 218 patients for whom preoperative DIC-CT images were obtained prior to undergoing LC. The association between gallblad...

    journal_title：Journal of hepato-biliary-pancreatic sciences

    pub_type： 杂志文章

    doi：10.1002/jhbp.718

    authors： Nakazawa A,Akamatsu N,Miyata Y,Komagome M,Maki A,Arita J,Ishizawa T,Kaneko J,Beck Y,Hasegawa K

    更新日期：2020-06-01 00:00:00

  • Reappraisal of the advantages of laparoscopic liver resection for intermediate hepatocellular carcinoma within a stage migration perspective: Propensity score analysis of the differential benefit.

    abstract：OBJECTIVE:The aim of the present study was to analyze the outcome of laparoscopic approach specifically in patients with Intermediate-stage disease and to define the differential benefit with Early-stage patients. METHODS:Six hundred twenty-two resections for HCC were dichotomized according to staging (Early and Inter...

    journal_title：Journal of hepato-biliary-pancreatic sciences

    pub_type： 杂志文章

    doi：10.1002/jhbp.736

    authors： Ratti F,Cipriani F,Fiorentini G,Catena M,Paganelli M,Aldrighetti L

    更新日期：2020-08-01 00:00:00

  • Japanese clinical practice guidelines for congenital biliary dilatation.

    abstract：:Until now, there have been no practical clinical guidelines for congenital biliary dilatation (CBD). In this review article, the Japanese Study Group on Congenital Biliary Dilatation (JSCBD) propose to establish clinical practice guidelines for CBD. Because the evidence-based literature is relatively small, we decided...

    journal_title：Journal of hepato-biliary-pancreatic sciences

    pub_type： 信件,评审

    doi：10.1002/jhbp.415

    authors： Ishibashi H,Shimada M,Kamisawa T,Fujii H,Hamada Y,Kubota M,Urushihara N,Endo I,Nio M,Taguchi T,Ando H,Japanese Study Group on Congenital Biliary Dilatation (JSCBD).

    更新日期：2017-01-01 00:00:00

  • Indocyanine green R15 ratio depends directly on liver perfusion flow rate.

    abstract：BACKGROUND:Indocyanine green (ICG) is a synthetic dye that is widely used to evaluate liver function in critically ill patients, before liver resection or after liver transplantation. Controversy still exists about the impact exerted on the ICG ratio after 15 min (ICG R15) by differences in liver perfusion rates, hyper...

    journal_title：Journal of hepato-biliary-pancreatic sciences

    pub_type： 杂志文章

    doi：10.1007/s00534-009-0160-0

    authors： Janssen MW,Druckrey-Fiskaaen KT,Omidi L,Sliwinski G,Thiele C,Donaubauer B,Polze N,Kaisers UX,Thiery J,Wittekind C,Hauss JP,Schön MR

    更新日期：2010-03-01 00:00:00

  • Liver transplantation for hepatocellular carcinoma in the world: the Taiwan experience.

    abstract：:Liver transplantation (LT) has been regarded as "potentially curative" in a cirrhotic patient with hepatocellular carcinoma (HCC) because it removes the cancer and eradicates the cirrhosis. In Taiwan, HCC ranks first among the leading causes of cancer mortality in males and 4th in females. The most common causes are c...

    journal_title：Journal of hepato-biliary-pancreatic sciences

    pub_type： 杂志文章,评审

    doi：10.1007/s00534-009-0166-7

    authors： Chen CL,Concejero AM

    更新日期：2010-09-01 00:00:00

  • Disparities in the management and prophylaxis of surgical site infection and pancreatic fistula after pancreatoduodenectomy.

    abstract：BACKGROUND:Pancreatoduodenectomy (PD) carries a high morbidity. Over time, pancreatic surgeons have altered their perioperative management in efforts to reduce morbidity rates, thereby creating major technical and management variations. We aim to evaluate the practice patterns of hepato-pancreato-biliary (HPB) surgeons...

    journal_title：Journal of hepato-biliary-pancreatic sciences

    pub_type： 杂志文章,多中心研究

    doi：10.1002/jhbp.443

    authors： Macedo FIB,Mowzoon M,Parikh J,Sathyanarayana SA,Jacobs MJ

    更新日期：2017-05-01 00:00:00

  • Comparison of laparoscopic major hepatectomy with propensity score matched open cases from the National Clinical Database in Japan.

    abstract：BACKGROUND:The National Clinical Database (NCD) in Japan is a nationwide registry that collects the data of more than 1,200,000 surgical cases annually from over 3,500 hospitals. Based on the NCD data, this study compared the perioperative outcomes of major laparoscopic liver resection (LLR) with those of major open li...

    journal_title：Journal of hepato-biliary-pancreatic sciences

    pub_type： 杂志文章

    doi：10.1002/jhbp.405

    authors： Takahara T,Wakabayashi G,Konno H,Gotoh M,Yamaue H,Yanaga K,Fujimoto J,Kaneko H,Unno M,Endo I,Seto Y,Miyata H,Miyazaki M,Yamamoto M

    更新日期：2016-11-01 00:00:00

  • Incidental intrahepatic cholangiocarcinoma in patients undergoing liver transplantation: a multi-center study in Japan.

    abstract：BACKGROUND:Intrahepatic cholangiocarcinoma had been considered a contraindication for liver transplantation because of poorer outcomes. However, incidental intrahepatic cholangiocarcinoma in the explanted liver has been reported because of the difficulty of obtaining an accurate diagnosis in cirrhotic livers on preoper...

    journal_title：Journal of hepato-biliary-pancreatic sciences

    pub_type： 杂志文章

    doi：10.1002/jhbp.896

    authors： Hara T,Eguchi S,Yoshizumi T,Akamatsu N,Kaido T,Hamada T,Takamura H,Shimamura T,Umeda Y,Shinoda M,Ogura Y,Fukumoto T,Kasahara M,Hibi T,Umeshita K,Furukawa H,Ohdan H

    更新日期：2021-01-19 00:00:00

  • Clinical diagnostic criteria of IgG4-related sclerosing cholangitis 2012.

    abstract：BACKGROUND:IgG4-sclerosing cholangitis (IgG4-SC) patients have an increased level of serum IgG4, dense infiltration of IgG4-positive plasma cells with extensive fibrosis in the bile duct wall, and a good response to steroid therapy. However, it is not easy to distinguish IgG4-SC from primary sclerosing cholangitis, pan...

    journal_title：Journal of hepato-biliary-pancreatic sciences

    pub_type： 杂志文章,实务指引

    doi：10.1007/s00534-012-0521-y

    authors： Ohara H,Okazaki K,Tsubouchi H,Inui K,Kawa S,Kamisawa T,Tazuma S,Uchida K,Hirano K,Yoshida H,Nishino T,Ko SB,Mizuno N,Hamano H,Kanno A,Notohara K,Hasebe O,Nakazawa T,Nakanuma Y,Takikawa H,Research Committee of IgG4

    更新日期：2012-09-01 00:00:00

  • Two-dimensional shear wave elastography with propagation-based reliability assessment for grading hepatic fibrosis and portal hypertension.

    abstract：BACKGROUND:The aim of the present study was to examine the diagnostic ability of two-dimensional shear wave elastography (2D-SWE) with propagation-based reliability for grading of hepatic fibrosis and portal hypertension. METHODS:This prospective study (UMIN000022838) consisted of 135 subjects. Phase I (n = 40) examin...

    journal_title：Journal of hepato-biliary-pancreatic sciences

    pub_type： 杂志文章

    doi：10.1002/jhbp.379

    authors： Maruyama H,Kobayashi K,Kiyono S,Sekimoto T,Kanda T,Yokosuka O

    更新日期：2016-09-01 00:00:00

  • Novel concept of bared type metallic stent for endoscopic bilateral stent-in-stent placement in patients with hilar malignant biliary obstruction (with video).

    abstract：:Highlight Takenaka and colleagues report on a novel bare uncovered self-expandable metal stent developed to be compatible with only 0.025-inch guide wires. This unprecedented feature makes the delivery tip thinner and more flexible than the conventional type and useful for endoscopic bilateral stent-in-stent placement...

    journal_title：Journal of hepato-biliary-pancreatic sciences

    pub_type： 杂志文章

    doi：10.1002/jhbp.698

    authors： Takenaka M,Nakai A,Kudo M

    更新日期：2020-05-01 00:00:00

  • Tips and tricks of the surgical technique for borderline resectable pancreatic cancer: mesenteric approach and modified distal pancreatectomy with en-bloc celiac axis resection.

    abstract：:Borderline resectable (BR) pancreatic cancer involves the portal vein and/or superior mesenteric vein (PV/SMV), major arteries including the superior mesenteric artery (SMA) or common hepatic artery (CHA), and sometimes includes the involvement of the celiac axis. We herein describe tips and tricks for a surgical tech...

    journal_title：Journal of hepato-biliary-pancreatic sciences

    pub_type： 杂志文章

    doi：10.1002/jhbp.184

    authors： Hirono S,Yamaue H

    更新日期：2015-02-01 00:00:00

  • Preoperative biliary drainage associated with biliary stricture after pancreaticoduodenectomy: a population-based study.

    abstract：BACKGROUND:The rate of preoperative biliary drainage for pancreaticoduodenectomy has been increasing despite most recent evidence that favors avoiding it. Only a few studies have focused on late surgical complications - biliary stricture after pancreaticoduodenectomy and have produced only inconclusive results. We eval...

    journal_title：Journal of hepato-biliary-pancreatic sciences

    pub_type： 杂志文章

    doi：10.1002/jhbp.559

    authors： Wu CH,Ho TW,Wu JM,Kuo TC,Yang CY,Lai FP,Tien YW

    更新日期：2018-06-01 00:00:00

  • Does adjuvant treatment improve prognosis after curative resection of ampulla of Vater carcinoma? A multicenter retrospective study.

    abstract：BACKGROUND/PURPOSE:Ampulla of Vater (AoV) carcinoma is a rare tumor that accounts for approximately 0.2% of gastrointestinal malignancies. There are no clinical guidelines concerning the treatment of AoV carcinoma. This study aimed to investigate the effectiveness of adjuvant treatment in AoV carcinoma following curati...

    journal_title：Journal of hepato-biliary-pancreatic sciences

    pub_type： 杂志文章

    doi：10.1002/jhbp.801

    authors： Kim HS,Jang JY,Yoon YS,Park SJ,Kwon W,Kim SW,Han HS,Han SS,Park JS,Yoon DS

    更新日期：2020-10-01 00:00:00