Abstract:
BACKGROUND/PURPOSE:Ampulla of Vater (AoV) carcinoma is a rare tumor that accounts for approximately 0.2% of gastrointestinal malignancies. There are no clinical guidelines concerning the treatment of AoV carcinoma. This study aimed to investigate the effectiveness of adjuvant treatment in AoV carcinoma following curative resection and define the "high-risk" group. METHODS:Clinical data of patients who underwent curative resection for AoV carcinoma in four hospitals, namely Yonsei Gangnam Severance Hospital, Seoul National University Hospital, Seoul National University Bundang Hospital, and National Cancer Center (n = 651; 2002-2015), were reviewed. Overall survival (OS) and recurrence-free survival (RFS) rates were compared using Kaplan-Meier estimates. RESULTS:Data of 651 patients who had undergone curative resection were retrospectively reviewed. Age, T stage, N stage, and differentiation type remained strong and independent risk factors for RFS and OS. In early-stage AoV carcinoma (T1N0, T2N0), the non-adjuvant group had better prognosis based on the RFS and OS than the adjuvant group (P < .001, P = .007). In advanced T stage (T3N0, T4N0), the adjuvant group had better prognosis than the non-adjuvant group, but the difference was not statistically significant (P > .05). In node-positive patients (any T, N1/2), adjuvant treatment did not affect RFS and OS (P > .05). CONCLUSIONS:Adjuvant treatment after curative resection of AoV carcinoma is not associated with improved survival. The high-risk group (node-positive or advanced T stage (T3, T4)) treated with adjuvant treatment was not statistically associated with improved survival; however, our study showed that the adjuvant treatment for the high-risk group might help achieve better patient outcome.
journal_name
J Hepatobiliary Pancreat Scijournal_title
Journal of hepato-biliary-pancreatic sciencesauthors
Kim HS,Jang JY,Yoon YS,Park SJ,Kwon W,Kim SW,Han HS,Han SS,Park JS,Yoon DSdoi
10.1002/jhbp.801subject
Has Abstractpub_date
2020-10-01 00:00:00pages
721-730issue
10eissn
1868-6974issn
1868-6982journal_volume
27pub_type
杂志文章abstract:BACKGROUND:The objective of this study was to evaluate our new protocol for performing non-operative management for selected unstable patients under hypotensive resuscitation using improved diagnostic imaging techniques. METHODS:This retrospective study included 77 consecutive patients with blunt liver injury. They we...
journal_title:Journal of hepato-biliary-pancreatic sciences
pub_type: 杂志文章
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journal_title:Journal of hepato-biliary-pancreatic sciences
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journal_title:Journal of hepato-biliary-pancreatic sciences
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journal_title:Journal of hepato-biliary-pancreatic sciences
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journal_title:Journal of hepato-biliary-pancreatic sciences
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journal_title:Journal of hepato-biliary-pancreatic sciences
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journal_title:Journal of hepato-biliary-pancreatic sciences
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journal_title:Journal of hepato-biliary-pancreatic sciences
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journal_title:Journal of hepato-biliary-pancreatic sciences
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doi:10.1007/s00534-010-0281-5
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journal_title:Journal of hepato-biliary-pancreatic sciences
pub_type: 杂志文章
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更新日期:2016-11-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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