当前位置： SCI文献检索 > Journal of Hepato-Biliary-Pancreatic Sciences期刊下所有文献 > Sinisan, a traditional Chinese medicine, attenuates experimental chronic pancreatitis induced by trinitrobenzene sulfonic acid in rats.

Sinisan, a traditional Chinese medicine, attenuates experimental chronic pancreatitis induced by trinitrobenzene sulfonic acid in rats.

Abstract：

BACKGROUND/PURPOSE:Sinisan, a traditional Chinese medicine, is effective for the treatment of gastrointestinal disorders. In this study, we investigated the potential protective role of Sinisan against chronic pancreatitis (CP) in rats. METHODS:CP was induced in rats by intrapancreatic injection of trinitrobenzene sulfonic acid (TNBS). Rats were randomly divided into a sham group, a TNBS-induced CP group and a Sinisan-treated group. Serum amylase and histological score were used to evaluate the severity of disease. The levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), cyclooxygenase-2 (COX-2), interleukin-10 (IL-10) and α-smooth muscle actin (α-SMA) were also measured in the three groups. Mechanical allodynia was measured with von Frey filaments. In addition, the protein levels of nerve growth factor (NGF) were measured in pancreatic tissues. RESULTS:Administration of Sinisan significantly decreased the severity of CP. In the Sinisan-treated group, serum amylase, TNF-α, IL-1β, COX-2 and α-SMA levels were lower and the level of IL-10 was upregulated compared with the TNBS-induced CP group. Furthermore, treatment with Sinisan significantly, though not completely, attenuated the allodynia. Simultaneously NGF expression was also significantly downregulated in the Sinisan-treated group compared with the TNBS-induced CP group. CONCLUSIONS:Sinisan could be an effective treatment modality for CP via its anti-inflammatory, anti-fibrotic and analgesic properties. It may be a promising drug candidate for the treatment of patients with CP.

journal_name

J Hepatobiliary Pancreat Sci

journal_title

Journal of hepato-biliary-pancreatic sciences

authors

Tang Y,Liao Y,Kawaguchi-Sakita N,Raut V,Fakhrejahani E,Qian N,Toi M

doi

10.1007/s00534-010-0368-z

subject

Has Abstract

pub_date

2011-07-01 00:00:00

pages

551-8

issue

4

eissn

1868-6974

issn

1868-6982

journal_volume

18

pub_type

杂志文章

相关文献

Journal of Hepato-Biliary-Pancreatic Sciences文献大全
  • Mucobilia: current aspects in the management of a rare cause of malignant biliary obstruction.

    abstract：:Mucobilia is a rare pathologic condition characterized by the abnormal secretion and accumulation of abundant mucus within the biliary tree. It is usually seen in association with mucin-producing hepatobiliary and pancreatic tumors. Neoplastic transformation of these tumors can range from low-grade dysplasia to invasi...

    journal_title：Journal of hepato-biliary-pancreatic sciences

    pub_type： 杂志文章,评审

    doi：10.1007/s00534-009-0150-2

    authors： Brown MA,Sakpal SV,Chamberlain RS

    更新日期：2010-05-01 00:00:00

  • Long-term outcomes and recurrence patterns of standard versus extended pancreatectomy for pancreatic head cancer: a multicenter prospective randomized controlled study.

    abstract：BACKGROUND:Our previous randomized controlled trial revealed no difference in 2-year overall survival (OS) between extended and standard resection for pancreatic adenocarcinoma. The present study evaluated the 5-year OS and recurrence patterns according to the extent of pancreatectomy. METHODS:Between 2006 and 2009, 1...

    journal_title：Journal of hepato-biliary-pancreatic sciences

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1002/jhbp.465

    authors： Jang JY,Kang JS,Han Y,Heo JS,Choi SH,Choi DW,Park SJ,Han SS,Yoon DS,Park JS,Yu HC,Kang KJ,Kim SG,Lee H,Kwon W,Yoon YS,Han HS,Kim SW

    更新日期：2017-07-01 00:00:00

  • Incidence and risk factors for anastomotic stenosis of continuous hepaticojejunostomy after pancreaticoduodenectomy.

    abstract：BACKGROUND:There have been no reports showing the incidence of anastomotic stenosis of continuous hepaticojejunostomy (HJ) and identifying its risk factors for patients who underwent pancreaticoduodenectomy (PD). METHOD:We retrospectively investigated 200 patients whose HJ was established by unified method, single lay...

    journal_title：Journal of hepato-biliary-pancreatic sciences

    pub_type： 杂志文章

    doi：10.1002/jhbp.385

    authors： Asano T,Natsume S,Senda Y,Sano T,Matsuo K,Kodera Y,Hara K,Ito S,Yamao K,Shimizu Y

    更新日期：2016-10-01 00:00:00

  • Basics and applications of stem cells in the pancreas.

    abstract：:Enormous efforts have been made to establish pancreatic stem/progenitor cells as a source for regenerative medicine for the treatment of diabetes mellitus. In recent years, it has been recognized that the self-renewal of beta cells is the dominant process involved in postnatal beta-cell regeneration and expansion. Nev...

    journal_title：Journal of hepato-biliary-pancreatic sciences

    pub_type： 杂志文章,评审

    doi：10.1007/s00534-012-0545-3

    authors： Sekine K,Taniguchi H

    更新日期：2012-11-01 00:00:00

  • Single operator peroral cholangioscopic guided therapy of bile duct stones.

    abstract：:Since the introduction of endoscopic sphincterotomy, stone clearance of the bile duct can be achieved by conventional endoscopic means in up to 90% of patients with stone disease. Several endoscopic therapies for difficult bile duct stones have been introduced. Laser therapy for stone fragmentation under direct visual...

    journal_title：Journal of hepato-biliary-pancreatic sciences

    pub_type： 杂志文章,评审

    doi：10.1007/s00534-010-0360-7

    authors： Seelhoff A,Schumacher B,Neuhaus H

    更新日期：2011-05-01 00:00:00

  • Evaluation of effects of a novel endoscopically applied radiofrequency ablation biliary catheter using an ex-vivo pig liver.

    abstract：BACKGROUND:The effects of ablation with various settings of powers and times using a newly developed radiofrequency (RF) ablation device, the Habib™ EndoHPB catheter, are not well known. In the present study, we examined the effects of a novel RF ablation catheter using resected fresh pig livers and evaluated the macro...

    journal_title：Journal of hepato-biliary-pancreatic sciences

    pub_type： 杂志文章

    doi：10.1007/s00534-011-0465-7

    authors： Itoi T,Isayama H,Sofuni A,Itokawa F,Tamura M,Watanabe Y,Moriyasu F,Kahaleh M,Habib N,Nagao T,Yokoyama T,Kasuya K,Kawakami H

    更新日期：2012-09-01 00:00:00

  • Left hepatectomy or left trisectionectomy with resection of the caudate lobe and extrahepatic bile duct for hilar cholangiocarcinoma (with video).

    abstract：PURPOSE:Although left-sided hepatectomy, such as a left hepatectomy or left trisectionectomy with resection of the caudate lobe and extrahepatic bile duct, is used to treat hilar cholangiocarcinoma predominantly involving the left side of the hepatic hilum, it is associated with several difficult technical points. The ...

    journal_title：Journal of hepato-biliary-pancreatic sciences

    pub_type： 杂志文章,评审

    doi：10.1007/s00534-011-0474-6

    authors： Uesaka K

    更新日期：2012-05-01 00:00:00

  • Surgical strategy of biliary papillomatosis in Western countries.

    abstract：:Surgical resection, considered the optimal treatment of biliary papillomatosis, often remains incomplete due to high risk of recurrence in view of positive margins or recurrence on the remnant bile duct because of its multifocality. Resection of the whole biliary tree by liver transplantation and duodenopancreatectomy...

    journal_title：Journal of hepato-biliary-pancreatic sciences

    pub_type： 杂志文章

    doi：10.1007/s00534-009-0151-1

    authors： Vibert E,Dokmak S,Belghiti J

    更新日期：2010-05-01 00:00:00

  • Left hepatectomy.

    abstract：:Left hepatectomy is one of the most common types of hepatectomy. In order to perform the procedure, surgeons need to possess all the basic skills for accomplishing any liver resection. The most important points to bear in mind in relation to left hepatectomy are: (1) a precise recognition of the surgical anatomy of th...

    journal_title：Journal of hepato-biliary-pancreatic sciences

    pub_type： 杂志文章

    doi：10.1007/s00534-011-0452-z

    authors： Kobayashi A,Miyagawa S

    更新日期：2012-01-01 00:00:00

  • Clinical characteristics and risk factors for stent-stone complex formation following biliary plastic stent placement in patients with common bile duct stones.

    abstract：BACKGROUND:Stent-stone complex (SSC) formation is one of the complications of endoscopic biliary stent placement. This study aimed to clarify the clinical characteristics and risk factors for SSC formation following plastic stent (PS) placement in patients with common bile duct (CBD) stones. METHODS:We retrospectively...

    journal_title：Journal of hepato-biliary-pancreatic sciences

    pub_type： 杂志文章

    doi：10.1002/jhbp.584

    authors： Kaneko J,Kawata K,Watanabe S,Chida T,Matsushita M,Suda T,Kobayashi Y

    更新日期：2018-10-01 00:00:00

  • Risk factors for major morbidity after hepatectomy for hepatocellular carcinoma in 293 recent cases.

    abstract：BACKGROUND/PURPOSE:The purpose of this study was to identify risk factors for major morbidity after hepatectomies for hepatocellular carcinoma (HCC). METHODS:Univariate and multivariate analyses of risk factors for major morbidity were performed in 293 patients who underwent hepatectomy for HCC between 2001 and 2008. ...

    journal_title：Journal of hepato-biliary-pancreatic sciences

    pub_type： 杂志文章

    doi：10.1007/s00534-010-0275-3

    authors： Sadamori H,Yagi T,Matsuda H,Shinoura S,Umeda Y,Yoshida R,Satoh D,Utsumi T,Ohnishi T

    更新日期：2010-09-01 00:00:00

  • The clinical impact and risk factors of latent pancreatic fistula after pancreatoduodenectomy.

    abstract：BACKGROUND:Latent pancreatic fistula (LPF) is difficult to diagnose during the early postoperative phase because of initially normal drain fluid amylase (DFA) levels. The present study investigated the clinical significance and risk factors of LPF after pancreatoduodenectomy. METHODS:A total of 662 patients who underw...

    journal_title：Journal of hepato-biliary-pancreatic sciences

    pub_type： 杂志文章

    doi：10.1002/jhbp.820

    authors： Ohgi K,Yamamoto Y,Sugiura T,Okamura Y,Ito T,Ashida R,Uesaka K

    更新日期：2020-12-01 00:00:00

  • Sex differences in outcomes of acute pancreatitis: Findings from a nationwide analysis.

    abstract：BACKGROUND:Sex is thought to play a significant role in predicting outcomes in numerous diseases. The role sex plays in acute pancreatitis (AP) remains limited. We sought to determine if sex is associated with hospitalization outcomes in this population, using a large national database. METHODS:This was a retrospectiv...

    journal_title：Journal of hepato-biliary-pancreatic sciences

    pub_type： 杂志文章

    doi：10.1002/jhbp.890

    authors： Sharma S,Weissman S,Aburayyan K,Acharya A,Aziz M,Systrom HK,Lew D,Vohra I,Feuerstein JD,Pandol SJ

    更新日期：2021-01-08 00:00:00

  • A phase II study of oral S-1 with concurrent radiotherapy followed by chemotherapy with S-1 alone for locally advanced pancreatic cancer.

    abstract：BACKGROUND/PURPOSE:S-1 is a new oral fluoropyrimidine anticancer agent shown to be effective for pancreatic cancer. In a previous phase I trial, we evaluated the safety of S-1 combined with radiotherapy to determine the maximum tolerated dose and dose-limiting toxicity in patients with unresectable pancreatic cancer. T...

    journal_title：Journal of hepato-biliary-pancreatic sciences

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00534-011-0400-y

    authors： Shinchi H,Maemura K,Mataki Y,Kurahara H,Sakoda M,Ueno S,Hiraki Y,Nakajo M,Natsugoe S,Takao S

    更新日期：2012-03-01 00:00:00

  • Usefulness of preoperative drip infusion cholangiography with computed tomography for predicting surgical difficulty during laparoscopic cholecystectomy.

    abstract：BACKGROUND:Drip infusion cholangiography with computed tomography (DIC-CT) is a major preoperative modality used for patients undergoing laparoscopic cholecystectomy (LC). METHODS:This study included 218 patients for whom preoperative DIC-CT images were obtained prior to undergoing LC. The association between gallblad...

    journal_title：Journal of hepato-biliary-pancreatic sciences

    pub_type： 杂志文章

    doi：10.1002/jhbp.718

    authors： Nakazawa A,Akamatsu N,Miyata Y,Komagome M,Maki A,Arita J,Ishizawa T,Kaneko J,Beck Y,Hasegawa K

    更新日期：2020-06-01 00:00:00

  • Expression of Bcl-2 19-kDa interacting protein 3 predicts prognosis after ampullary carcinoma resection.

    abstract：BACKGROUND:An adequate management strategy for ampullary carcinoma (AC), a rare neoplasm, has yet to be determined. The aim of this study was to identify specific molecular markers allowing for the adequate management of AC. METHODS:The clinicopathological data of 41 patients who underwent curative resection of AC wer...

    journal_title：Journal of hepato-biliary-pancreatic sciences

    pub_type： 杂志文章

    doi：10.1002/jhbp.367

    authors： Fujimoto T,Ohtsuka T,Date K,Kimura H,Matsunaga T,Mori Y,Miyasaka Y,Mochidome N,Oda Y,Nakamura M

    更新日期：2016-08-01 00:00:00

  • Reducing the incidence of post-hepatectomy hepatic complications by preoperatively applying parameters predictive of liver function.

    abstract：BACKGROUND/PURPOSE:To prevent or reduce hepatic complications after hepatectomy, it is important to employ preoperative predictive parameters and to determine the indications for hepatectomy. In the present study, we evaluated risk parameters in patients who underwent hepatectomy between 1994 and 2003, and selected thr...

    journal_title：Journal of hepato-biliary-pancreatic sciences

    pub_type： 杂志文章

    doi：10.1007/s00534-010-0281-5

    authors： Nanashima A,Tobinaga S,Abo T,Nonaka T,Takeshita H,Hidaka S,Sawai T,Nagayasu T

    更新日期：2010-11-01 00:00:00

  • Multivariate logistic regression analysis for prediction of clinically relevant pancreatic fistula in the early phase after pancreaticoduodenectomy.

    abstract：BACKGROUND:Postoperative pancreatic fistula (PF) remains a major complication after pancreaticoduodenectomy (PD). We aimed to investigate the predictors of clinically relevant PF after PD. METHODS:We retrospectively analyzed the predictive factors of relevant grade B/C PF using logistic regression analysis of 100 cons...

    journal_title：Journal of hepato-biliary-pancreatic sciences

    pub_type： 杂志文章

    doi：10.1002/jhbp.11

    authors： Kosaka H,Kuroda N,Suzumura K,Asano Y,Okada T,Fujimoto J

    更新日期：2014-02-01 00:00:00

  • Comparison of laparoscopic major hepatectomy with propensity score matched open cases from the National Clinical Database in Japan.

    abstract：BACKGROUND:The National Clinical Database (NCD) in Japan is a nationwide registry that collects the data of more than 1,200,000 surgical cases annually from over 3,500 hospitals. Based on the NCD data, this study compared the perioperative outcomes of major laparoscopic liver resection (LLR) with those of major open li...

    journal_title：Journal of hepato-biliary-pancreatic sciences

    pub_type： 杂志文章

    doi：10.1002/jhbp.405

    authors： Takahara T,Wakabayashi G,Konno H,Gotoh M,Yamaue H,Yanaga K,Fujimoto J,Kaneko H,Unno M,Endo I,Seto Y,Miyata H,Miyazaki M,Yamamoto M

    更新日期：2016-11-01 00:00:00

  • The evolving application of single-port robotic surgery in general surgery.

    abstract：:Advances in the field of minimally invasive surgery have grown since the original advent of conventional multiport laparoscopic surgery. The recent development of single incision laparoscopic surgery remains a relatively novel technique, and has had mixed reviews as to whether it has been associated with lower pain sc...

    journal_title：Journal of hepato-biliary-pancreatic sciences

    pub_type： 历史文章,杂志文章,评审

    doi：10.1002/jhbp.37

    authors： Qadan M,Curet MJ,Wren SM

    更新日期：2014-01-01 00:00:00

  • Feasibility of one-step endoscopic metal stenting for distal malignant biliary obstruction.

    abstract：BACKGROUND:We aimed to clarify the clinical usefulness of one-step self-expandable metal stent (SEMS) placement for distal malignant biliary obstruction by comparing with two-step SEMS placement. METHODS:We retrospectively compared early complications, bilirubin level decreasing rate, and period of hospitalization bet...

    journal_title：Journal of hepato-biliary-pancreatic sciences

    pub_type： 杂志文章

    doi：10.1002/jhbp.22

    authors： Shimizu S,Naitoh I,Nakazawa T,Hayashi K,Miyabe K,Kondo H,Yoshida M,Yamashita H,Ohara H,Joh T

    更新日期：2014-03-01 00:00:00

  • Congenital absence of the portal vein: translated version.

    abstract：:Congenital portosystemic shunt (CPS) is classified into type I (congenital absence of the portal vein) and type II, depending on the presence or absence of the intrahepatic portal vein. Reports still exist on cases in which psychiatric diseases or mental retardation was diagnosed or cases in which diagnosis and treatm...

    journal_title：Journal of hepato-biliary-pancreatic sciences

    pub_type： 杂志文章,评审

    doi：10.1002/jhbp.572

    authors： Sanada Y,Mizuta K

    更新日期：2018-08-01 00:00:00

  • Segmentectomy of the liver.

    abstract：:Segmentectomy is anatomical resection of segments based on the classification of Couinaud. This procedure is performed mainly for hepatocellular carcinoma. Invasion of portal vein and intrahepatic metastases often occur with hepatocellular carcinoma. Thus, it is desirable to perform anatomical resection of the cancer-...

    journal_title：Journal of hepato-biliary-pancreatic sciences

    pub_type： 杂志文章

    doi：10.1007/s00534-011-0448-8

    authors： Yoshida H,Katayose Y,Rikiyama T,Motoi F,Onogawa T,Egawa S,Unno M

    更新日期：2012-01-01 00:00:00

  • Proposal of size-based surgical indication criteria for liver hemangioma based on a nationwide survey in Japan.

    abstract：BACKGROUND:Surgical indications for liver hemangioma remain unclear. METHODS:Of 510 patients undergoing surgical resection for liver hemangioma in 118 Japanese centers between 1998 and 2012, abdominal symptoms, diagnostic accuracy, and surgical outcomes were analyzed to propose size-based surgical indications. Patient...

    journal_title：Journal of hepato-biliary-pancreatic sciences

    pub_type： 杂志文章

    doi：10.1002/jhbp.464

    authors： Sakamoto Y,Kokudo N,Watadani T,Shibahara J,Yamamoto M,Yamaue H,Japanese Society of Hepato-Biliary-Pancreatic Surgery.

    更新日期：2017-07-01 00:00:00

  • Major hepatectomy for perihilar cholangiocarcinoma.

    abstract：BACKGROUND/PURPOSE:Hilar cholangiocarcinoma and intrahepatic cholangiocarcinoma involving the hepatic hilus are defined as "perihilar cholangiocarcinoma". The principle of surgical treatment is hemi-hepatectomy or trisectionectomy of the liver, caudate lobectomy, and resection of the extrahepatic bile duct for complete...

    journal_title：Journal of hepato-biliary-pancreatic sciences

    pub_type： 杂志文章

    doi：10.1007/s00534-009-0206-3

    authors： Unno M,Katayose Y,Rikiyama T,Yoshida H,Yamamoto K,Morikawa T,Hayashi H,Motoi F,Egawa S

    更新日期：2010-07-01 00:00:00

  • Inferior head resection of the pancreas for intraductal papillary mucinous neoplasms.

    abstract：BACKGROUND:Previous reports have suggested that patients with intraductal papillary mucinous neoplasm (IPMN) have a favorable prognosis after surgical resection. Thus, a variety of types of partial pancreatic resections have been advocated for treating these low-grade malignant tumors. However, the surgical outcome of ...

    journal_title：Journal of hepato-biliary-pancreatic sciences

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s00534-009-0173-8

    authors： Nakagohri T,Kinoshita T,Konishi M,Takahashi S,Gotohda N,Kobayashi S,Kojima M,Miyauchi H,Asano T

    更新日期：2010-11-01 00:00:00

  • Homing effect of adipose-derived stem cells to the injured liver: the shift of stromal cell-derived factor 1 expressions.

    abstract：BACKGROUND:Whether systemically transplanted human adipose-derived stem cells (ADSCs) homed to the injured liver in nude mice under stress with subsequent hepatectomy (Hx) and ischemia-reperfusion (I/R) was investigated in the present study. The types of cells in the liver that were involved in the homing of ADSCs were...

    journal_title：Journal of hepato-biliary-pancreatic sciences

    pub_type： 杂志文章

    doi：10.1002/jhbp.147

    authors： Saito Y,Shimada M,Utsunomiya T,Ikemoto T,Yamada S,Morine Y,Imura S,Mori H,Arakawa Y,Kanamoto M,Iwahashi S,Takasu C

    更新日期：2014-12-01 00:00:00

  • Early prophylactic antibiotics administration for acute necrotizing pancreatitis: a meta-analysis of randomized controlled trials.

    abstract：BACKGROUND:The effectiveness of prophylactic antibiotics use for acute necrotizing pancreatitis has been explored and a number of systematic reviews have been published with conflicting results. The timing of antibiotics administration can be fundamental to their effectiveness, but thus far no reviews have focused on t...

    journal_title：Journal of hepato-biliary-pancreatic sciences

    pub_type： 杂志文章,meta分析,评审

    doi：10.1002/jhbp.221

    authors： Ukai T,Shikata S,Inoue M,Noguchi Y,Igarashi H,Isaji S,Mayumi T,Yoshida M,Takemura YC

    更新日期：2015-04-01 00:00:00

  • Significance of imaging modalities for preoperative evaluation of the pancreaticobiliary system in surgery for pediatric choledochal cyst.

    abstract：OBJECTIVE:Roles of magnetic resonance cholangiopancreatography (MRCP), endoscopic retrograde cholangiopancreatography (ERCP), drip infusion cholangiography with computed tomography (DIC-CT), and intraoperative cholangiopancreatography (IOCP) in visualizing pancreaticobiliary anatomy for pediatric choledocal cyst (CC) o...

    journal_title：Journal of hepato-biliary-pancreatic sciences

    pub_type： 杂志文章

    doi：10.1002/jhbp.347

    authors： Saito T,Terui K,Mitsunaga T,Nakata M,Yoshida H

    更新日期：2016-06-01 00:00:00

  • Reappraisal of the advantages of laparoscopic liver resection for intermediate hepatocellular carcinoma within a stage migration perspective: Propensity score analysis of the differential benefit.

    abstract：OBJECTIVE:The aim of the present study was to analyze the outcome of laparoscopic approach specifically in patients with Intermediate-stage disease and to define the differential benefit with Early-stage patients. METHODS:Six hundred twenty-two resections for HCC were dichotomized according to staging (Early and Inter...

    journal_title：Journal of hepato-biliary-pancreatic sciences

    pub_type： 杂志文章

    doi：10.1002/jhbp.736

    authors： Ratti F,Cipriani F,Fiorentini G,Catena M,Paganelli M,Aldrighetti L

    更新日期：2020-08-01 00:00:00