Cancer stem cells as therapeutic targets of hepato-biliary-pancreatic cancers.

Abstract:

:Heterogeneity is one of the essential hallmarks of malignancies. Within bulk cancer cells, a striking variability differs in biological characteristics including the proliferation rate, cell-cell interaction, metastatic tendency and even sensitivity to anticancer therapies. Such diversity makes the investigation and treatment of the cancers complicated. Increasing evidence suggests this plasticity of cancers is a result of self-renewing and differentiation of a small subpopulation of cancer cells with stem-like properties, called cancer stem cells (CSCs). More importantly, CSCs are believed to be responsible for the resistance to conventional therapies and metastatic abilities in clinical practice. This review summarizes the molecular pathogenesis of hepato-biliary-pancreatic CSCs on the basis of the recent studies, and promising strategy of novel therapy targeting the signal transduction pathways or potentially epigenetic addictions of CSCs.

authors

Tanaka S

doi

10.1002/jhbp.248

subject

Has Abstract

pub_date

2015-07-01 00:00:00

pages

531-7

issue

7

eissn

1868-6974

issn

1868-6982

journal_volume

22

pub_type

杂志文章,评审
  • STATs profiling reveals predominantly-activated STAT3 in cholangiocarcinoma genesis and progression.

    abstract:BACKGROUND:We investigated the aberrant expression of the STAT family in humans and liver fluke (Opisthorchis viverrini, Ov)-induced hamster cholangiocarcinoma (CCA) tissues. METHODS:The expression and phosphorylation of STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b and STAT6 in human hamster CCA tissues were immunohisto...

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 杂志文章

    doi:10.1002/jhbp.131

    authors: Dokduang H,Techasen A,Namwat N,Khuntikeo N,Pairojkul C,Murakami Y,Loilome W,Yongvanit P

    更新日期:2014-10-01 00:00:00

  • Multivariate logistic regression analysis for prediction of clinically relevant pancreatic fistula in the early phase after pancreaticoduodenectomy.

    abstract:BACKGROUND:Postoperative pancreatic fistula (PF) remains a major complication after pancreaticoduodenectomy (PD). We aimed to investigate the predictors of clinically relevant PF after PD. METHODS:We retrospectively analyzed the predictive factors of relevant grade B/C PF using logistic regression analysis of 100 cons...

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 杂志文章

    doi:10.1002/jhbp.11

    authors: Kosaka H,Kuroda N,Suzumura K,Asano Y,Okada T,Fujimoto J

    更新日期:2014-02-01 00:00:00

  • Usefulness of endoscopic biopsy using FOXP3+ Treg up-regulation in the duodenal papilla in the differential diagnosis between autoimmune pancreatitis and pancreatic cancer.

    abstract:BACKGROUND AND STUDY AIMS:Expression of the forkhead/winged helix family of transcription factor P3+ regulatory T cells (FOXP3(+) Treg), a master gene of regulatory T cells (Treg) is observed in patients with autoimmune pancreatitis (AIP). We investigated the usefulness of detection of FOXP3(+) Treg in the main duodena...

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 杂志文章

    doi:10.1007/s00534-010-0359-0

    authors: Kubota K,Kato S,Watanabe S,Fujita K,Yoneda M,Takahashi H,Inamori M,Shimamura T,Kirikoshi H,Kobayashi N,Saito S,Hisatomi K,Matsuhashi N,Nakajima A

    更新日期:2011-05-01 00:00:00

  • Incidence and risk factors for anastomotic stenosis of continuous hepaticojejunostomy after pancreaticoduodenectomy.

    abstract:BACKGROUND:There have been no reports showing the incidence of anastomotic stenosis of continuous hepaticojejunostomy (HJ) and identifying its risk factors for patients who underwent pancreaticoduodenectomy (PD). METHOD:We retrospectively investigated 200 patients whose HJ was established by unified method, single lay...

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 杂志文章

    doi:10.1002/jhbp.385

    authors: Asano T,Natsume S,Senda Y,Sano T,Matsuo K,Kodera Y,Hara K,Ito S,Yamao K,Shimizu Y

    更新日期:2016-10-01 00:00:00

  • Pancreaticoduodenectomy with venous reconstruction using cold-stored vein allografts: long-term results of a single center experience.

    abstract:BACKGROUND:The use of cadaveric vein allografts was first described by our group as a feasible option for venous reconstruction. The aim of this study was to report long-term results of this innovative technique. METHODS:Cold-stored veins harvested from donor cadavers were used as homologous grafts for venous reconstr...

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 杂志文章

    doi:10.1002/jhbp.299

    authors: Meniconi RL,Santoro R,Guglielmo N,Vennarecci G,Lepiane P,Colasanti M,Ettorre GM

    更新日期:2016-01-01 00:00:00

  • Duodenum-preserving versus pylorus-preserving pancreatic head resection for benign and premalignant lesions.

    abstract:BACKGROUND/PURPOSE:Pylorus-preserving pancreaticoduodenectomy (PPPD) is the treatment of choice for benign or premalignant pancreatic head lesions. Duodenum-preserving pancreatic head resection (DPPHR) has been reported in only 132 patients. This study aimed to compare the long-term results of DPPHR and PPPD. METHODS:...

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 杂志文章

    doi:10.1007/s00534-010-0317-x

    authors: Pedrazzoli S,Canton SA,Sperti C

    更新日期:2011-01-01 00:00:00

  • Tips and tricks of surgical technique for pancreatic cancer: portal vein resection and reconstruction (with videos).

    abstract::Surgical resection is the only hope for cure in patients with pancreatic cancer. To improve the resectability and achieve better prognosis of this lethal disease, extended resection for pancreatic cancer has been applied. We have performed portal vein resection aggressively for pancreatic cancer with portal vein invas...

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 杂志文章

    doi:10.1002/jhbp.128

    authors: Yoshitomi H,Kato A,Shimizu H,Ohtsuka M,Furukawa K,Takayashiki T,Kuboki S,Takano S,Okamura D,Suzuki D,Sakai N,Kagawa S,Miyazaki M

    更新日期:2014-09-01 00:00:00

  • Pathogenesis and classification of intrahepatic cholangiocarcinoma: different characters of perihilar large duct type versus peripheral small duct type.

    abstract::Intrahepatic cholangiocarcinomas (ICCs) are made up of heterogenous carcinomas arising from different anatomical sites of the liver. Two types of candidate stem/progenitor cells of the biliary tree are postulated to exist at the peribiliary glands for large bile ducts and at the canals of Hering for small ducts and he...

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 杂志文章,评审

    doi:10.1002/jhbp.154

    authors: Aishima S,Oda Y

    更新日期:2015-02-01 00:00:00

  • Liver transplantation for hepatocellular carcinoma in the world: the Taiwan experience.

    abstract::Liver transplantation (LT) has been regarded as "potentially curative" in a cirrhotic patient with hepatocellular carcinoma (HCC) because it removes the cancer and eradicates the cirrhosis. In Taiwan, HCC ranks first among the leading causes of cancer mortality in males and 4th in females. The most common causes are c...

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 杂志文章,评审

    doi:10.1007/s00534-009-0166-7

    authors: Chen CL,Concejero AM

    更新日期:2010-09-01 00:00:00

  • Mucobilia: current aspects in the management of a rare cause of malignant biliary obstruction.

    abstract::Mucobilia is a rare pathologic condition characterized by the abnormal secretion and accumulation of abundant mucus within the biliary tree. It is usually seen in association with mucin-producing hepatobiliary and pancreatic tumors. Neoplastic transformation of these tumors can range from low-grade dysplasia to invasi...

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 杂志文章,评审

    doi:10.1007/s00534-009-0150-2

    authors: Brown MA,Sakpal SV,Chamberlain RS

    更新日期:2010-05-01 00:00:00

  • Outcomes of pancreaticoduodenectomy in patients with chronic hepatic dysfunction including liver cirrhosis: results of a retrospective multicenter study by the Japanese Society of Hepato-Biliary-Pancreatic Surgery.

    abstract:BACKGROUND:Since there is no reliable evidence on the safety of pancreaticoduodenectomy (PD) in chronic hepatic dysfunction (CHD) including liver cirrhosis (LC), the effects of CHD on patients undergoing PD were investigated. METHODS:This multi-institutional retrospective study analyzed 529 patients with CHD, includin...

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 杂志文章,多中心研究

    doi:10.1002/jhbp.630

    authors: Futagawa Y,Yanaga K,Kosuge T,Suka M,Isaji S,Hirano S,Murakami Y,Yamamoto M,Yamaue H

    更新日期:2019-07-01 00:00:00

  • Pure laparoscopic versus open hemihepatectomy: a critical assessment and realistic expectations - a propensity score-based analysis of right and left hemihepatectomies from nine European tertiary referral centers.

    abstract:INTRODUCTION:A stronger evidence level is needed to confirm the benefits and limits of laparoscopic hemihepatectomies. METHODS:Laparoscopic and open hemihepatectomies from nine European referral centers were compared after propensity score matching (right and left hemihepatectomies separately, and benign and malignant...

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 杂志文章,多中心研究

    doi:10.1002/jhbp.662

    authors: Cipriani F,Alzoubi M,Fuks D,Ratti F,Kawai T,Berardi G,Barkhatov L,Lainas P,Van der Poel M,Faoury M,Besselink MG,D'Hondt M,Dagher I,Edwin B,Troisi RI,Scatton O,Gayet B,Aldrighetti L,Abu Hilal M

    更新日期:2020-01-01 00:00:00

  • Left hepatectomy or left trisectionectomy with resection of the caudate lobe and extrahepatic bile duct for hilar cholangiocarcinoma (with video).

    abstract:PURPOSE:Although left-sided hepatectomy, such as a left hepatectomy or left trisectionectomy with resection of the caudate lobe and extrahepatic bile duct, is used to treat hilar cholangiocarcinoma predominantly involving the left side of the hepatic hilum, it is associated with several difficult technical points. The ...

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 杂志文章,评审

    doi:10.1007/s00534-011-0474-6

    authors: Uesaka K

    更新日期:2012-05-01 00:00:00

  • Major hepatectomy for perihilar cholangiocarcinoma.

    abstract:BACKGROUND/PURPOSE:Hilar cholangiocarcinoma and intrahepatic cholangiocarcinoma involving the hepatic hilus are defined as "perihilar cholangiocarcinoma". The principle of surgical treatment is hemi-hepatectomy or trisectionectomy of the liver, caudate lobectomy, and resection of the extrahepatic bile duct for complete...

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 杂志文章

    doi:10.1007/s00534-009-0206-3

    authors: Unno M,Katayose Y,Rikiyama T,Yoshida H,Yamamoto K,Morikawa T,Hayashi H,Motoi F,Egawa S

    更新日期:2010-07-01 00:00:00

  • Expression of Bcl-2 19-kDa interacting protein 3 predicts prognosis after ampullary carcinoma resection.

    abstract:BACKGROUND:An adequate management strategy for ampullary carcinoma (AC), a rare neoplasm, has yet to be determined. The aim of this study was to identify specific molecular markers allowing for the adequate management of AC. METHODS:The clinicopathological data of 41 patients who underwent curative resection of AC wer...

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 杂志文章

    doi:10.1002/jhbp.367

    authors: Fujimoto T,Ohtsuka T,Date K,Kimura H,Matsunaga T,Mori Y,Miyasaka Y,Mochidome N,Oda Y,Nakamura M

    更新日期:2016-08-01 00:00:00

  • Does adjuvant treatment improve prognosis after curative resection of ampulla of Vater carcinoma? A multicenter retrospective study.

    abstract:BACKGROUND/PURPOSE:Ampulla of Vater (AoV) carcinoma is a rare tumor that accounts for approximately 0.2% of gastrointestinal malignancies. There are no clinical guidelines concerning the treatment of AoV carcinoma. This study aimed to investigate the effectiveness of adjuvant treatment in AoV carcinoma following curati...

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 杂志文章

    doi:10.1002/jhbp.801

    authors: Kim HS,Jang JY,Yoon YS,Park SJ,Kwon W,Kim SW,Han HS,Han SS,Park JS,Yoon DS

    更新日期:2020-10-01 00:00:00

  • Tokyo Guidelines 2018: diagnostic criteria and severity grading of acute cholangitis (with videos).

    abstract::Although the diagnostic and severity grading criteria on the 2013 Tokyo Guidelines (TG13) are used worldwide as the primary standard for management of acute cholangitis (AC), they need to be validated through implementation and assessment in actual clinical practice. Here, we conduct a systematic review of the literat...

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 信件,评审

    doi:10.1002/jhbp.512

    authors: Kiriyama S,Kozaka K,Takada T,Strasberg SM,Pitt HA,Gabata T,Hata J,Liau KH,Miura F,Horiguchi A,Liu KH,Su CH,Wada K,Jagannath P,Itoi T,Gouma DJ,Mori Y,Mukai S,Giménez ME,Huang WS,Kim MH,Okamoto K,Belli G,Derve

    更新日期:2018-01-01 00:00:00

  • Transpancreatic mattress suture with Vicryl mesh around the stump decreases postoperative pancreatic fistula after distal pancreatectomy.

    abstract:BACKGROUND:Postoperative pancreatic fistula (POPF) after distal pancreatectomy (DP) remains the most common surgical complication. We have developed a novel stump closure technique after DP using transpancreatic mattress suture with Vicryl mesh (TMV) and reported our initial findings. The purpose of this study is to ev...

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 杂志文章

    doi:10.1002/jhbp.664

    authors: Yoshida Y,Matsumoto I,Matsumoto M,Kawaguchi K,Murase T,Kamei K,Satoi S,Takebe A,Nakai T,Takeyama Y

    更新日期:2019-11-01 00:00:00

  • Clinical impact of endoscopic papillectomy for benign-malignant borderline lesions of the major duodenal papilla.

    abstract:BACKGROUND AND PURPOSE:The present study retrospectively analyzed the clinical impact of endoscopic papillectomy on the selection of a treatment strategy for patients with benign-malignant borderline lesions of the major duodenal papilla. PATIENTS AND METHODS:Between November 1995 and July 2009, 28 patients were selec...

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 杂志文章

    doi:10.1007/s00534-010-0327-8

    authors: Harano M,Ryozawa S,Iwano H,Taba K,Sen-Yo M,Sakaida I

    更新日期:2011-03-01 00:00:00

  • Whereabouts of an internal short stent placed across the pancreaticojejunostomy following pancreatoduodenectomy.

    abstract:BACKGROUND/PURPOSE:It is generally thought that an internal short stent placed across the pancreaticojejunostomy (PJ) following pancreatoduodenectomy (PD) usually passes spontaneously through the rectum thereafter; however, we experienced some patients who presented with pancreatitis and cholangitis owing to delayed de...

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 杂志文章

    doi:10.1007/s00534-012-0533-7

    authors: Kadowaki S,Miura F,Amano H,Toyota N,Wada K,Shibuya M,Maeno S,Takada T,Sano K

    更新日期:2012-09-01 00:00:00

  • Basic knowledge of and a small trick for atraumatic needle driving in laparoscopic suturing.

    abstract::Highlight Although recent advances in robotic surgery have enabled more precise movements of the needle driver, a sophisticated laparoscopic suturing technique is still desired. Honda and colleagues describe the basic knowledge of and a small but useful trick for atraumatic needle driving in laparoscopic suturing, bas...

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 杂志文章

    doi:10.1002/jhbp.814

    authors: Honda G,Ome Y,Yoshida N,Kawamoto Y

    更新日期:2020-10-01 00:00:00

  • Genetic lineage tracing, a powerful tool to investigate the embryonic organogenesis and adult organ maintenance of the pancreas.

    abstract::Revealing the mechanism of adult organ maintenance and regeneration after injury is fundamental to our understanding of the pathogenesis of diseases. Considering the results of pulse and chase experiments using inducible insulin-Cre or Elastase-Cre, and more recently HNF1b-Cre, adult pancreatic cells (beta, acinar, an...

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 杂志文章,评审

    doi:10.1007/s00534-010-0307-z

    authors: Kawaguchi Y,Takaori K,Uemoto S

    更新日期:2011-01-01 00:00:00

  • The evolving application of single-port robotic surgery in general surgery.

    abstract::Advances in the field of minimally invasive surgery have grown since the original advent of conventional multiport laparoscopic surgery. The recent development of single incision laparoscopic surgery remains a relatively novel technique, and has had mixed reviews as to whether it has been associated with lower pain sc...

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 历史文章,杂志文章,评审

    doi:10.1002/jhbp.37

    authors: Qadan M,Curet MJ,Wren SM

    更新日期:2014-01-01 00:00:00

  • Optimal timing for performing percutaneous transhepatic gallbladder drainage and subsequent cholecystectomy for better management of acute cholecystitis.

    abstract:BACKGROUND:We aimed to clarify the appropriate timing for performing percutaneous transhepatic gallbladder drainage (PTGBD) and cholecystectomy, and the effect of PTGBD on surgical difficulty in acute cholecystitis patients. METHODS:We retrospectively examined 46 patients who underwent laparoscopic cholecystectomy (LC...

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 评论,杂志文章

    doi:10.1002/jhbp.294

    authors: Yamada K,Yamashita Y,Yamada T,Takeno S,Noritomi T

    更新日期:2015-12-01 00:00:00

  • Influence of duration of type 1 diabetes on long-term pancreatic transplant outcomes.

    abstract:BACKGROUND:There are no multicenter studies on the influence of diabetes duration on pancreatic transplant outcomes. Our study aimed to determine how type 1 diabetes duration influenced survival of pancreatic grafts. METHODS:The data of 8,139 patients who received pancreas transplants during 2006-2015 were extracted f...

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 杂志文章

    doi:10.1002/jhbp.677

    authors: Zhou J,Dong Y,Mei S,Gu Y,Li Z,Xiang J,Zheng H,Chen Z,Huang Z,Hu Z

    更新日期:2019-12-01 00:00:00

  • Female donor to male recipient gender discordance results in inferior graft survival: a prospective study of 1,042 liver transplants.

    abstract:BACKGROUND:The influence of donor-recipient gender mismatch on outcomes after liver transplantation (LT) is controversial. The aim of this study was to evaluate the effect of donor and recipient gender discordance on graft survival. METHODS:All patients who underwent primary LT from 1994-2012 at a single-center were i...

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 杂志文章

    doi:10.1002/jhbp.40

    authors: Croome KP,Segal D,Hernandez-Alejandro R,Adams PC,Thomson A,Chandok N

    更新日期:2014-04-01 00:00:00

  • Usefulness of preoperative drip infusion cholangiography with computed tomography for predicting surgical difficulty during laparoscopic cholecystectomy.

    abstract:BACKGROUND:Drip infusion cholangiography with computed tomography (DIC-CT) is a major preoperative modality used for patients undergoing laparoscopic cholecystectomy (LC). METHODS:This study included 218 patients for whom preoperative DIC-CT images were obtained prior to undergoing LC. The association between gallblad...

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 杂志文章

    doi:10.1002/jhbp.718

    authors: Nakazawa A,Akamatsu N,Miyata Y,Komagome M,Maki A,Arita J,Ishizawa T,Kaneko J,Beck Y,Hasegawa K

    更新日期:2020-06-01 00:00:00

  • Propofol inhibits pancreatic cancer progress under hypoxia via ADAM8.

    abstract:BACKGROUND:To investigate the potential anti-tumoral properties of propofol in pancreatic cancer and elucidate the underlying mechanisms. METHODS:The relative expression of ADAM metallopeptidase domain 8 (ADAM8) in response to hypoxia in Panc1 cells was analyzed by western blotting. The enzymatic activity was determin...

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 杂志文章

    doi:10.1002/jhbp.624

    authors: Gao Y,Yu X,Zhang F,Dai J

    更新日期:2019-06-01 00:00:00

  • Recent advances in visualization, imaging, and navigation in hepatobiliary and pancreatic sciences.

    abstract:BACKGROUND/PURPOSE:Recent introduction of multi-detector CT (MDCT) and high-speed magnetic resonance (MR) imaging have dramatically advanced visualization and imaging technology in diagnostic and therapeutic strategy in hepatobiliary pancreatic disease. However, image diagnostics have progressed with a background of th...

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 杂志文章,评审

    doi:10.1007/s00534-009-0192-5

    authors: Sugimoto M

    更新日期:2010-09-01 00:00:00

  • Long-term and perioperative outcomes of laparoscopic versus open liver resection for hepatocellular carcinoma with propensity score matching: a multi-institutional Japanese study.

    abstract:BACKGROUND:The aim of this study was to compare the long-term outcomes and perioperative outcomes of laparoscopic liver resection (LLR) with those of open liver resection (OLR) for hepatocellular carcinoma (HCC) between well-matched patient groups. METHODS:Hepatocellular carcinoma patients underwent primary liver rese...

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 杂志文章,多中心研究

    doi:10.1002/jhbp.276

    authors: Takahara T,Wakabayashi G,Beppu T,Aihara A,Hasegawa K,Gotohda N,Hatano E,Tanahashi Y,Mizuguchi T,Kamiyama T,Ikeda T,Tanaka S,Taniai N,Baba H,Tanabe M,Kokudo N,Konishi M,Uemoto S,Sugioka A,Hirata K,Taketomi A,Maeh

    更新日期:2015-10-01 00:00:00