Incidental intrahepatic cholangiocarcinoma in patients undergoing liver transplantation: a multi-center study in Japan.

Abstract:

BACKGROUND:Intrahepatic cholangiocarcinoma had been considered a contraindication for liver transplantation because of poorer outcomes. However, incidental intrahepatic cholangiocarcinoma in the explanted liver has been reported because of the difficulty of obtaining an accurate diagnosis in cirrhotic livers on preoperative imaging. METHODS:We conducted a nationwide survey to analyze the incidence of incidental intrahepatic cholangiocarcinoma and outcomes after liver transplantation, in Japan. RESULTS:Forty-five of 64 institutions (70%) responded to our initial investigation. Between January 2001 and December 2015, 6627 liver transplantations were performed in these 45 institutions, with 19 cases (0.3%) of incidental intrahepatic cholangiocarcinoma reported from 12 transplant centers. Six cases were diagnosed as hepatocellular carcinoma preoperatively. The 1-, 3-, and 5-year recurrence-free survival rates were 79%, 45%, and 45%, respectively. Tumor recurrence after liver transplantation was found in 10 patients (53%). The 1-, 3-, and 5-year overall survival rates were 79%, 63%, and 46%, respectively. CONCLUSIONS:Intrahepatic cholangiocarcinoma at liver transplantation is associated with a high risk of recurrence and poor prognosis, even these tumors are detected incidentally in the explanted liver.

authors

Hara T,Eguchi S,Yoshizumi T,Akamatsu N,Kaido T,Hamada T,Takamura H,Shimamura T,Umeda Y,Shinoda M,Ogura Y,Fukumoto T,Kasahara M,Hibi T,Umeshita K,Furukawa H,Ohdan H

doi

10.1002/jhbp.896

subject

Has Abstract

pub_date

2021-01-19 00:00:00

eissn

1868-6974

issn

1868-6982

pub_type

杂志文章
  • Liver functional reserve estimation: state of the art and relevance for local treatments: the Eastern perspective.

    abstract::Liver function reserve estimation is important for selecting the appropriate patients for hepatectomy or ablation of tumors. Many liver function tests have been devised, but the indocyanine green (ICG) clearance test remains the most popular for its simplicity and perhaps accuracy. Compared with the Child-Pugh classif...

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 杂志文章,评审

    doi:10.1007/s00534-009-0229-9

    authors: Fan ST

    更新日期:2010-07-01 00:00:00

  • Duodenum-preserving versus pylorus-preserving pancreatic head resection for benign and premalignant lesions.

    abstract:BACKGROUND/PURPOSE:Pylorus-preserving pancreaticoduodenectomy (PPPD) is the treatment of choice for benign or premalignant pancreatic head lesions. Duodenum-preserving pancreatic head resection (DPPHR) has been reported in only 132 patients. This study aimed to compare the long-term results of DPPHR and PPPD. METHODS:...

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 杂志文章

    doi:10.1007/s00534-010-0317-x

    authors: Pedrazzoli S,Canton SA,Sperti C

    更新日期:2011-01-01 00:00:00

  • Retransplantation using living-donor right-liver grafts.

    abstract:BACKGROUND:This study reviews the outcomes of retransplantation using living-donor right-liver grafts. METHODS:A retrospective study of liver retransplants performed between 1996 and 2013 was conducted. The retransplants were divided into the DD group (with deceased donors) and the LD group (with living donors). Survi...

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 杂志文章

    doi:10.1002/jhbp.100

    authors: Dai WC,Chan SC,Chok KS,Cheung TT,Sharr WW,Chan AC,Fung JY,Wong TC,Lo CM

    更新日期:2014-08-01 00:00:00

  • A comparison of islet autotransplantation with allotransplantation and factors elevating acute portal pressure in clinical islet transplantation.

    abstract:BACKGROUND:Acute portal pressure rise is occasionally observed during intraportal islet infusion, especially in islet autotransplantation (IAT) where tissue purification is rarely applied. In this paper we investigate factors associated with acute portal pressure rise, a known risk factor for portal vein thrombosis. M...

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 杂志文章

    doi:10.1007/s00534-011-0441-2

    authors: Kawahara T,Kin T,Shapiro AM

    更新日期:2012-05-01 00:00:00

  • Living donor pancreas transplantation in Japan.

    abstract:BACKGROUND/PURPOSE:Living-donor pancreas transplants (LDPs) were introduced at Chiba-East National Hospital in 2004, and 12 LDPs have been performed at this institution to date. Based on the outcome of these 12 LDPs, the efficacy and safety of LDPs are herein discussed. METHODS:Twelve diabetic patients underwent LDPs;...

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 杂志文章

    doi:10.1007/s00534-009-0148-9

    authors: Kenmochi T,Asano T,Maruyama M,Saigo K,Akutsu N,Iwashita C,Ohtsuki K,Suzuki A,Miyazaki M

    更新日期:2010-03-01 00:00:00

  • Evaluation of effects of a novel endoscopically applied radiofrequency ablation biliary catheter using an ex-vivo pig liver.

    abstract:BACKGROUND:The effects of ablation with various settings of powers and times using a newly developed radiofrequency (RF) ablation device, the Habib™ EndoHPB catheter, are not well known. In the present study, we examined the effects of a novel RF ablation catheter using resected fresh pig livers and evaluated the macro...

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 杂志文章

    doi:10.1007/s00534-011-0465-7

    authors: Itoi T,Isayama H,Sofuni A,Itokawa F,Tamura M,Watanabe Y,Moriyasu F,Kahaleh M,Habib N,Nagao T,Yokoyama T,Kasuya K,Kawakami H

    更新日期:2012-09-01 00:00:00

  • Single institution outcomes in the first 3 years of pancreas transplantation from brain dead donors.

    abstract:BACKGROUND:A total of 26 pancreas transplants from brain dead donors, including 21 simultaneous pancreas and kidney (SPK) transplantation procedures, have been performed at Fujita Health University Hospital since the new pancreas transplant program was initiated in August 2012. The objective of this study is to investi...

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 杂志文章

    doi:10.1002/jhbp.339

    authors: Ito T,Kenmochi T,Ono S,Oshima M,Aida N,Suzuki A,Hasegawa M,Kusaka M,Hoshinaga K

    更新日期:2016-05-01 00:00:00

  • Intraductal oncocytic papillary neoplasms of the pancreas and bile ducts: a description of five new cases and review based on a systematic survey of the literature.

    abstract:BACKGROUND:Intraductal oncocytic papillary neoplasms (IOPN) are rare tumors of the pancreatic and biliary ductal system. It is not absolutely clear if the molecular and clinicopathologic characteristics of IOPN differ significantly from other related lesions, namely intraductal papillary mucinous neoplasms (IPMN). Ther...

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 杂志文章,评审

    doi:10.1007/s00534-010-0268-2

    authors: Liszka L,Pajak J,Zielińska-Pajak E,Krzych L,Gołka D,Mrowiec S,Lampe P

    更新日期:2010-05-01 00:00:00

  • Clinical impact of endoscopic papillectomy for benign-malignant borderline lesions of the major duodenal papilla.

    abstract:BACKGROUND AND PURPOSE:The present study retrospectively analyzed the clinical impact of endoscopic papillectomy on the selection of a treatment strategy for patients with benign-malignant borderline lesions of the major duodenal papilla. PATIENTS AND METHODS:Between November 1995 and July 2009, 28 patients were selec...

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 杂志文章

    doi:10.1007/s00534-010-0327-8

    authors: Harano M,Ryozawa S,Iwano H,Taba K,Sen-Yo M,Sakaida I

    更新日期:2011-03-01 00:00:00

  • Impact of delayed gastric emptying after pancreaticoduodenectomy on survival.

    abstract:BACKGROUND:Delayed gastric emptying (DGE), a common postoperative complication of pancreaticoduodenectomy, is not considered a life-threatening complication. In the present study, we analyzed the risk factors for DGE and its impact on long-term prognosis. METHODS:We analyzed 383 patients who underwent pancreaticoduode...

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 杂志文章

    doi:10.1002/jhbp.482

    authors: Futagawa Y,Kanehira M,Furukawa K,Kitamura H,Yoshida S,Usuba T,Misawa T,Okamoto T,Yanaga K

    更新日期:2017-08-01 00:00:00

  • Preoperative criterion identifying a low-risk group for lymph node metastasis in intrahepatic cholangiocarcinoma.

    abstract:BACKGROUND:Imaging study cannot identify patients with potential low-risk for lymph node (LN) metastasis in intrahepatic cholangiocarcinoma (ICC). The purpose of this study was to identify a low-risk group for LN metastasis in ICC using preoperatively available factors. METHODS:Data from 127 consecutive patients, who ...

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 杂志文章

    doi:10.1002/jhbp.552

    authors: Yoh T,Hatano E,Seo S,Terajima H,Uchida Y,Taura K,Yasuchika K,Uemoto S

    更新日期:2018-06-01 00:00:00

  • Predictive performance of Blumgart T staging for perihilar cholangiocarcinoma in a Japanese center.

    abstract:BACKGROUND:The Blumgart system has been used for local tumor assessment in perihilar cholangiocarcinoma to predict resectability and survival, and T3 tumors are considered unresectable disease. The aim was to validate the predictive performance of this system using a Japanese cohort. METHODS:Medical records of consecu...

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 杂志文章

    doi:10.1002/jhbp.694

    authors: Ebata T,Mizuno T,Yokoyama Y,Igami T,Yamaguchi J,Onoe S,Watanabe N,Nagino M

    更新日期:2020-03-01 00:00:00

  • Feasibility of one-step endoscopic metal stenting for distal malignant biliary obstruction.

    abstract:BACKGROUND:We aimed to clarify the clinical usefulness of one-step self-expandable metal stent (SEMS) placement for distal malignant biliary obstruction by comparing with two-step SEMS placement. METHODS:We retrospectively compared early complications, bilirubin level decreasing rate, and period of hospitalization bet...

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 杂志文章

    doi:10.1002/jhbp.22

    authors: Shimizu S,Naitoh I,Nakazawa T,Hayashi K,Miyabe K,Kondo H,Yoshida M,Yamashita H,Ohara H,Joh T

    更新日期:2014-03-01 00:00:00

  • Diagnostic and prognostic value of immunohistochemical expression of S100P and IMP3 in transpapillary biliary forceps biopsy samples of extrahepatic bile duct carcinoma.

    abstract:BACKGROUND:Because the biopsy specimen of extrahepatic bile duct carcinoma (EHBDC) is small and shows reactive changes, the histological distinction between malignant and benign tissue can be difficult. Recent studies reported that S100P and insulin-like growth factor II mRNA-binding protein 3 (IMP3) were not only diag...

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 杂志文章

    doi:10.1007/s00534-012-0581-z

    authors: Kawashima H,Itoh A,Ohno E,Miyahara R,Ohmiya N,Tanaka T,Shimoyama Y,Nakamura S,Ebata T,Nagino M,Goto H,Hirooka Y

    更新日期:2013-04-01 00:00:00

  • Outcomes of pancreaticoduodenectomy in patients with chronic hepatic dysfunction including liver cirrhosis: results of a retrospective multicenter study by the Japanese Society of Hepato-Biliary-Pancreatic Surgery.

    abstract:BACKGROUND:Since there is no reliable evidence on the safety of pancreaticoduodenectomy (PD) in chronic hepatic dysfunction (CHD) including liver cirrhosis (LC), the effects of CHD on patients undergoing PD were investigated. METHODS:This multi-institutional retrospective study analyzed 529 patients with CHD, includin...

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 杂志文章,多中心研究

    doi:10.1002/jhbp.630

    authors: Futagawa Y,Yanaga K,Kosuge T,Suka M,Isaji S,Hirano S,Murakami Y,Yamamoto M,Yamaue H

    更新日期:2019-07-01 00:00:00

  • Single operator peroral cholangioscopic guided therapy of bile duct stones.

    abstract::Since the introduction of endoscopic sphincterotomy, stone clearance of the bile duct can be achieved by conventional endoscopic means in up to 90% of patients with stone disease. Several endoscopic therapies for difficult bile duct stones have been introduced. Laser therapy for stone fragmentation under direct visual...

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 杂志文章,评审

    doi:10.1007/s00534-010-0360-7

    authors: Seelhoff A,Schumacher B,Neuhaus H

    更新日期:2011-05-01 00:00:00

  • Randomized clinical trial of peritoneal lavage for preventing surgical site infection in elective liver surgery.

    abstract:BACKGROUND:Although intraoperative peritoneal lavage is often performed routinely with the aim of reducing peritoneal contamination, little evidence of lavage benefits in elective liver resection without bile duct resection is available. We addressed the issue with a randomized clinical trial. METHODS:We prospectively...

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/jhbp.222

    authors: Tanaka K,Matsuo K,Kawaguchi D,Murakami T,Hiroshima Y,Hirano A,Sato S,Endo I,Taguri M,Koda K

    更新日期:2015-06-01 00:00:00

  • Clinical characteristics and risk factors for stent-stone complex formation following biliary plastic stent placement in patients with common bile duct stones.

    abstract:BACKGROUND:Stent-stone complex (SSC) formation is one of the complications of endoscopic biliary stent placement. This study aimed to clarify the clinical characteristics and risk factors for SSC formation following plastic stent (PS) placement in patients with common bile duct (CBD) stones. METHODS:We retrospectively...

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 杂志文章

    doi:10.1002/jhbp.584

    authors: Kaneko J,Kawata K,Watanabe S,Chida T,Matsushita M,Suda T,Kobayashi Y

    更新日期:2018-10-01 00:00:00

  • Bench-top testing of suction forces generated through endoscopic ultrasound-guided aspiration needles.

    abstract:BACKGROUND:Adequate needle size and tissue acquisition techniques for endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) need further elucidation. Moreover, the actual negative pressure and suction forces of FNA needles remain unknown. We evaluated the suction forces of 19-gauge, 22-gauge, and 25-gauge conve...

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 杂志文章

    doi:10.1002/jhbp.201

    authors: Katanuma A,Itoi T,Baron TH,Yasuda I,Kin T,Yane K,Maguchi H,Yamazaki H,Sano I,Minami R,Manabu SY,Ikarashi S,Osanai M,Takahashi K

    更新日期:2015-05-01 00:00:00

  • Tips and tricks of the surgical technique for borderline resectable pancreatic cancer: mesenteric approach and modified distal pancreatectomy with en-bloc celiac axis resection.

    abstract::Borderline resectable (BR) pancreatic cancer involves the portal vein and/or superior mesenteric vein (PV/SMV), major arteries including the superior mesenteric artery (SMA) or common hepatic artery (CHA), and sometimes includes the involvement of the celiac axis. We herein describe tips and tricks for a surgical tech...

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 杂志文章

    doi:10.1002/jhbp.184

    authors: Hirono S,Yamaue H

    更新日期:2015-02-01 00:00:00

  • Clinical practice guidelines for the management of biliary tract cancers 2019: The 3rd English edition.

    abstract:BACKGROUND:The Japanese Society of Hepato-Biliary-Pancreatic Surgery launched the clinical practice guidelines for the management of biliary tract cancers (cholangiocarcinoma, gallbladder cancer, and ampullary cancer) in 2007, then published the 2nd version in 2014. METHODS:In this 3rd version, clinical questions (CQs...

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 杂志文章

    doi:10.1002/jhbp.870

    authors: Nagino M,Hirano S,Yoshitomi H,Aoki T,Uesaka K,Unno M,Ebata T,Konishi M,Sano K,Shimada K,Shimizu H,Higuchi R,Wakai T,Isayama H,Okusaka T,Tsuyuguchi T,Hirooka Y,Furuse J,Maguchi H,Suzuki K,Yamazaki H,Kijima H,Ya

    更新日期:2021-01-01 00:00:00

  • Major hepatectomy for perihilar cholangiocarcinoma.

    abstract:BACKGROUND/PURPOSE:Hilar cholangiocarcinoma and intrahepatic cholangiocarcinoma involving the hepatic hilus are defined as "perihilar cholangiocarcinoma". The principle of surgical treatment is hemi-hepatectomy or trisectionectomy of the liver, caudate lobectomy, and resection of the extrahepatic bile duct for complete...

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 杂志文章

    doi:10.1007/s00534-009-0206-3

    authors: Unno M,Katayose Y,Rikiyama T,Yoshida H,Yamamoto K,Morikawa T,Hayashi H,Motoi F,Egawa S

    更新日期:2010-07-01 00:00:00

  • Small-for-size graft, small-for-size syndrome and inflow modulation in living donor liver transplantation.

    abstract::The extended application of living donor liver transplantation (LDLT) has revealed the problem of graft size mismatching called "small-for-size syndrome (SFSS)." The initial trials to resolve this problem involved increasing the procured graft size, from left to right, and even extending to include a right lobe graft....

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 杂志文章,评审

    doi:10.1002/jhbp.822

    authors: Ikegami T,Onda S,Furukawa K,Haruki K,Shirai Y,Gocho T

    更新日期:2020-11-01 00:00:00

  • Congenital absence of the portal vein: translated version.

    abstract::Congenital portosystemic shunt (CPS) is classified into type I (congenital absence of the portal vein) and type II, depending on the presence or absence of the intrahepatic portal vein. Reports still exist on cases in which psychiatric diseases or mental retardation was diagnosed or cases in which diagnosis and treatm...

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 杂志文章,评审

    doi:10.1002/jhbp.572

    authors: Sanada Y,Mizuta K

    更新日期:2018-08-01 00:00:00

  • Percutaneous and endoscopic gallbladder drainage for acute cholecystitis: international multicenter comparative study using propensity score-matched analysis.

    abstract:BACKGROUND:Tokyo Guideline 2013 (TG13) proposed three drainage techniques for the treatment of acute cholecystitis. We evaluated the clinical efficacy and adverse events between percutaneous transhepatic intervention (PTGBI) including percutaneous transhepatic gallbladder drainage (PTGBD) and percutaneous transhepatic ...

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 杂志文章,多中心研究

    doi:10.1002/jhbp.454

    authors: Itoi T,Takada T,Hwang TL,Endo I,Akazawa K,Miura F,Chen MF,Jan YY,Ker CG,Wang HP,Gomi H,Yokoe M,Kiriyama S,Wada K,Yamaue H,Miyazaki M,Yamamoto M

    更新日期:2017-06-01 00:00:00

  • Comparison of laparoscopic major hepatectomy with propensity score matched open cases from the National Clinical Database in Japan.

    abstract:BACKGROUND:The National Clinical Database (NCD) in Japan is a nationwide registry that collects the data of more than 1,200,000 surgical cases annually from over 3,500 hospitals. Based on the NCD data, this study compared the perioperative outcomes of major laparoscopic liver resection (LLR) with those of major open li...

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 杂志文章

    doi:10.1002/jhbp.405

    authors: Takahara T,Wakabayashi G,Konno H,Gotoh M,Yamaue H,Yanaga K,Fujimoto J,Kaneko H,Unno M,Endo I,Seto Y,Miyata H,Miyazaki M,Yamamoto M

    更新日期:2016-11-01 00:00:00

  • Clinical application of the biomarkers for the selection of adjuvant chemotherapy in pancreatic ductal adenocarcinoma.

    abstract:BACKGROUND:For the establishment of personalized therapy, we investigated biomarkers that can contribute to the selection of adjuvant therapy for pancreatic ductal adenocarcinoma (PDAC). METHODS:Between 2005 and 2014, of 141 consecutive patients with PDAC who underwent R0 or R1 resection, 61 patients given gemcitabine...

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 杂志文章

    doi:10.1002/jhbp.366

    authors: Oba A,Ban D,Kirimura S,Akahoshi K,Mitsunori Y,Matsumura S,Ochiai T,Kudo A,Tanaka S,Minoru T

    更新日期:2016-08-01 00:00:00

  • Risk factors and characteristics of young patients with the biliary tract carcinoma: results of a project study for biliary surgery by the Japanese Society of Hepato-Biliary-Pancreatic Surgery.

    abstract:PURPOSE:This study aimed to elucidate the characteristics of biliary tract carcinoma (BTC) in young patients. METHODS:This is a nationwide multicenter, retrospective cohort study supervised by the Japanese Society of Hepato-Biliary-Pancreatic Surgery (JSHBPS). Clinicopathological data of patients aged <50 years diagno...

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 杂志文章

    doi:10.1002/jhbp.776

    authors: Ariake K,Unno M,Yoshida H,Kubo S,Horiguchi A,Yamaue H,Yamamoto M

    更新日期:2020-09-01 00:00:00

  • Expression of Bcl-2 19-kDa interacting protein 3 predicts prognosis after ampullary carcinoma resection.

    abstract:BACKGROUND:An adequate management strategy for ampullary carcinoma (AC), a rare neoplasm, has yet to be determined. The aim of this study was to identify specific molecular markers allowing for the adequate management of AC. METHODS:The clinicopathological data of 41 patients who underwent curative resection of AC wer...

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 杂志文章

    doi:10.1002/jhbp.367

    authors: Fujimoto T,Ohtsuka T,Date K,Kimura H,Matsunaga T,Mori Y,Miyasaka Y,Mochidome N,Oda Y,Nakamura M

    更新日期:2016-08-01 00:00:00

  • Incidence and risk factors for anastomotic stenosis of continuous hepaticojejunostomy after pancreaticoduodenectomy.

    abstract:BACKGROUND:There have been no reports showing the incidence of anastomotic stenosis of continuous hepaticojejunostomy (HJ) and identifying its risk factors for patients who underwent pancreaticoduodenectomy (PD). METHOD:We retrospectively investigated 200 patients whose HJ was established by unified method, single lay...

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 杂志文章

    doi:10.1002/jhbp.385

    authors: Asano T,Natsume S,Senda Y,Sano T,Matsuo K,Kodera Y,Hara K,Ito S,Yamao K,Shimizu Y

    更新日期:2016-10-01 00:00:00