Clinical application of the biomarkers for the selection of adjuvant chemotherapy in pancreatic ductal adenocarcinoma.

abstract：BACKGROUND:An aberrant right posterior sectoral hepatic duct (PHD) draining into extrahepatic bile duct, gallbladder or cystic duct directly is a common and critical anomaly during cholecystectomy. This study aimed to investigate the frequency of aberrant PHD and describe why PHD is critical. METHODS:In 753 consecutiv...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Kurata M,Honda G,Okuda Y,Kobayashi S,Sakamoto K,Iwasaki S,Chiba K,Tabata T,Kuruma S,Kamisawa T

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND:Acute portal pressure rise is occasionally observed during intraportal islet infusion, especially in islet autotransplantation (IAT) where tissue purification is rarely applied. In this paper we investigate factors associated with acute portal pressure rise, a known risk factor for portal vein thrombosis. M...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Kawahara T,Kin T,Shapiro AM

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND:Delayed gastric emptying (DGE), a common postoperative complication of pancreaticoduodenectomy, is not considered a life-threatening complication. In the present study, we analyzed the risk factors for DGE and its impact on long-term prognosis. METHODS:We analyzed 383 patients who underwent pancreaticoduode...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Futagawa Y,Kanehira M,Furukawa K,Kitamura H,Yoshida S,Usuba T,Misawa T,Okamoto T,Yanaga K

更新日期：2017-08-01 00:00:00

abstract：:Enormous efforts have been made to establish pancreatic stem/progenitor cells as a source for regenerative medicine for the treatment of diabetes mellitus. In recent years, it has been recognized that the self-renewal of beta cells is the dominant process involved in postnatal beta-cell regeneration and expansion. Nev...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Sekine K,Taniguchi H

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:Recently, a new digital cholangiopancreatoscopy (DCPS) has been developed. The aim of this study is to retrospectively evaluate the utility of new DCPS in patients with pancreaticobiliary diseases. METHODS:Digital cholangiopancreatoscopy was used in 26 patients (16 men) with pancreaticobiliary diseases that...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Tanaka R,Itoi T,Honjo M,Tsuchiya T,Kurihara T,Tsuji S,Tonozuka R,Kamada K,Sofuni A,Mukai S

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:We investigated the aberrant expression of the STAT family in humans and liver fluke (Opisthorchis viverrini, Ov)-induced hamster cholangiocarcinoma (CCA) tissues. METHODS:The expression and phosphorylation of STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b and STAT6 in human hamster CCA tissues were immunohisto...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Dokduang H,Techasen A,Namwat N,Khuntikeo N,Pairojkul C,Murakami Y,Loilome W,Yongvanit P

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND:A total of 26 pancreas transplants from brain dead donors, including 21 simultaneous pancreas and kidney (SPK) transplantation procedures, have been performed at Fujita Health University Hospital since the new pancreas transplant program was initiated in August 2012. The objective of this study is to investi...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Ito T,Kenmochi T,Ono S,Oshima M,Aida N,Suzuki A,Hasegawa M,Kusaka M,Hoshinaga K

更新日期：2016-05-01 00:00:00

abstract：:For the resection of advanced liver tumors in which the tumor thrombus extends into the intrathoracic inferior vena cava (IVC) above the diaphragm, surgeons need very skillful techniques and much experience. However, after detachment of the line of fusion of the pericardium to the diaphragm (LFPD), the intrathoracic I...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Mizuno S,Kato H,Azumi Y,Kishiwada M,Hamada T,Usui M,Sakurai H,Tabata M,Shimpo H,Isaji S

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND:Although intraoperative peritoneal lavage is often performed routinely with the aim of reducing peritoneal contamination, little evidence of lavage benefits in elective liver resection without bile duct resection is available. We addressed the issue with a randomized clinical trial. METHODS:We prospectively...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Tanaka K,Matsuo K,Kawaguchi D,Murakami T,Hiroshima Y,Hirano A,Sato S,Endo I,Taguri M,Koda K

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:The aim was to examine the diagnostic ability of an endocytoscope system (ECS) for detecting the longitudinal extent of bile duct cancer. METHODS:We observed the surfaces of the bile duct of 28 consecutive patients undergoing biliary surgery both directly and under methylene blue staining by using an ECS. B...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Yoshikawa T,Hakamada K,Ogasawara H,Kimura N,Kudo D,Sakamoto Y,Ishido K,Toyoki Y,Morohashi S,Kijima H

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:The effects of ablation with various settings of powers and times using a newly developed radiofrequency (RF) ablation device, the Habib™ EndoHPB catheter, are not well known. In the present study, we examined the effects of a novel RF ablation catheter using resected fresh pig livers and evaluated the macro...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Itoi T,Isayama H,Sofuni A,Itokawa F,Tamura M,Watanabe Y,Moriyasu F,Kahaleh M,Habib N,Nagao T,Yokoyama T,Kasuya K,Kawakami H

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:Previous reports have suggested that patients with intraductal papillary mucinous neoplasm (IPMN) have a favorable prognosis after surgical resection. Thus, a variety of types of partial pancreatic resections have been advocated for treating these low-grade malignant tumors. However, the surgical outcome of ...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Nakagohri T,Kinoshita T,Konishi M,Takahashi S,Gotohda N,Kobayashi S,Kojima M,Miyauchi H,Asano T

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND:We aimed to clarify the clinical usefulness of one-step self-expandable metal stent (SEMS) placement for distal malignant biliary obstruction by comparing with two-step SEMS placement. METHODS:We retrospectively compared early complications, bilirubin level decreasing rate, and period of hospitalization bet...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Shimizu S,Naitoh I,Nakazawa T,Hayashi K,Miyabe K,Kondo H,Yoshida M,Yamashita H,Ohara H,Joh T

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:Since the publication of the Tokyo Guidelines (TG13) for the management of acute cholecystitis (AC), multidirectional studies have been published. However, epidemiological research about AC with big data was not projected. The aim of this study was to reveal the actual clinical conditions of AC. METHOD:The ...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Yokoe M,Takada T,Hwang TL,Endo I,Akazawa K,Miura F,Mayumi T,Mori R,Chen MF,Jan YY,Ker CG,Wang HP,Itoi T,Gomi H,Kiriyama S,Wada K,Yamaue H,Miyazaki M,Yamamoto M

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND:To investigate the potential anti-tumoral properties of propofol in pancreatic cancer and elucidate the underlying mechanisms. METHODS:The relative expression of ADAM metallopeptidase domain 8 (ADAM8) in response to hypoxia in Panc1 cells was analyzed by western blotting. The enzymatic activity was determin...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Gao Y,Yu X,Zhang F,Dai J

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND:Imaging study cannot identify patients with potential low-risk for lymph node (LN) metastasis in intrahepatic cholangiocarcinoma (ICC). The purpose of this study was to identify a low-risk group for LN metastasis in ICC using preoperatively available factors. METHODS:Data from 127 consecutive patients, who ...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Yoh T,Hatano E,Seo S,Terajima H,Uchida Y,Taura K,Yasuchika K,Uemoto S

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:IgG4-sclerosing cholangitis (IgG4-SC) patients have an increased level of serum IgG4, dense infiltration of IgG4-positive plasma cells with extensive fibrosis in the bile duct wall, and a good response to steroid therapy. However, it is not easy to distinguish IgG4-SC from primary sclerosing cholangitis, pan...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Ohara H,Okazaki K,Tsubouchi H,Inui K,Kawa S,Kamisawa T,Tazuma S,Uchida K,Hirano K,Yoshida H,Nishino T,Ko SB,Mizuno N,Hamano H,Kanno A,Notohara K,Hasebe O,Nakazawa T,Nakanuma Y,Takikawa H,Research Committee of IgG4

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND/PURPOSE:The purpose of the present study was to assess long-term outcomes following liver resection for colorectal liver metastases (CRLM) with concurrent extrahepatic disease and to identify the preoperative prognostic factors for selection of operative candidates. METHODS:In this retrospective, multi-inst...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Sawada Y,Sahara K,Endo I,Sakamoto K,Honda G,Beppu T,Kotake K,Yamamoto M,Takahashi K,Hasegawa K,Itabashi M,Hashiguchi Y,Kotera Y,Kobayashi S,Yamaguchi T,Tabuchi K,Kobayashi H,Yamaguchi K,Morita S,Natsume S,Miyazaki

更新日期：2020-11-01 00:00:00

abstract：:Steady progress is being made in endoscopic biliary intervention, especially endoscopic ultrasonography (EUS)-guided procedures. The EUS-guided rendezvous technique (EUS-RV) is a salvage method for failed selective biliary cannulation. The overall success rate of EUS-RV in 247 cases from seven published articles was 7...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Isayama H,Nakai Y,Kawakubo K,Kawakami H,Itoi T,Yamamoto N,Kogure H,Koike K

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND:Hypoxia is an important condition to promote angiogenesis that is essential to tumor progression, including pancreatic ductal adenocarcinoma (PDAC). We evaluated whether the immunohistochemistry for hypoxia inducible factor-1α (HIF-1α) was correlated with hepatic metastases in PDAC. METHODS:We examined the ...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Matsuo Y,Ding Q,Desaki R,Maemura K,Mataki Y,Shinchi H,Natsugoe S,Takao S

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:There are no multicenter studies on the influence of diabetes duration on pancreatic transplant outcomes. Our study aimed to determine how type 1 diabetes duration influenced survival of pancreatic grafts. METHODS:The data of 8,139 patients who received pancreas transplants during 2006-2015 were extracted f...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Zhou J,Dong Y,Mei S,Gu Y,Li Z,Xiang J,Zheng H,Chen Z,Huang Z,Hu Z

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The present study retrospectively analyzed the clinical impact of endoscopic papillectomy on the selection of a treatment strategy for patients with benign-malignant borderline lesions of the major duodenal papilla. PATIENTS AND METHODS:Between November 1995 and July 2009, 28 patients were selec...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Harano M,Ryozawa S,Iwano H,Taba K,Sen-Yo M,Sakaida I

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:The influence of donor-recipient gender mismatch on outcomes after liver transplantation (LT) is controversial. The aim of this study was to evaluate the effect of donor and recipient gender discordance on graft survival. METHODS:All patients who underwent primary LT from 1994-2012 at a single-center were i...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Croome KP,Segal D,Hernandez-Alejandro R,Adams PC,Thomson A,Chandok N

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:Resection using a stapler is a popular approach to distal pancreatectomy. However, the resulting leakage of pancreatic juice represents a serious problem. We have developed a force-fluorescence measurement as a first step towards the quantitative evaluation of pancreatic leakage due to tissue tearing under c...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Kobayashi E,Tsuchiya S,Akagi Y,Tomii N,Nakagawa K,Inai K,Muragaki Y,Asano T,Kim D

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:An adequate management strategy for ampullary carcinoma (AC), a rare neoplasm, has yet to be determined. The aim of this study was to identify specific molecular markers allowing for the adequate management of AC. METHODS:The clinicopathological data of 41 patients who underwent curative resection of AC wer...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Fujimoto T,Ohtsuka T,Date K,Kimura H,Matsunaga T,Mori Y,Miyasaka Y,Mochidome N,Oda Y,Nakamura M

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND:Since there is no reliable evidence on the safety of pancreaticoduodenectomy (PD) in chronic hepatic dysfunction (CHD) including liver cirrhosis (LC), the effects of CHD on patients undergoing PD were investigated. METHODS:This multi-institutional retrospective study analyzed 529 patients with CHD, includin...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Futagawa Y,Yanaga K,Kosuge T,Suka M,Isaji S,Hirano S,Murakami Y,Yamamoto M,Yamaue H

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:The study aim was to determine the short- and long-term results of lateral pancreaticojejunostomy for chronic pancreatitis at a single center in Japan. METHODS:The records of 64 consecutive patients were retrospectively reviewed. All patients underwent surgery at Hiroshima University Hospital between Decemb...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Sudo T,Murakami Y,Uemura K,Hashimoto Y,Kondo N,Nakagawa N,Sueda T

更新日期：2014-06-01 00:00:00

abstract：:Mucobilia is a rare pathologic condition characterized by the abnormal secretion and accumulation of abundant mucus within the biliary tree. It is usually seen in association with mucin-producing hepatobiliary and pancreatic tumors. Neoplastic transformation of these tumors can range from low-grade dysplasia to invasi...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Brown MA,Sakpal SV,Chamberlain RS

更新日期：2010-05-01 00:00:00

abstract：PURPOSE:This study aimed to elucidate the characteristics of biliary tract carcinoma (BTC) in young patients. METHODS:This is a nationwide multicenter, retrospective cohort study supervised by the Japanese Society of Hepato-Biliary-Pancreatic Surgery (JSHBPS). Clinicopathological data of patients aged <50 years diagno...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Ariake K,Unno M,Yoshida H,Kubo S,Horiguchi A,Yamaue H,Yamamoto M

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:We aimed to clarify the appropriate timing for performing percutaneous transhepatic gallbladder drainage (PTGBD) and cholecystectomy, and the effect of PTGBD on surgical difficulty in acute cholecystitis patients. METHODS:We retrospectively examined 46 patients who underwent laparoscopic cholecystectomy (LC...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Yamada K,Yamashita Y,Yamada T,Takeno S,Noritomi T

更新日期：2015-12-01 00:00:00