Sex differences in outcomes of acute pancreatitis: Findings from a nationwide analysis.

Abstract:

BACKGROUND:Sex is thought to play a significant role in predicting outcomes in numerous diseases. The role sex plays in acute pancreatitis (AP) remains limited. We sought to determine if sex is associated with hospitalization outcomes in this population, using a large national database. METHODS:This was a retrospective study of adult patients with AP utilizing the 2016 and 2017 National Inpatient Sample via ICD-10 codes. The clinical courses of females were compared to that of males. The primary outcome was all-cause inpatient mortality. Secondary outcomes, including healthcare utilization, were assessed. Statistical analyses were performed using STATA, version 16.1. RESULTS:Of the 553 480 adult patients hospitalized with AP; 25.3% had AP secondary to alcohol (61.4% male, 38.6% female) and 17.44% secondary to gallstones (48.6% male, 51.4% female). Females were significantly older than males (52.81 years vs 50.97 years, P < .01). Females had a significantly lower likelihood of mortality (aOR: 0.69), shock (aOR: 0.64), sepsis (aOR: 0.70), acute kidney injury (aOR 0.66), intensive care unit admission (aOR 0.53), and pancreatic drainage (aOR 0.61) as compared to males (all with P < .01). There was no significant difference between females and males with regards to mean length of stay and hospitalization charges and costs. CONCLUSIONS:In this large cohort of patients admitted for AP, despite being significantly older, we found that females had significantly improved clinical outcomes, including lower mortality, compared to males. Further prospective studies are needed to accurately understand these differences to guide clinical practice.

authors

Sharma S,Weissman S,Aburayyan K,Acharya A,Aziz M,Systrom HK,Lew D,Vohra I,Feuerstein JD,Pandol SJ

doi

10.1002/jhbp.890

subject

Has Abstract

pub_date

2021-01-08 00:00:00

eissn

1868-6974

issn

1868-6982

pub_type

杂志文章
  • Japanese clinical practice guidelines for congenital biliary dilatation.

    abstract::Until now, there have been no practical clinical guidelines for congenital biliary dilatation (CBD). In this review article, the Japanese Study Group on Congenital Biliary Dilatation (JSCBD) propose to establish clinical practice guidelines for CBD. Because the evidence-based literature is relatively small, we decided...

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 信件,评审

    doi:10.1002/jhbp.415

    authors: Ishibashi H,Shimada M,Kamisawa T,Fujii H,Hamada Y,Kubota M,Urushihara N,Endo I,Nio M,Taguchi T,Ando H,Japanese Study Group on Congenital Biliary Dilatation (JSCBD).

    更新日期:2017-01-01 00:00:00

  • Clinical impact of endoscopic papillectomy for benign-malignant borderline lesions of the major duodenal papilla.

    abstract:BACKGROUND AND PURPOSE:The present study retrospectively analyzed the clinical impact of endoscopic papillectomy on the selection of a treatment strategy for patients with benign-malignant borderline lesions of the major duodenal papilla. PATIENTS AND METHODS:Between November 1995 and July 2009, 28 patients were selec...

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 杂志文章

    doi:10.1007/s00534-010-0327-8

    authors: Harano M,Ryozawa S,Iwano H,Taba K,Sen-Yo M,Sakaida I

    更新日期:2011-03-01 00:00:00

  • Risk factors for major morbidity after hepatectomy for hepatocellular carcinoma in 293 recent cases.

    abstract:BACKGROUND/PURPOSE:The purpose of this study was to identify risk factors for major morbidity after hepatectomies for hepatocellular carcinoma (HCC). METHODS:Univariate and multivariate analyses of risk factors for major morbidity were performed in 293 patients who underwent hepatectomy for HCC between 2001 and 2008. ...

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 杂志文章

    doi:10.1007/s00534-010-0275-3

    authors: Sadamori H,Yagi T,Matsuda H,Shinoura S,Umeda Y,Yoshida R,Satoh D,Utsumi T,Ohnishi T

    更新日期:2010-09-01 00:00:00

  • Cancer stem cells as therapeutic targets of hepato-biliary-pancreatic cancers.

    abstract::Heterogeneity is one of the essential hallmarks of malignancies. Within bulk cancer cells, a striking variability differs in biological characteristics including the proliferation rate, cell-cell interaction, metastatic tendency and even sensitivity to anticancer therapies. Such diversity makes the investigation and t...

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 杂志文章,评审

    doi:10.1002/jhbp.248

    authors: Tanaka S

    更新日期:2015-07-01 00:00:00

  • Pathogenesis and classification of intrahepatic cholangiocarcinoma: different characters of perihilar large duct type versus peripheral small duct type.

    abstract::Intrahepatic cholangiocarcinomas (ICCs) are made up of heterogenous carcinomas arising from different anatomical sites of the liver. Two types of candidate stem/progenitor cells of the biliary tree are postulated to exist at the peribiliary glands for large bile ducts and at the canals of Hering for small ducts and he...

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 杂志文章,评审

    doi:10.1002/jhbp.154

    authors: Aishima S,Oda Y

    更新日期:2015-02-01 00:00:00

  • Randomized clinical trial of peritoneal lavage for preventing surgical site infection in elective liver surgery.

    abstract:BACKGROUND:Although intraoperative peritoneal lavage is often performed routinely with the aim of reducing peritoneal contamination, little evidence of lavage benefits in elective liver resection without bile duct resection is available. We addressed the issue with a randomized clinical trial. METHODS:We prospectively...

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/jhbp.222

    authors: Tanaka K,Matsuo K,Kawaguchi D,Murakami T,Hiroshima Y,Hirano A,Sato S,Endo I,Taguri M,Koda K

    更新日期:2015-06-01 00:00:00

  • Left hepatectomy or left trisectionectomy with resection of the caudate lobe and extrahepatic bile duct for hilar cholangiocarcinoma (with video).

    abstract:PURPOSE:Although left-sided hepatectomy, such as a left hepatectomy or left trisectionectomy with resection of the caudate lobe and extrahepatic bile duct, is used to treat hilar cholangiocarcinoma predominantly involving the left side of the hepatic hilum, it is associated with several difficult technical points. The ...

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 杂志文章,评审

    doi:10.1007/s00534-011-0474-6

    authors: Uesaka K

    更新日期:2012-05-01 00:00:00

  • Technical refinements of bile duct division in living donor liver surgery.

    abstract:BACKGROUND/PURPOSE:In spite of the great risk involved, the donor bile duct division procedure has not been thoroughly addressed in the literature. The purpose of this study is to show the appropriate approach to bile duct division in living donor hepatectomy. METHODS:Of 87 living donor liver surgeries, we performed b...

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 杂志文章

    doi:10.1007/s00534-010-0322-0

    authors: Takatsuki M,Eguchi S,Yamanouchi K,Hidaka M,Soyama A,Kanematsu T

    更新日期:2011-03-01 00:00:00

  • Basic knowledge of and a small trick for atraumatic needle driving in laparoscopic suturing.

    abstract::Highlight Although recent advances in robotic surgery have enabled more precise movements of the needle driver, a sophisticated laparoscopic suturing technique is still desired. Honda and colleagues describe the basic knowledge of and a small but useful trick for atraumatic needle driving in laparoscopic suturing, bas...

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 杂志文章

    doi:10.1002/jhbp.814

    authors: Honda G,Ome Y,Yoshida N,Kawamoto Y

    更新日期:2020-10-01 00:00:00

  • Tokyo Guidelines 2018: management strategies for gallbladder drainage in patients with acute cholecystitis (with videos).

    abstract::Since the publication of the Tokyo Guidelines in 2007 and their revision in 2013, appropriate management for acute cholecystitis has been more clearly established. Since the last revision, several manuscripts, especially for alternative endoscopic techniques, have been reported; therefore, additional evaluation and re...

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 信件,评审

    doi:10.1002/jhbp.504

    authors: Mori Y,Itoi T,Baron TH,Takada T,Strasberg SM,Pitt HA,Ukai T,Shikata S,Noguchi Y,Teoh AYB,Kim MH,Asbun HJ,Endo I,Yokoe M,Miura F,Okamoto K,Suzuki K,Umezawa A,Iwashita Y,Hibi T,Wakabayashi G,Han HS,Yoon YS,Cho

    更新日期:2018-01-01 00:00:00

  • Indocyanine green R15 ratio depends directly on liver perfusion flow rate.

    abstract:BACKGROUND:Indocyanine green (ICG) is a synthetic dye that is widely used to evaluate liver function in critically ill patients, before liver resection or after liver transplantation. Controversy still exists about the impact exerted on the ICG ratio after 15 min (ICG R15) by differences in liver perfusion rates, hyper...

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 杂志文章

    doi:10.1007/s00534-009-0160-0

    authors: Janssen MW,Druckrey-Fiskaaen KT,Omidi L,Sliwinski G,Thiele C,Donaubauer B,Polze N,Kaisers UX,Thiery J,Wittekind C,Hauss JP,Schön MR

    更新日期:2010-03-01 00:00:00

  • Gemcitabine-cisplatin versus gemcitabine-oxaliplatin doublet chemotherapy in advanced gallbladder cancers: a match pair analysis.

    abstract:BACKGROUND:Gemcitabine-cisplatin (GC) and gemcitabine-oxaliplatin (GO) are the most commonly used regimens in advanced gallbladder cancer (GBC). METHODS:The data of patients with advanced GBC, treated between January 2013 and June 2015 were retrieved. A 1:1 matching without replacement was performed by using nearest n...

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 杂志文章

    doi:10.1002/jhbp.439

    authors: Ramaswamy A,Ostwal V,Pinninti R,Kannan S,Bhargava P,Nashikkar C,Mirani J,Banavali S

    更新日期:2017-05-01 00:00:00

  • Feasibility of one-step endoscopic metal stenting for distal malignant biliary obstruction.

    abstract:BACKGROUND:We aimed to clarify the clinical usefulness of one-step self-expandable metal stent (SEMS) placement for distal malignant biliary obstruction by comparing with two-step SEMS placement. METHODS:We retrospectively compared early complications, bilirubin level decreasing rate, and period of hospitalization bet...

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 杂志文章

    doi:10.1002/jhbp.22

    authors: Shimizu S,Naitoh I,Nakazawa T,Hayashi K,Miyabe K,Kondo H,Yoshida M,Yamashita H,Ohara H,Joh T

    更新日期:2014-03-01 00:00:00

  • Preoperative biliary drainage associated with biliary stricture after pancreaticoduodenectomy: a population-based study.

    abstract:BACKGROUND:The rate of preoperative biliary drainage for pancreaticoduodenectomy has been increasing despite most recent evidence that favors avoiding it. Only a few studies have focused on late surgical complications - biliary stricture after pancreaticoduodenectomy and have produced only inconclusive results. We eval...

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 杂志文章

    doi:10.1002/jhbp.559

    authors: Wu CH,Ho TW,Wu JM,Kuo TC,Yang CY,Lai FP,Tien YW

    更新日期:2018-06-01 00:00:00

  • Propofol inhibits pancreatic cancer progress under hypoxia via ADAM8.

    abstract:BACKGROUND:To investigate the potential anti-tumoral properties of propofol in pancreatic cancer and elucidate the underlying mechanisms. METHODS:The relative expression of ADAM metallopeptidase domain 8 (ADAM8) in response to hypoxia in Panc1 cells was analyzed by western blotting. The enzymatic activity was determin...

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 杂志文章

    doi:10.1002/jhbp.624

    authors: Gao Y,Yu X,Zhang F,Dai J

    更新日期:2019-06-01 00:00:00

  • Congenital absence of the portal vein: translated version.

    abstract::Congenital portosystemic shunt (CPS) is classified into type I (congenital absence of the portal vein) and type II, depending on the presence or absence of the intrahepatic portal vein. Reports still exist on cases in which psychiatric diseases or mental retardation was diagnosed or cases in which diagnosis and treatm...

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 杂志文章,评审

    doi:10.1002/jhbp.572

    authors: Sanada Y,Mizuta K

    更新日期:2018-08-01 00:00:00

  • Reappraisal of the advantages of laparoscopic liver resection for intermediate hepatocellular carcinoma within a stage migration perspective: Propensity score analysis of the differential benefit.

    abstract:OBJECTIVE:The aim of the present study was to analyze the outcome of laparoscopic approach specifically in patients with Intermediate-stage disease and to define the differential benefit with Early-stage patients. METHODS:Six hundred twenty-two resections for HCC were dichotomized according to staging (Early and Inter...

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 杂志文章

    doi:10.1002/jhbp.736

    authors: Ratti F,Cipriani F,Fiorentini G,Catena M,Paganelli M,Aldrighetti L

    更新日期:2020-08-01 00:00:00

  • Role of thrombospondin-1 expression in colorectal liver metastasis and its molecular mechanism.

    abstract:BACKGROUND:Thrombospondin-1 (THBS-1), a glycoprotein, is an endogenous inhibitor of angiogenesis and tumor growth. In this study, we investigated the clinical role and mechanism of THBS-1 expression in colorectal liver metastases, focusing on the relationships between its expression and tumor growth, epithelial-mesench...

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 杂志文章

    doi:10.1002/jhbp.376

    authors: Teraoku H,Morine Y,Ikemoto T,Saito Y,Yamada S,Yoshikawa M,Takasu C,Higashijima J,Imura S,Shimada M

    更新日期:2016-09-01 00:00:00

  • Preoperative criterion identifying a low-risk group for lymph node metastasis in intrahepatic cholangiocarcinoma.

    abstract:BACKGROUND:Imaging study cannot identify patients with potential low-risk for lymph node (LN) metastasis in intrahepatic cholangiocarcinoma (ICC). The purpose of this study was to identify a low-risk group for LN metastasis in ICC using preoperatively available factors. METHODS:Data from 127 consecutive patients, who ...

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 杂志文章

    doi:10.1002/jhbp.552

    authors: Yoh T,Hatano E,Seo S,Terajima H,Uchida Y,Taura K,Yasuchika K,Uemoto S

    更新日期:2018-06-01 00:00:00

  • Novel concept of bared type metallic stent for endoscopic bilateral stent-in-stent placement in patients with hilar malignant biliary obstruction (with video).

    abstract::Highlight Takenaka and colleagues report on a novel bare uncovered self-expandable metal stent developed to be compatible with only 0.025-inch guide wires. This unprecedented feature makes the delivery tip thinner and more flexible than the conventional type and useful for endoscopic bilateral stent-in-stent placement...

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 杂志文章

    doi:10.1002/jhbp.698

    authors: Takenaka M,Nakai A,Kudo M

    更新日期:2020-05-01 00:00:00

  • Bile aspiration cytology in diagnosis of bile duct carcinoma: factors associated with positive yields.

    abstract:BACKGROUND/PURPOSE:In bile duct carcinoma (BDC) patients, bile aspiration cytology (BAC) is an established method for cytodiagnosis. However, almost all previous reports investigated the biliary strictures caused not only by BDC but also by gallbladder and pancreatic carcinomas. Therefore, BAC in BDC patients only has ...

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 杂志文章

    doi:10.1007/s00534-011-0419-0

    authors: Abdelghani YA,Arisaka Y,Masuda D,Takii M,Ashida R,Makhlouf MM,Fouad YM,Tsuji M,Kurisu Y,Higuchi K

    更新日期:2012-07-01 00:00:00

  • The endoscopic ultrasonography-guided rendezvous technique for biliary cannulation: a technical review.

    abstract::Steady progress is being made in endoscopic biliary intervention, especially endoscopic ultrasonography (EUS)-guided procedures. The EUS-guided rendezvous technique (EUS-RV) is a salvage method for failed selective biliary cannulation. The overall success rate of EUS-RV in 247 cases from seven published articles was 7...

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 杂志文章,评审

    doi:10.1007/s00534-012-0577-8

    authors: Isayama H,Nakai Y,Kawakubo K,Kawakami H,Itoi T,Yamamoto N,Kogure H,Koike K

    更新日期:2013-04-01 00:00:00

  • Disparities in the management and prophylaxis of surgical site infection and pancreatic fistula after pancreatoduodenectomy.

    abstract:BACKGROUND:Pancreatoduodenectomy (PD) carries a high morbidity. Over time, pancreatic surgeons have altered their perioperative management in efforts to reduce morbidity rates, thereby creating major technical and management variations. We aim to evaluate the practice patterns of hepato-pancreato-biliary (HPB) surgeons...

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 杂志文章,多中心研究

    doi:10.1002/jhbp.443

    authors: Macedo FIB,Mowzoon M,Parikh J,Sathyanarayana SA,Jacobs MJ

    更新日期:2017-05-01 00:00:00

  • Homing effect of adipose-derived stem cells to the injured liver: the shift of stromal cell-derived factor 1 expressions.

    abstract:BACKGROUND:Whether systemically transplanted human adipose-derived stem cells (ADSCs) homed to the injured liver in nude mice under stress with subsequent hepatectomy (Hx) and ischemia-reperfusion (I/R) was investigated in the present study. The types of cells in the liver that were involved in the homing of ADSCs were...

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 杂志文章

    doi:10.1002/jhbp.147

    authors: Saito Y,Shimada M,Utsunomiya T,Ikemoto T,Yamada S,Morine Y,Imura S,Mori H,Arakawa Y,Kanamoto M,Iwahashi S,Takasu C

    更新日期:2014-12-01 00:00:00

  • Living donor pancreas transplantation in Japan.

    abstract:BACKGROUND/PURPOSE:Living-donor pancreas transplants (LDPs) were introduced at Chiba-East National Hospital in 2004, and 12 LDPs have been performed at this institution to date. Based on the outcome of these 12 LDPs, the efficacy and safety of LDPs are herein discussed. METHODS:Twelve diabetic patients underwent LDPs;...

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 杂志文章

    doi:10.1007/s00534-009-0148-9

    authors: Kenmochi T,Asano T,Maruyama M,Saigo K,Akutsu N,Iwashita C,Ohtsuki K,Suzuki A,Miyazaki M

    更新日期:2010-03-01 00:00:00

  • Long-term outcome of liver resection for colorectal metastases in the presence of extrahepatic disease: A multi-institutional Japanese study.

    abstract:BACKGROUND/PURPOSE:The purpose of the present study was to assess long-term outcomes following liver resection for colorectal liver metastases (CRLM) with concurrent extrahepatic disease and to identify the preoperative prognostic factors for selection of operative candidates. METHODS:In this retrospective, multi-inst...

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 杂志文章

    doi:10.1002/jhbp.810

    authors: Sawada Y,Sahara K,Endo I,Sakamoto K,Honda G,Beppu T,Kotake K,Yamamoto M,Takahashi K,Hasegawa K,Itabashi M,Hashiguchi Y,Kotera Y,Kobayashi S,Yamaguchi T,Tabuchi K,Kobayashi H,Yamaguchi K,Morita S,Natsume S,Miyazaki

    更新日期:2020-11-01 00:00:00

  • Whereabouts of an internal short stent placed across the pancreaticojejunostomy following pancreatoduodenectomy.

    abstract:BACKGROUND/PURPOSE:It is generally thought that an internal short stent placed across the pancreaticojejunostomy (PJ) following pancreatoduodenectomy (PD) usually passes spontaneously through the rectum thereafter; however, we experienced some patients who presented with pancreatitis and cholangitis owing to delayed de...

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 杂志文章

    doi:10.1007/s00534-012-0533-7

    authors: Kadowaki S,Miura F,Amano H,Toyota N,Wada K,Shibuya M,Maeno S,Takada T,Sano K

    更新日期:2012-09-01 00:00:00

  • The evolving application of single-port robotic surgery in general surgery.

    abstract::Advances in the field of minimally invasive surgery have grown since the original advent of conventional multiport laparoscopic surgery. The recent development of single incision laparoscopic surgery remains a relatively novel technique, and has had mixed reviews as to whether it has been associated with lower pain sc...

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 历史文章,杂志文章,评审

    doi:10.1002/jhbp.37

    authors: Qadan M,Curet MJ,Wren SM

    更新日期:2014-01-01 00:00:00

  • Incidence and risk factors for anastomotic stenosis of continuous hepaticojejunostomy after pancreaticoduodenectomy.

    abstract:BACKGROUND:There have been no reports showing the incidence of anastomotic stenosis of continuous hepaticojejunostomy (HJ) and identifying its risk factors for patients who underwent pancreaticoduodenectomy (PD). METHOD:We retrospectively investigated 200 patients whose HJ was established by unified method, single lay...

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 杂志文章

    doi:10.1002/jhbp.385

    authors: Asano T,Natsume S,Senda Y,Sano T,Matsuo K,Kodera Y,Hara K,Ito S,Yamao K,Shimizu Y

    更新日期:2016-10-01 00:00:00

  • Descriptive review of acute cholecystitis: Japan-Taiwan collaborative epidemiological study.

    abstract:BACKGROUND:Since the publication of the Tokyo Guidelines (TG13) for the management of acute cholecystitis (AC), multidirectional studies have been published. However, epidemiological research about AC with big data was not projected. The aim of this study was to reveal the actual clinical conditions of AC. METHOD:The ...

    journal_title:Journal of hepato-biliary-pancreatic sciences

    pub_type: 杂志文章,多中心研究

    doi:10.1002/jhbp.450

    authors: Yokoe M,Takada T,Hwang TL,Endo I,Akazawa K,Miura F,Mayumi T,Mori R,Chen MF,Jan YY,Ker CG,Wang HP,Itoi T,Gomi H,Kiriyama S,Wada K,Yamaue H,Miyazaki M,Yamamoto M

    更新日期:2017-06-01 00:00:00