Pathogenesis and classification of intrahepatic cholangiocarcinoma: different characters of perihilar large duct type versus peripheral small duct type.

abstract：:The Milan criteria (MC) have been widely accepted as an effective way of selecting patients with early-stage hepatocellular carcinoma (HCC) for curative liver transplantation (LT). However, since a substantial subset of HCC patients exists that is beyond the MC but with the potential for good outcomes after LT, severa...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Takada Y,Tohyama T,Watanabe J

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:Since there is no reliable evidence on the safety of pancreaticoduodenectomy (PD) in chronic hepatic dysfunction (CHD) including liver cirrhosis (LC), the effects of CHD on patients undergoing PD were investigated. METHODS:This multi-institutional retrospective study analyzed 529 patients with CHD, includin...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Futagawa Y,Yanaga K,Kosuge T,Suka M,Isaji S,Hirano S,Murakami Y,Yamamoto M,Yamaue H

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND/PURPOSE:Laparoscopic cholecystectomy is difficult to perform in patients with a low-lying costal arch that entirely covers the liver. We conducted this study to clarify the factors related to a low-lying costal arch and establish countermeasures to circumvent this characteristic. METHODS:The study included ...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Tajima Y,Kuroki T,Kitasato A,Adachi T,Kosaka T,Okamoto T,Fujita F,Kanetaka K,Susumu S,Mochizuki S,Torashima Y,Kanematsu T

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Anoikis is a specialized cell apoptosis triggered by loss of cell adhesion. Acquisition of anoikis resistance is a key cancer hallmark that has been associated with metastasis of human malignancies. Cholangiocarcinoma (CCA) is a highly metastatic cancer of the bile duct, in which mechanisms underlying its re...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Huyen NT,Prachayasittikul V,Chan-On W

更新日期：2016-07-01 00:00:00

abstract：:Advances in the field of minimally invasive surgery have grown since the original advent of conventional multiport laparoscopic surgery. The recent development of single incision laparoscopic surgery remains a relatively novel technique, and has had mixed reviews as to whether it has been associated with lower pain sc...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Qadan M,Curet MJ,Wren SM

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:To investigate the potential anti-tumoral properties of propofol in pancreatic cancer and elucidate the underlying mechanisms. METHODS:The relative expression of ADAM metallopeptidase domain 8 (ADAM8) in response to hypoxia in Panc1 cells was analyzed by western blotting. The enzymatic activity was determin...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Gao Y,Yu X,Zhang F,Dai J

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND:Resection using a stapler is a popular approach to distal pancreatectomy. However, the resulting leakage of pancreatic juice represents a serious problem. We have developed a force-fluorescence measurement as a first step towards the quantitative evaluation of pancreatic leakage due to tissue tearing under c...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Kobayashi E,Tsuchiya S,Akagi Y,Tomii N,Nakagawa K,Inai K,Muragaki Y,Asano T,Kim D

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:The Japanese Society of Hepato-Biliary-Pancreatic Surgery launched the clinical practice guidelines for the management of biliary tract cancers (cholangiocarcinoma, gallbladder cancer, and ampullary cancer) in 2007, then published the 2nd version in 2014. METHODS:In this 3rd version, clinical questions (CQs...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Nagino M,Hirano S,Yoshitomi H,Aoki T,Uesaka K,Unno M,Ebata T,Konishi M,Sano K,Shimada K,Shimizu H,Higuchi R,Wakai T,Isayama H,Okusaka T,Tsuyuguchi T,Hirooka Y,Furuse J,Maguchi H,Suzuki K,Yamazaki H,Kijima H,Ya

更新日期：2021-01-01 00:00:00

abstract：:Surgical intervention and, more recently, endoscopic intervention have been performed for the treatment of malignant gastric outlet obstruction. Recently, endoscopic ultrasonography (EUS)-guided gastrojejunostomy using special devices has been established. In line with this, we have developed a novel EUS-guided double...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Itoi T,Ishii K,Tanaka R,Umeda J,Tonozuka R

更新日期：2015-01-01 00:00:00

abstract：:Heterogeneity is one of the essential hallmarks of malignancies. Within bulk cancer cells, a striking variability differs in biological characteristics including the proliferation rate, cell-cell interaction, metastatic tendency and even sensitivity to anticancer therapies. Such diversity makes the investigation and t...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Tanaka S

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND:Thrombospondin-1 (THBS-1), a glycoprotein, is an endogenous inhibitor of angiogenesis and tumor growth. In this study, we investigated the clinical role and mechanism of THBS-1 expression in colorectal liver metastases, focusing on the relationships between its expression and tumor growth, epithelial-mesench...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Teraoku H,Morine Y,Ikemoto T,Saito Y,Yamada S,Yoshikawa M,Takasu C,Higashijima J,Imura S,Shimada M

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND/PURPOSE:S-1 is a new oral fluoropyrimidine anticancer agent shown to be effective for pancreatic cancer. In a previous phase I trial, we evaluated the safety of S-1 combined with radiotherapy to determine the maximum tolerated dose and dose-limiting toxicity in patients with unresectable pancreatic cancer. T...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Shinchi H,Maemura K,Mataki Y,Kurahara H,Sakoda M,Ueno S,Hiraki Y,Nakajo M,Natsugoe S,Takao S

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND/PURPOSE:It is generally thought that an internal short stent placed across the pancreaticojejunostomy (PJ) following pancreatoduodenectomy (PD) usually passes spontaneously through the rectum thereafter; however, we experienced some patients who presented with pancreatitis and cholangitis owing to delayed de...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Kadowaki S,Miura F,Amano H,Toyota N,Wada K,Shibuya M,Maeno S,Takada T,Sano K

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:We investigated the aberrant expression of the STAT family in humans and liver fluke (Opisthorchis viverrini, Ov)-induced hamster cholangiocarcinoma (CCA) tissues. METHODS:The expression and phosphorylation of STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b and STAT6 in human hamster CCA tissues were immunohisto...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Dokduang H,Techasen A,Namwat N,Khuntikeo N,Pairojkul C,Murakami Y,Loilome W,Yongvanit P

更新日期：2014-10-01 00:00:00

abstract：:Highlight Although recent advances in robotic surgery have enabled more precise movements of the needle driver, a sophisticated laparoscopic suturing technique is still desired. Honda and colleagues describe the basic knowledge of and a small but useful trick for atraumatic needle driving in laparoscopic suturing, bas...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Honda G,Ome Y,Yoshida N,Kawamoto Y

更新日期：2020-10-01 00:00:00

abstract：:Mucobilia is a rare pathologic condition characterized by the abnormal secretion and accumulation of abundant mucus within the biliary tree. It is usually seen in association with mucin-producing hepatobiliary and pancreatic tumors. Neoplastic transformation of these tumors can range from low-grade dysplasia to invasi...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Brown MA,Sakpal SV,Chamberlain RS

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND:This study reviews the outcomes of retransplantation using living-donor right-liver grafts. METHODS:A retrospective study of liver retransplants performed between 1996 and 2013 was conducted. The retransplants were divided into the DD group (with deceased donors) and the LD group (with living donors). Survi...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Dai WC,Chan SC,Chok KS,Cheung TT,Sharr WW,Chan AC,Fung JY,Wong TC,Lo CM

更新日期：2014-08-01 00:00:00

abstract：:Borderline resectable (BR) pancreatic cancer involves the portal vein and/or superior mesenteric vein (PV/SMV), major arteries including the superior mesenteric artery (SMA) or common hepatic artery (CHA), and sometimes includes the involvement of the celiac axis. We herein describe tips and tricks for a surgical tech...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Hirono S,Yamaue H

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND:Delayed gastric emptying (DGE), a common postoperative complication of pancreaticoduodenectomy, is not considered a life-threatening complication. In the present study, we analyzed the risk factors for DGE and its impact on long-term prognosis. METHODS:We analyzed 383 patients who underwent pancreaticoduode...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Futagawa Y,Kanehira M,Furukawa K,Kitamura H,Yoshida S,Usuba T,Misawa T,Okamoto T,Yanaga K

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:The effects of ablation with various settings of powers and times using a newly developed radiofrequency (RF) ablation device, the Habib™ EndoHPB catheter, are not well known. In the present study, we examined the effects of a novel RF ablation catheter using resected fresh pig livers and evaluated the macro...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Itoi T,Isayama H,Sofuni A,Itokawa F,Tamura M,Watanabe Y,Moriyasu F,Kahaleh M,Habib N,Nagao T,Yokoyama T,Kasuya K,Kawakami H

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:Peroral pancreatoscopy (POPS) using a mother-baby endoscope system is often useful for assessment of intraductal papillary mucinous neoplasm (IPMN) of the pancreas with main pancreatic duct (MPD) involvement, but is not widely used for several reasons. The aim of this study was to evaluate the usefulness of ...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Nagayoshi Y,Aso T,Ohtsuka T,Kono H,Ideno N,Igarashi H,Takahata S,Oda Y,Ito T,Tanaka M

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:Sex is thought to play a significant role in predicting outcomes in numerous diseases. The role sex plays in acute pancreatitis (AP) remains limited. We sought to determine if sex is associated with hospitalization outcomes in this population, using a large national database. METHODS:This was a retrospectiv...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Sharma S,Weissman S,Aburayyan K,Acharya A,Aziz M,Systrom HK,Lew D,Vohra I,Feuerstein JD,Pandol SJ

更新日期：2021-01-08 00:00:00

abstract：BACKGROUND:Stent-stone complex (SSC) formation is one of the complications of endoscopic biliary stent placement. This study aimed to clarify the clinical characteristics and risk factors for SSC formation following plastic stent (PS) placement in patients with common bile duct (CBD) stones. METHODS:We retrospectively...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Kaneko J,Kawata K,Watanabe S,Chida T,Matsushita M,Suda T,Kobayashi Y

更新日期：2018-10-01 00:00:00

abstract：:Segmentectomy is anatomical resection of segments based on the classification of Couinaud. This procedure is performed mainly for hepatocellular carcinoma. Invasion of portal vein and intrahepatic metastases often occur with hepatocellular carcinoma. Thus, it is desirable to perform anatomical resection of the cancer-...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Yoshida H,Katayose Y,Rikiyama T,Motoi F,Onogawa T,Egawa S,Unno M

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:We aimed to clarify the clinical usefulness of one-step self-expandable metal stent (SEMS) placement for distal malignant biliary obstruction by comparing with two-step SEMS placement. METHODS:We retrospectively compared early complications, bilirubin level decreasing rate, and period of hospitalization bet...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Shimizu S,Naitoh I,Nakazawa T,Hayashi K,Miyabe K,Kondo H,Yoshida M,Yamashita H,Ohara H,Joh T

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:Tokyo Guideline 2013 (TG13) proposed three drainage techniques for the treatment of acute cholecystitis. We evaluated the clinical efficacy and adverse events between percutaneous transhepatic intervention (PTGBI) including percutaneous transhepatic gallbladder drainage (PTGBD) and percutaneous transhepatic ...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Itoi T,Takada T,Hwang TL,Endo I,Akazawa K,Miura F,Chen MF,Jan YY,Ker CG,Wang HP,Gomi H,Yokoe M,Kiriyama S,Wada K,Yamaue H,Miyazaki M,Yamamoto M

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND AND STUDY AIMS:Expression of the forkhead/winged helix family of transcription factor P3+ regulatory T cells (FOXP3(+) Treg), a master gene of regulatory T cells (Treg) is observed in patients with autoimmune pancreatitis (AIP). We investigated the usefulness of detection of FOXP3(+) Treg in the main duodena...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Kubota K,Kato S,Watanabe S,Fujita K,Yoneda M,Takahashi H,Inamori M,Shimamura T,Kirikoshi H,Kobayashi N,Saito S,Hisatomi K,Matsuhashi N,Nakajima A

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND:Hypoxia is an important condition to promote angiogenesis that is essential to tumor progression, including pancreatic ductal adenocarcinoma (PDAC). We evaluated whether the immunohistochemistry for hypoxia inducible factor-1α (HIF-1α) was correlated with hepatic metastases in PDAC. METHODS:We examined the ...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Matsuo Y,Ding Q,Desaki R,Maemura K,Mataki Y,Shinchi H,Natsugoe S,Takao S

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:For the establishment of personalized therapy, we investigated biomarkers that can contribute to the selection of adjuvant therapy for pancreatic ductal adenocarcinoma (PDAC). METHODS:Between 2005 and 2014, of 141 consecutive patients with PDAC who underwent R0 or R1 resection, 61 patients given gemcitabine...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Oba A,Ban D,Kirimura S,Akahoshi K,Mitsunori Y,Matsumura S,Ochiai T,Kudo A,Tanaka S,Minoru T

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND:Surgical indications for liver hemangioma remain unclear. METHODS:Of 510 patients undergoing surgical resection for liver hemangioma in 118 Japanese centers between 1998 and 2012, abdominal symptoms, diagnostic accuracy, and surgical outcomes were analyzed to propose size-based surgical indications. Patient...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Sakamoto Y,Kokudo N,Watadani T,Shibahara J,Yamamoto M,Yamaue H,Japanese Society of Hepato-Biliary-Pancreatic Surgery.

更新日期：2017-07-01 00:00:00