Abstract:
BACKGROUND/PURPOSE:The purpose of the present study was to assess long-term outcomes following liver resection for colorectal liver metastases (CRLM) with concurrent extrahepatic disease and to identify the preoperative prognostic factors for selection of operative candidates. METHODS:In this retrospective, multi-institutional study, 3820 patients diagnosed with CRLM during 2005-2007 were identified using nationwide survey data. Data of identified patients with concurrent extrahepatic lesions were analyzed to estimate the impact of liver resection on overall survival (OS) and to identify preoperative, prognostic indicators. RESULTS:Three- and 5-year OS rates after liver resection in 251 CRLM patients with extrahepatic disease (lung, n = 116; lymph node, n = 51; peritoneal, n = 37; multiple sites, n = 23) were 50.2% and 32.0%, respectively. Multivariate analysis revealed that a primary tumor in the right colon, lymph node metastasis from the primary tumor, serum carbohydrate antigen (CA) 19-9 level >37 UI/mL, the site of extrahepatic disease, and residual liver tumor after hepatectomy were associated with higher mortality. We proposed a preoperative risk scoring system based on these factors that adequately discriminated 5-year OS after liver resection in training and validation datasets. CONCLUSIONS:Performing R0 liver resection for colorectal liver metastases with treatable extrahepatic disease may prolong survival. Our proposed scoring system may help select appropriate candidates for liver resection.
journal_name
J Hepatobiliary Pancreat Scijournal_title
Journal of hepato-biliary-pancreatic sciencesauthors
Sawada Y,Sahara K,Endo I,Sakamoto K,Honda G,Beppu T,Kotake K,Yamamoto M,Takahashi K,Hasegawa K,Itabashi M,Hashiguchi Y,Kotera Y,Kobayashi S,Yamaguchi T,Tabuchi K,Kobayashi H,Yamaguchi K,Morita S,Natsume S,Miyazakidoi
10.1002/jhbp.810subject
Has Abstractpub_date
2020-11-01 00:00:00pages
810-818issue
11eissn
1868-6974issn
1868-6982journal_volume
27pub_type
杂志文章abstract:BACKGROUND:Aspirin is widely used for the secondary prevention of ischemic stroke and cardiovascular disease. Perioperative aspirin may decrease thrombotic morbidity, but may also increase hemorrhagic morbidity. In particular, liver resection carries risks of bleeding, leading to higher risks of hemorrhagic morbidity. ...
journal_title:Journal of hepato-biliary-pancreatic sciences
pub_type: 杂志文章
doi:10.1002/jhbp.461
更新日期:2017-07-01 00:00:00
abstract:BACKGROUND:Pancreaticobiliary malignant diseases are primarily treated by surgical resection. However, the surgical indications for elderly patients, especially for pancreaticoduodenectomy (PD), must be carefully considered due to patient compliance. Whether PD can contribute to better prognoses in elderly patients rem...
journal_title:Journal of hepato-biliary-pancreatic sciences
pub_type: 杂志文章
doi:10.1002/jhbp.840
更新日期:2020-10-15 00:00:00
abstract:BACKGROUND:Anoikis is a specialized cell apoptosis triggered by loss of cell adhesion. Acquisition of anoikis resistance is a key cancer hallmark that has been associated with metastasis of human malignancies. Cholangiocarcinoma (CCA) is a highly metastatic cancer of the bile duct, in which mechanisms underlying its re...
journal_title:Journal of hepato-biliary-pancreatic sciences
pub_type: 杂志文章
doi:10.1002/jhbp.354
更新日期:2016-07-01 00:00:00
abstract:BACKGROUND AND STUDY AIMS:Expression of the forkhead/winged helix family of transcription factor P3+ regulatory T cells (FOXP3(+) Treg), a master gene of regulatory T cells (Treg) is observed in patients with autoimmune pancreatitis (AIP). We investigated the usefulness of detection of FOXP3(+) Treg in the main duodena...
journal_title:Journal of hepato-biliary-pancreatic sciences
pub_type: 杂志文章
doi:10.1007/s00534-010-0359-0
更新日期:2011-05-01 00:00:00
abstract:OBJECTIVE:Roles of magnetic resonance cholangiopancreatography (MRCP), endoscopic retrograde cholangiopancreatography (ERCP), drip infusion cholangiography with computed tomography (DIC-CT), and intraoperative cholangiopancreatography (IOCP) in visualizing pancreaticobiliary anatomy for pediatric choledocal cyst (CC) o...
journal_title:Journal of hepato-biliary-pancreatic sciences
pub_type: 杂志文章
doi:10.1002/jhbp.347
更新日期:2016-06-01 00:00:00
abstract:BACKGROUND:Previous reports have suggested that patients with intraductal papillary mucinous neoplasm (IPMN) have a favorable prognosis after surgical resection. Thus, a variety of types of partial pancreatic resections have been advocated for treating these low-grade malignant tumors. However, the surgical outcome of ...
journal_title:Journal of hepato-biliary-pancreatic sciences
pub_type: 杂志文章,多中心研究
doi:10.1007/s00534-009-0173-8
更新日期:2010-11-01 00:00:00
abstract:BACKGROUND:Resection using a stapler is a popular approach to distal pancreatectomy. However, the resulting leakage of pancreatic juice represents a serious problem. We have developed a force-fluorescence measurement as a first step towards the quantitative evaluation of pancreatic leakage due to tissue tearing under c...
journal_title:Journal of hepato-biliary-pancreatic sciences
pub_type: 杂志文章
doi:10.1002/jhbp.775
更新日期:2020-11-01 00:00:00
abstract:BACKGROUND:Sex is thought to play a significant role in predicting outcomes in numerous diseases. The role sex plays in acute pancreatitis (AP) remains limited. We sought to determine if sex is associated with hospitalization outcomes in this population, using a large national database. METHODS:This was a retrospectiv...
journal_title:Journal of hepato-biliary-pancreatic sciences
pub_type: 杂志文章
doi:10.1002/jhbp.890
更新日期:2021-01-08 00:00:00
abstract:BACKGROUND:Since the publication of the Tokyo Guidelines (TG13) for the management of acute cholecystitis (AC), multidirectional studies have been published. However, epidemiological research about AC with big data was not projected. The aim of this study was to reveal the actual clinical conditions of AC. METHOD:The ...
journal_title:Journal of hepato-biliary-pancreatic sciences
pub_type: 杂志文章,多中心研究
doi:10.1002/jhbp.450
更新日期:2017-06-01 00:00:00
abstract:BACKGROUND/PURPOSE:Sinisan, a traditional Chinese medicine, is effective for the treatment of gastrointestinal disorders. In this study, we investigated the potential protective role of Sinisan against chronic pancreatitis (CP) in rats. METHODS:CP was induced in rats by intrapancreatic injection of trinitrobenzene sul...
journal_title:Journal of hepato-biliary-pancreatic sciences
pub_type: 杂志文章
doi:10.1007/s00534-010-0368-z
更新日期:2011-07-01 00:00:00
abstract:BACKGROUND:Hypoxia is an important condition to promote angiogenesis that is essential to tumor progression, including pancreatic ductal adenocarcinoma (PDAC). We evaluated whether the immunohistochemistry for hypoxia inducible factor-1α (HIF-1α) was correlated with hepatic metastases in PDAC. METHODS:We examined the ...
journal_title:Journal of hepato-biliary-pancreatic sciences
pub_type: 杂志文章
doi:10.1002/jhbp.6
更新日期:2014-02-01 00:00:00
abstract:BACKGROUND:A total of 26 pancreas transplants from brain dead donors, including 21 simultaneous pancreas and kidney (SPK) transplantation procedures, have been performed at Fujita Health University Hospital since the new pancreas transplant program was initiated in August 2012. The objective of this study is to investi...
journal_title:Journal of hepato-biliary-pancreatic sciences
pub_type: 杂志文章
doi:10.1002/jhbp.339
更新日期:2016-05-01 00:00:00
abstract::Highlight Although recent advances in robotic surgery have enabled more precise movements of the needle driver, a sophisticated laparoscopic suturing technique is still desired. Honda and colleagues describe the basic knowledge of and a small but useful trick for atraumatic needle driving in laparoscopic suturing, bas...
journal_title:Journal of hepato-biliary-pancreatic sciences
pub_type: 杂志文章
doi:10.1002/jhbp.814
更新日期:2020-10-01 00:00:00
abstract:BACKGROUND:Since there is no reliable evidence on the safety of pancreaticoduodenectomy (PD) in chronic hepatic dysfunction (CHD) including liver cirrhosis (LC), the effects of CHD on patients undergoing PD were investigated. METHODS:This multi-institutional retrospective study analyzed 529 patients with CHD, includin...
journal_title:Journal of hepato-biliary-pancreatic sciences
pub_type: 杂志文章,多中心研究
doi:10.1002/jhbp.630
更新日期:2019-07-01 00:00:00
abstract::Mucobilia is a rare pathologic condition characterized by the abnormal secretion and accumulation of abundant mucus within the biliary tree. It is usually seen in association with mucin-producing hepatobiliary and pancreatic tumors. Neoplastic transformation of these tumors can range from low-grade dysplasia to invasi...
journal_title:Journal of hepato-biliary-pancreatic sciences
pub_type: 杂志文章,评审
doi:10.1007/s00534-009-0150-2
更新日期:2010-05-01 00:00:00
abstract:BACKGROUND:Although intraoperative peritoneal lavage is often performed routinely with the aim of reducing peritoneal contamination, little evidence of lavage benefits in elective liver resection without bile duct resection is available. We addressed the issue with a randomized clinical trial. METHODS:We prospectively...
journal_title:Journal of hepato-biliary-pancreatic sciences
pub_type: 杂志文章,随机对照试验
doi:10.1002/jhbp.222
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND:Indocyanine green (ICG) is a synthetic dye that is widely used to evaluate liver function in critically ill patients, before liver resection or after liver transplantation. Controversy still exists about the impact exerted on the ICG ratio after 15 min (ICG R15) by differences in liver perfusion rates, hyper...
journal_title:Journal of hepato-biliary-pancreatic sciences
pub_type: 杂志文章
doi:10.1007/s00534-009-0160-0
更新日期:2010-03-01 00:00:00
abstract::Liver function reserve estimation is important for selecting the appropriate patients for hepatectomy or ablation of tumors. Many liver function tests have been devised, but the indocyanine green (ICG) clearance test remains the most popular for its simplicity and perhaps accuracy. Compared with the Child-Pugh classif...
journal_title:Journal of hepato-biliary-pancreatic sciences
pub_type: 杂志文章,评审
doi:10.1007/s00534-009-0229-9
更新日期:2010-07-01 00:00:00
abstract:BACKGROUND:Postoperative pancreatic fistula (PF) remains a major complication after pancreaticoduodenectomy (PD). We aimed to investigate the predictors of clinically relevant PF after PD. METHODS:We retrospectively analyzed the predictive factors of relevant grade B/C PF using logistic regression analysis of 100 cons...
journal_title:Journal of hepato-biliary-pancreatic sciences
pub_type: 杂志文章
doi:10.1002/jhbp.11
更新日期:2014-02-01 00:00:00
abstract::In the EASL and AASLD guidelines, hepatic resection (HR) is considered the first option for patients in stage 0 (very early HCC). This statement was not based on randomized controlled trials (RCTs) versus other therapies, but on the oncological assumption that HR is the better procedure for obtaining complete tumor ab...
journal_title:Journal of hepato-biliary-pancreatic sciences
pub_type: 杂志文章,评审
doi:10.1007/s00534-009-0244-x
更新日期:2010-07-01 00:00:00
abstract:BACKGROUND/PURPOSE:Recent introduction of multi-detector CT (MDCT) and high-speed magnetic resonance (MR) imaging have dramatically advanced visualization and imaging technology in diagnostic and therapeutic strategy in hepatobiliary pancreatic disease. However, image diagnostics have progressed with a background of th...
journal_title:Journal of hepato-biliary-pancreatic sciences
pub_type: 杂志文章,评审
doi:10.1007/s00534-009-0192-5
更新日期:2010-09-01 00:00:00
abstract::Many authors at high-volume centers all over the world have reported improved outcomes of hilar cholangiocarcinoma by several aggressive surgical approaches such as extended hepatic resection, combined vascular resection, and hepatopancreaticoduodenectomy in recent years. There has been great progress in the surgical ...
journal_title:Journal of hepato-biliary-pancreatic sciences
pub_type: 杂志文章
doi:10.1007/s00534-009-0207-2
更新日期:2010-07-01 00:00:00
abstract:BACKGROUND:The aim of this study was to compare the long-term outcomes and perioperative outcomes of laparoscopic liver resection (LLR) with those of open liver resection (OLR) for hepatocellular carcinoma (HCC) between well-matched patient groups. METHODS:Hepatocellular carcinoma patients underwent primary liver rese...
journal_title:Journal of hepato-biliary-pancreatic sciences
pub_type: 杂志文章,多中心研究
doi:10.1002/jhbp.276
更新日期:2015-10-01 00:00:00
abstract::Left hepatectomy is one of the most common types of hepatectomy. In order to perform the procedure, surgeons need to possess all the basic skills for accomplishing any liver resection. The most important points to bear in mind in relation to left hepatectomy are: (1) a precise recognition of the surgical anatomy of th...
journal_title:Journal of hepato-biliary-pancreatic sciences
pub_type: 杂志文章
doi:10.1007/s00534-011-0452-z
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:IgG4-sclerosing cholangitis (IgG4-SC) patients have an increased level of serum IgG4, dense infiltration of IgG4-positive plasma cells with extensive fibrosis in the bile duct wall, and a good response to steroid therapy. However, it is not easy to distinguish IgG4-SC from primary sclerosing cholangitis, pan...
journal_title:Journal of hepato-biliary-pancreatic sciences
pub_type: 杂志文章,实务指引
doi:10.1007/s00534-012-0521-y
更新日期:2012-09-01 00:00:00
abstract::Surgical intervention and, more recently, endoscopic intervention have been performed for the treatment of malignant gastric outlet obstruction. Recently, endoscopic ultrasonography (EUS)-guided gastrojejunostomy using special devices has been established. In line with this, we have developed a novel EUS-guided double...
journal_title:Journal of hepato-biliary-pancreatic sciences
pub_type: 杂志文章,评审
doi:10.1002/jhbp.148
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND/PURPOSE:Ampulla of Vater (AoV) carcinoma is a rare tumor that accounts for approximately 0.2% of gastrointestinal malignancies. There are no clinical guidelines concerning the treatment of AoV carcinoma. This study aimed to investigate the effectiveness of adjuvant treatment in AoV carcinoma following curati...
journal_title:Journal of hepato-biliary-pancreatic sciences
pub_type: 杂志文章
doi:10.1002/jhbp.801
更新日期:2020-10-01 00:00:00
abstract::Since the introduction of endoscopic sphincterotomy, stone clearance of the bile duct can be achieved by conventional endoscopic means in up to 90% of patients with stone disease. Several endoscopic therapies for difficult bile duct stones have been introduced. Laser therapy for stone fragmentation under direct visual...
journal_title:Journal of hepato-biliary-pancreatic sciences
pub_type: 杂志文章,评审
doi:10.1007/s00534-010-0360-7
更新日期:2011-05-01 00:00:00
abstract:BACKGROUND/PURPOSE:Pylorus-preserving pancreaticoduodenectomy (PPPD) is the treatment of choice for benign or premalignant pancreatic head lesions. Duodenum-preserving pancreatic head resection (DPPHR) has been reported in only 132 patients. This study aimed to compare the long-term results of DPPHR and PPPD. METHODS:...
journal_title:Journal of hepato-biliary-pancreatic sciences
pub_type: 杂志文章
doi:10.1007/s00534-010-0317-x
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:The rate of preoperative biliary drainage for pancreaticoduodenectomy has been increasing despite most recent evidence that favors avoiding it. Only a few studies have focused on late surgical complications - biliary stricture after pancreaticoduodenectomy and have produced only inconclusive results. We eval...
journal_title:Journal of hepato-biliary-pancreatic sciences
pub_type: 杂志文章
doi:10.1002/jhbp.559
更新日期:2018-06-01 00:00:00